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Research Outputs

  1. 2020
  2. Howard, D, Folkersen, L, Coleman, J, Adams, M, Glanville, K, Werge, T, Hagenaars, S, Han, B, Porteous, D, Campbell, A, Clarke, T-K, Breen, G, Sullivan, PF, Wray, NR, Lewis, C & McIntosh, A 2020, 'Genetic stratification of depression in UK Biobank', Translational psychiatry.
  3. Glanville, KP, Coleman, JRI, Hanscombe, KB, Euesden, J, Choi, SW, Purves, K, Breen, G, Air, TM, Andlauer, TMF, Baune, BT, Binder, EB, Blackwood, DHR, Boomsma, DI, Buttenschøn, HN, Colodro-Conde, L, Dannlowski, U, Direk, N, Dunn, EC, Forstner, AJ, de Geus, EJC, Grabe, HJ, Hamilton, SP, Jones, I, Jones, LA, Knowles, JA, Kutalik, Z, Levinson, DF, Lewis, G, Lind, PA, Lucae, S, Lucae, S, Magnusson., PKE, McGuffin, P, McIntosh, A, Milaneschi, Y, Lewis, CM, Mostafavi, S, Muller-Myhsok, B, Pedersen, NL, Penninx, BW, Potash, JB, Preisig, M, Ripke, S, Shi, J, Shyn, SI, Smoller, JW, Streit, F, Sullivan, PF, Tiemeier, H, Uher, R, der Auwera, SV, Weissman, MM, O'Reilly, PF & Lewis, CM 2020, 'Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression', Biological psychiatry, vol. 87, no. 5, pp. 419-430. https://doi.org/10.1016/j.biopsych.2019.06.031
  4. Fabbri, C, Kasper, S, Kautzky, A, Zohar, J, Souery, D, Montgomery, S, Albani, D, Forloni, G, Ferentinos, P, Rujescu, D, Mendlewicz, J, Uher, R, Lewis, CM & Serretti, A 2020, 'A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotyping', Translational psychiatry, vol. 10, no. 1, 50. https://doi.org/10.1038/s41398-020-0738-5
  5. Bipolar Disorder Working Group of the Psychiatric Genomics Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2020, 'The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls', Biological psychiatry. https://doi.org/10.1016/j.biopsych.2019.10.015
  6. 2019
  7. Paul, R, Andlauer, TFM, Czamara, D, Hoehn, D, Lucae, S, Pütz, B, Lewis, CM, Uher, R, Müller-Myhsok, B, Ising, M & Sämann, PG 2019, 'Treatment response classes in major depressive disorder identified by model-based clustering and validated by clinical prediction models', Translational psychiatry, vol. 9, no. 1, 187. https://doi.org/10.1038/s41398-019-0524-4
  8. Maybury, CM, Porter, HF, Kloczko, E, Duckworth, M, Cotton, A, Thornberry, K, Dew, T, Crook, M, Natas, S, Miquel, R, Lewis, CM, Wong, T, Smith, CH & Barker, JN 2019, 'Prevalence of Advanced Liver Fibrosis in Patients With Severe Psoriasis', JAMA dermatology, vol. 155, no. 9, pp. 1028-1032. https://doi.org/10.1001/jamadermatol.2019.0721
  9. Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Mullins, N, Bigdeli, TB, Børglum, AD, Coleman, JRI, Demontis, D, Mehta, D, Power, RA, Ripke, S, Stahl, EA, Starnawska, A, Anjorin, A, Corvin, A, Sanders, AR, Forstner, AJ, Reif, A, Koller, AC, Świątkowska, B, Baune, BT, Müller-Myhsok, B, Penninx, BWJH, Pato, CN, Zai, CC, Rujescu, D, Hougaard, DM, Quested, D, Levinson, DF, Binder, EB, Byrne, EM, Agerbo, E, Streit, F, Mayoral, F, Bellivier, F, Degenhardt, F, Breen, GD, Morken, G, Turecki, G, Rouleau, G, Grabe, HJ, Volzke, H, Jones, I, Giegling, I, Agartz, I, Melle, I, Lawrence, J, Walters, JTR, Strohmaier, J, Shi, J, Hauser, J, Biernacka, JM, Vincent, JB, Kelsoe, J, Strauss, JS, Lissowska, J, Pimm, J, Smoller, JW, Guzman-Parra, J, Berger, K, Scott, LJ, Jones, LA, Azevedo, MH, Trzaskowski, M, Kogevinas, M, Rietschel, M, Boks, MP, Ising, M, Grigoroiu-Serbanescu, M, Hamshere, ML, Leboyer, M, Frye, MA, Alda, M, Nordentoft, M, Boehnke, M, O'Donovan, MC, Owen, MJ, Pato, MT, Renteria, ME, Wray, NR, Bass, N, Craddock, N, Smeland, OB, Andreassen, OA, Mors, O, Gejman, PV, Sklar, P, McGrath, PJ, Hoffmann, P, McGuffin, P, Lee, PH, Mortensen, PB, Kahn, RS, Ophoff, RA, Adolfsson, R, Van der Auwera Affiliations, S, Djurovic, S, Kloiber, S, Heilmann-Heimbach, S, Jamain, S, Hamilton, SP, Mcelroy, SL, Lucae, S, Cichon, S, Schulze, TG, Hansen, T, Werge, T, Air, TM, Nimgaonkar, V, Appadurai, V, Cahn, W, Milaneschi, Y, Fanous, AH, Kendler, KS, McQuillin, A & Lewis, CM 2019, 'Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores', The American Journal of Psychiatry, vol. 176, no. 8, pp. 651-660. https://doi.org/10.1176/appi.ajp.2019.18080957
  10. Zhang, X, Abdellaoui, A, Rucker, J, de Jong, S, Potash, JB, Weissman, MM, Shi, J, Knowles, JA, Pato, C, Pato, M, Sobell, J, Smit, JH, Hottenga, JJ, de Geus, EJC, Lewis, CM, Buttenschøn, HN, Craddock, N, Jones, I, Jones, L, McGuffin, P, Mors, O, Owen, MJ, Preisig, M, Rietschel, M, Rice, JP, Rivera, M, Uher, R, Gejman, PV, Sanders, AR, Boomsma, D, Penninx, BWJH, Breen, G & Levinson, DF 2019, 'Genome-wide burden of rare short deletions is enriched in Major Depressive Disorder in four cohorts', Biological psychiatry, vol. 85, no. 12, pp. 1065-1073. https://doi.org/10.1016/j.biopsych.2019.02.022
  11. Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2019, 'Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns', Nature Communications, vol. 10, no. 1, 2548, pp. 1-18. https://doi.org/10.1038/s41467-019-10461-0
  12. Tyrrell, J, Mulugeta, A, Wood, AR, Zhou, A, Beaumont, RN, Tuke, MA, Jones, SE, Ruth, KS, Yaghootkar, H, Sharp, S, Thompson, WD, Ji, Y, Harrison, J, Freathy, RM, Murray, A, Weedon, MN, Lewis, C, Frayling, TM & Hyppönen, E 2019, 'Using genetics to understand the causal influence of higher BMI on depression', International Journal of Epidemiology, vol. 48, no. 3, pp. 834-848. https://doi.org/10.1093/ije/dyy223
  13. Polimanti, R, Peterson, RE, Ong, JS, MacGregor, S, Edwards, AC, Clarke, TK, Frank, J, Gerring, Z, Gillespie, NA, Lind, PA, Maes, HH, Martin, NG, Mbarek, H, Medland, SE, Streit, F, Agrawal, A, Edenberg, HJ, Kendler, KS, Lewis, CM, Sullivan, PF, Wray, NR, Gelernter, J & Derks, EM 2019, 'Evidence of causal effect of major depression on alcohol dependence: Findings from the psychiatric genomics consortium', Psychological Medicine, vol. 49, no. 7, pp. 1218-1226. https://doi.org/10.1017/S0033291719000667
  14. EU-GEI WP2 Group, Di Forti, M, Quattrone, D, Freeman, TP, Tripoli, G, Gayer-Anderson, C, Quigley, H, Rodriguez, V, Jongsma, HE, Ferraro, L, La Cascia, C, La Barbera, D, Tarricone, I, Berardi, D, Szöke, A, Arango, C, Tortelli, A, Velthorst, E, Bernardo, M, Del-Ben, CM, Menezes, PR, Selten, JP, Jones, PB, Kirkbride, JB, Rutten, BPF, de Haan, L, Sham, PC, van Os, J, Lewis, CM, Lynskey, M, Morgan, C, Murray, RM, Amoretti, S, Arrojo, M, Baudin, G, Beards, S, Bernardo, M, Bobes, J, Bonetto, C, Cabrera, B, Carracedo, A, Charpeaud, T, Costas, J, Cristofalo, D, Cuadrado, P, Díaz-Caneja, CM, Ferchiou, A, Franke, N, Frijda, F, Hubbard, K & Stilo, SA 2019, 'The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study', The Lancet Psychiatry, vol. 6, no. 5, pp. 427-436. https://doi.org/10.1016/S2215-0366(19)30048-3
  15. Chen, WC, Bye, H, Matejcic, M, Amar, A, Govender, D, Khew, YW, Beynon, V, Kerr, R, Singh, E, Prescott, NJ, Lewis, CM, Babb de Villiers, C, Parker, MI & Mathew, CG 2019, 'Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population', Carcinogenesis, vol. 40, no. 4, bgz026, pp. 513-520. https://doi.org/10.1093/carcin/bgz026
  16. Howard, DM, Adams, MJ, Clarke, T, Hafferty, JD, Gibson, J, Shirali, M, Coleman, JRI, Hagenaars, SP, Ward, J, Wigmore, EM, Alloza, C, Shen, X, Barbu, MC, Xu, EY, Whalley, HC, Marioni, RE, Porteous, DJ, Davies, G, Deary, IJ, Hemani, G, Berger, K, Teismann, H, Rawal, R, Arolt, V, Baune, BT, Dannlowski, U, Domschke, K, Tian, C, Hinds, DA, Trzaskowski, M, Byrne, EM, Ripke, S, Smith, DJ, Sullivan, PF, Wray, NR, Breen, G, Lewis, CM & Mcintosh, AM 2019, 'Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions', Nature Neuroscience, vol. 22, no. 3, pp. 343-352. https://doi.org/10.1038/s41593-018-0326-7
  17. Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, BUPGEN, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23andMe Research Team 2019, 'Identification of common genetic risk variants for autism spectrum disorder', Nature Genetics, vol. 51, no. 3, pp. 431-444. https://doi.org/10.1038/s41588-019-0344-8
  18. Wigmore, EM, Hafferty, JD, Hall, LS, Howard, DM, Clarke, T-K, Fabbri, C, Lewis, CM, Uher, R, Navrady, LB, Adams, MJ, Zeng, Y, Campbell, A, Gibson, J, Thomson, PA, Hayward, C, Smith, BH, Hocking, LJ, Padmanabhan, S, Deary, IJ, Porteous, DJ, Mors, O, Mattheisen, M, Nicodemus, KK & McIntosh, AM 2019, 'Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP', The pharmacogenomics journal. https://doi.org/10.1038/s41397-019-0067-3
  19. Bipolar Disorder Working Group of the Psychiatric Genomics Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2019, 'Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders', Molecular Psychiatry. https://doi.org/10.1038/s41380-019-0558-2
  20. Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2019, 'Cannabis use, depression and self-harm: phenotypic and genetic relationships', Addiction. https://doi.org/10.1111/add.14845
  21. Traylor, M, Knevel, R, Cui, J, Taylor, J, Harm-Jan, W, Conaghan, PG, Cope, AP, Curtis, C, Emery, P, Newhouse, S, Patel, H, Steer, S, Gregersen, P, Shadick, NA, Weinblatt, ME, van der Helm-Van Mil, A, Barrett, JH, Morgan, AW, Lewis, CM & Scott, IC 2019, 'Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases', PLoS ONE, vol. 14, no. 10, e0223246. https://doi.org/10.1371/journal.pone.0223246
  22. 2018
  23. Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium 2018, 'Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder', Communications Biology, vol. 1, no. 1, 163. https://doi.org/10.1038/s42003-018-0155-y
  24. Ren, H, Fabbri, C, Uher, R, Rietschel, M, Mors, O, Henigsberg, N, Hauser, J, Zobel, A, Maier, W, Dernovsek, MZ, Souery, D, Cattaneo, A, Breen, G, Craig, IW, Farmer, AE, McGuffin, P, Lewis, CM & Aitchison, KJ 2018, 'Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)', Translational psychiatry, vol. 8, no. 1, 150. https://doi.org/10.1038/s41398-018-0198-3
  25. Fabbri, C, Kasper, S, Kautzky, A, Bartova, L, Dold, M, Zohar, J, Souery, D, Montgomery, S, Albani, D, Raimondi, I, Dikeos, D, Rujescu, D, Uher, R, Lewis, CM, Mendlewicz, J & Serretti, A 2018, 'Genome-wide association study of treatment-resistance in depression and meta-analysis of three independent samples', British Journal of Psychiatry, vol. 214, no. 1, pp. 36-41. https://doi.org/10.1192/bjp.2018.256
  26. O'Brien, HE, Hannon, E, Hill, MJ, Toste, CC, Robertson, MJ, Morgan, JE, McLaughlin, G, Lewis, CM, Schalkwyk, LC, Hall, LS, Pardiñas, AF, Owen, MJ, O'Donovan, MC, Mill, J & Bray, NJ 2018, 'Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders', Genome Biology, vol. 19, no. 1. https://doi.org/10.1186/s13059-018-1567-1
  27. Hanscombe, KB, Morris, DL, Noble, JA, Dilthey, AT, Tombleson, P, Kaufman, KM, Comeau, M, Langefeld, CD, Alarcon-Riquelme, ME, Gaffney, PM, Jacob, CO, Sivils, KL, Tsao, BP, Alarcon, GS, Brown, EE, Croker, J, Edberg, J, Gilkeson, G, James, JA, Kamen, DL, Kelly, JA, McCune, J, Merrill, JT, Petri, M, Ramsey-Goldman, R, Reveille, JD, Salmon, JE, Scofield, H, Utset, T, Wallace, DJ, Weisman, MH, Kimberly, RP, Harley, JB, Lewis, CM, Criswell, LA & Vyse, TJ 2018, 'Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans', Human Molecular Genetics, vol. 27, no. 21, 27(21), pp. 3813-3824. https://doi.org/10.1093/hmg/ddy280
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