King's College London

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Research Outputs

  1. 2017
  2. Predicting causal variants affecting expression by using whole-genome sequencing and RNA-seq from multiple human tissues

    Brown, A. A., Viñuela, A., Delaneau, O., Spector, T. D., Small, K. S. & Dermitzakis, E. T., 1 Dec 2017, In : Nature Genetics. 49, 12, p. 1747-1751

    Research output: Contribution to journalLetter

  3. Exome-wide association study of plasma lipids in >300,000 individuals

    Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Alves, A. C., Amouyel, P., Di Angelantonio, E., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., Bis, J. C. & 31 others, Boehnke, M., Boerwinkle, E., Bork-Jensen, J., Bottinger, E. P., Brandslund, I., Brown, M., Busonero, F., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. E., Chen, Y-D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Connell, J. M., Cucca, F., Cupples, L. A., Damrauer, S. M., Davies, G., Deary, I. J., Dedoussis, G., Denny, J. C., Dominiczak, A., Dubé, M-P., Ebeling, T., Eiriksdottir, G., Esko, T., Small, K. S., Spector, T. D. & Charge Diabetes Working Group, Dec 2017, In : Nature Genetics. 49, 12, p. 1758-1766 9 p.

    Research output: Contribution to journalLetter

  4. Acne and Telomere Length: A New Spectrum between Senescence and Apoptosis Pathways

    Ribero, S., Sanna, M., Visconti, A., Navarini, A., Aviv, A., Glass, D., Spector, T. D., Smith, C., Simpson, M., Barker, J., Mangino, M., Falchi, M. & Bataille, V., Feb 2017, In : Journal of Investigative Dermatology. 137, 2, p. 513-515

    Research output: Contribution to journalLetter

  5. Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

    Wahl, S., Drong, A., Lehne, B., Loh, M., Scott, W. R., Kunze, S., Tsai, P-C., Ried, J. S., Zhang, W., Yang, Y., Tan, S., Fiorito, G., Franke, L., Guarrera, S., Kasela, S., Kriebel, J., Richmond, R. C., Adamo, M., Afzal, U., Ala-Korpela, M. & 87 others, Albetti, B., Ammerpohl, O., Apperley, J. F., Beekman, M., Bertazzi, P. A., Black, S. L., Blancher, C., Bonder, M-J., Brosch, M., Carstensen-Kirberg, M., de Craen, A. J. M., de Lusignan, S., Dehghan, A., Elkalaawy, M., Fischer, K., Franco, O. H., Gaunt, T. R., Hampe, J., Hashemi, M., Isaacs, A., Jenkinson, A., Jha, S., Kato, N., Krogh, V., Laffan, M., Meisinger, C., Meitinger, T., Mok, Z. Y., Motta, V., Ng, H. K., Nikolakopoulou, Z., Nteliopoulos, G., Panico, S., Pervjakova, N., Prokisch, H., Rathmann, W., Roden, M., Rota, F., Rozario, M. A., Sandling, J. K., Schafmayer, C., Schramm, K., Siebert, R., Slagboom, P. E., Soininen, P., Stolk, L., Strauch, K., Tai, E-S., Tarantini, L., Thorand, B., Tigchelaar, E. F., Tumino, R., Uitterlinden, A. G., van Duijn, C., van Meurs, J. B. J., Vineis, P., Wickremasinghe, A. R., Wijmenga, C., Yang, T-P., Yuan, W., Zhernakova, A., Batterham, R. L., Smith, G. D., Deloukas, P., Heijmans, B. T., Herder, C., Hofman, A., Lindgren, C. M., Milani, L., van der Harst, P., Peters, A., Illig, T., Relton, C. L., Waldenberger, M., Järvelin, M-R., Bollati, V., Soong, R., Spector, T. D., Scott, J., McCarthy, M. I., Elliott, P., Bell, J. T., Matullo, G., Gieger, C., Kooner, J. S., Grallert, H. & Chambers, J. C., 5 Jan 2017, In : NATURE. 541, p. 81-86 6 p.

    Research output: Contribution to journalLetter

  6. 2016
  7. 2015
  8. Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins

    Buil, A., Brown, A. A., Lappalainen, T., Viñuela, A., Davies, M. N., Zheng, H. F., Richards, J. B., Glass, D., Small, K. S., Durbin, R., Spector, T. D. & Dermitzakis, E. T., Jan 2015, In : Nature Genetics. 47, 1, p. 88-91 4 p.

    Research output: Contribution to journalLetter

  9. 2014
  10. Contribution of the COMT Val158Met variant to symptomatic knee osteoarthritis

    Neogi, T., Soni, A., Doherty, S. A., Laslett, L. L., Maciewicz, R. A., Hart, D. J., Zhang, W., Muir, K. R., Wheeler, M., Cooper, C., Spector, T. D., Cicuttini, F., Jones, G., Nevitt, M., Liu, Y., Arden, N. K., Doherty, M. & Valdes, A. M., Jan 2014, In : Annals of the Rheumatic Diseases. 73, 1, p. 315-317 3 p., N/A.

    Research output: Contribution to journalLetter

  11. 2013
  12. Common variants associated with plasma triglycerides and risk for coronary artery disease

    Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H-Y., Demirkan, A., Den Hertog, H. M., Donnelly, L. A., Ehret, G. B., Esko, T. & 243 others, Feitosa, M. F., Ferreira, T., Fischer, K., Fontanillas, P., Fraser, R. M., Freitag, D. F., Gurdasani, D., Heikkila, K., Hyppoenen, E., Isaacs, A., Jackson, A. U., Johansson, A., Johnson, T., Kaakinen, M., Kettunen, J., Kleber, M. E., Li, X., Luan, J., Lyytikainen, L-P., Magnusson, P. K. E., Mangino, M., Mihailov, E., Montasser, M. E., Mueller-Nurasyid, M., Nolte, I. M., O'Connell, J. R., Palmer, C. D., Perola, M., Petersen, A-K., Sanna, S., Saxena, R., Service, S. K., Shah, S., Shungin, D., Sidore, C., Song, C., Strawbridge, R. J., Surakka, I., Tanaka, T., Teslovich, T. M., Thorleifsson, G., Van den Herik, E. G., Voight, B. F., Volcik, K. A., Waite, L. L., Wong, A., Wu, Y., Zhang, W., Absher, D., Asiki, G., Barroso, I., Been, L. F., Bolton, J. L., Bonnycastle, L. L., Brambilla, P., Burnett, M. S., Cesana, G., Dimitriou, M., Doney, A. S. F., Doering, A., Elliott, P., Epstein, S. E., Eyjolfsson, G. I., Gigante, B., Goodarzi, M. O., Grallert, H., Gravito, M. L., Groves, C. J., Hallmans, G., Hartikainen, A-L., Hayward, C., Hernandez, D., Hicks, A. A., Holm, H., Hung, Y-J., Illig, T., Jones, M. R., Kaleebu, P., Kastelein, J. J. P., Khaw, K-T., Kim, E., Klopp, N., Komulainen, P., Kumari, M., Langenberg, C., Lehtimaki, T., Lin, S-Y., Lindstrom, J., Loos, R. J. F., Mach, F., McArdle, W. L., Meisinger, C., Mitchell, B. D., Mueller, G., Nagaraja, R., Narisu, N., Nieminen, T. V. M., Nsubuga, R. N., Olafsson, I., Ong, K. K., Palotie, A., Papamarkou, T., Pomilla, C., Pouta, A., Rader, D. J., Reilly, M. P., Ridker, P. M., Rivadeneira, F., Rudan, I., Ruokonen, A., Samani, N., Scharnagl, H., Seeley, J., Silander, K., Stancakova, A., Stirrups, K., Swift, A. J., Tiret, L., Uitterlinden, A. G., van Pelt, L. J., Vedantam, S., Wainwright, N., Wijmenga, C., Wild, S. H., Willemsen, G., Wilsgaard, T., Wilson, J. F., Young, E. H., Zhao, J. H., Adair, L. S., Arveiler, D., Assimes, T. L., Bandinelli, S., Bennett, F., Bochud, M., Boehm, B. O., Boomsma, D. I., Borecki, I. B., Bornstein, S. R., Bovet, P., Burnier, M., Campbell, H., Chakravarti, A., Chambers, J. C., Chen, Y-D. I., Collins, F. S., Cooper, R. S., Danesh, J., Dedoussis, G., de Faire, U., Feranil, A. B., Ferrieres, J., Ferrucci, L., Freimer, N. B., Gieger, C., Groop, L. C., Gudnason, V., Gyllensten, U., Hamsten, A., Harris, T. B., Hingorani, A., Hirschhorn, J. N., Hofman, A., Hovingh, G. K., Hsiung, C. A., Humphries, S. E., Hunt, S. C., Hveem, K., Iribarren, C., Jarvelin, M-R., Jula, A., Kahonen, M., Kaprio, J., Kesaniemi, A., Kivimaki, M., Kooner, J. S., Koudstaal, P. J., Krauss, R. M., Kuh, D., Kuusisto, J., Kyvik, K. O., Laakso, M., Lakka, T. A., Lind, L., Lindgren, C. M., Martin, N. G., Maerz, W., McCarthy, M. I., McKenzie, C. A., Meneton, P., Metspalu, A., Moilanen, L., Morris, A. D., Munroe, P. B., Njolstad, I., Pedersen, N. L., Power, C., Pramstaller, P. P., Price, J. F., Psaty, B. M., Quertermous, T., Rauramaa, R., Saleheen, D., Salomaa, V., Sanghera, D. K., Saramies, J., Schwarz, P. E. H., Sheu, W. H-H., Shuldiner, A. R., Siegbahn, A., Spector, T. D., Stefansson, K., Strachan, D. P., Tayo, B. O., Tremoli, E., Tuomilehto, J., Uusitupa, M., van Duijn, C. M., Vollenweider, P., Wallentin, L., Wareham, N. J., Whitfield, J. B., Wolffenbuttel, B. H. R., Altshuler, D., Ordovas, J. M., Boerwinkle, E., Palmer, C. N. A., Thorsteinsdottir, U., Chasman, D. I., Rotter, J. I., Franks, P. W., Ripatti, S., Cupples, L. A., Sandhu, M. S., Rich, S. S., Boehnke, M., Deloukas, P., Mohlke, K. L., Ingelsson, E., Abecasis, G. R., Daly, M. J., Neale, B. M. & Kathiresan, S., Nov 2013, In : Nature Genetics. 45, 11, p. 1345-1352 8 p., N/A.

    Research output: Contribution to journalLetter

  13. The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome- wide statistical significance in males

    Evangelou, E., Valdes, A. M., Castano-Betancourt, M. C., Doherty, M., Doherty, S., Esko, T., Ingvarsson, T., Ioannidis, J. P. A., Kloppenburg, M., Metspalu, A., Ntzani, E. E., Panoutsopoulou, K., Slagboom, P. E., Southam, L., Spector, T. D., Styrkarsdottir, U., Stefanson, K., Uitterlinden, A. G., Wheeler, M., Zeggini, E. & 4 others, Meulenbelt, I., van Meurs, J. B., arcOGEN Consortium & TREAT-OA Consortium, Jul 2013, In : Annals of the Rheumatic Diseases. 72, 7, p. 1264-1265 2 p., N/A.

    Research output: Contribution to journalLetter

  14. Identification of seven loci affecting mean telomere length and their association with disease

    Codd, V., Nelson, C. P., Albrecht, E., Mangino, M., Deelen, J., Buxton, J. L., Hottenga, J. J., Fischer, K., Esko, T., Surakka, I., Broer, L., Nyholt, D. R., Leach, I. M., Salo, P., H??gg, S., Matthews, M. K., Palmen, J., Norata, G. D., O'reilly, P. F., Saleheen, D. & 80 others, Amin, N., Balmforth, A. J., Beekman, M., De Boer, R. A., B??hringer, S., Braund, P. S., Burton, P. R., Craen, A. J. M., Denniff, M., Dong, Y., Douroudis, K., Dubinina, E., Eriksson, J. G., Garlaschelli, K., Guo, D., Hartikainen, A., Henders, A. K., Houwing-duistermaat, J. J., Kananen, L., Karssen, L. C., Kettunen, J., Klopp, N., Lagou, V., Van Leeuwen, E. M., Madden, P. A., M??gi, R., Magnusson, P. K. E., M??nnist??, S., Mccarthy, M. I., Medland, S. E., Mihailov, E., Montgomery, G. W., Oostra, B. A., Palotie, A., Peters, A., Pollard, H., Pouta, A., Prokopenko, I., Ripatti, S., Salomaa, V., Suchiman, H. E. D., Valdes, A. M., Verweij, N., Viñuela, A., Wang, X., Wichmann, H., Widen, E., Willemsen, G., Wright, M. J., Xia, K., Xiao, X., Van Veldhuisen, D. J., Catapano, A. L., Tobin, M. D., Hall, A. S., Blakemore, A. I. F., Van Gilst, W. H., Zhu, H., Consortium, C., Erdmann, J., Reilly, M. P., Kathiresan, S., Schunkert, H., Talmud, P. J., Pedersen, N. L., Perola, M., Ouwehand, W., Kaprio, J., Martin, N. G., Van Duijn, C. M., Hovatta, I., Gieger, C., Metspalu, A., Boomsma, D. I., Jarvelin, M., Slagboom, P. E., Thompson, J. R., Spector, T. D., Van Der Harst, P. & Samani, N. J., Apr 2013, In : Nature Genetics. 45, 4, p. 422-427 6 p., N/A.

    Research output: Contribution to journalLetter

  15. 2012
  16. A Large-Scale Population-Based Analysis of Common Genetic Variation in the Thyroid Hormone Receptor Alpha Locus and Bone

    Medici, M., Rivadeneira, F., van der Deure, W. M., Hofman, A., van Meurs, J. B. J., Styrkarsdottir, U., van Duijn, C. M., Spector, T., Kiel, D. P., Uitterlinden, A. G., Visser, T. J. & Peeters, R. P., 1 Feb 2012, In : Thyroid. 22, 2, p. 223 - 224 2 p.

    Research output: Contribution to journalLetter

  17. 2011
  18. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

    Wain, L. V., Verwoert, G. C., O'Reilly, P. F., Shi, G., Johnson, T., Johnson, A. D., Bochud, M., Rice, K. M., Henneman, P., Smith, A. V., Ehret, G. B., Amin, N., Larson, M. G., Mooser, V., Hadley, D., D??rr, M., Bis, J. C., Aspelund, T., Esko, T., Janssens, A. C. J. W. & 204 others, Zhao, J. H., Heath, S., Laan, M., Fu, J., Pistis, G., Luan, J., Arora, P., Lucas, G., Pirastu, N., Pichler, I., Jackson, A. U., Webster, R. J., Zhang, F., Peden, J. F., Schmidt, H., Tanaka, T., Campbell, H., Igl, W., Milaneschi, Y., Hottenga, J., Vitart, V., Chasman, D. I., Trompet, S., Bragg-gresham, J. L., Alizadeh, B. Z., Chambers, J. C., Guo, X., Lehtim??ki, T., K??hnel, B., Lopez, L. M., Pola??ek, O., Boban, M., Nelson, C. P., Morrison, A. C., Pihur, V., Ganesh, S. K., Hofman, A., Kundu, S., Mattace-raso, F. U. S., Rivadeneira, F., Sijbrands, E. J. G., Uitterlinden, A. G., Hwang, S., Vasan, R. S., Wang, T. J., Bergmann, S., Vollenweider, P., Waeber, G., Laitinen, J., Pouta, A., Zitting, P., Mcardle, W. L., Kroemer, H. K., V??lker, U., V??lzke, H., Glazer, N. L., Taylor, K. D., Harris, T. B., Alavere, H., Haller, T., Keis, A., Tammesoo, M., Aulchenko, Y., Barroso, I., Khaw, K., Galan, P., Hercberg, S., Lathrop, M., Eyheramendy, S., Org, E., S??ber, S., Lu, X., Nolte, I. M., Penninx, B. W., Corre, T., Masciullo, C., Sala, C., Groop, L., Voight, B. F., Melander, O., O'donnell, C. J., Salomaa, V., D'adamo, A. P., Fabretto, A., Faletra, F., Ulivi, S., Del Greco M, F., Facheris, M., Collins, F. S., Bergman, R. N., Beilby, J. P., Hung, J., Musk, A. W., Mangino, M., Shin, S., Soranzo, N., Watkins, H., Goel, A., Hamsten, A., Gider, P., Loitfelder, M., Zeginigg, M., Hernandez, D., Najjar, S. S., Navarro, P., Wild, S. H., Corsi, A. M., Singleton, A., De Geus, E. J. C., Willemsen, G., Parker, A. N., Rose, L. M., Buckley, B., Stott, D., Orru, M., Uda, M., Van Der Klauw, M. M., Zhang, W., Li, X., Scott, J., Chen, Y. I., Burke, G. L., K??h??nen, M., Viikari, J., D??ring, A., Meitinger, T., Davies, G., Starr, J. M., Emilsson, V., Plump, A., Lindeman, J. H., Hoen, P. A. C. ., K??nig, I. R., Felix, J. F., Clarke, R., Hopewell, J. C., Ongen, H., Breteler, M., Debette, S., Destefano, A. L., Fornage, M., Mitchell, G. F., Smith, N. L., Holm, H., Stefansson, K., Thorleifsson, G., Thorsteinsdottir, U., Samani, N. J., Preuss, M., Rudan, I., Hayward, C., Deary, I. J., Wichmann, H., Raitakari, O. T., Palmas, W., Kooner, J. S., Stolk, R. P., Jukema, J. W., Wright, A. F., Boomsma, D. I., Bandinelli, S., Gyllensten, U. B., Wilson, J. F., Ferrucci, L., Schmidt, R., Farrall, M., Spector, T. D., Palmer, L. J., Tuomilehto, J., Pfeufer, A., Gasparini, P., Siscovick, D., Altshuler, D., Loos, R. J. F., Toniolo, D., Snieder, H., Gieger, C., Meneton, P., Wareham, N. J., Oostra, B. A., Metspalu, A., Launer, L., Rettig, R., Strachan, D. P., Beckmann, J. S., Witteman, J. C. M., Erdmann, J., Van Dijk, K. W., Boerwinkle, E., Boehnke, M., Ridker, P. M., Jarvelin, M., Chakravarti, A., Abecasis, G. R., Gudnason, V., Newton-cheh, C., Levy, D., Munroe, P. B., Psaty, B. M., Caulfield, M. J., Rao, D. C., Tobin, M. D., Elliott, P. & Van Duijn, C. M., Oct 2011, In : Nature Genetics. 43, 10, p. 1005-1011

    Research output: Contribution to journalLetter

  19. The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance

    Valdes, A. M., Evangelou, E., Kerkhof, H. J. M., Tamm, A., Doherty, S. A., Kisand, K., Tamm, A., Kerna, I., Uitterlinden, A., Hofman, A., Rivadeneira, F., Cooper, C., Dennison, E. M., Zhang, W., Muir, K. R., Ioannidis, J. P. A., Wheeler, M., Maciewicz, R. A., van Meurs, J. B., Arden, N. K. & 2 others, Spector, T. D. & Doherty, M., May 2011, In : Annals of the Rheumatic Diseases. 70, 5, p. 873-5 3 p.

    Research output: Contribution to journalLetter

  20. Genome-Wide Association Study of Hoarding Traits

    Perroud, N., Guipponi, M., Pertusa, A., Fullana, M. A., Iervolino, A. C., Cherkas, L., Spector, T., Collier, D. & Mataix-Cols, D., Mar 2011, In : American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 156B, 2, p. 240 - 242 3 p.

    Research output: Contribution to journalLetter

  21. 2010
  22. Response

    Burri, A. V., Cherkas, L. & Spector, T. D., 2010, In : JOURNAL OF SEXUAL MEDICINE. 7, 6, p. 2292 - 2294 3 p.

    Research output: Contribution to journalLetter

  23. 2007
  24. Antiplatelet agents for prevention of pre-eclampsia

    Chandiramani, M., Seed, P., Poston, L. & Shennan, A. H., 2007, In : The Lancet. 370, 9600, p. 1685 - 1685 1 p.

    Research output: Contribution to journalLetter

  25. 2006
  26. Replication in genetic association studies - reply.

    Spector, TD., Ahmadi, KR. & Valdes, AM., Sep 2006, In : Arthritis & Rheumatism. 54, 9, p. 3064 - 3065 2 p.

    Research output: Contribution to journalLetter

  27. 2002
  28. Activation of coagulation and fibrinolytic system and thrombotic tendency - Reply

    Ariens, R. A. S., de Lange, M., Snieder, H., Spector, T. D. & Grant, P. J., 2002, In : The Lancet. 360, 9335, p. 802 - 802 1 p.

    Research output: Contribution to journalLetter

  29. Determinants of size at birth

    Arden, N. K., Cooper, C. & Spector, T. D., 2002, In : QJM. 95, 5, p. 331 - 332 2 p.

    Research output: Contribution to journalLetter

  30. Preventing patient falls

    Oliver, D., Martin, F. & Seed, P., 2002, In : Age and Ageing. 31, 1, p. 75 - 76 2 p.

    Research output: Contribution to journalLetter

  31. 2001
  32. Chronic fatigue in general practice - Response

    Ridsdale, L., Godfrey, E. & Seed, P., 2001, In : British Journal of General Practice. 51, 465, p. 317 - 318 2 p.

    Research output: Contribution to journalLetter

  33. Cognitive behaviour therapy and chronic fatigue syndrome - Response

    Ridsdale, L., Godfrey, E. & Seed, P., 2001, In : British Journal of General Practice. 51, 465, p. 316 - 317 2 p.

    Research output: Contribution to journalLetter

  34. Epidural analgesia during labour

    Kenyon, A. P., Seed, P. & Shennan, A., 2001, In : British Journal of Anaesthesia. 86, 1, p. 150 - 151 2 p.

    Research output: Contribution to journalLetter

  35. Prevention of pre-eclampsia

    Shennan, A. H., Poston, L., Chappell, L. C. & Seed, P. T., 2001, In : The Lancet. 357, 9267, p. 1534 - 1534 1 p.

    Research output: Contribution to journalLetter

  36. 2000
  37. Genetic factors and osteoporotic fractures in elderly people - Twin data support genetic contribution to risk of fracture

    MacGregor, A. J., Snieder, H. & Spector, T. D., 2000, In : BMJ, British Medical Journal (Clinical Research Ed.). 320, 7250, p. 1669 - 1670 2 p.

    Research output: Contribution to journalLetter

  38. 1999
  39. Contamination hazard due to iodine-131 therapy for thyrotoxicosis

    Barrington, S. F., O'Doherty, M. J., Kettle, A. G., Thomson, W. H., Mountford, P. J., Burrell, D. N., Farrell, R. J., Batchelor, S., Seed, P. & Harding, L. K., 1999, In : European Journal of Nuclear Medicine. 26, 12, p. 1632 1 p.

    Research output: Contribution to journalLetter

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