King's College London

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Research Outputs

  1. 2017
  2. Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

    de Lange, K. M., Moutsianas, L., Lee, J. C., Lamb, C. A., Luo, Y., Kennedy, N. A., Jostins, L., Rice, D. L., Gutierrez-Achury, J., Ji, S-G., Heap, G., Nimmo, E. R., Edwards, C., Henderson, P., Mowat, C., Sanderson, J., Satsangi, J., Simmons, A., Wilson, D. C., Tremelling, M. & 12 others, Hart, A., Mathew, C. G., Newman, W. G., Parkes, M., Lees, C. W., Uhlig, H., Hawkey, C., Prescott, N. J., Ahmad, T., Mansfield, J. C., Anderson, C. A. & Barrett, J. C., 2017, In : Nature Genetics. 49, 2, p. 256-261

    Research output: Contribution to journalLetter

  3. 2013
  4. Negligible impact of rare autoimmune-locus coding-region variants on missing heritability

    Hunt, K. A., Mistry, V., Bockett, N. A., Ahmad, T., Ban, M., Barker, J. N., Barrett, J. C., Blackburn, H., Brand, O., Burren, O., Capon, F., Compston, A., Gough, S. C. L., Jostins, L., Kong, Y., Lee, J. C., Lek, M., MacArthur, D. G., Mansfield, J. C., Mathew, C. G. & 17 others, Mein, C. A., Mirza, M., Nutland, S., Onengut-Gumuscu, S., Papouli, E., Parkes, M., Rich, S. S., Sawcer, S., Satsangi, J., Simmonds, M. J., Trembath, R. C., Walker, N. M., Wozniak, E., Todd, J. A., Simpson, M. A., Plagnol, V. & van Heel, D. A., 13 Jun 2013, In : NATURE. 498, 7453, p. 232-235 4 p.

    Research output: Contribution to journalLetter

  5. Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis

    Fakiola, M., Strange, A., Cordell, H. J., Miller, E. N., Pirinen, M., Su, Z., Mishra, A., Mehrotra, S., Monteiro, G. R., Band, G., Bellenguez, C., Dronov, S., Edkins, S., Freeman, C., Giannoulatou, E., Gray, E., Hunt, S. E., Lacerda, H. G., Langford, C., Pearson, R. & 31 others, Pontes, N. N., Rai, M., Singh, S. P., Smith, L., Sousa, O., Vukcevic, D., Bramon-Bosch, E., Brown, M. A., Casas, J. P., Corvin, A., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Wilson, M. E., Deloukas, P., Peltonen, L., Christiansen, F., Witt, C., Jeronimo, S. M. B., Sundar, S., Spencer, C. C. A., Blackwell, J. M. & LeishGEN Consortium, 1 Feb 2013, In : Nature Genetics. 45, 2, p. 208-213 6 p.

    Research output: Contribution to journalLetter

  6. 2012
  7. Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine- induced psychopathology

    Stone, J., Dietrich, C., Edden, R., Mehta, M. A., De Simoni, S., Reed, L. J., Krystal, J. H., Nutt, D. & Barker, G. J., Jul 2012, In : Molecular Psychiatry. 17, 7, p. 664-665 2 p., N/A.

    Research output: Contribution to journalLetter

  8. Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

    Hunt, K. A., Smyth, D. J., Balschun, T., Ban, M., Mistry, V., Ahmad, T., Anand, V., Barrett, J. C., Bhaw-Rosun, L., Bockett, N. A., Brand, O. J., Brouwer, E., Concannon, P., Cooper, J. D., Dias, K-R. M., van Diemen, C. C., Dubois, P. C., Edkins, S., Foelster-Holst, R., Fransen, K. & 45 others, Glass, D. N., Heap, G. A. R., Hofmann, S., Huizinga, T. W. J., Hunt, S., Langford, C., Lee, J., Mansfield, J., Marrosu, M. G., Mathew, C. G., Mein, C. A., Mueller-Quernheim, J., Nutland, S., Onengut-Gumuscu, S., Ouwehand, W., Pearce, K., Prescott, N. J., Posthumus, M. D., Potter, S., Rosati, G., Sambrook, J., Satsangi, J., Schreiber, S., Shtir, C., Simmonds, M. J., Sudman, M., Thompson, S. D., Toes, R., Trynka, G., Vyse, T. J., Walker, N. M., Weidinger, S., Zhernakova, A., Zoledziewska, M., Weersma, R. K., Gough, S. C. L., Sawcer, S., Wijmenga, C., Parkes, M., Cucca, F., Franke, A., Deloukas, P., Rich, S. S., Todd, J. A. & van Heel, D. A., Jan 2012, In : Nature Genetics. 44, 1, p. 3 - 5 3 p.

    Research output: Contribution to journalLetter

  9. 2011
  10. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

    Sawcer, S., Hellenthal, G., Pirinen, M., Spencer, C. C. A., Patsopoulos, N. A., Moutsianas, L., Dilthey, A., Su, Z., Freeman, C., Hunt, S. E., Edkins, S., Gray, E., Booth, D. R., Potter, S. C., Goris, A., Band, G., Oturai, A. B., Strange, A., Saarela, J., Bellenguez, C. & 222 others, Fontaine, B., Gillman, M., Hemmer, B., Gwilliam, R., Zipp, F., Jayakumar, A., Martin, R., Leslie, S., Hawkins, S., Giannoulatou, E., D'alfonso, S., Blackburn, H., Boneschi, F. M., Liddle, J., Harbo, H. F., Perez, M. L., Spurkland, A., Waller, M. J., Mycko, M. P., Ricketts, M., Comabella, M., Hammond, N., Kockum, I., McCann, O. T., Ban, M., Whittaker, P., Kemppinen, A., Weston, P., Hawkins, C., Widaa, S., Zajicek, J., Dronov, S., Robertson, N., Bumpstead, S. J., Barcellos, L. F., Ravindrarajah, R., Abraham, R., Alfredsson, L., Ardlie, K., Aubin, C., Baker, A., Baker, K., Baranzini, S. E., Bergamaschi, L., Bergamaschi, R., Bernstein, A., Berthele, A., Boggild, M., Bradfield, J. P., Brassat, D., Broadley, S. A., Buck, D., Butzkueven, H., Capra, R., Carroll, W. M., Cavalla, P., Celius, E. G., Cepok, S., Chiavacci, R., Clerget-Darpoux, F., Clysters, K., Comi, G., Cossburn, M., Cournu-Rebeix, I., Cox, M. B., Cozen, W., Cree, B. A. C., Cross, A. H., Cusi, D., Daly, M. J., Davis, E., de Bakker, P. I. W., Debouverie, M., D'hooghe, M. B., Dixon, K., Dobosi, R., Dubois, B., Ellinghaus, D., Elovaara, I., Esposito, F., Fontenille, C., Foote, S., Franke, A., Galimberti, D., Ghezzi, A., Glessner, J., Gomez, R., Gout, O., Graham, C., Grant, S. F. A., Guerini, F. R., Hakonarson, H., Hall, P., Hamsten, A., Hartung, H-P., Heard, R. N., Heath, S., Hobart, J., Hoshi, M., Infante-Duarte, C., Ingram, G., Ingram, W., Islam, T., Jagodic, M., Kabesch, M., Kermode, A. G., Kilpatrick, T. J., Kim, C., Klopp, N., Koivisto, K., Larsson, M., Lathrop, M., Lechner-Scott, J. S., Leone, M. A., Leppa, V., Liljedahl, U., Bomfim, I. L., Lincoln, R. R., Link, J., Liu, J., Lorentzen, A. R., Lupoli, S., Macciardi, F., Mack, T., Marriott, M., Martinelli, V., Mason, D., McCauley, J. L., Mentch, F., Mero, I-L., Mihalova, T., Montalban, X., Mottershead, J., Myhr, K-M., Naldi, P., Ollier, W., Page, A., Palotie, A., Pelletier, J., Piccio, L., Pickersgill, T., Piehl, F., Pobywajlo, S., Quach, H. L., Ramsay, P. P., Reunanen, M., Reynolds, R., Rioux, J., Rodegher, M., Roesner, S., Rubio, J. P., Rueckert, I-M., Salvetti, M., Salvi, E., Santaniello, A., Schaefer, C. A., Schreiber, S., Schulze, C., Scott, R. J., Sellebjerg, F., Selmaj, K. W., Sexton, D., Shen, L., Simms-Acuna, B., Skidmore, S., Sleiman, P. M. A., Smestad, C., Sorensen, P. S., Sondergaard, H. B., Stankovich, J., Strange, R. C., Sulonen, A-M., Sundqvist, E., Syvaenen, A-C., Taddeo, F., Taylor, B., Blackwell, J. M., Tienari, P., Bramon, E., Tourbah, A., Brown, M. A., Tronczynska, E., Casas, J. P., Tubridy, N., Corvin, A., Vickery, J., Jankowski, J., Villoslada, P., Markus, H. S., Wang, K., Mathew, C. G., Wason, J., Palmer, C. N. A., Wichmann, H-E., Plomin, R., Willoughby, E., Rautanen, A., Winkelmann, J., Wittig, M., Trembath, R. C., Yaouanq, J., Viswanathan, A. C., Zhang, H., Wood, N. W., Zuvich, R., Deloukas, P., Langford, C., Duncanson, A., Oksenberg, J. R., Pericak-Vance, M. A., Haines, J. L., Olsson, T., Hillert, J., Ivinson, A. J., De Jager, P. L., Peltonen, L., Stewart, G. J., Hafler, D. A., Hauser, S. L., McVean, G., Donnelly, P. & Compston, A., 11 Aug 2011, In : NATURE. 476, 7359, p. 214 - 219 6 p.

    Research output: Contribution to journalLetter

  11. Reply to: Hippocampal Glutamate Levels and Striatal Dopamine D-2/3 Receptor Occupancy in Subjects at Ultra High Risk of Psychosis

    Stone, J., Howes, O. D., Egerton, A., Kambeitz, J., Allen, P., Lythgoe, D. J., O'Gorman, R. L., McLean, M. A., Barker, G. J. & McGuire, P., 1 Jul 2011, In : Biological psychiatry. 70, 1, p. e3 - e4 2 p.

    Research output: Contribution to journalLetter

  12. Modulation of orbitofrontal response to amphetamine by a functional variant of DAT1 and in vitro confirmation

    Brotons, O., O'Daly, O., Guindalini, C., Howard, M., Bubb, J., Barker, G., Dalton, J., Quinn, J., Murray, R. M., Breen, G. & Shergill, S., Feb 2011, In : Molecular Psychiatry. 16, 2, p. 124 - 126 3 p.

    Research output: Contribution to journalLetter

  13. 2010
  14. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

    Franke, A., McGovern, D. P. B., Barrett, J. C., Wang, K., Radford-Smith, G. L., Ahmad, T., Lees, C. W., Balschun, T., Lee, J., Roberts, R., Anderson, C. A., Bis, J. C., Bumpstead, S., Ellinghaus, D., Festen, E. M., Georges, M., Green, T., Haritunians, T., Jostins, L., Latiano, A. & 76 others, Mathew, C. G., Montgomery, G. W., Prescott, N. J., Raychaudhuri, S., Rotter, J. I., Schumm, P., Sharma, Y., Simms, L. A., Taylor, K. D., Whiteman, D., Wijmenga, C., Baldassano, R. N., Barclay, M., Bayless, T. M., Brand, S., Buening, C., Cohen, A., Colombel, J-F., Cottone, M., Stronati, L., Denson, T., De Vos, M., D'Inca, R., Dubinsky, M., Edwards, C., Florin, T., Franchimont, D., Gearry, R., Glas, J., Van Gossum, A., Guthery, S. L., Halfvarson, J., Verspaget, H. W., Hugot, J-P., Karban, A., Laukens, D., Lawrance, I., Lemann, M., Levine, A., Libioulle, C., Louis, E., Mowat, C., Newman, W., Panes, J., Phillips, A., Proctor, D. D., Regueiro, M., Russell, R., Rutgeerts, P., Sanderson, J., Sans, M., Seibold, F., Steinhart, A. H., Stokkers, P. C. F., Torkvist, L., Kullak-Ublick, G., Wilson, D., Walters, T., Targan, S. R., Brant, S. R., Rioux, J. D., D'Amato, M., Weersma, R. K., Kugathasan, S., Griffiths, A. M., Mansfield, J. C., Vermeire, S., Duerr, R. H., Silverberg, M. S., Satsangi, J., Schreiber, S., Cho, J. H., Annese, V., Hakonarson, H., Daly, M. J. & Parkes, M., Dec 2010, In : Nature Genetics. 42, 12, p. 1118 - U121 9 p.

    Research output: Contribution to journalLetter

  15. 2009
  16. Is there core diffusion tensor imaging pathology in schizophrenia? Reply

    Kanaan, R. A., Barker, G. & McGuire, P., Jul 2009, In : British Journal of Psychiatry. 195, 1, p. 87 - 87 1 p.

    Research output: Contribution to journalLetter

  17. 2007
  18. Interleukin-23R arg381 gln is associated with susceptibility to Crohn's disease but not with phenotype in an Italian population - Reply

    Tremelling, M., Lees, C., Mansfiel, J., Mathew, C., Jewell, D., Satsangi, J. & Parkes, M., Sep 2007, In : Gastroenterology. 133, 3, p. 1051 - 1052 2 p.

    Research output: Contribution to journalLetter

  19. Combined evidence from three large British association studies rejects TUCAN/CARD8 as an IBD susceptibility gene

    Fisher, S. A., Mirza, M. M., Onnie, C. M., Soars, D., Lewis, C. M., Prescott, N. J., Mathew, C. G., Sanderson, J., Forbes, A., Todhunter, C., Donaldson, P. & Mansfield, J., May 2007, In : Gastroenterology. 132, 5, p. 2078 - 2080 3 p.

    Research output: Contribution to journalLetter

  20. 2005
  21. A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.

    Meetei, A. R., Medhurst, A., Ling, C., Xue, Y., Singh, T. R., Bier, P., Steltenpool, J., Stone, S., Dokal, I., Mathew, C. G., Hoatlin, M., Joenje, H., de Winter, J. P. & Wang, W., Sep 2005, In : Nature Genetics. 37, 9, p. 958 - 963 6 p.

    Research output: Contribution to journalLetter

  22. No association of the NFKB1 promoter polymorphism with ulcerative colitis in a British case control cohort.

    Mirza, M. M., Fisher, S. A., Onnie, C., Sanderson, J., Forbes, A., Lewis, C. M. & Mathew, C. G., Aug 2005, In : Gut. 54, 8, p. 1205 - 1206 2 p.

    Research output: Contribution to journalLetter

  23. Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease.

    van Heel, D. A., Ghosh, S., Butler, M., Lundberg, A. M. C., Ahmad, T., McGovern, D. P. B., Onnie, C., Negoro, K., Goldthorpe, S., Foxwell, B. M. J., Mathew, C. G., Forbes, A., Jewell, D. P. & Playford, R. J., 2005, In : The Lancet. 365, 9473, p. 1794 - 1796 3 p.

    Research output: Contribution to journalLetter

  24. 2004
  25. Genetic association between EPHX1 and Crohn's disease: population stratification, genotyping error, or random chance?

    Cuthbert, A. P., Fisher, S. A., Lewis, C. M., Mathew, C. G., Sanderson, J. & Forbes, A., 2004, In : Gut. 53, 9, p. 1386 - 1386 1 p.

    Research output: Contribution to journalLetter

  26. 2003
  27. Lack of association between the C3435T MDR1 gene polymorphism and inflammatory bowel disease in two independent northern European populations

    Croucher, P. J. P., Mascheretti, S., Foelsch, U. R., Hampe, J., Schreiber, S. & Mathew, C. G., Dec 2003, In : Gastroenterology. 125, 6, p. 1919 - 1920 2 p.

    Research output: Contribution to journalLetter

  28. 2000
  29. Low prevalence of germline BRCA1 mutations in early onset breast cancer without a family history

    Ellis, D., Greenman, J., Hodgson, S., McCall, S., Lalloo, F., Cameron, J., Izatt, L., Scott, G., Jacobs, C., Watts, S., Chorley, W., Perrett, C., Macdermot, K., Mohammed, S., Evans, G. & Mathew, C. G., 2000, In : Journal of Medical Genetics. 37, 10, p. 792 - 794 3 p.

    Research output: Contribution to journalLetter

  30. 1999
  31. Blunt-head trauma associated with widespread water-diffusion changes

    WIESHMANN, UC., SYMMS, MR., CLARK, CA., LEMIEUX, L., PARKER, GJM., Barker, G. & SHORVON, SD., 10 Apr 1999, In : The Lancet. 353, 9160, p. 1242-1243 2 p.

    Research output: Contribution to journalLetter

  32. 1997
  33. Proton magnetic resonance spectroscopy in a pathologically confirmed acute demyelinating lesion

    SILVER, NC., BARKER, RA., MACMANUS, DG., Barker, G., THOM, M., THOMAS, DGT., MCDONALD, WI. & MILLER, DH., Mar 1997, In : Journal of Neurology. 244, 3, p. 204-207 4 p.

    Research output: Contribution to journalLetter

  34. 1996
  35. Decreased magnetisation transfer ratio due to demyelination: A case of central pontine myelinolysis

    SILVER, NC., Barker, G., MACMANUS, DG., MILLER, DH., THORPE, JW. & HOWARD, RS., 1996, In : Journal of Neurology, Neurosurgery and Psychiatry. 61, 2, p. 208-209 2 p.

    Research output: Contribution to journalLetter

  36. 1994
  37. Detection of multiple sclerosis by magnetic resonance imaging

    THORPE, JW., Barker, G., MACMANUS, DG., MOSELEY, IF., TOFTS, PS. & MILLER, DH., 29 Oct 1994, In : The Lancet. 344, 8931, p. 1235 1 p.

    Research output: Contribution to journalLetter

  38. Proton MRS in Huntington's disease

    DAVIE, CA., Barker, G., QUINN, N., TOFTS, PS. & MILLER, DH., 18 Jun 1994, In : The Lancet. 343, 8912, p. 1580 1 p.

    Research output: Contribution to journalLetter

  39. 1993
  40. MRS to differentiate multiple system atrophy from idiopathic Parkinson's disease

    DAVIE, CA., WENNING, GK., Barker, G., BRENNAN, A., QUINN, N. & MILLER, DH., 11 Sep 1993, In : The Lancet. 342, 8872, p. 681-682 2 p.

    Research output: Contribution to journalLetter

  41. Detection of myelin breakdown products by proton magnetic resonance spectroscopy

    DAVIE, CA., Barker, G., TOFTS, PS., HAWKINS, CP., BRENNAN, A., MILLER, DH. & MCDONALD, WI., 6 Mar 1993, In : The Lancet. 341, 8845, p. 630-631 2 p.

    Research output: Contribution to journalLetter

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