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Research Outputs

  1. 2017
  2. Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants

    Krishnan, M. L., Van Steenwinckel, J., Schang, A., Yan, J., Arnadottir, J., Le Charpentier, T., Csaba, Z., Dournaud, P., Cipriani, S., Auvynet, C., Titomanlio, L., Pansiot, J., Ball, G., Boardman, J. P., Walley, A. J., Saxena, A., Mirza, G., Fleiss, B., Edwards, A. D., Petretto, E. & 1 others, Gressens, P., 1 Dec 2017, In : Nature Communications. 8, 1

    Research output: Contribution to journalArticle

  3. Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease

    Horgusluoglu-Moloch, E., Nho, K., Risacher, S. L., Kim, S., Foroud, T., Shaw, L. M., Trojanowski, J. Q., Aisen, P. S., Petersen, R. C., Jack, C. R., Lovestone, S., Simmons, A., Weiner, M. W. & Saykin, A. J., 1 Dec 2017, In : Neurobiology of Aging. 60, p. 92-103 12 p.

    Research output: Contribution to journalArticle

  4. Feasibility and acceptability of a patient-reported outcome intervention in chronic heart failure

    Kane, P. M., Daveson, B. A., Ryan, K., Ellis-Smith, C. I., Mahon, N. G., McAdam, B., McQuilllan, R., Tracey, C., Howley, C., O'Gara, G., Raleigh, C., Higginson, I. J., Koffman, J., Murtagh, F. E. M. & BuildCARE, Dec 2017, In : BMJ Supportive and Palliative Care.

    Research output: Contribution to journalArticle

  5. Social and clinical determinants of preferences and their achievement at the end of life: prospective cohort study of older adults receiving palliative care in three countries

    Higginson, I. J., Daveson, B. A., Morrison, R. S., Yi, D., Meier, D., Smith, M., Ryan, K., McQuillan, R., Johnston, B. M., Normand, C. & BuildCARE, 23 Nov 2017, In : BMC Geriatrics . 17, 1, p. 271

    Research output: Contribution to journalArticle

  6. DISCOVERY, REPLICATION AND EXTENSION STUDY OF PLASMA PROTEOMIC BIOMARKERS RELATING TO BRAIN AMYLOID BURDEN (CSF Aβ OR AMYLOID-PET) IN THE EMIF-AD BIOMARKER DISCOVERY COHORT: 2017 Abstract Supplement

    Westwood, S., Baird, A. L., Hye, A., Bos, I., Vos, S. J. B., Vandenberghe, R., Scheltens, P., Engelborghs, S., Frisoni, G. B., Molinuevo, J. L., Wallin, A., Lleó, A., Popp, J., Martinez-Lage, P., Snowden, S. G., Legido-Quigley, C., Bertram, L., Barkhof, F., Zetterberg, H., Streffer, J. & 2 others, Visser, P. J. & Lovestone, S., 20 Oct 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P361-P362

    Research output: Contribution to journalArticle

  7. PET TAU AND AMYLOID-BETA DIFFER IN THEIR RELATIONSHIP TO AGE, COGNITION AND CSF BIOMARKERS IN MILD ALZHEIMER’S DISEASE: AN OBSERVATIONAL STUDY: 2017 Abstract Supplement

    Koychev, I. G., Gunn, R. N., Firouzian, A., Lawson, J., Zamboni, G., Ridha, B. H., Sahakian, B., Rowe, J. B., Thomas, A., Rochester, L., Ffytche, D., Howard, R. J., Zetterberg, H., MacKay, C. & Lovestone, S., 20 Oct 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P243

    Research output: Contribution to journalPoster abstract

  8. PET TAU AND AMYLOID-BETA DIFFER IN THEIR RELATIONSHIP TO AGE, COGNITION AND CSF BIOMARKERS IN MILD ALZHEIMER’S DISEASE: AN OBSERVATIONAL STUDY: 2017 Abstract Supplement

    Koychev, I. G., Gunn, R. N., Firouzian, A., Lawson, J., Zamboni, G., Ridha, B. H., Sahakian, B., Rowe, J. B., Thomas, A., Rochester, L., Ffytche, D., Howard, R. J., Zetterberg, H., MacKay, C. & Lovestone, S., 20 Oct 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P456-P457

    Research output: Contribution to journalPoster abstract

  9. Amyloid beta synaptotoxicity is Wnt–planar cell polarity dependent and blocked by fasudil

    Sellers, K. J., Elliott, C., Jackson, J., Ghosh, A., Ribe, E., Rojo-Sanchís, A., Jarosz-Griffiths, H. H., Watson, I. A., Xia, W., Semenov, M., Morin, P., Hooper, N. M., Porter, R., Preston, J., Al-Shawi, R., Baillie, G., Lovestone, S., Cuadrado, A., Harte, M., Simons, P. & 2 others, Srivastava, D. P. & Killick, R., 19 Oct 2017, In : Alzheimer's & Dementia.

    Research output: Contribution to journalArticle

  10. Palliative care and management of troublesome symptoms for people with chronic obstructive pulmonary disease

    Maddocks, M., Lovell, N., Booth, S., Man, W. D. C. & Higginson, I. J., 2 Sep 2017, In : Lancet. 390, 10098, p. 988-1002 15 p.

    Research output: Contribution to journalReview article

  11. Editorial

    Higginson, I. J., Sep 2017, In : Palliative Medicine. 31, 8, p. 681-683 3 p.

    Research output: Contribution to journalArticle

  12. The TEAM Approach to Improving Oncology Outcomes by Incorporating Palliative Care in Practice

    Bakitas, M. A., El-Jawahri, A., Farquhar, M., Ferrell, B., Grudzen, C., Higginson, I., Temel, J. S. & Zimmermann, C., Sep 2017, In : Journal of oncology practice / American Society of Clinical Oncology. 13, 9, p. 557-566 10 p.

    Research output: Contribution to journalArticle

  13. Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury

    Shiow, L. R., Favrais, G., Schirmer, L., Schang, A-L., Cipriani, S., Andres, C., Wright, J. N., Nobuta, H., Fleiss, B., Gressens, P. & Rowitch, D. H., 30 Aug 2017, In : Glia.

    Research output: Contribution to journalArticle

  14. Valuing attributes of home palliative care with service users: a pilot discrete choice experiment

    Gomes, B., de Brito, M., Sarmento, V. P., Yi, D., Soares, D., Fernandes, J., Fonseca, B., Gonçalves, E., Ferreira, P. L. & Higginson, I. J., 8 Aug 2017, In : Journal of pain and symptom management.

    Research output: Contribution to journalArticle

  15. EXPLORING THE RELATIONSHIP BETWEEN ANAEMIA AND ALZHEIMER’S DISEASE: 2017 Abstract Supplement

    Winchester, L., Nevado-Holgado, A. J. & Lovestone, S., 20 Jul 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P221

    Research output: Contribution to journalMeeting abstract

  16. NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

    Rojo, A. I., Pajares, M., Rada, P., Nuñez, A., Nevado-Holgado, A. J., Killik, R., Van Leuven, F., Ribe, E., Lovestone, S., Yamamoto, M. & Cuadrado, A., 5 Jul 2017, In : Redox Biology.

    Research output: Contribution to journalArticle

  17. DISCOVERY AND VALIDATION OF MULTIMODAL BIOMARKER SIGNATURES RELATING TO ALZHEIMER'S DISEASE PATHOLOGY AND PROGRESSION: 2017 Abstract Supplement

    Westwood, S., Hye, A., Lleó, A., Nevado-Holgado, A. J., Baird, A. L., Wallin, A., Leslie, A., Jimenez, B., Liu, B. Y., Legido-Quigley, C., Dima, D., Ruvolo, D., Holmes, E., D'Hondt, E., Westman, E., Barkhof, F., Frisoni, G. B., Zetterberg, H., Bos, I., Pearce, J. & 27 others, Streffer, J., Molinuevo, J. L., Popp, J., Bertram, L., Whiley, L., Maslen, L., Gomez-Romero, M., David, M., Lewis, M., Kurbatova, N., Ashton, N. J., Voyle, N., Kowalczyk, O., Martinez-Lage, P., Proitsi, P., Scheltens, P., Visser, P. J., Dobson, R. JB., Vandenberghe, R., Engelborghs, S., Vos, S. J. B., Snowden, S. G., Athersuch, T., Ashby, T., Kimhofer, T., Verachtert, W. & Lovestone, S., Jul 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P174-P175

    Research output: Contribution to journalMeeting abstract

  18. Persistently Altered Metabolic Phenotype following Perinatal Excitotoxic Brain Injury

    Blaise, B. J., Schwendimann, L., Chhor, V., Degos, V., Hodson, M. P., Dallmann, G., Keller, M., Gressens, P. & Fleiss, B., Jul 2017, In : Developmental Neuroscience. 39, p. 182-191 10 p.

    Research output: Contribution to journalArticle

  19. Cognitive-emotional interventions for breathlessness in adults with advanced diseases

    Bolzani, A., Rolser, S. M., Kalies, H., Maddocks, M., Rehfuess, E., Hutchinson, A., Gysels, M., Higginson, I. J., Booth, S. & Bausewein, C., 21 Jun 2017, In : The Cochrane database of systematic reviews. 2017, 6, CD012682.

    Research output: Contribution to journalArticle

  20. Physical interventions for breathlessness in adults with advanced diseases

    Bolzani, A., Rolser, S. M., Kalies, H., Maddocks, M., Rehfuess, E., Gysels, M., Higginson, I. J., Booth, S. & Bausewein, C., 21 Jun 2017, In : The Cochrane database of systematic reviews. 2017, 6, p. 1-13 13 p., CD012684.

    Research output: Contribution to journalArticle

  21. Respiratory interventions for breathlessness in adults with advanced diseases

    Bolzani, A., Rolser, S. M., Kalies, H., Maddocks, M., Rehfuess, E., Swan, F., Gysels, M., Higginson, I. J., Booth, S. & Bausewein, C., 21 Jun 2017, In : The Cochrane database of systematic reviews. 2017, 6, CD012683.

    Research output: Contribution to journalArticle

  22. About the "surprise question"

    Costantini, M., Higginson, I. J., Merlo, D. F., Di Leo, S. & Tanzi, S., 12 Jun 2017, In : CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 189, 23, p. E807

    Research output: Contribution to journalArticle

  23. Golgi trafficking defects in postnatal microcephaly: The evidence for "Golgipathies"

    Passemard, S., Perez, F., Colin-Lemesre, E., Rasika, S., Gressens, P. & El Ghouzzi, V., Jun 2017, In : Progress in Neurobiology. 153, p. 46-63 18 p.

    Research output: Contribution to journalArticle

  24. Randomised clinical trial of early specialist palliative care plus standard care versus standard care alone in patients with advanced cancer: The Danish Palliative Care Trial

    Groenvold, M., Petersen, M. A., Damkier, A., Neergaard, M. A., Nielsen, J. B., Pedersen, L., Sjøgren, P., Strömgren, A. S., Vejlgaard, T. B., Gluud, C., Lindschou, J., Fayers, P., Higginson, I. J. & Johnsen, A. T., 12 May 2017, In : Palliative Medicine.

    Research output: Contribution to journalArticle

  25. Long-Term Neuropathological Changes Associated with Cerebral Palsy in a Nonhuman Primate Model of Hypoxic-Ischemic Encephalopathy

    McAdams, R. M., Fleiss, B., Traudt, C., Schwendimann, L., Snyder, J. M., Haynes, R. L., Natarajan, N., Gressens, P. & Juul, S. E., 10 May 2017, In : Developmental Neuroscience. 39, 1-4, p. 124-140

    Research output: Contribution to journalArticle

  26. Strategies to address the shortcomings of commonly used advanced chronic heart failure descriptors to improve recruitment in palliative care research: A parallel mixed-methods feasibility study

    Kane, P. M., Murtagh, F. EM., Ryan, K. R., Brice, M., Mahon, N. G., McAdam, B., McQuillan, R., O’Gara, G., Raleigh, C., Tracey, C., Howley, C., Higginson, I. J. & Daveson, B. A., 10 May 2017, In : Palliative Medicine. p. 0269216317706426

    Research output: Contribution to journalArticle

  27. Mitochondrial genes are altered in blood early in Alzheimer's disease

    Lunnon, K., Keohane, A., Pidsley, R., Newhouse, S., Riddoch-Contreras, J., Thubron, E. B., Devall, M., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Schalkwyk, L., Dobson, R., Malik, A. N., Powell, J., Lovestone, S. & Hodges, A., 1 May 2017, In : Neurobiology of Aging. 53, p. 36-47 12 p.

    Research output: Contribution to journalArticle

  28. Dexmedetomidine Combined with Therapeutic Hypothermia Is Associated with Cardiovascular Instability and Neurotoxicity in a Piglet Model of Perinatal Asphyxia

    Ezzati, M., Kawano, G., Rocha-Ferreira, E., Alonso-Alconada, D., Hassell, J. K., Broad, K. D., Fierens, I., Fleiss, B., Bainbridge, A., Price, D. L., Kaynezhad, P., Anderson, B., Hristova, M., Tachtsidis, I., Golay, X., Gressens, P., Sanders, R. D. & Robertson, N. J., 8 Apr 2017, In : Developmental Neuroscience.

    Research output: Contribution to journalArticle

  29. Surgery increases cell death and induces changes in gene expression compared with anesthesia alone in the developing piglet brain

    Broad, K. D., Kawano, G., Fierens, I., Rocha-Ferreira, E., Hristova, M., Ezzati, M., Rostami, J., Alonso-Alconada, D., Chaban, B., Hassell, J., Fleiss, B., Gressens, P., Sanders, R. D. & Robertson, N. J., 29 Mar 2017, In : PLoS ONE. 12, 3, 15 p., e0173413.

    Research output: Contribution to journalArticle

  30. Do we have adequate tools and skills to manage uncertainty among patients and families in ICU?

    Harding, R., Hopkins, P., Metaxa, V. & Higginson, I. J., Mar 2017, In : Intensive Care Medicine. 43, 4, p. 463–464

    Research output: Contribution to journalLetter

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