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Research Outputs

  1. 2017
  2. Acylated ghrelin treatment normalizes skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rat chronic heart failure

    Barazzoni, R., Gortan Cappellari, G., Palus, S., Vinci, P., Ruozi, G., Zanetti, M., Semolic, A., Ebner, N., von Haehling, S., Sinagra, G., Giacca, M. & Springer, J., 1 Dec 2017, In : Journal of Cachexia, Sarcopenia and Muscle. 8, 6, p. 991-998 8 p.

    Research output: Contribution to journalArticle

  3. Identification of HSP90 inhibitors as a novel class of senolytics

    Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., Corbo, L., Tang, P., Bukata, C., Ring, N., Giacca, M., Li, X., Tchkonia, T., Kirkland, J. L., Niedernhofer, L. J. & Robbins, P. D., 1 Dec 2017, In : Nature Communications. 8, 1, 422.

    Research output: Contribution to journalArticle

  4. In Vivo Functional Selection Identifies Cardiotrophin-1 as a Cardiac Engraftment Factor for Mesenchymal Stromal Cells

    Bortolotti, F., Ruozi, G., Falcione, A., Doimo, S., Dal Ferro, M., Lesizza, P., Zentilin, L., Banks, L., Zacchigna, S. & Giacca, M., 17 Oct 2017, In : Circulation. 136, 16, p. 1509-1524 16 p.

    Research output: Contribution to journalArticle

  5. Repeated AAV-mediated gene transfer by serotype switching enables long-lasting therapeutic levels of hUgt1a1 enzyme in a mouse model of Crigler-Najjar Syndrome Type i

    Bočkor, L., Bortolussi, G., Iaconcig, A., Chiaruttini, G., Tiribelli, C., Giacca, M., Benvenuti, F., Zentilin, L. & Muro, A. F., 1 Oct 2017, In : Gene Therapy. 24, 10, p. 649-660 12 p.

    Research output: Contribution to journalArticle

  6. Cardiomyocyte regeneration: A consensus statement

    Eschenhagen, T., Bolli, R., Braun, T., Field, L. J., Fleischmann, B. K., Frisén, J., Giacca, M., Hare, J. M., Houser, S., Lee, R. T., Marbán, E., Martin, J. F., Molkentin, J. D., Murry, C. E., Riley, P. R., Ruiz-Lozano, P., Sadek, H. A., Sussman, M. A. & Hill, J. A., 1 Aug 2017, In : Circulation. 136, 7, p. 680-686 7 p.

    Research output: Contribution to journalArticle

  7. Id genes are essential for early heart formation

    Cunningham, T. J., Yu, M. S., McKeithan, W. L., Spiering, S., Carrette, F., Huang, C. T., Bushway, P. J., Tierney, M., Albini, S., Giacca, M., Mano, M., Puri, P. L., Sacco, A., Ruiz-Lozano, P., Riou, J. F., Umbhauer, M., Duester, G., Mercola, M. & Colas, A. R., 1 Jul 2017, In : Genes and Development. 31, 13, p. 1325-1338 14 p.

    Research output: Contribution to journalArticle

  8. Inhibition of Non Canonical HIV-1 Tat Secretion Through the Cellular Na+,K+-ATPase Blocks HIV-1 Infection

    Agostini, S., Ali, H., Vardabasso, C., Fittipaldi, A., Tasciotti, E., Cereseto, A., Bugatti, A., Rusnati, M., Lusic, M. & Giacca, M., 1 Jul 2017, In : EBioMedicine. 21, p. 170-181 12 p.

    Research output: Contribution to journalArticle

  9. Unacylated Ghrelin Enhances Satellite Cell Function and Relieves the Dystrophic Phenotype in Duchenne Muscular Dystrophy mdx Model

    Reano, S., Angelino, E., Ferrara, M., Malacarne, V., Sustova, H., Sabry, O., Agosti, E., Clerici, S., Ruozi, G., Zentilin, L., Prodam, F., Geuna, S., Giacca, M., Graziani, A. & Filigheddu, N., 1 Jul 2017, In : Stem Cells. 35, 7, p. 1733-1746 14 p.

    Research output: Contribution to journalArticle

  10. NEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes

    Brulet, R., Matsuda, T., Zhang, L., Miranda, C., Giacca, M., Kaspar, B. K., Nakashima, K. & Hsieh, J., 6 Jun 2017, In : Stem cell reports. 8, 6, p. 1506-1515 10 p.

    Research output: Contribution to journalArticle

  11. Intravenous lipid infusion and total plasma fatty acids positively modulate plasma acylated ghrelin in vivo

    Barazzoni, R., Gortan Cappellari, G., Semolic, A., Ius, M., Dore, F., Giacca, M., Zanetti, M., Vinci, P. & Guarnieri, G., 1 Jun 2017, In : CLINICAL NUTRITION. 36, 3, p. 775-781 7 p.

    Research output: Contribution to journalArticle

  12. AAV9-mediated engineering of autotransplanted kidney of non-human primates

    Tomasoni, S., Trionfini, P., Azzollini, N., Zentilin, L., Giacca, M., Aiello, S., Longaretti, L., Cozzi, E., Baldan, N., Remuzzi, G. & Benigni, A., 1 May 2017, In : Gene Therapy. 24, 5, p. 308-313 6 p.

    Research output: Contribution to journalArticle

  13. Single-Dose Intracardiac Injection of Pro-Regenerative MicroRNAs Improves Cardiac Function after Myocardial Infarction

    Lesizza, P., Prosdocimo, G., Martinelli, V., Sinagra, G., Zacchigna, S. & Giacca, M., 14 Apr 2017, In : Circulation Research. 120, 8, p. 1298-1304 7 p.

    Research output: Contribution to journalArticle

  14. Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members

    Conti, A., Majorini, M. T., Fontanella, E., Bardelli, A., Giacca, M., Delia, D., Mano, M. & Lecis, D., 28 Mar 2017, In : Cancer Letters. 389, p. 59-69 11 p.

    Research output: Contribution to journalArticle

  15. Neuronal hemoglobin affects dopaminergic cells' response to stress

    Codrich, M., Bertuzzi, M., Russo, R., Francescatto, M., Espinoza, S., Zentilin, L., Giacca, M., Cesselli, D., Beltrami, A. P., Ascenzi, P., Zucchelli, S., Persichetti, F., Leanza, G. & Gustincich, S., 5 Jan 2017, In : Cell Death and Disease. 8, 1, e2538.

    Research output: Contribution to journalArticle

  16. Epigenetic silencing of miR-296 and miR-512 ensures hTERT dependent apoptosis protection and telomere maintenance in basal-type breast cancer cells

    Dinami, R., Buemi, V., Sestito, R., Zappone, A., Ciani, Y., Mano, M., Petti, E., Sacconi, A., Blandino, G., Giacca, M., Piazza, S., Benetti, R. & Schoeftner, S., 1 Jan 2017, In : Oncotarget. 8, 56, p. 95674-95691 18 p.

    Research output: Contribution to journalArticle

  17. MIB2 variants altering NOTCH signalling result in left ventricle hypertrabeculation/non-compaction and are associated with Méné trier-like gastropathy

    Piccolo, P., Attanasio, S., Secco, I., Sangermano, R., Strisciuglio, C., Limongelli, G., Miele, E., Mutarelli, M., Banfi, S., Nigro, V., Pons, T., Valencia, A., Zentilin, L., Campione, S., Nardone, G., Lynnes, T. C., Celestino-Soper, P. B. S., Spoonamore, K. G., D'Armiento, F. P., Giacca, M. & 4 others, Staiano, A., Vatta, M., Collesi, C. & Brunetti-Pierri, N., 1 Jan 2017, In : Human Molecular Genetics. 26, 1, p. 33-43 11 p.

    Research output: Contribution to journalArticle

  18. Postnatal cardiac gene editing using CRISPR/Cas9 with AAV9-mediated delivery of short guide RNAs results in mosaic gene disruption

    Johansen, A. K., Molenaar, B., Versteeg, D., Leitoguinho, A. R., Demkes, C., Spanjaard, B., De Ruiter, H., Moqadam, F. A., Kooijman, L., Zentilin, L., Giacca, M. & Van Rooij, E., 1 Jan 2017, In : Circulation Research. 121, 10, p. 1168-1181 14 p.

    Research output: Contribution to journalArticle

  19. Unacylated ghrelin normalizes skeletal muscle oxidative stress and prevents muscle catabolism by enhancing tissue mitophagy in experimental chronic kidney disease

    Cappellari, G. G., Semolic, A., Ruozi, G., Vinci, P., Guarnieri, G., Bortolotti, F., Barbetta, D., Zanetti, M., Giacca, M. & Barazzoni, R., 1 Jan 2017, In : Faseb Journal. 31, 12, p. 5159-5171 13 p.

    Research output: Contribution to journalArticle

  20. 2016
  21. Gene Therapy With Angiotensin-(1-9) Preserves Left Ventricular Systolic Function After Myocardial Infarction

    Fattah, C., Nather, K., McCarroll, C. S., Hortigon-Vinagre, M. P., Zamora, V., Flores-Munoz, M., McArthur, L., Zentilin, L., Giacca, M., Touyz, R. M., Smith, G. L., Loughrey, C. M. & Nicklin, S. A., 20 Dec 2016, In : Journal of the American College of Cardiology. 68, 24, p. 2652-2666 15 p.

    Research output: Contribution to journalArticle

  22. HIV Latency TORn Down

    Giacca, M., 14 Dec 2016, In : Cell Host and Microbe. 20, 6, p. 700-702 3 p.

    Research output: Contribution to journalShort survey

  23. Plasma total and unacylated ghrelin predict 5-year changes in insulin resistance

    Barazzoni, R., Gortan Cappellari, G., Semolic, A., Ius, M., Mamolo, L., Dore, F., Giacca, M., Zanetti, M., Vinci, P. & Guarnieri, G., 1 Oct 2016, In : CLINICAL NUTRITION. 35, 5, p. 1168-1173 6 p.

    Research output: Contribution to journalArticle

  24. Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization

    Ottaviani, G., Martinelli, V., Rupel, K., Caronni, N., Naseem, A., Zandonà, L., Perinetti, G., Gobbo, M., Di Lenarda, R., Bussani, R., Benvenuti, F., Giacca, M., Biasotto, M. & Zacchigna, S., 1 Sep 2016, In : EBioMedicine. 11, p. 165-172 8 p.

    Research output: Contribution to journalArticle

  25. VEGF121 and VEGF165 differentially promote vessel maturation and tumor growth in mice and humans

    Kazemi, M., Carrer, A., Moimas, S., Zandonà, L., Bussani, R., Casagranda, B., Palmisano, S., Prelazzi, P., Giacca, M., Zentilin, L., De Manzini, N., Giacca, M. & Zacchigna, S., 1 May 2016, In : Cancer Gene Therapy. 23, 5, p. 125-132 8 p.

    Research output: Contribution to journalArticle

  26. Unacylated ghrelin reduces skeletal muscle reactive oxygen species generation and inflammation and prevents high-fat diet-induced hyperglycemia and whole-body insulin resistance in rodents

    Cappellari, G. G., Zanetti, M., Semolic, A., Vinci, P., Ruozi, G., Falcione, A., Filigheddu, N., Guarnieri, G., Graziani, A., Giacca, M. & Barazzoni, R., 1 Apr 2016, In : Diabetes. 65, 4, p. 874-886 13 p.

    Research output: Contribution to journalArticle

  27. A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9

    Carroll, K. J., Makarewich, C. A., McAnally, J., Anderson, D. M., Zentilin, L., Liu, N., Giacca, M., Bassel-Duby, R. & Olson, E. N., 12 Jan 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 2, p. 338-343 6 p.

    Research output: Contribution to journalArticle

  28. 2015
  29. Unacylated ghrelin does not alter mitochondrial function, redox state and triglyceride content in rat liver in vivo

    Gortan Cappellari, G., Zanetti, M., Semolic, A., Vinci, P., Ruozi, G., De Nardo, M., Filigheddu, N., Guarnieri, G., Giacca, M., Graziani, A. & Barazzoni, R., 1 Dec 2015, In : Clinical Nutrition Experimental. 4, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  30. Local delivery of the Neuregulin1 receptor ecto-domain (ecto-ErbB4) has a positive effect on regenerated nerve fiber maturation

    Gambarotta, G., Pascal, D., Ronchi, G., Morano, M., Jager, S. B., Moimas, S., Zentilin, L., Giacca, M., Perroteau, I., Tos, P., Geuna, S. & Raimondo, S., 1 Nov 2015, In : Gene Therapy. 22, 11, p. 901-907 7 p.

    Research output: Contribution to journalArticle

  31. Genome-wide RNAi screening identifies host restriction factors critical for in vivo AAV transduction

    Mano, M., Ippodrino, R., Zentilin, L., Zacchigna, S. & Giacca, M., 8 Sep 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 36, p. 11276-11281 6 p.

    Research output: Contribution to journalArticle

  32. Nuclear architecture dictates HIV-1 integration site selection

    Marini, B., Kertesz-Farkas, A., Ali, H., Lucic, B., Lisek, K., Manganaro, L., Pongor, S., Luzzati, R., Recchia, A., Mavilio, F., Giacca, M. & Lusic, M., 14 May 2015, In : Nature. 521, 7551, p. 227-231 5 p.

    Research output: Contribution to journalArticle

  33. Proliferation of multiple cell types in the skeletal muscle tissue elicited by acute p21 suppression

    Biferi, M. G., Nicoletti, C., Falcone, G., Puggioni, E. M. R., Passaro, N., Mazzola, A., Pajalunga, D., Zaccagnini, G., Rizzuto, E., Auricchio, A., Zentilin, L., De Luca, G., Giacca, M., Martelli, F., Musio, A., Musarò, A. & Crescenzi, M., 9 May 2015, In : Molecular Therapy. 23, 5, p. 885-895 11 p.

    Research output: Contribution to journalArticle

  34. DNA-protein interaction dynamics at the Lamin B2 replication origin http://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.973337

    Puzzi, L., Marchetti, L., Peverali, F. A., Biamonti, G. & Giacca, M., 1 Jan 2015, In : Cell Cycle. 14, 1, p. 64-73 10 p.

    Research output: Contribution to journalArticle

  35. Exercise-induced increases in cell free DNA in human plasma originate predominantly from cells of the haematopoietic lineage

    Tug, S., Helmig, S., Deichmann, E. R., Schmeier-Jürchott, A., Wagner, E., Zimmermann, T., Radsak, M., Giacca, M. & Simon, P., 1 Jan 2015, In : Exercise Immunology Review. 21, p. 164-173 10 p.

    Research output: Contribution to journalArticle

  36. In vivo therapeutic potential of mesenchymal stromal cells depends on the source and the isolation procedure

    Bortolotti, F., Ukovich, L., Razban, V., Martinelli, V., Ruozi, G., Pelos, B., Dore, F., Giacca, M. & Zacchigna, S., 1 Jan 2015, In : Stem cell reports. 4, 3, p. 332-339 8 p.

    Research output: Contribution to journalArticle

  37. Intracoronary Cytoprotective Gene Therapy: A Study of VEGF-B 167 in a Pre-Clinical Animal Model of Dilated Cardiomyopathy

    Woitek, F., Zentilin, L., Hoffman, N. E., Powers, J. C., Ottiger, I., Parikh, S., Kulczycki, A. M., Hurst, M., Ring, N., Wang, T., Shaikh, F., Gross, P., Singh, H., Kolpakov, M. A., Linke, A., Houser, S. R., Rizzo, V., Sabri, A., Madesh, M., Giacca, M. & 1 others, Recchia, F. A., 1 Jan 2015, In : Journal of the American College of Cardiology. 66, 2, p. 139-153 15 p., 21362.

    Research output: Contribution to journalArticle

  38. AAV-mediated in vivo functional selection of tissue-protective factors against ischaemia

    Ruozi, G., Bortolotti, F., Falcione, A., Dal Ferro, M., Ukovich, L., MacEdo, A., Zentilin, L., Filigheddu, N., Cappellari, G. G., Baldini, G., Zweyer, M., Barazzoni, R., Graziani, A., Zacchigna, S. & Giacca, M., 2015, In : Nature Communications. 6, p. 1-15 7388.

    Research output: Contribution to journalArticle

  39. 2014
  40. Ground control to major tom: "prepare for HIV Landing"

    Lusic, M. & Giacca, M., 12 Nov 2014, In : Cell Host and Microbe. 16, 5, p. 557-559 3 p.

    Research output: Contribution to journalShort survey

  41. Transgene detection by digital droplet PCR

    Moser, D. A., Braga, L., Raso, A., Zacchigna, S., Giacca, M. & Simon, P., 6 Nov 2014, In : PLoS ONE. 9, 11, e111781.

    Research output: Contribution to journalArticle

  42. Epigenetic modification at Notch responsive promoters blunts efficacy of inducing Notch pathway reactivation after myocardial infarction

    Felician, G., Collesi, C., Lusic, M., Martinelli, V., Dal Ferro, M., Zentilin, L., Zacchigna, S. & Giacca, M., 12 Sep 2014, In : Circulation Research. 115, 7, p. 636-649 14 p.

    Research output: Contribution to journalArticle

  43. Functional high-throughput screening identifies the miR-15 microRNA family as cellular restriction factors for Salmonella infection

    Maudet, C., Mano, M., Sunkavalli, U., Sharan, M., Giacca, M., Förstner, K. U. & Eulalio, A., 22 Aug 2014, In : Nature Communications. 5, 4718.

    Research output: Contribution to journalArticle

  44. The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response

    Puente, B. N., Kimura, W., Muralidhar, S. A., Moon, J., Amatruda, J. F., Phelps, K. L., Grinsfelder, D., Rothermel, B. A., Chen, R., Garcia, J. A., Santos, C. X., Thet, S., Mori, E., Kinter, M. T., Rindler, P. M., Zacchigna, S., Mukherjee, S., Chen, D. J., Mahmoud, A. I., Giacca, M. & 5 others, Rabinovitch, P. S., Aroumougame, A., Shah, A. M., Szweda, L. I. & Sadek, H. A., 24 Apr 2014, In : Cell. 157, 3, p. 565-579 15 p.

    Research output: Contribution to journalArticle

  45. Evaluation of nutritional status in head and neck radio-treated patients affected by oral mucositis: Efficacy of class IV laser therapy

    Gobbo, M., Ottaviani, G., Perinetti, G., Ciriello, F., Beorchia, A., Giacca, M., Di Lenarda, R., Rupel, K., Tirelli, G., Zacchigna, S. & Biasotto, M., 1 Jan 2014, In : Supportive Care in Cancer. 22, 7, p. 1851-1856 6 p.

    Research output: Contribution to journalArticle

  46. HIV-1 integrase binding to its cellular partners: A perspective from computational biology

    Quy, V. C., Carnevale, V., Manganaro, L., Lusic, M., Rossetti, G., Leone, V., Fenollar-Ferrer, C., Raugei, S., Del Sal, G., Giacca, M. & Carloni, P., 1 Jan 2014, In : Current Pharmaceutical Design. 20, 21, p. 3412-3421 10 p.

    Research output: Contribution to journalArticle

  47. Life-long correction of hyperbilirubinemia with a neonatal liver-specific AAV-mediated gene transfer in a lethal mouse model of Crigler-Najjar syndrome

    Bortolussi, G., Zentillin, L., Vaníkova, J., Bockor, L., Bellarosa, C., Mancarella, A., Vianello, E., Tiribelli, C., Giacca, M., Vitek, L. & Muro, A. F., 1 Jan 2014, In : Human Gene Therapy. 25, 9, p. 844-855 12 p.

    Research output: Contribution to journalArticle

  48. Manufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard material

    Ayuso, E., Blouin, V., Lock, M., Mcgorray, S., Leon, X., Alvira, M. R., Auricchio, A., Bucher, S., Chtarto, A., Clark, K. R., Darmon, C., Doria, M., Fountain, W., Gao, G., Gao, K., Giacca, M., Kleinschmidt, J., Leuchs, B., Melas, C., Mizukami, H. & 16 others, Müller, M., Noordman, Y., Bockstael, O., Ozawa, K., Pythoud, C., Sumaroka, M., Surosky, R., Tenenbaum, L., Van Der Linden, I., Weins, B., Wright, J. F., Zhang, X., Zentilin, L., Bosch, F., Snyder, R. O. & Moullier, P., 1 Jan 2014, In : Human Gene Therapy. 25, 11, p. 977-987 11 p.

    Research output: Contribution to journalArticle

  49. Notch1 activity in the olfactory bulb is odour-dependent and contributes to olfactory behaviour

    Brai, E., Marathe, S., Zentilin, L., Giacca, M., Nimpf, J., Kretz, R., Scotti, A. & Alberi, L., 1 Jan 2014, In : European Journal of Neuroscience. 40, 10, p. 3436-3449 14 p.

    Research output: Contribution to journalArticle

  50. Reversible acetylation regulates vascular endothelial growth factor receptor-2 activity

    Zecchin, A., Pattarini, L., Gutierrez, M. I., Mano, M., Mai, A., Valente, S., Myers, M. P., Pantano, S. & Giacca, M., 1 Jan 2014, In : Journal of Molecular Cell Biology. 6, 2, p. 116-127 12 p.

    Research output: Contribution to journalArticle

  51. 2013
  52. Effect of class IV laser therapy on chemotherapy-induced oral mucositis: A clinical and experimental study

    Ottaviani, G., Gobbo, M., Sturnega, M., Martinelli, V., Mano, M., Zanconati, F., Bussani, R., Perinetti, G., Long, C. S., Di Lenarda, R., Giacca, M., Biasotto, M. & Zacchigna, S., 1 Dec 2013, In : American Journal of Pathology. 183, 6, p. 1747-1757 11 p.

    Research output: Contribution to journalArticle

  53. Macrophage MicroRNA-155 Promotes Cardiac Hypertrophy and Failure

    Heymans, S., Corsten, M. F., Verhesen, W., Carai, P., van Leeuwen, R. E. W., Custers, K., Peters, T., Hazebroek, M., Stoeger, L., Wijnands, E., Janssen, B. J., Creemers, E. E., Pinto, Y. M., Grimm, D., Schuermann, N., Vigorito, E., Thum, T., Stassen, F., Yin, X., Mayr, M. & 9 others, de Windt, L. J., Lutgens, E., Wouters, K., de Winther, M. P. J., Zacchigna, S., Giacca, M., van Bilsen, M., Papageorgiou, A-P. & Schroen, B., 24 Sep 2013, In : Circulation (Baltimore). 128, 13, p. 1420-1432 13 p., N/A.

    Research output: Contribution to journalArticle

  54. Carbon nanotubes instruct physiological growth and functionally mature syncytia: Nongenetic engineering of cardiac myocytes

    Martinelli, V., Cellot, G., Toma, F. M., Long, C. S., Caldwell, J. H., Zentilin, L., Giacca, M., Turco, A., Prato, M., Ballerini, L. & Mestroni, L., 23 Jul 2013, In : ACS Nano. 7, 7, p. 5746-5756 11 p.

    Research output: Contribution to journalArticle

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