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Research Outputs

  1. 2017
  2. CAR: A key regulator of adhesion and inflammation

    Ortiz-Zapater, E., Santis, G. & Parsons, M., 1 Aug 2017, In : The international journal of biochemistry & cell biology. 89, p. 1-5 5 p.

    Research output: Contribution to journalShort survey

  3. Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

    Menzies, F. M., Fleming, A., Caricasole, A., Bento, C. F., Andrews, S. P., Ashkenazi, A., Füllgrabe, J., Jackson, A., Jimenez Sanchez, M., Karabiyik, C., Licitra, F., Lopez Ramirez, A., Pavel, M., Puri, C., Renna, M., Ricketts, T., Schlotawa, L., Vicinanza, M., Won, H., Zhu, Y. & 2 others, Skidmore, J. & Rubinsztein, D. C., 8 Mar 2017, In : Neuron. 93, 5, p. 1015-1034 20 p.

    Research output: Contribution to journalReview article

  4. 2016
  5. Fascin Regulates Nuclear Movement and Deformation in Migrating Cells

    Jayo, A., Malboubi, M., Antoku, S., Chang, W., Ortiz-Zapater, E., Groen, C., Pfisterer, K., Tootle, T., Charras, G., Gundersen, GG. & Parsons, M., 22 Aug 2016, In : Developmental Cell. 38, 4, p. 371-383 13 p.

    Research output: Contribution to journalArticle

  6. TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers

    Morton, P. E., Hicks, A., Ortiz-Zapater, E., Raghavan, S., Pike, R., Noble, A., Woodfin, A., Jenkins, G., Rayner, E., Santis, G. & Parsons, M., 19 May 2016, In : Scientific Reports. 6, 26321.

    Research output: Contribution to journalArticle

  7. CCT complex restricts neuropathogenic protein aggregation via autophagy

    Pavel, M., Imarisio, S., Menzies, F. M., Jimenez-Sanchez, M., Siddiqi, F. H., Wu, X., Renna, M., O'Kane, C. J., Crowther, D. C. & Rubinsztein, D. C., 2016, In : Nature Communications. 7, 13821.

    Research output: Contribution to journalArticle

  8. The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway

    Bento, C. F., Ashkenazi, A., Jimenez-Sanchez, M. & Rubinsztein, D. C., 2016, In : Nature Communications. 7, 11803.

    Research output: Contribution to journalArticle

  9. 2015
  10. Huntington's disease - The sting in the tail

    Jimenez-Sanchez, M. & Rubinsztein, D. C., 2 Sep 2015, In : The EMBO journal. 34, 17, p. 2215-2216 2 p.

    Research output: Contribution to journalComment/debate

  11. SiRNA screen identifies QPCT as a druggable target for Huntington's disease

    Jimenez-Sanchez, M., Lam, W., Hannus, M., Sönnichsen, B., Imarisio, S., Fleming, A., Tarditi, A., Menzies, F., Ed Dami, T., Xu, C., Gonzalez-Couto, E., Lazzeroni, G., Heitz, F., Diamanti, D., Massai, L., Satagopam, V. P., Marconi, G., Caramelli, C., Nencini, A., Andreini, M. & 9 others, Sardone, G. L., Caradonna, N. P., Porcari, V., Scali, C., Schneider, R., Pollio, G., O'Kane, C. J., Caricasole, A. & Rubinsztein, D. C., 1 May 2015, In : Nature Chemical Biology. 11, 5, p. 347-354 8 p.

    Research output: Contribution to journalArticle

  12. Corrigendum: PICALM modulates autophagy activity and tau accumulation

    Moreau, K., Fleming, A., Imarisio, S., Lopez Ramirez, A., Mercer, J. L., Jimenez-Sanchez, M., Bento, C. F., Puri, C., Zavodszky, E., Siddiqi, F., Lavau, C. P., Betton, M., O'Kane, C. J., Wechsler, D. S. & Rubinsztein, D. C., 28 Jan 2015, In : Nature Communications. 6, 6110.

    Research output: Contribution to journalComment/debate

  13. 2014
  14. The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility

    Kiuchi, T., Ortiz-Zapater, E., Monypenny, J., Matthews, D. R., Nguyen, L. K., Barbeau, J., Coban, O., Lawler, K., Burford, B., Rolfe, D. J., de Rinaldis, E., Dafou, D., Simpson, M. A., Woodman, N., Pinder, S., Gillett, C. E., Devauges, V., Poland, S. P., Fruhwirth, G., Marra, P. & 12 others, Boersma, Y. L., Plückthun, A., Gullick, W. J., Yarden, Y., Santis, G., Winn, M., Kholodenko, B. N., Martin-Fernandez, M. L., Parker, P., Tutt, A., Ameer-Beg, S. M. & Ng, T., 19 Aug 2014, In : Science Signaling. 7, 339, ra78.

    Research output: Contribution to journalArticle

  15. Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy

    Zavodszky, E., Seaman, M. N. J., Moreau, K., Jimenez-Sanchez, M., Breusegem, S. Y., Harbour, M. E. & Rubinsztein, D. C., 13 May 2014, In : Nature Communications. 5, 3828.

    Research output: Contribution to journalArticle

  16. PICALM modulates autophagy activity and tau accumulation

    Moreau, K., Fleming, A., Imarisio, S., Lopez Ramirez, A., Mercer, J. L., Jimenez-Sanchez, M., Bento, C. F., Puri, C., Zavodszky, E., Siddiqi, F., Lavau, C. P., Betton, M., O'Kane, C. J., Wechsler, D. S. & Rubinsztein, D. C., 2014, In : Nature Communications. 5, 4998.

    Research output: Contribution to journalArticle

  17. 2013
  18. Phosphoproteomic analysis of protein kinase c signaling in saccharomyces cerevisiae reveals Slt2 mitogen-activated protein kinase (mapk)-dependent phosphorylation of eisosome core components

    Mascaraque, V., Hernaez, M. L., Jiménez-Sánchez, M., Hansen, R., Gil, C., Martín, H., Cid, V. J. & Molina, M., Mar 2013, In : Molecular & cellular proteomics : MCP. 12, 3, p. 557-574 18 p.

    Research output: Contribution to journalArticle

  19. 2012
  20. Autophagy and polyglutamine diseases

    Jimenez-Sanchez, M., Thomson, F., Zavodszky, E. & Rubinsztein, D. C., May 2012, In : Progress in Neurobiology. 97, 2, p. 67-82 16 p.

    Research output: Contribution to journalReview article

  21. The Hedgehog signalling pathway regulates autophagy

    Jimenez-Sanchez, M., Menzies, F. M., Chang, Y. Y., Simecek, N., Neufeld, T. P. & Rubinsztein, D. C., 2012, In : Nature Communications. 3, 1200.

    Research output: Contribution to journalArticle

  22. 2010
  23. Regulation of mammalian autophagy in physiology and pathophysiology

    Ravikumar, B., Sarkar, S., Davies, J. E., Futter, M., Garcia-Arencibia, M., Green-Thompson, Z. W., Jimenez-Sanchez, M., Korolchuk, V. I., Lichtenberg, M., Luo, S., Massey, D. C. O., Menzies, F. M., Moreau, K., Narayanan, U., Renna, M., Siddiqi, F. H., Underwood, B. R., Winslow And, A. R. & Rubinsztein, D. C., Oct 2010, In : Physiological Reviews. 90, 4, p. 1383-1435 53 p.

    Research output: Contribution to journalReview article

  24. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases

    Renna, M., Jimenez-Sanchez, M., Sarkar, S. & Rubinsztein, D. C., 9 Apr 2010, In : Journal of Biological Chemistry. 285, 15, p. 11061-11067 7 p.

    Research output: Contribution to journalShort survey

  25. 2009
  26. Mammalian macroautophagy at a glance

    Ravikumar, B., Futter, M., Jahreiss, L., Korolchuk, V. I., Lichtenberg, M., Luo, S., Massey, D. C. O., Menzies, F. M., Narayanan, U., Renna, M., Jimenez-Sanchez, M., Sarkar, S., Underwood, B., Winslow, A. & Rubinsztein, D. C., 1 Jun 2009, In : Journal of Cell Science. 122, 11, p. 1707-1711 5 p.

    Research output: Contribution to journalArticle

  27. 2007
  28. Retrophosphorylation of Mkk1 and Mkk2 MAPKKs by the Slt2 MAPK in the yeast cell integrity pathway

    Jiménez-Sánchez, M., Cid, V. J. & Molina, M., 26 Oct 2007, In : Journal of Biological Chemistry. 282, 43, p. 31174-31185 12 p.

    Research output: Contribution to journalArticle

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