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Research Outputs

  1. 2017
  2. Amyloid beta synaptotoxicity is Wnt–planar cell polarity dependent and blocked by fasudil

    Sellers, K. J., Elliott, C., Jackson, J., Ghosh, A., Ribe, E., Rojo-Sanchís, A., Jarosz-Griffiths, H. H., Watson, I. A., Xia, W., Semenov, M., Morin, P., Hooper, N. M., Porter, R., Preston, J., Al-Shawi, R., Baillie, G., Lovestone, S., Cuadrado, A., Harte, M., Simons, P. & 2 others, Srivastava, D. P. & Killick, R., 19 Oct 2017, In : Alzheimer's & Dementia.

    Research output: Contribution to journalArticle

  3. CAR: A key regulator of adhesion and inflammation

    Ortiz-Zapater, E., Santis, G. & Parsons, M., 1 Aug 2017, In : The international journal of biochemistry & cell biology. 89, p. 1-5 5 p.

    Research output: Contribution to journalShort survey

  4. NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

    Rojo, A. I., Pajares, M., Rada, P., Nuñez, A., Nevado-Holgado, A. J., Killik, R., Van Leuven, F., Ribe, E., Lovestone, S., Yamamoto, M. & Cuadrado, A., 5 Jul 2017, In : Redox Biology.

    Research output: Contribution to journalArticle

  5. Knockdown of the schizophrenia susceptibility gene TCF4 alters gene expression and proliferation of progenitor cells from the developing human neocortex

    Hill, M. J., Killick, R., Navarrete, K., Maruszak, A., McLaughlin, G. M., Williams, B. P. & Bray, N. J., 1 May 2017, In : Journal of psychiatry & neuroscience : JPN. 42, 3, p. 181-188 8 p.

    Research output: Contribution to journalArticle

  6. 2016
  7. Fascin Regulates Nuclear Movement and Deformation in Migrating Cells

    Jayo, A., Malboubi, M., Antoku, S., Chang, W., Ortiz-Zapater, E., Groen, C., Pfisterer, K., Tootle, T., Charras, G., Gundersen, GG. & Parsons, M., 22 Aug 2016, In : Developmental Cell. 38, 4, p. 371-383 13 p.

    Research output: Contribution to journalArticle

  8. TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers

    Morton, P. E., Hicks, A., Ortiz-Zapater, E., Raghavan, S., Pike, R., Noble, A., Woodfin, A., Jenkins, G., Rayner, E., Santis, G. & Parsons, M., 19 May 2016, In : Scientific Reports. 6, 26321.

    Research output: Contribution to journalArticle

  9. 2015
  10. Reducing β-amyloid by inhibition of BACE1: How low should you go?

    Killick, R., Hardy, J. & Simons, J. P., Apr 2015, In : Biological psychiatry. 77, 8, p. 683-684 2 p.

    Research output: Contribution to journalShort survey

  11. The Notch intracellular domain represses CRE-dependent transcription

    Hallaq, R., Volpicelli, F., Cuchillo-Ibanez, I., Hooper, C., Mizuno, K., Uwanogho, D., Causevic, M., Asuni, A., To, A., Soriano, S., Giese, K. P., Lovestone, S. & Killick, R., Mar 2015, In : Cellular Signalling. 27, 3, p. 621–629 9 p.

    Research output: Contribution to journalArticle

  12. 2014
  13. Investigating the role of rare coding variability in Mendelian dementia genes (APP, PSEN1, PSEN2, GRN, MAPT, and PRNP) in late-onset Alzheimer's disease

    Sassi, C., Guerreiro, R., Gibbs, R., Ding, J., Lupton, M. K., Troakes, C., Al-Sarraj, S., Niblock, M., Gallo, J. M., Adnan, J., Killick, R., Brown, K. S., Medway, C., Lord, J., Turton, J., Bras, J., Morgan, K., Powell, J. F., Singleton, A. & Hardy, J., Dec 2014, In : Neurobiology of Aging. 35, 12, p. 2881.e1-2881.e6 6 p.

    Research output: Contribution to journalArticle

  14. Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology

    Sattlecker, M., Kiddle, S. J., Newhouse, S., Proitsi, P., Nelson, S., Williams, S., Johnston, C., Killick, R., Simmons, A., Westman, E., Hodges, A., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., the AddNeuroMed Consortium & Dobson, R. J. B., Nov 2014, In : Alzheimer's & Dementia. 10, 6, p. 724-734 11 p.

    Research output: Contribution to journalArticle

  15. The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility

    Kiuchi, T., Ortiz-Zapater, E., Monypenny, J., Matthews, D. R., Nguyen, L. K., Barbeau, J., Coban, O., Lawler, K., Burford, B., Rolfe, D. J., de Rinaldis, E., Dafou, D., Simpson, M. A., Woodman, N., Pinder, S., Gillett, C. E., Devauges, V., Poland, S. P., Fruhwirth, G., Marra, P. & 12 others, Boersma, Y. L., Plückthun, A., Gullick, W. J., Yarden, Y., Santis, G., Winn, M., Kholodenko, B. N., Martin-Fernandez, M. L., Parker, P., Tutt, A., Ameer-Beg, S. M. & Ng, T., 19 Aug 2014, In : Science Signaling. 7, 339, ra78.

    Research output: Contribution to journalArticle

  16. Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

    Killick, R., Ribe, E. M., Al-Shawi, R., Malik, B., Hooper, C., Fernandes, C., Dobson, R., Nolan, P. M., Lourdusamy, A., Furney, S., Lin, K., Breen, G., Wroe, R., To, A. W. M., Leroy, K., Causevic, M., Usardi, A., Robinson, M., Noble, W., Williamson, R. & 9 others, Lunnon, K., Kellie, S., Reynolds, C. H., Bazenet, C., Hodges, A., Brion, J-P., Stephenson, J., Paul Simons, J. & Lovestone, S., 1 Jan 2014, In : Molecular Psychiatry. 19, 1, p. 88-98 11 p.

    Research output: Contribution to journalArticle

  17. An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum

    Ludtmann, M. H. R., Otto, G. P., Schilde, C., Chen, Z-H., Allan, C. Y., Brace, S., Beesley, P. W., Kimmel, A. R., Fisher, P., Killick, R. & Williams, R. S. B., 2014, In : Journal of Cell Science. 127, 7, p. 1576-1584 9 p.

    Research output: Contribution to journalArticle

  18. 2013
  19. Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH

    Killick, R., Hughes, T. R., Morgan, B. P. & Lovestone, S., 15 Jan 2013, In : Neuroscience Letters. 533, p. 96-99 4 p.

    Research output: Contribution to journalArticle

  20. 2012
  21. Wnt3a induces exosome secretion from primary cultured rat microglia

    Hooper, C., Sainz-Fuertes, R., Lynham, S., Hye, A., Killick, R., Warley, A., Bolondi, C., Pocock, J. & Lovestone, S., 23 Nov 2012, In : BMC NEUROSCIENCE. 13, 17 p., 144.

    Research output: Contribution to journalArticle

  22. Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus

    Hamilton, G., Killick, R., Lambert, J-C., Amouyel, P., Carrasquillo, M. M., Pankratz, V. S., Graff-Radford, N. R., Dickson, D. W., Petersen, R. C., Younkin, S. G., Powell, J. F., Wade-Martins, R., Genetic Environm Risk, Translational Genomics Res Inst & EADI, Aug 2012, In : Neurobiology of Aging. 33, 8, p. N/A 13 p., 1848.e1.

    Research output: Contribution to journalArticle

  23. 2011
  24. Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets

    Agostini, M., Tucci, P., Killick, R., Candi, E., Sayan, B. S., Cervo, P. R. D. V., Nicotera, P., McKeon, F., Knight, R. A., Mak, T. W. & Melino, G., 27 Dec 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 52, p. 21093 - 21098 6 p.

    Research output: Contribution to journalArticle

  25. p73: A Multifunctional Protein in Neurobiology

    Killick, R., Niklison-Chirou, M., Tomasini, R., Bano, D., Rufini, A., Grespi, F., Velletri, T., Tucci, P., Sayan, B. S., Conforti, F., Gallagher, E., Nicotera, P., Mak, T. W., Melino, G., Knight, R. A. & Agostini, M., Apr 2011, In : Molecular Neurobiology. 43, 2, p. 139-146 8 p.

    Research output: Contribution to journalArticle

  26. Plasma Biomarkers of Brain Atrophy in Alzheimer's Disease

    Thambisetty, M., Simmons, A., Hye, A., Campbell, J., Westman, E., Zhang, Y., Wahlund, L-O., Kinsey, A., Causevic, M., Killick, R., Kloszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Spenger, C. & Lovestone, S., 2011, In : PL o S One . 6, 12, e28527.

    Research output: Contribution to journalArticle

  27. 2010
  28. Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

    Thambisetty, M., Simmons, A., Velayudhan, L., Hye, A., Campbell, J., Zhang, Y., Wahlund, L-O., Westman, E., Kinsey, A., Güntert, A., Proitsi, P., Powell, J., Causevic, M., Killick, R., Lunnon, K., Lynham, S., Broadstock, M., Choudhry, F., Howlett, D. R., Williams, R. J. & 27 others, Sharp, S. I., Mitchelmore, C., Tunnard, C., Leung, R., Foy, C., O'Brien, D., Breen, G., Furney, S. J., Ward, M., Kloszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Hodges, A., Murphy, D. G. M., Parkins, S., Richardson, J. C., Resnick, S. M., Ferrucci, L., Wong, D. F., Zhou, Y., Muehlboeck, S., Evans, A., Francis, P. T., Spenger, C. & Lovestone, S., Jul 2010, In : Archives of General Psychiatry. 67, 7, p. 739-48 10 p.

    Research output: Contribution to journalArticle

  29. Inhibition of GSK-3 Ameliorates A beta Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

    Sofola, O., Kerr, F., Rogers, I., Killick, R., Augustin, H., Gandy, C., Allen, M. J., Hardy, J., Lovestone, S. & Partridge, L., 2010, In : PL o S Genetics. 6, 9, e1001087.

    Research output: Contribution to journalArticle

  30. 2009
  31. Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

    Killick, R., Scales, G., Leroy, K., Causevic, M., Hooper, C., Irvine, E. E., Choudhury, A. I., Drinkwater, L., Kerr, F., Al-Qassab, H., Stephenson, J., Yilmaz, Z., Giese, K. P., Brion, J-P., Withers, D. J. & Lovestone, S., 14 Aug 2009, In : Biochemical and Biophysical Research Communications. 386, 1, p. 257 - 262 6 p.

    Research output: Contribution to journalArticle

  32. 2008
  33. Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system

    Al-Shawi, R., Hafner, A., Olson, J., Chun, S., Raza, S., Thrasivoulou, C., Lovestone, S., Killick, R., Simons, P. & Cowen, T., Apr 2008, In : European Journal of Neuroscience. 27, 8, p. 2103-2114 12 p.

    Research output: Contribution to journalArticle

  34. The GSK3 hypothesis of Alzheimer's disease

    Hooper, C., Killick, R. & Lovestone, S., Mar 2008, In : Journal of Neurochemistry. 104, 6, p. 1433 - 1439 7 p.

    Research output: Contribution to journalArticle

  35. Specific isoforms of p73 control the induction of cell death induced by the viral proteins, E1A or apoptin

    Klanrit, P., Flinterman, M. B., Odell, E. W., Melino, G., Killick, R., Norris, J. S. & Tavassoli, M., 15 Jan 2008, In : CELL CYCLE. 7, 2, p. 205 - 215 11 p.

    Research output: Contribution to journalArticle

  36. Positional Pathway Screen of wnt Signaling Genes in Schizophrenia: Association with DKK4

    Proitsi, P., Li, T., Hamilton, G., Di Forti, M., Collier, D., Killick, R., Chen, R., Sham, P., Murray, R., Powell, J. & Lovestone, S., 1 Jan 2008, In : Biological psychiatry. 63, 1, p. 13 - 16 4 p.

    Research output: Contribution to journalArticle

  37. 2007
  38. A structural switch of presenilin 1 by glycogen synthase kinase 3 beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling

    Prager, K., Wang-Eckhardt, L. H., Fluhrer, R., Killick, R., Barth, E., Hampel, H., Haass, C. & Walter, J., 11 May 2007, In : Journal of Biological Chemistry. 282, 19, p. 14083 - 14093 11 p.

    Research output: Contribution to journalArticle

  39. p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells

    Hooper, C., Meimaridou, E., Tavassoli, M., Melino, G., Lovestone, S. & Killick, R., 11 May 2007, In : Neuroscience Letters. 418, 1, p. 34 - 37 4 p.

    Research output: Contribution to journalArticle

  40. The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons

    Hooper, C., Chapple, J. P., Lovestone, S. & Killick, R., 26 Mar 2007, In : Neuroscience Letters. 415, 2, p. 135 - 139 5 p.

    Research output: Contribution to journalArticle

  41. Glycogen synthase kinase-3 inhibition is integral to long-term potentiation

    Hooper, C., Markevich, V., Plattner, F., Killick, R., Schofield, E., Engel, T., Hernandez, F., Anderton, B., Rosenblum, K., Bliss, T., Cooke, S. F., Avila, J., Lucas, J. J., Giese, K. P., Stephenson, J. & Lovestone, S., Jan 2007, In : European Journal of Neuroscience. 25, 1, p. 81 - 86 6 p.

    Research output: Contribution to journalArticle

  42. Glycogen synthase kinase-3 inhibition is integral to long-term potentiation.

    Hooper, C., Markevich, V., Plattner, F., Killick, R., Schofield, E., Engel, T., Hernandez, F., Anderton, B. H., Rosenblum, K., Bliss, T. V. P., Cooke, S. F., Avila, J., Lucas, J. J., Giese, K. P., Stephenson, J. D. & Lovestone, S. H., Jan 2007, In : European Journal of Neuroscience.

    Research output: Contribution to journalArticle

  43. 2006
  44. GSK3 alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt

    Asuni, A. A., Hooper, C., Reynolds, C. H., Lovestone, S., Anderton, B. H. & Killick, R., Dec 2006, In : European Journal of Neuroscience. 24, 12, p. 3387 - 3392 6 p.

    Research output: Contribution to journalArticle

  45. TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones

    Hooper, C., Tavassoli, M., Chapple, J. P., Uwanogho, D., Goodyear, R., Melino, G., Lovestone, S. & Killick, R., Nov 2006, In : Journal of Neurochemistry. 99, 3, p. 989 - 999 11 p.

    Research output: Contribution to journalArticle

  46. TAp73a induces tau phosphorylation in HEK293a cells via a transcription-dependent mechanism

    Hooper, C., Killick, R., Tavassoli, M., Melino, G. & Lovestone, S., 2006, In : Neuroscience Letters. 401, 1-2, p. 30 - 34 5 p.

    Research output: Contribution to journalArticle

  47. 2005
  48. E1A activates transcription of p73 and Noxa to induce apoptosis

    Flinterman, M., Guelen, L., Ezzati-Nik, S., Killick, R., Melino, G., Tominaga, K., Mymryk, J. S., Gaken, J. & Tavassoli, M., 18 Feb 2005, In : Journal of Biological Chemistry. 280, 7, p. 5945 - 5959 15 p.

    Research output: Contribution to journalArticle

  49. 2004
  50. 2003
  51. Alzheimer-associated C allele of the promoter polymorphism-22C > T causes a critical neuron-specific decrease of presenilin 1 expression

    Theuns, J., Remacle, J., Killick, R., Corsmit, E., Vennekens, K., Huylebroeck, D., Cruts, M. & Van Broeckhoven, C., 15 Apr 2003, In : Human Molecular Genetics. 12, 8, p. 869 - 877 9 p.

    Research output: Contribution to journalArticle

  52. 2001
  53. Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase.

    Mudher, A., Chapman, S., Richardson, J., Asuni, A., Gibb, G., Pollard, C., Killick, R., Iqbal, T., Raymond, L., Varndell, I., Sheppard, P., Makoff, A., Gower, E., Soden, P. E., Lewis, P., Murphy, M., Golde, T. E., Rupniak, H. T., Anderton, B. H. & Lovestone, S., 15 Jul 2001, In : Journal of Neuroscience. 21, 14, p. 4987 - 4995 9 p.

    Research output: Contribution to journalArticle

  54. OCP1, an F-box protein, co-localizes with OCP2/SKP1 in the cochlear epithelial gap junction region

    Henzl, M. T., O'Neal, J., Killick, R., Thalmann, I. & Thalmann, R., 2001, In : Hearing Research. 157, 1-2, p. 100 - 111 12 p.

    Research output: Contribution to journalArticle

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