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Research Outputs

  1. 2021
  2. The Effects of Acute Δ9-Tetrahydrocannabinol on Striatal Glutamatergic Function: A Proton Magnetic Resonance Spectroscopy Study

    Bloomfield, M. A. P., Petrilli, K., Lees, R., Hindocha, C., Beck, K., Turner, R. J., Onwordi, E. C., Rane, N., Lythgoe, D. J., Stone, J. M., Curran, H. V., Howes, O. D. & Freeman, T. P., Jun 2021, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 6, 6, p. 660-667 8 p.

    Research output: Contribution to journalArticlepeer-review

  3. Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study

    Rogdaki, M., Devroye, C., Ciampoli, M., Veronese, M., Ashok, A., McCutcheon, R. A., Jauhar, S., Bonoldi, I., Gudbrandsen, M., Daly, E., van Amelsvoort, T., Van Den Bree, M., Owen, M. J., Turkheimer, F., Papaleo, F. & Howes, O. D., 12 May 2021, In: Molecular Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  4. Meta-analysis of the Glial Marker TSPO in Psychosis Revisited: Reconciling Inconclusive Findings of Patient–Control Differences

    Plavén-Sigray, P., Matheson, G. J., Coughlin, J. M., Hafizi, S., Laurikainen, H., Ottoy, J., De Picker, L., Rusjan, P., Hietala, J., Howes, O. D., Mizrahi, R., Morrens, M., Pomper, M. G. & Cervenka, S., 1 Feb 2021, In: Biological psychiatry. 89, 3, p. e5-e8

    Research output: Contribution to journalLetterpeer-review

  5. 2020
  6. The role of dopamine dysregulation and evidence for the transdiagnostic nature of elevated dopamine synthesis in psychosis: a positron emission tomography (PET) study comparing schizophrenia, delusional disorder, and other psychotic disorders

    Cheng, P. W. C., Chang, W. C., Lo, G. G., Chan, K. W. S., Lee, H. M. E., Hui, L. M. C., Suen, Y. N., Leung, Y. L. E., Au Yeung, K. M. P., Chen, S., Mak, K. F. H., Sham, P. C., Santangelo, B., Veronese, M., Ho, C-L., Chen, Y. H. E. & Howes, O. D., 1 Oct 2020, In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 45, 11, p. 1870-1876 7 p.

    Research output: Contribution to journalArticlepeer-review

  7. Dopamine dysregulation in psychotic relapse after antipsychotic discontinuation: an [18F]DOPA and [11C]raclopride PET study in first-episode psychosis

    Kim, S., Shin, S. H., Santangelo, B., Veronese, M., Kang, S. K., Lee, J. S., Cheon, G. J., Lee, W., Kwon, J. S., Howes, O. D. & Kim, E., 14 Sep 2020, In: Molecular Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  8. Aberrant Salience, Information Processing, and Dopaminergic Signaling in People at Clinical High Risk for Psychosis

    Howes, O. D., Hird, E. J., Adams, R. A., Corlett, P. R. & McGuire, P., 15 Aug 2020, In: Biological psychiatry. 88, 4, p. 304-314 11 p.

    Research output: Contribution to journalReview articlepeer-review

  9. Heterogeneity of Striatal Dopamine Function in Schizophrenia: Meta-analysis of Variance

    Brugger, S. P., Angelescu, I., Abi-Dargham, A., Mizrahi, R., Shahrezaei, V. & Howes, O. D., 1 Feb 2020, In: Biological psychiatry. 87, 3, p. 215-224 10 p.

    Research output: Contribution to journalArticlepeer-review

  10. 2019
  11. Disrupted-in-schizophrenia 1 functional polymorphisms and D2/D3 receptor availability: A [11C]-(+)-PHNO imaging study

    Dahoun, T., Nour, M. M., Adams, R. A., Trossbach, S., Lee, S. H., Patel, H., Curtis, C., Korth, C. & Howes, O. D., 1 Nov 2019, In: Genes, Brain and Behavior. 18, 8, e12596.

    Research output: Contribution to journalArticlepeer-review

  12. The effects of cannabinoid 1 receptor compounds on memory: a meta-analysis and systematic review across species

    Borgan, F., Beck, K. E., Butler, E. R., McCutcheon, R. A., Veronese, M., Vernon, A. C. & Howes, O. D., 1 Nov 2019, In: Psychopharmacology. 236, 11, p. 3257-3270 14 p.

    Research output: Contribution to journalArticlepeer-review

  13. Schizophrenia-An Overview

    McCutcheon, R. A., Reis Marques, T. & Howes, O. D., 30 Oct 2019, In: JAMA Psychiatry. p. 1-10 10 p.

    Research output: Contribution to journalReview articlepeer-review

  14. Treatment of First-Episode Schizophrenia in a Young Woman

    McCutcheon, R. A., Reis Marques, T. & Howes, O. D., 30 Oct 2019, In: JAMA Psychiatry.

    Research output: Contribution to journalShort surveypeer-review

  15. In Vivo Availability of Cannabinoid 1 Receptor Levels in Patients With First-Episode Psychosis

    METSY Group, 1 Oct 2019, In: JAMA Psychiatry. 76, 10, p. 1074-1084 11 p.

    Research output: Contribution to journalArticlepeer-review

  16. Making decisions about antipsychotics: a qualitative study of patient experience and the development of a decision aid.

    Kaar, S. J., Gobjila, C., Butler, E. R., Henderson, R. C. & Howes, O. D., 21 Sep 2019, (Accepted/In press) In: BMC Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  17. The efficacy and heterogeneity of antipsychotic response in schizophrenia: A meta-analysis

    McCutcheon, R. A., Pillinger, T., Mizuno, Y., Montgomery, A., Pandian, H., Vano, L., Marques, T. R. & Howes, O. D., 30 Aug 2019, In: Molecular Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  18. Correction: Regulation of dopaminergic function: An [18F]-DOPA PET apomorphine challenge study in humans

    Jauhar, S., Veronese, M., Rogdaki, M., Bloomfield, M., Natesan, S., Turkheimer, F., Kapur, S. & Howes, O. D., 11 Jun 2019, In: Translational psychiatry. 9, 1, p. 168 168.

    Research output: Contribution to journalComment/debatepeer-review

  19. Cannabinoid 1 receptor levels and cognition in patients with first episode psychosis: a positron emission tomography study in two independent cohorts of patients

    Borgan, F., Laurikainen, H., Veronese, M., Reis Marques, T., Haaparanta-Solin, M., Solin, O., Dahoun, T., Rogdaki, M., Salokangas, R. KR., Karukivi, M., Di Forti, M., Turkheimer, F., Hietala, J. & Howes, O., 23 Apr 2019, (Accepted/In press) In: JAMA Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  20. Clinical guidance on the identification and management of treatment-resistant schizophrenia

    Kane, J. M., Agid, O., Baldwin, M. L., Howes, O., Lindenmayer, J. P., Marder, S., Olfson, M., Potkin, S. G. & Correll, C. U., 1 Mar 2019, In: Journal of Clinical Psychiatry. 80, 2, 18com12123.

    Research output: Contribution to journalArticlepeer-review

  21. Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge

    Erritzoe, D., Ashok, A. H., Searle, G. E., Colasanti, A., Turton, S., Lewis, Y., Huiban, M., Moz, S., Passchier, J., Saleem, A., Beaver, J., Lingford-Hughes, A., Nutt, D. J., Howes, O. D., Gunn, R. N., Knudsen, G. M. & Rabiner, E. A., 1 Jan 2019, In: Neuropsychopharmacology.

    Research output: Contribution to journalArticlepeer-review

  22. 2018
  23. Frontostriatal functional connectivity and striatal dopamine synthesis capacity in schizophrenia in terms of antipsychotic responsiveness: an [18F]DOPA PET and fMRI study

    Kim, S., Jung, W. H., Howes, O. D., Veronese, M., Turkheimer, F. E., Lee, Y-S., Lee, J. S., Kim, E. & Kwon, J. S., 21 Nov 2018, In: Psychological Medicine. p. 1-10 10 p.

    Research output: Contribution to journalArticlepeer-review

  24. Association of hippocampal glutamate levels with adverse outcomes in individuals at clinical high risk for psychosis

    Bossong, M. G., Antoniades, M., Azis, M., Samson, C. A., Quinn, B., Bonoldi, I., Modinos, G., Perez, J., Howes, O. D., Stone, J. M., Allen, P. & McGuire, P., 14 Nov 2018, In: JAMA Psychiatry. 76, 2, p. 199-207

    Research output: Contribution to journalArticlepeer-review

  25. Comment on " in Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates"

    McGinnity, C. J., Årstad, E., Beck, K., Brooks, D. J., Coles, J. P., Duncan, J. S., Galovic, M., Hinz, R., Hirani, E., Howes, O. D., Jones, P. A., Koepp, M. J., Luo, F., Riaño Barros, D. A., Singh, N., Trigg, W. & Hammers, A., 11 Oct 2018, In: Acs chemical neuroscience. 0, 0

    Research output: Contribution to journalArticlepeer-review

  26. Correction: Altered activation and connectivity in a hippocampal-basal ganglia-midbrain circuit during salience processing in subjects at ultra high risk for psychosis

    Winton-Brown, T., Schmidt, A., Roiser, J. P., Howes, O. D., Egerton, A., Fusar-Poli, P., Bunzeck, N., Grace, A. A., Duzel, E., Kapur, S. & McGuire, P., 31 Aug 2018, In: Translational psychiatry. 8, 1, p. 170

    Research output: Contribution to journalArticlepeer-review

  27. Platform for systems medicine research and diagnostic applications in psychotic disorders—The METSY project

    Frank, E., Maier, D., Pajula, J., Suvitaival, T., Borgan, F., Butz-Ostendorf, M., Fischer, A., Hietala, J., Howes, O., Hyötyläinen, T., Janssen, J., Laurikainen, H., Moreno, C., Suvisaari, J., Van Gils, M. & Orešič, M., 1 Feb 2018, In: European Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  28. Higher serotonin transporter availability in early-onset obsessive–compulsive disorder patients undergoing escitalopram treatment: A [11C]DASB PET study

    Lee, J., Kim, B. H., Kim, E., Howes, O. D., Cho, K. I. K., Yoon, Y. B. & Kwon, J. S., 1 Jan 2018, In: Human Psychopharmacology. 33, 1, e2642.

    Research output: Contribution to journalArticlepeer-review

  29. 2017
  30. Impaired glucose homeostasis in first-episode schizophrenia: A systematic review and meta-analysis

    Pillinger, T., Beck, K., Gobjila, C., Donocik, J. G., Jauhar, S. & Howes, O. D., 1 Mar 2017, In: JAMA Psychiatry. 74, 3, p. 261-269 9 p.

    Research output: Contribution to journalArticlepeer-review

  31. Inflammation and the neural diathesis-stress hypothesis of schizophrenia: A reconceptualization

    Howes, O. & McCutcheon, R., 7 Feb 2017, In: Translational psychiatry. 7, 2, e1024.

    Research output: Contribution to journalReview articlepeer-review

  32. 2016
  33. Fronto-limbic engagement during moral processing in stimulant users

    Blackwood, N. J. & Howes, O. D., 1 Sep 2016, In: Psychopharmacology. 233, 17, p. 3075-3076 2 p.

    Research output: Contribution to journalArticlepeer-review

  34. Regional Differences in Serotonin Transporter Occupancy by Escitalopram: An [(11)C]DASB PK-PD Study

    Kim, E., Howes, O. D., Kim, B-H., Chon, M-W., Seo, S., Turkheimer, F. E., Lee, J. S., Lee, Y-S. & Kwon, J. S., 24 Aug 2016, In: Clinical Pharmacokinetics.

    Research output: Contribution to journalArticlepeer-review

  35. Consistent biological findings in major depression: Results from serotonin transporter meta-analyses

    Kambeitz, J. & Howes, O. D., 15 Jul 2016, In: Journal of Affective Disorders. 199, p. 171 1 p.

    Research output: Contribution to journalComment/debatepeer-review

  36. Targeting glutamate to treat schizophrenia: lessons from recent clinical studies

    Beck, K., Javitt, D. C. & Howes, O., 1 Jul 2016, In: Psychopharmacology. 233, 13, p. 2425-2428 4 p.

    Research output: Contribution to journalEditorialpeer-review

  37. Evidence-based guidelines for treating bipolar disorder: Revised third edition recommendations from the British Association for Psychopharmacology

    Goodwin, G. M., Haddad, P. M., Ferrier, I. N., Aronson, J. K., Barnes, T. R. H., Cipriani, A., Coghill, D. R., Fazel, S., Geddes, J. R., Grunze, H., Holmes, E. A., Howes, O., Hudson, S., Hunt, N., Jones, I., MacMillan, I. C., McAllister-Williams, H., Miklowitz, D. R., Morriss, R., Munafò, M. & 7 others, Paton, C., Saharkian, B. J., Saunders, K. E. A., Sinclair, J. M. A., Taylor, D., Vieta, E. & Young, A. H., 1 Jun 2016, In: Journal of psychopharmacology (Oxford, England). 30, 6, p. 495-553 59 p.

    Research output: Contribution to journalArticlepeer-review

  38. Immune influences on the brain: New findings and implications for treatment

    Duka, T., Harrison, N. A. & Howes, O. D., 1 May 2016, In: Psychopharmacology. 233, 9, p. 1539-1541 3 p.

    Research output: Contribution to journalEditorialpeer-review

  39. Response to Narendran and Frankle: The Interpretation of PET Microglial Imaging in Schizophrenia

    Bloomfield, P. S., Howes, O. D., Turkheimer, F., Selvaraj, S. & Veronese, M., 1 May 2016, In: The American Journal of Psychiatry. 173, 5, p. 537-8 2 p.

    Research output: Contribution to journalLetterpeer-review

  40. Optimising treatment of schizophrenia: The role of adjunctive fluvoxamine

    Gee, S. & Howes, O., 1 Mar 2016, In: Psychopharmacology. 233, 5, p. 739-740 2 p.

    Research output: Contribution to journalEditorialpeer-review

  41. Dopamine and the aberrant salience hypothesis of schizophrenia

    Howes, O. D. & Nour, M. M., 1 Feb 2016, In: World Psychiatry. 15, 1, p. 3-4 2 p.

    Research output: Contribution to journalEditorialpeer-review

  42. 2015
  43. Altered serotonin transporter binding potential in patients with obsessive-compulsive disorder under escitalopram treatment: [11C]DASB PET study

    Kim, E., Howes, O. D., Park, J. W., Kim, S. N., Shin, S. A., Kim, B. H., Turkheimer, F. E., Lee, Y. S. & Kwon, J. S., 1 Oct 2015, (Accepted/In press) In: Psychological Medicine. 10 p.

    Research output: Contribution to journalArticlepeer-review

  44. Further human evidence for striatal dopamine release induced by administration of ∆9-tetrahydrocannabinol (THC): selectivity to limbic striatum

    Bossong, M., Mehta, M., van Berckel, B., Howes, O., Kahn, R. S. & Stokes, P., Aug 2015, In: Psychopharmacology. 232, 15, p. 2723-2729 7 p.

    Research output: Contribution to journalArticlepeer-review

  45. Treatment resistant or resistant to treatment? Antipsychotic plasma levels in patients with poorly controlled psychotic symptoms

    McCutcheon, R., Beck, K., Bloomfield, M. A. P., Marques, T. R., Rogdaki, M. & Howes, O. D., Aug 2015, In: Journal of psychopharmacology (Oxford, England). 29, 8, p. 892-7 6 p.

    Research output: Contribution to journalArticlepeer-review

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