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Research Outputs

  1. 2017
  2. Amyloid beta synaptotoxicity is Wnt–planar cell polarity dependent and blocked by fasudil

    Sellers, K. J., Elliott, C., Jackson, J., Ghosh, A., Ribe, E., Rojo-Sanchís, A., Jarosz-Griffiths, H. H., Watson, I. A., Xia, W., Semenov, M., Morin, P., Hooper, N. M., Porter, R., Preston, J., Al-Shawi, R., Baillie, G., Lovestone, S., Cuadrado, A., Harte, M., Simons, P. & 2 others, Srivastava, D. P. & Killick, R., 19 Oct 2017, In : Alzheimer's & Dementia.

    Research output: Contribution to journalArticle

  3. CAR: A key regulator of adhesion and inflammation

    Ortiz-Zapater, E., Santis, G. & Parsons, M., 1 Aug 2017, In : The international journal of biochemistry & cell biology. 89, p. 1-5 5 p.

    Research output: Contribution to journalShort survey

  4. NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

    Rojo, A. I., Pajares, M., Rada, P., Nuñez, A., Nevado-Holgado, A. J., Killik, R., Van Leuven, F., Ribe, E., Lovestone, S., Yamamoto, M. & Cuadrado, A., 5 Jul 2017, In : Redox Biology.

    Research output: Contribution to journalArticle

  5. Growth rate as a direct regulator of the start network to set cell size

    Aldea, M., Jenkins, K. & Csikász-Nagy, A., 26 May 2017, In : Frontiers in Cell and Developmental Biology. 5, MAY, 6 p., 57.

    Research output: Contribution to journalShort survey

  6. Knockdown of the schizophrenia susceptibility gene TCF4 alters gene expression and proliferation of progenitor cells from the developing human neocortex

    Hill, M. J., Killick, R., Navarrete, K., Maruszak, A., McLaughlin, G. M., Williams, B. P. & Bray, N. J., 1 May 2017, In : Journal of psychiatry & neuroscience : JPN. 42, 3, p. 181-188 8 p.

    Research output: Contribution to journalArticle

  7. 2016
  8. How Does p73 Cause Neuronal Defects?

    Niklison-Chirou, M. V., Killick, R., Knight, R. A., Nicotera, P., Melino, G. & Agostini, M., 1 Sep 2016, In : Molecular Neurobiology. 53, 7, p. 4509-4520 12 p.

    Research output: Contribution to journalReview article

  9. Fascin Regulates Nuclear Movement and Deformation in Migrating Cells

    Jayo, A., Malboubi, M., Antoku, S., Chang, W., Ortiz-Zapater, E., Groen, C., Pfisterer, K., Tootle, T., Charras, G., Gundersen, GG. & Parsons, M., 22 Aug 2016, In : Developmental Cell. 38, 4, p. 371-383 13 p.

    Research output: Contribution to journalArticle

  10. Modelling chronotaxicity of cellular energy metabolism to facilitate the identification of altered metabolic states

    Lancaster, G., Suprunenko, Y. F., Jenkins, K. & Stefanovska, A., 3 Aug 2016, In : Scientific Reports. 6, 29584.

    Research output: Contribution to journalArticle

  11. TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers

    Morton, P. E., Hicks, A., Ortiz-Zapater, E., Raghavan, S., Pike, R., Noble, A., Woodfin, A., Jenkins, G., Rayner, E., Santis, G. & Parsons, M., 19 May 2016, In : Scientific Reports. 6, 26321.

    Research output: Contribution to journalArticle

  12. 2015
  13. Reducing β-amyloid by inhibition of BACE1: How low should you go?

    Killick, R., Hardy, J. & Simons, J. P., Apr 2015, In : Biological psychiatry. 77, 8, p. 683-684 2 p.

    Research output: Contribution to journalShort survey

  14. The Notch intracellular domain represses CRE-dependent transcription

    Hallaq, R., Volpicelli, F., Cuchillo-Ibanez, I., Hooper, C., Mizuno, K., Uwanogho, D., Causevic, M., Asuni, A., To, A., Soriano, S., Giese, K. P., Lovestone, S. & Killick, R., Mar 2015, In : Cellular Signalling. 27, 3, p. 621–629 9 p.

    Research output: Contribution to journalArticle

  15. 2014
  16. Investigating the role of rare coding variability in Mendelian dementia genes (APP, PSEN1, PSEN2, GRN, MAPT, and PRNP) in late-onset Alzheimer's disease

    Sassi, C., Guerreiro, R., Gibbs, R., Ding, J., Lupton, M. K., Troakes, C., Al-Sarraj, S., Niblock, M., Gallo, J. M., Adnan, J., Killick, R., Brown, K. S., Medway, C., Lord, J., Turton, J., Bras, J., Morgan, K., Powell, J. F., Singleton, A. & Hardy, J., Dec 2014, In : Neurobiology of Aging. 35, 12, p. 2881.e1-2881.e6 6 p.

    Research output: Contribution to journalArticle

  17. Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology

    Sattlecker, M., Kiddle, S. J., Newhouse, S., Proitsi, P., Nelson, S., Williams, S., Johnston, C., Killick, R., Simmons, A., Westman, E., Hodges, A., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., the AddNeuroMed Consortium & Dobson, R. J. B., Nov 2014, In : Alzheimer's & Dementia. 10, 6, p. 724-734 11 p.

    Research output: Contribution to journalArticle

  18. The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility

    Kiuchi, T., Ortiz-Zapater, E., Monypenny, J., Matthews, D. R., Nguyen, L. K., Barbeau, J., Coban, O., Lawler, K., Burford, B., Rolfe, D. J., de Rinaldis, E., Dafou, D., Simpson, M. A., Woodman, N., Pinder, S., Gillett, C. E., Devauges, V., Poland, S. P., Fruhwirth, G., Marra, P. & 12 others, Boersma, Y. L., Plückthun, A., Gullick, W. J., Yarden, Y., Santis, G., Winn, M., Kholodenko, B. N., Martin-Fernandez, M. L., Parker, P., Tutt, A., Ameer-Beg, S. M. & Ng, T., 19 Aug 2014, In : Science Signaling. 7, 339, ra78.

    Research output: Contribution to journalArticle

  19. Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

    Killick, R., Ribe, E. M., Al-Shawi, R., Malik, B., Hooper, C., Fernandes, C., Dobson, R., Nolan, P. M., Lourdusamy, A., Furney, S., Lin, K., Breen, G., Wroe, R., To, A. W. M., Leroy, K., Causevic, M., Usardi, A., Robinson, M., Noble, W., Williamson, R. & 9 others, Lunnon, K., Kellie, S., Reynolds, C. H., Bazenet, C., Hodges, A., Brion, J-P., Stephenson, J., Paul Simons, J. & Lovestone, S., 1 Jan 2014, In : Molecular Psychiatry. 19, 1, p. 88-98 11 p.

    Research output: Contribution to journalArticle

  20. An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum

    Ludtmann, M. H. R., Otto, G. P., Schilde, C., Chen, Z-H., Allan, C. Y., Brace, S., Beesley, P. W., Kimmel, A. R., Fisher, P., Killick, R. & Williams, R. S. B., 2014, In : Journal of Cell Science. 127, 7, p. 1576-1584 9 p.

    Research output: Contribution to journalArticle

  21. 2013
  22. Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH

    Killick, R., Hughes, T. R., Morgan, B. P. & Lovestone, S., 15 Jan 2013, In : Neuroscience Letters. 533, p. 96-99 4 p.

    Research output: Contribution to journalArticle

  23. 2012
  24. Wnt3a induces exosome secretion from primary cultured rat microglia

    Hooper, C., Sainz-Fuertes, R., Lynham, S., Hye, A., Killick, R., Warley, A., Bolondi, C., Pocock, J. & Lovestone, S., 23 Nov 2012, In : BMC NEUROSCIENCE. 13, 17 p., 144.

    Research output: Contribution to journalArticle

  25. Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus

    Hamilton, G., Killick, R., Lambert, J-C., Amouyel, P., Carrasquillo, M. M., Pankratz, V. S., Graff-Radford, N. R., Dickson, D. W., Petersen, R. C., Younkin, S. G., Powell, J. F., Wade-Martins, R., Genetic Environm Risk, Translational Genomics Res Inst & EADI, Aug 2012, In : Neurobiology of Aging. 33, 8, p. N/A 13 p., 1848.e1.

    Research output: Contribution to journalArticle

  26. 2011
  27. Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets

    Agostini, M., Tucci, P., Killick, R., Candi, E., Sayan, B. S., Cervo, P. R. D. V., Nicotera, P., McKeon, F., Knight, R. A., Mak, T. W. & Melino, G., 27 Dec 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 52, p. 21093 - 21098 6 p.

    Research output: Contribution to journalArticle

  28. p73: A Multifunctional Protein in Neurobiology

    Killick, R., Niklison-Chirou, M., Tomasini, R., Bano, D., Rufini, A., Grespi, F., Velletri, T., Tucci, P., Sayan, B. S., Conforti, F., Gallagher, E., Nicotera, P., Mak, T. W., Melino, G., Knight, R. A. & Agostini, M., Apr 2011, In : Molecular Neurobiology. 43, 2, p. 139-146 8 p.

    Research output: Contribution to journalArticle

  29. Plasma Biomarkers of Brain Atrophy in Alzheimer's Disease

    Thambisetty, M., Simmons, A., Hye, A., Campbell, J., Westman, E., Zhang, Y., Wahlund, L-O., Kinsey, A., Causevic, M., Killick, R., Kloszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Spenger, C. & Lovestone, S., 2011, In : PL o S One . 6, 12, e28527.

    Research output: Contribution to journalArticle

  30. 2010
  31. Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

    Thambisetty, M., Simmons, A., Velayudhan, L., Hye, A., Campbell, J., Zhang, Y., Wahlund, L-O., Westman, E., Kinsey, A., Güntert, A., Proitsi, P., Powell, J., Causevic, M., Killick, R., Lunnon, K., Lynham, S., Broadstock, M., Choudhry, F., Howlett, D. R., Williams, R. J. & 27 others, Sharp, S. I., Mitchelmore, C., Tunnard, C., Leung, R., Foy, C., O'Brien, D., Breen, G., Furney, S. J., Ward, M., Kloszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Hodges, A., Murphy, D. G. M., Parkins, S., Richardson, J. C., Resnick, S. M., Ferrucci, L., Wong, D. F., Zhou, Y., Muehlboeck, S., Evans, A., Francis, P. T., Spenger, C. & Lovestone, S., Jul 2010, In : Archives of General Psychiatry. 67, 7, p. 739-48 10 p.

    Research output: Contribution to journalArticle

  32. Inhibition of GSK-3 Ameliorates A beta Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

    Sofola, O., Kerr, F., Rogers, I., Killick, R., Augustin, H., Gandy, C., Allen, M. J., Hardy, J., Lovestone, S. & Partridge, L., 2010, In : PL o S Genetics. 6, 9, e1001087.

    Research output: Contribution to journalArticle

  33. 2009
  34. Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

    Killick, R., Scales, G., Leroy, K., Causevic, M., Hooper, C., Irvine, E. E., Choudhury, A. I., Drinkwater, L., Kerr, F., Al-Qassab, H., Stephenson, J., Yilmaz, Z., Giese, K. P., Brion, J-P., Withers, D. J. & Lovestone, S., 14 Aug 2009, In : Biochemical and Biophysical Research Communications. 386, 1, p. 257 - 262 6 p.

    Research output: Contribution to journalArticle

  35. 2008
  36. Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system

    Al-Shawi, R., Hafner, A., Olson, J., Chun, S., Raza, S., Thrasivoulou, C., Lovestone, S., Killick, R., Simons, P. & Cowen, T., Apr 2008, In : European Journal of Neuroscience. 27, 8, p. 2103-2114 12 p.

    Research output: Contribution to journalArticle

  37. The GSK3 hypothesis of Alzheimer's disease

    Hooper, C., Killick, R. & Lovestone, S., Mar 2008, In : Journal of Neurochemistry. 104, 6, p. 1433 - 1439 7 p.

    Research output: Contribution to journalArticle

  38. Specific isoforms of p73 control the induction of cell death induced by the viral proteins, E1A or apoptin

    Klanrit, P., Flinterman, M. B., Odell, E. W., Melino, G., Killick, R., Norris, J. S. & Tavassoli, M., 15 Jan 2008, In : CELL CYCLE. 7, 2, p. 205 - 215 11 p.

    Research output: Contribution to journalArticle

  39. Positional Pathway Screen of wnt Signaling Genes in Schizophrenia: Association with DKK4

    Proitsi, P., Li, T., Hamilton, G., Di Forti, M., Collier, D., Killick, R., Chen, R., Sham, P., Murray, R., Powell, J. & Lovestone, S., 1 Jan 2008, In : Biological psychiatry. 63, 1, p. 13 - 16 4 p.

    Research output: Contribution to journalArticle

  40. 2007
  41. A structural switch of presenilin 1 by glycogen synthase kinase 3 beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling

    Prager, K., Wang-Eckhardt, L. H., Fluhrer, R., Killick, R., Barth, E., Hampel, H., Haass, C. & Walter, J., 11 May 2007, In : Journal of Biological Chemistry. 282, 19, p. 14083 - 14093 11 p.

    Research output: Contribution to journalArticle

  42. p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells

    Hooper, C., Meimaridou, E., Tavassoli, M., Melino, G., Lovestone, S. & Killick, R., 11 May 2007, In : Neuroscience Letters. 418, 1, p. 34 - 37 4 p.

    Research output: Contribution to journalArticle

  43. Schizophrenia as a GSK-3 dysregulation disorder

    Lovestone, S., Killick, R., Di Forti, M. & Murray, R., Apr 2007, In : Trends in Neurosciences. 30, 4, p. 142 - 149 8 p.

    Research output: Contribution to journalLiterature review

  44. The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons

    Hooper, C., Chapple, J. P., Lovestone, S. & Killick, R., 26 Mar 2007, In : Neuroscience Letters. 415, 2, p. 135 - 139 5 p.

    Research output: Contribution to journalArticle

  45. Glycogen synthase kinase-3 inhibition is integral to long-term potentiation

    Hooper, C., Markevich, V., Plattner, F., Killick, R., Schofield, E., Engel, T., Hernandez, F., Anderton, B., Rosenblum, K., Bliss, T., Cooke, S. F., Avila, J., Lucas, J. J., Giese, K. P., Stephenson, J. & Lovestone, S., Jan 2007, In : European Journal of Neuroscience. 25, 1, p. 81 - 86 6 p.

    Research output: Contribution to journalArticle

  46. Glycogen synthase kinase-3 inhibition is integral to long-term potentiation.

    Hooper, C., Markevich, V., Plattner, F., Killick, R., Schofield, E., Engel, T., Hernandez, F., Anderton, B. H., Rosenblum, K., Bliss, T. V. P., Cooke, S. F., Avila, J., Lucas, J. J., Giese, K. P., Stephenson, J. D. & Lovestone, S. H., Jan 2007, In : European Journal of Neuroscience.

    Research output: Contribution to journalArticle

  47. 2006
  48. GSK3 alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt

    Asuni, A. A., Hooper, C., Reynolds, C. H., Lovestone, S., Anderton, B. H. & Killick, R., Dec 2006, In : European Journal of Neuroscience. 24, 12, p. 3387 - 3392 6 p.

    Research output: Contribution to journalArticle

  49. TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones

    Hooper, C., Tavassoli, M., Chapple, J. P., Uwanogho, D., Goodyear, R., Melino, G., Lovestone, S. & Killick, R., Nov 2006, In : Journal of Neurochemistry. 99, 3, p. 989 - 999 11 p.

    Research output: Contribution to journalArticle

  50. TAp73a induces tau phosphorylation in HEK293a cells via a transcription-dependent mechanism

    Hooper, C., Killick, R., Tavassoli, M., Melino, G. & Lovestone, S., 2006, In : Neuroscience Letters. 401, 1-2, p. 30 - 34 5 p.

    Research output: Contribution to journalArticle

  51. 2005
  52. E1A activates transcription of p73 and Noxa to induce apoptosis

    Flinterman, M., Guelen, L., Ezzati-Nik, S., Killick, R., Melino, G., Tominaga, K., Mymryk, J. S., Gaken, J. & Tavassoli, M., 18 Feb 2005, In : Journal of Biological Chemistry. 280, 7, p. 5945 - 5959 15 p.

    Research output: Contribution to journalArticle

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