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Research Outputs

  1. 2020
  2. Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants

    Persyn, E., Hanscombe, K. B., Howson, J. M. M., Lewis, C. M., Traylor, M. & Markus, H. S., 1 Dec 2020, In : Nature Communications. 11, 1, 2175.

    Research output: Contribution to journalArticle

  3. Genetic stratification of depression in UK Biobank

    Howard, D., Folkersen, L., Coleman, J., Adams, M., Glanville, K., Werge, T., Hagenaars, S., Han, B., Porteous, D., Campbell, A., Clarke, T-K., Breen, G., Sullivan, P. F., Wray, N. R., Lewis, C. & McIntosh, A., 24 May 2020, In : Translational psychiatry.

    Research output: Contribution to journalArticle

  4. Johannesburg Cancer Study (JCS): contribution to knowledge and opportunities arising from 20 years of data collection in an African setting

    Chen, W. C., Singh, E., Muchengeti, M., Bradshaw, D., Mathew, C. G., Babb de Villiers, C., Lewis, C. M., Waterboer, T., Newton, R. & Sitas, F., Apr 2020, In : Cancer Epidemiology. 65, 101701.

    Research output: Contribution to journalArticle

  5. Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

    Glanville, K. P., Coleman, J. R. I., Hanscombe, K. B., Euesden, J., Choi, S. W., Purves, K., Breen, G., Air, T. M., Andlauer, T. M. F., Baune, B. T., Binder, E. B., Blackwood, D. H. R., Boomsma, D. I., Buttenschøn, H. N., Colodro-Conde, L., Dannlowski, U., Direk, N., Dunn, E. C., Forstner, A. J., de Geus, E. J. C. & 34 others, Grabe, H. J., Hamilton, S. P., Jones, I., Jones, L. A., Knowles, J. A., Kutalik, Z., Levinson, D. F., Lewis, G., Lind, P. A., Lucae, S., Lucae, S., Magnusson., P. K. E., McGuffin, P., McIntosh, A., Milaneschi, Y., Lewis, C. M., Mostafavi, S., Muller-Myhsok, B., Pedersen, N. L., Penninx, B. W., Potash, J. B., Preisig, M., Ripke, S., Shi, J., Shyn, S. I., Smoller, J. W., Streit, F., Sullivan, P. F., Tiemeier, H., Uher, R., der Auwera, S. V., Weissman, M. M., O'Reilly, P. F. & Lewis, C. M., 1 Mar 2020, In : Biological psychiatry. 87, 5, p. 419-430 12 p.

    Research output: Contribution to journalArticle

  6. A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotyping

    Fabbri, C., Kasper, S., Kautzky, A., Zohar, J., Souery, D., Montgomery, S., Albani, D., Forloni, G., Ferentinos, P., Rujescu, D., Mendlewicz, J., Uher, R., Lewis, C. M. & Serretti, A., 3 Feb 2020, In : Translational psychiatry. 10, 1, 50.

    Research output: Contribution to journalArticle

  7. Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

    Coleman, J. R. I., Peyrot, W. J., Purves, K., Davis, K. A. S., Rayner, C., Choi, S. W., Huebel, C., Gaspar, H. A., Kan, C., der Auwera, S. V., Adams, M. J., Lyall, D., Choi, K. W., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Dunn, E. C., Vassos, E., Danese, A., Maughan, B., Grabe, H. J., Lewis, C. M. & 7 others, O'Reilly, P. F., McIntosh, A. M., Smith, D. J., Wray, N. R., Hotopf, M., Eley, T. C. & Breen, G., 23 Jan 2020, In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

  8. The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

    Bipolar Disorder Working Group of the Psychiatric Genomics Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 1 Jan 2020, In : Biological psychiatry.

    Research output: Contribution to journalArticle

  9. 2019
  10. Treatment response classes in major depressive disorder identified by model-based clustering and validated by clinical prediction models

    Paul, R., Andlauer, T. F. M., Czamara, D., Hoehn, D., Lucae, S., Pütz, B., Lewis, C. M., Uher, R., Müller-Myhsok, B., Ising, M. & Sämann, P. G., 1 Dec 2019, In : Translational psychiatry. 9, 1, 187.

    Research output: Contribution to journalArticle

  11. Genetic variation of the endocannabinoids system and risk of first episode psychosis

    Quattrone, D., Vassos, E., Richards, A., Reininghaus, U., Sham, P., O'Donovan, M. C., Lewis, C. M., Murray, R. M. & Di Forti, M., 24 Sep 2019, Genetic variation of the endocannabinoids system and risk of first episode psychosis.

    Research output: Chapter in Book/Report/Conference proceedingConference paper

  12. Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals: Genomic Precision Medicine May Dispense With Ethnicity

    Iniesta, R., Campbell, D., Venturini, C., Faconti, L., Singh, S., Irvin, M. R., Cooper-DeHoff, R. M., Johnson, J. A., Turner, S. T., Arnett, D. K., Weale, M. E., Warren, H., Munroe, P. B., Cruickshank, K., Padmanabhan, S., Lewis, C. & Chowienczyk, P., 1 Sep 2019, In : Hypertension (Dallas, Tex. : 1979). 74, 3, p. 614-622 9 p.

    Research output: Contribution to journalArticle

  13. Prevalence of Advanced Liver Fibrosis in Patients With Severe Psoriasis

    Maybury, C. M., Porter, H. F., Kloczko, E., Duckworth, M., Cotton, A., Thornberry, K., Dew, T., Crook, M., Natas, S., Miquel, R., Lewis, C. M., Wong, T., Smith, C. H. & Barker, J. N., 1 Sep 2019, In : JAMA dermatology. 155, 9, p. 1028-1032 5 p.

    Research output: Contribution to journalArticle

  14. Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Mullins, N., Bigdeli, T. B., Børglum, A. D., Coleman, J. R. I., Demontis, D., Mehta, D., Power, R. A., Ripke, S., Stahl, E. A., Starnawska, A., Anjorin, A., Corvin, A., Sanders, A. R., Forstner, A. J., Reif, A., Koller, A. C., Świątkowska, B., Baune, B. T. & 95 others, Müller-Myhsok, B., Penninx, B. W. J. H., Pato, C. N., Zai, C. C., Rujescu, D., Hougaard, D. M., Quested, D., Levinson, D. F., Binder, E. B., Byrne, E. M., Agerbo, E., Streit, F., Mayoral, F., Bellivier, F., Degenhardt, F., Breen, G. D., Morken, G., Turecki, G., Rouleau, G., Grabe, H. J., Volzke, H., Jones, I., Giegling, I., Agartz, I., Melle, I., Lawrence, J., Walters, J. T. R., Strohmaier, J., Shi, J., Hauser, J., Biernacka, J. M., Vincent, J. B., Kelsoe, J., Strauss, J. S., Lissowska, J., Pimm, J., Smoller, J. W., Guzman-Parra, J., Berger, K., Scott, L. J., Jones, L. A., Azevedo, M. H., Trzaskowski, M., Kogevinas, M., Rietschel, M., Boks, M. P., Ising, M., Grigoroiu-Serbanescu, M., Hamshere, M. L., Leboyer, M., Frye, M. A., Alda, M., Nordentoft, M., Boehnke, M., O'Donovan, M. C., Owen, M. J., Pato, M. T., Renteria, M. E., Wray, N. R., Bass, N., Craddock, N., Smeland, O. B., Andreassen, O. A., Mors, O., Gejman, P. V., Sklar, P., McGrath, P. J., Hoffmann, P., McGuffin, P., Lee, P. H., Mortensen, P. B., Kahn, R. S., Ophoff, R. A., Adolfsson, R., Van der Auwera Affiliations, S., Djurovic, S., Kloiber, S., Heilmann-Heimbach, S., Jamain, S., Hamilton, S. P., Mcelroy, S. L., Lucae, S., Cichon, S., Schulze, T. G., Hansen, T., Werge, T., Air, T. M., Nimgaonkar, V., Appadurai, V., Cahn, W., Milaneschi, Y., Fanous, A. H., Kendler, K. S., McQuillin, A. & Lewis, C. M., 1 Aug 2019, In : The American Journal of Psychiatry. 176, 8, p. 651-660 10 p.

    Research output: Contribution to journalArticle

  15. Polygenic risk for circulating reproductive hormone levels and their influence on hippocampal volume and depression susceptibility

    Smeeth, D. M., Dima, D., Jones, L., Jones, I., Craddock, N., Owen, M. J., Rietschel, M., Maier, W., Korszun, A., Rice, J. P., Mors, O., Preisig, M., Uher, R., Lewis, C. M., Thuret, S. & Powell, T. R., Aug 2019, In : Psychoneuroendocrinology. 106, p. 284-292 9 p.

    Research output: Contribution to journalArticle

  16. Genome-wide survey of copy number variants finds MAPT duplications in progressive supranuclear palsy

    NNIPPS and BBBIPPS Study Groups, 1 Jul 2019, In : Movement Disorders. 34, 7, p. 1049-1059 11 p.

    Research output: Contribution to journalArticle

  17. Genome-wide burden of rare short deletions is enriched in Major Depressive Disorder in four cohorts

    Zhang, X., Abdellaoui, A., Rucker, J., de Jong, S., Potash, J. B., Weissman, M. M., Shi, J., Knowles, J. A., Pato, C., Pato, M., Sobell, J., Smit, J. H., Hottenga, J. J., de Geus, E. J. C., Lewis, C. M., Buttenschøn, H. N., Craddock, N., Jones, I., Jones, L., McGuffin, P. & 13 others, Mors, O., Owen, M. J., Preisig, M., Rietschel, M., Rice, J. P., Rivera, M., Uher, R., Gejman, P. V., Sanders, A. R., Boomsma, D., Penninx, B. W. J. H., Breen, G. & Levinson, D. F., 15 Jun 2019, In : Biological psychiatry. 85, 12, p. 1065-1073 9 p.

    Research output: Contribution to journalArticle

  18. Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 11 Jun 2019, In : Nature Communications. 10, 1, p. 1-18 18 p., 2548.

    Research output: Contribution to journalArticle

  19. Using genetics to understand the causal influence of higher BMI on depression

    Tyrrell, J., Mulugeta, A., Wood, A. R., Zhou, A., Beaumont, R. N., Tuke, M. A., Jones, S. E., Ruth, K. S., Yaghootkar, H., Sharp, S., Thompson, W. D., Ji, Y., Harrison, J., Freathy, R. M., Murray, A., Weedon, M. N., Lewis, C., Frayling, T. M. & Hyppönen, E., 1 Jun 2019, In : International Journal of Epidemiology. 48, 3, p. 834-848 15 p.

    Research output: Contribution to journalArticle

  20. ukbTools: An R package to manage and query UK Biobank data

    Hanscombe, K. B., Coleman, J. R. I., Traylor, M. & Lewis, C. M., 31 May 2019, In : PLoS ONE. 14, 5, 6 p., e0214311.

    Research output: Contribution to journalArticle

  21. Evidence of causal effect of major depression on alcohol dependence: Findings from the psychiatric genomics consortium

    Polimanti, R., Peterson, R. E., Ong, J. S., MacGregor, S., Edwards, A. C., Clarke, T. K., Frank, J., Gerring, Z., Gillespie, N. A., Lind, P. A., Maes, H. H., Martin, N. G., Mbarek, H., Medland, S. E., Streit, F., Agrawal, A., Edenberg, H. J., Kendler, K. S., Lewis, C. M., Sullivan, P. F. & 3 others, Wray, N. R., Gelernter, J. & Derks, E. M., 1 May 2019, In : Psychological Medicine. 49, 7, p. 1218-1226 9 p.

    Research output: Contribution to journalArticle

  22. Progressing Polygenic Medicine in Psychiatry Through Electronic Health Records

    Lewis, C. M. & Hagenaars, S. P., 1 May 2019, In : JAMA Psychiatry. 76, 5, p. 470-472 3 p.

    Research output: Contribution to journalEditorial

  23. The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study

    EU-GEI WP2 Group, Di Forti, M., Quattrone, D., Freeman, T. P., Tripoli, G., Gayer-Anderson, C., Quigley, H., Rodriguez, V., Jongsma, H. E., Ferraro, L., La Cascia, C., La Barbera, D., Tarricone, I., Berardi, D., Szöke, A., Arango, C., Tortelli, A., Velthorst, E., Bernardo, M., Del-Ben, C. M. & 31 others, Menezes, P. R., Selten, J. P., Jones, P. B., Kirkbride, J. B., Rutten, B. PF., de Haan, L., Sham, P. C., van Os, J., Lewis, C. M., Lynskey, M., Morgan, C., Murray, R. M., Amoretti, S., Arrojo, M., Baudin, G., Beards, S., Bernardo, M., Bobes, J., Bonetto, C., Cabrera, B., Carracedo, A., Charpeaud, T., Costas, J., Cristofalo, D., Cuadrado, P., Díaz-Caneja, C. M., Ferchiou, A., Franke, N., Frijda, F., Hubbard, K. & Stilo, S. A., 1 May 2019, In : The Lancet Psychiatry. 6, 5, p. 427-436 10 p.

    Research output: Contribution to journalArticle

  24. Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder

    eQTLGen Consortium, May 2019, In : Nature Genetics. 51, 5, p. 793-803 11 p.

    Research output: Contribution to journalArticle

  25. Uncovering the Genetic Architecture of Major Depression

    McIntosh, A. M., Sullivan, P. F. & Lewis, C. M., 3 Apr 2019, In : Neuron. 102, 1, p. 91-103 13 p.

    Research output: Contribution to journalReview article

  26. Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population

    Chen, W. C., Bye, H., Matejcic, M., Amar, A., Govender, D., Khew, Y. W., Beynon, V., Kerr, R., Singh, E., Prescott, N. J., Lewis, C. M., Babb de Villiers, C., Parker, M. I. & Mathew, C. G., Apr 2019, In : Carcinogenesis. 40, 4, p. 513-520 8 p., bgz026.

    Research output: Contribution to journalArticle

  27. Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

    Howard, D. M., Adams, M. J., Clarke, T., Hafferty, J. D., Gibson, J., Shirali, M., Coleman, J. R. I., Hagenaars, S. P., Ward, J., Wigmore, E. M., Alloza, C., Shen, X., Barbu, M. C., Xu, E. Y., Whalley, H. C., Marioni, R. E., Porteous, D. J., Davies, G., Deary, I. J., Hemani, G. & 18 others, Berger, K., Teismann, H., Rawal, R., Arolt, V., Baune, B. T., Dannlowski, U., Domschke, K., Tian, C., Hinds, D. A., Trzaskowski, M., Byrne, E. M., Ripke, S., Smith, D. J., Sullivan, P. F., Wray, N. R., Breen, G., Lewis, C. M. & Mcintosh, A. M., Mar 2019, In : Nature Neuroscience. 22, 3, p. 343-352 10 p.

    Research output: Contribution to journalArticle

  28. Identification of common genetic risk variants for autism spectrum disorder

    Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, BUPGEN, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23andMe Research Team, 25 Feb 2019, In : Nature Genetics. 51, 3, p. 431-444 14 p.

    Research output: Contribution to journalArticle

  29. Quantifying between-cohort and between-sex genetic heterogeneity in major depressive disorder

    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 1 Feb 2019, In : American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 180, 6, p. 439-447 9 p.

    Research output: Contribution to journalArticle

  30. Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP

    Wigmore, E. M., Hafferty, J. D., Hall, L. S., Howard, D. M., Clarke, T-K., Fabbri, C., Lewis, C. M., Uher, R., Navrady, L. B., Adams, M. J., Zeng, Y., Campbell, A., Gibson, J., Thomson, P. A., Hayward, C., Smith, B. H., Hocking, L. J., Padmanabhan, S., Deary, I. J., Porteous, D. J. & 4 others, Mors, O., Mattheisen, M., Nicodemus, K. K. & McIntosh, A. M., 31 Jan 2019, In : The pharmacogenomics journal.

    Research output: Contribution to journalArticle

  31. Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

    Bipolar Disorder Working Group of the Psychiatric Genomics Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 1 Jan 2019, In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

  32. Cannabis use, depression and self-harm: phenotypic and genetic relationships

    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 1 Jan 2019, In : Addiction.

    Research output: Contribution to journalArticle

  33. Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases

    Traylor, M., Knevel, R., Cui, J., Taylor, J., Harm-Jan, W., Conaghan, P. G., Cope, A. P., Curtis, C., Emery, P., Newhouse, S., Patel, H., Steer, S., Gregersen, P., Shadick, N. A., Weinblatt, M. E., van der Helm-Van Mil, A., Barrett, J. H., Morgan, A. W., Lewis, C. M. & Scott, I. C., 1 Jan 2019, In : PLoS ONE. 14, 10, e0223246.

    Research output: Contribution to journalArticle

  34. IS THE ERA OF CANDIDATE GENES X CANNABIS USE REALLY DEAD?

    Quattrone, D., Lewis, C., Richards, A., Vassos, E., Gayer-Anderson, C., Ferraro, L., Tripoli, G., Rutten, B., O'Donovan, M., Morgan, C., Van Os, J., Sham, P., Reininghaus, U., Murray, R. & Di Forti, M., 2019, In : European Neuropsychopharmacology. 29, p. 1324-1325

    Research output: Contribution to journalMeeting Abstract

  35. 2018
  36. Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

    Generation Scotland, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Coleman, J. R. I., Eley, T. C., Gaspar, H. A., McGuffin, P., Mullins, N., O'Reilly, P. F., Lewis, C. M. & Breen, G., 20 Dec 2018, In : PLoS ONE. 13, 12, e0209160.

    Research output: Contribution to journalArticle

  37. Telomere length as a predictor of emotional processing in the brain

    Powell, T. R., De Jong, S., Breen, G., Lewis, C. M. & Dima, D., 4 Dec 2018, In : Human Brain Mapping.

    Research output: Contribution to journalArticle

  38. Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

    Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, 1 Dec 2018, In : Communications Biology. 1, 1, 163.

    Research output: Contribution to journalArticle

  39. Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)

    Ren, H., Fabbri, C., Uher, R., Rietschel, M., Mors, O., Henigsberg, N., Hauser, J., Zobel, A., Maier, W., Dernovsek, M. Z., Souery, D., Cattaneo, A., Breen, G., Craig, I. W., Farmer, A. E., McGuffin, P., Lewis, C. M. & Aitchison, K. J., 1 Dec 2018, In : Translational psychiatry. 8, 1, 150.

    Research output: Contribution to journalArticle

  40. Genome-wide association study of treatment-resistance in depression and meta-analysis of three independent samples

    Fabbri, C., Kasper, S., Kautzky, A., Bartova, L., Dold, M., Zohar, J., Souery, D., Montgomery, S., Albani, D., Raimondi, I., Dikeos, D., Rujescu, D., Uher, R., Lewis, C. M., Mendlewicz, J. & Serretti, A., 23 Nov 2018, In : British Journal of Psychiatry. 214, 1, p. 36-41

    Research output: Contribution to journalArticle

  41. Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders

    O'Brien, H. E., Hannon, E., Hill, M. J., Toste, C. C., Robertson, M. J., Morgan, J. E., McLaughlin, G., Lewis, C. M., Schalkwyk, L. C., Hall, L. S., Pardiñas, A. F., Owen, M. J., O'Donovan, M. C., Mill, J. & Bray, N. J., 12 Nov 2018, In : Genome Biology. 19, 1, 1 p.

    Research output: Contribution to journalArticle

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