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  1. 2015
  2. SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment

    Mian, S. A., Rouault-Pierre, K., Smith, A. E., Seidl, T., Pizzitola, I., Kizilors, A., Kulasekararaj, A. G., Bonnet, D. & Mufti, G. J., 8 Dec 2015, In : Nature Communications. 6, 10004.

    Research output: Contribution to journalArticle

  3. TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts

    Kucab, J. E., Zwart, E. P., van Steeg, H., Luijten, M., Schmeiser, H. H., Phillips, D. H. & Arlt, V. M., 8 Dec 2015, In : DNA REPAIR.

    Research output: Contribution to journalArticle

  4. A Randomized Trial of Progesterone in Women with Recurrent Miscarriages

    Coomarasamy, A., Williams, H., Truchanowicz, E., Seed, P. T., Small, R., Quenby, S., Gupta, P., Dawood, F., Koot, Y. E. M., Bender Atik, R., Bloemenkamp, K. W. M., Brady, R., Briley, A. L., Cavallaro, R., Cheong, Y. C., Chu, J. J., Eapen, A., Ewies, A., Hoek, A., Kaaijk, E. M. & 15 others, Koks, C. A. M., Li, T-C., MacLean, M., Mol, B. W., Moore, J., Ross, J. A., Sharpe, L., Stewart, J., Vaithilingam, N., Farquharson, R. G., Kilby, M. D., Khalaf, Y., Goddijn, M., Regan, L. & Rai, R., 26 Nov 2015, In : New England Journal of Medicine. 373, 22, p. 2141-8 8 p.

    Research output: Contribution to journalArticle

  5. The genome as a record of environmental exposure

    Nik-Zainal, S., Kucab, J. E., Morganella, S., Glodzik, D., Alexandrov, L. B., Arlt, V. M., Weninger, A., Hollstein, M., Stratton, M. R. & Phillips, D. H., Nov 2015, In : Mutagenesis. 30, 6, p. 763-770 8 p.

    Research output: Contribution to journalArticle

  6. Application of the pMHC array to characterise tumour antigen specific T cell populations in leukaemia patients at disease diagnosis

    Brooks, S. E., Bonney, S. A., Lee, C., Publicover, A., Khan, G., Smits, E. L., Sigurdardottir, D., Arno, M., Li, D., Mills, K. I., Pulford, K., Banham, A. H., Van Tendeloo, V., Mufti, G. J., Rammensee, H. G., Elliott, T. J., Orchard, K. H. & Guinn, B. A., 22 Oct 2015, In : PL o S One . 10, 10, e0140483.

    Research output: Contribution to journalArticle

  7. Achievement of complete remission predicts outcome of allogeneic haematopoietic stem cell transplantation in patients with chronic myelomonocytic leukaemia. A study of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation

    Symeonidis, A., Van Biezen, A., de Wreede, L., Piciocchi, A., Finke, J., Beelen, D., Bornhäuser, M., Cornelissen, J., Volin, L., Mufti, G., Chalandon, Y., Ganser, A., Bruno, B., Niederwieser, D., Kobbe, G., Schwerdtfeger, R., de Witte, T., Robin, M. & Kröger, N., 1 Oct 2015, In : British Journal of Haematology. 171, 2, p. 239-246 8 p.

    Research output: Contribution to journalArticle

  8. Azacitidine treatment for patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 3q abnormalities

    Wanquet, A., Prebet, T., Berthon, C., Sebert, M., Roux, C., Kulasekararaj, A., Micol, J. B., Esterni, B., Itzykson, R., Thepot, S., Recher, C., Delaunay, J., Dreyfus, F., Mufti, G., Fenaux, P. & Vey, N., 1 Oct 2015, In : American Journal of Hematology. 90, 10, p. 859-863 5 p.

    Research output: Contribution to journalArticle

  9. JAK inhibition induces silencing of T Helper cytokine secretion and a profound reduction in T regulatory cells

    Keohane, C., Kordasti, S., Seidl, T., Perez Abellan, P., Thomas, N. S. B., Harrison, C. N., Mclornan, D. P. & Mufti, G. J., 1 Oct 2015, In : British Journal of Haematology. 171, 1, p. 60-73

    Research output: Contribution to journalArticle

  10. Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial

    Poston, L., Bell, R., Croker, H., Flynn, A. C., Godfrey, K. M., Goff, L., Hayes, L., Khazaezadeh, N., Nelson, S. M., Oteng-Ntim, E., Pasupathy, D., Patel, N., Robson, S. C., Sandall, J., Sanders, T. A. B., Sattar, N., Seed, P. T., Wardle, J., Whitworth, M. K., Briley, A. L. & 1 others, UPBEAT Trial Consortium, Oct 2015, In : The Lancet Diabetes and Endocrinology. 3, 10, p. 767-777 11 p.

    Research output: Contribution to journalArticle

  11. Chronic relapsing remitting Sweet syndrome - a harbinger of myelodysplastic syndrome

    Kulasekararaj, A. G., Kordasti, S., Basu, T., Salisbury, J. R., Mufti, G. J. & du Vivier, A. W. P., Sep 2015, In : British Journal of Haematology. 170, 5, p. 649-656 8 p.

    Research output: Contribution to journalArticle

  12. Prenatal exposure to polycyclic aromatic hydrocarbons/aromatics, BDNF and child development

    Perera, F., Phillips, D. H., Wang, Y., Roen, E., Herbstman, J., Rauh, V., Wang, S. & Tang, D., 21 Aug 2015, In : Environmental Research. 142, p. 602-608 7 p., 6575.

    Research output: Contribution to journalArticle

  13. Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundus height

    Griffin, M., Seed, P. T., Webster, L., Myers, J., Mackillop, L., Simpson, N., Anumba, D., Khalil, A., Denbow, M., Sau, A., Hinshaw, K., Von Dadelszen, P., Benton, S., Girling, J., Redman, C. W. G., Chappell, L. C. & Shennan, A. H., 1 Aug 2015, In : Ultrasound in Obstetrics and Gynecology. 46, 2, p. 182-190 9 p.

    Research output: Contribution to journalArticle

  14. A mismatch between population health literacy and the complexity of health information: An observational study

    Rowlands, G., Protheroe, J., Winkley, J., Richardson, M., Seed, P. T. & Rudd, R., 1 Jun 2015, In : The British journal of general practice : the journal of the Royal College of General Practitioners. 65, 635, p. 379-386 8 p.

    Research output: Contribution to journalArticle

  15. Adverse maternal and perinatal outcomes in pregnant women with sickle cell disease: Systematic review and meta-analysis

    Oteng-Ntim, E., Meeks, D., Seed, P. T., Webster, L., Howard, J., Doyle, P. & Chappell, L. C., 21 May 2015, In : Blood. 125, 21, p. 3316-3325 10 p.

    Research output: Contribution to journalArticle

  16. RIPOSTE: A framework for improving the design and analysis of laboratory-based research

    Masca, N. G. D., Hensor, E. M. A., Cornelius, V., Buffa, F. M., Marriott, H. M., Eales, J. M., Messenger, M. P., Anderson, A. E., Boot, C., Bunce, C., Goldin, R. D., Harris, J., Hinchliffe, R. F., Junaid, H., Kingston, S., Martin-Ruiz, C., Nelson, C. P., Peacock, J., Seed, P. T., Shinkins, B. & 4 others, Staples, K. J., Toombs, J., Wright, A. K. A. & Dawn Teare, M., 7 May 2015, In : eLife. 4, p. 1-27 27 p.

    Research output: Contribution to journalArticle

  17. Quantitative fetal fibronectin to predict preterm birth in asymptomatic women at high risk

    Abbott, D. S., Hezelgrave, N. L., Seed, P. T., Norman, J. E., David, A. L., Bennett, P. R., Girling, J. C., Chandirimani, M., Stock, S. J., Carter, J., Cate, R., Kurtzman, J., Tribe, R. M. & Shennan, A. H., 1 May 2015, In : Obstetrics and Gynecology. 125, 5, p. 1168-1176 9 p.

    Research output: Contribution to journalArticle

  18. The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Stiborova, M. & Phillips, D. H., 1 May 2015, In : Toxicology Research. 4, 3, p. 548-562 15 p.

    Research output: Contribution to journalLiterature review

  19. CSNK1A1 mutations and isolated del(5q) abnormality in myelodysplastic syndrome: A retrospective mutational analysis

    Smith, A. E., Kulasekararaj, A. G., Jiang, J., Mian, S., Mohamedali, A., Gaken, J., Ireland, R., Czepulkowski, B., Best, S. & Mufti, G. J., May 2015, In : The Lancet Haematology. 2, 5, p. e212-e221

    Research output: Contribution to journalArticle

  20. Pulmonary inflammation impacts on CYP1A1-mediated respiratory tract DNA damage induced by the carcinogenic air pollutant benzo[a]pyrene

    Arlt, V. M., Krais, A., Godschalk, R. W., Riffo-Vasquez, Y., Mrizova, I., Roufosse, C. A., Corbin, C., Shi, Q., Frei, E., Stiborova, M., van Schooten, F-J., Phillips, D. H. & Spina, D., 23 Apr 2015, In : Toxicological sciences : an official journal of the Society of Toxicology. 146, 2, p. 213-225 13 p.

    Research output: Contribution to journalArticle

  21. TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts

    Kucab, J. E., van Steeg, H., Luijten, M., Schmeiser, H. H., White, P. A., Phillips, D. H. & Arlt, V. M., 1 Mar 2015, In : Mutation Research. 773, p. 48-62 15 p.

    Research output: Contribution to journalArticle

  22. Dalteparin for pregnant women with thrombophilia

    Hunt, B. J., Seed, P. T. & Lefkou, E., 21 Feb 2015, In : Lancet. 385, 9969, p. 689 1 p.

    Research output: Contribution to journalLiterature review

  23. Endothelial and platelet microparticles in patients with antiphospholipid antibodies

    Breen, K. A., Sanchez, K., Kirkman, N., Seed, P. T., Parmar, K., Moore, G. W. & Hunt, B. J., 1 Feb 2015, In : Thrombosis Research. 135, 2, p. 368-374 7 p.

    Research output: Contribution to journalArticle

  24. Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts

    Krais, A. M., Mühlbauer, K-R., Kucab, J. E., Chinbuah, H., Cornelius, M. G., Wei, Q-X., Hollstein, M., Phillips, D. H., Arlt, V. M. & Schmeiser, H. H., Feb 2015, In : Toxicology in Vitro. 29, 1, p. 34-43 10 p.

    Research output: Contribution to journalArticle

  25. A novel zinc finger gene, ZNF465, is inappropriately expressed in acute myeloid leukaemia cells

    Collin, J. F., Wells, J. W., Czepulkowski, B., Lyne, L., Duriez, P. J., Banham, A. H., Mufti, G. J. & Guinn, B. A., 1 Jan 2015, In : Genes Chromosomes and Cancer. 54, 5, p. 288-302 15 p.

    Research output: Contribution to journalArticle

  26. Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks' gestation in nulliparous women who subsequently develop pre-eclampsia

    Mistry, H. D., Gill, C. A., Kurlak, L. O., Seed, P. T., Hesketh, J. E., Méplan, C., Schomburg, L., Chappell, L. C., Morgan, L., Poston, L. & on behalf of SCOPE consortium, 1 Jan 2015, In : Free Radical Biology and Medicine. 78, p. 147-155 9 p.

    Research output: Contribution to journalArticle

  27. Shock index: An effective predictor of outcome in postpartum haemorrhage?

    Nathan, H. L., El Ayadi, A., Hezelgrave, N. L., Seed, P., Butrick, E., Miller, S., Briley, A., Bewley, S. & Shennan, A. H., 1 Jan 2015, In : BJOG: An International Journal of Obstetrics and Gynaecology. 122, 2, p. 268-275 8 p.

    Research output: Contribution to journalArticle

  28. Assessment of a Full Dilatation Cesarean Delivery Simulator

    Vousden, N., Hamakarim, Z., Briley, A., Girling, J., Seed, P. T., Tydeman, G. & Shennan, A. H., 2015, In : Obstetrics and Gynecology.

    Research output: Contribution to journalArticle

  29. Science forum: RIPOSTE: a framework for improving the design and analysis of laboratory-based research.

    Masca, N. G. D., Hensor, E. M. A., Cornelius, V. R., Buffa, F. M., Marriott, H. M., Eales, J. M., Messenger, M. P., Anderson, A. E., Boot, C., Bunce, C., Goldin, R. D., Harris, J., Hinchliffe, R. F., Junaid, H., Kingston, S., Martin-Ruiz, C., Nelson, C. P., Peacock, J., Seed, P. T., Shinkins, B. & 4 others, Staples, K. J., Toombs, J., Wright, A. K. A. & Teare, M. D., 2015, eLife. p. e05519 (eLife; vol. 4).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  30. 2014
  31. Relationship of different platelet response criteria and patient outcomes in a romiplostim myelodysplastic syndromes trial

    Platzbecker, U., Sekeres, M. A., Kantarjian, H., Giagounidis, A., Mufti, G. J., Jia, C., Yang, A. S. & Fenaux, P., Dec 2014, In : Leukemia. 28, 12, p. 2418-2421 4 p.

    Research output: Contribution to journalLetter

  32. Successful treatment of aplastic anaemia associated with HIV infection with eltrombopag: implications for a possible immunomodulatory role

    Bart-Smith, E. E., Kordasti, S., Kulasekararaj, A. G., Richardson, D., Mufti, G. J. & Marsh, J. C. W., 28 Nov 2014, In : Aids. 28, 18, p. 2786-2788 3 p.

    Research output: Contribution to journalLetter

  33. Development and validation of a model to predict platelet response to romiplostim in patients with lower-risk myelodysplastic syndromes

    Sekeres, M. A., Giagounidis, A., Kantarjian, H., Mufti, G. J., Fenaux, P., Jia, C., Yang, A. S. & Platzbecker, U., Nov 2014, In : British Journal of Haematology. 167, 3, p. 337-345 9 p.

    Research output: Contribution to journalArticle

  34. Nonmyeloablative Peripheral Blood Haploidentical Stem Cell Transplantation for Refractory Severe Aplastic Anemia

    Clay, J., Kulasekararaj, A. G., Potter, V., Grimaldi, F., McLornan, D., Raj, K., de Lavallade, H., Kenyon, M., Pagliuca, T., Mufti, G. & Marsh, J. C. W., Nov 2014, In : BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. 20, 11, p. 1711-1716 6 p.

    Research output: Contribution to journalArticle

  35. Transplant-acquired food allergy (TAFA) following cord blood stem cell transplantation in two adult patients with haematological malignancies

    Feliu, J., Clay, J., Raj, K., Barber, L., Devlia, V., Shaw, B., Pagliuca, T. & Mufti, G., Nov 2014, In : British Journal of Haematology. 167, 3, p. 426-428 3 p.

    Research output: Contribution to journalLetter

  36. Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice

    Zuo, J., Brewer, D. S., Arlt, V. M., Cooper, C. S. & Phillips, D. H., 8 Oct 2014, In : BMC GENOMICS. 15, 20 p., 880.

    Research output: Contribution to journalArticle

  37. AN INTERVENTION TRIAL FOR PEOPLE WITH EPILEPSY ATTENDING A&E

    Ridsdale, L. L., McCrone, P. R., Morgan, M. A., Seed, P., Goldstein, L. H. & Noble, A. J., 1 Oct 2014, In : Journal of Neurology, Neurosurgery and Psychiatry. 85, e4, p. A20 1 p., 075.

    Research output: Contribution to journalMeeting abstract

  38. Endocervical and high vaginal quantitative fetal fibronectin in predicting preterm birth

    Kuhrt, K., Unwin, C., Hezelgrave, N., Seed, P. & Shennan, A., 1 Oct 2014, In : JOURNAL OF MATERNAL FETAL AND NEONATAL MEDICINE. 27, 15, p. 1576-1579 4 p.

    Research output: Contribution to journalArticle

  39. Prediction of gestational diabetes in obese pregnant women from the UK Pregnancies Better Eating and Activity (UPBEAT) pilot trial

    Maitland, R. A., Seed, P. T., Briley, A. L., Homsy, M., Thomas, S., Pasupathy, D., Robson, S. C., Nelson, S. M., Sattar, N., Poston, L. & UPBEAT Trial Consortium, Aug 2014, In : Diabetic Medicine. 31, 8, p. 963-970 8 p.

    Research output: Contribution to journalArticle

  40. Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy

    Schmeiser, H. H., Nortier, J. L., Singh, R., da Costa, G. G., Sennesael, J., Cassuto-Viguier, E., Ambrosetti, D., Rorive, S., Pozdzik, A., Phillips, D. H., Stiborova, M. & Arlt, V. M., 15 Jul 2014, In : International Journal of Cancer. 135, 2, p. 502-507 6 p.

    Research output: Contribution to journalArticle

  41. Long term follow-up of BEAM-autologous and BEAM-alemtuzumab allogeneic stem cell transplantation in relapsed advanced stage follicular lymphoma

    Noriega, V., Kaur, H., Devereux, S., Byrne, J., Marcus, R., Haynes, A., Yallop, D., McMillan, A., Ingram, W., Khan, A., Kenyon, M., Potter, V., Russell, N., Mufti, G. J. & Pagliuca, A., Jul 2014, In : Leukemia Research. 38, 7, p. 737-743 7 p.

    Research output: Contribution to journalArticle

  42. Variation of DNA damage levels in peripheral blood mononuclear cells isolated in different laboratories

    Godschalk, R. W. L., Ersson, C., Stępnik, M., Ferliłska, M., Palus, J., Teixeira, J. P., Costa, S., Jones, G. D. D., Higgins, J. A., Kain, J., Möller, L., Forchhammer, L., Loft, S., Lorenzo, Y., Collins, A. R., van Schooten, F-J., Laffon, B., Valdiglesias, V., Cooke, M., Mistry, V. & 12 others, Karbaschi, M., Phillips, D. H., Sozeri, O., Routledge, M. N., Nelson-Smith, K., Riso, P., Porrini, M., López de Cerain, A., Azqueta, A., Matullo, G., Allione, A. & Møller, P., Jul 2014, In : Mutagenesis. 29, 4, p. 241-249 9 p.

    Research output: Contribution to journalArticle

  43. Results of a Randomized, Double-Blind Study of Romiplostim Versus Placebo in Patients With Low/Intermediate-1-Risk Myelodysplastic Syndrome and Thrombocytopenia

    Giagounidis, A., Mufti, G. J., Fenaux, P., Sekeres, M. A., Szer, J., Platzbecker, U., Kuendgen, A., Gaidano, G., Wiktor-Jedrzejczak, W., Hu, K., Woodard, P., Yang, A. S. & Kantarjian, H. M., 15 Jun 2014, In : Cancer. 120, 12, p. 1838-1846 9 p.

    Research output: Contribution to journalArticle

  44. MGMT promoter hypermethylation and K-RAS, PTEN and TP53 mutations in tamoxifen-exposed and non-exposed endometrial cancer cases

    Nagy, E., Gajjar, K. B., Patel, I. I., Taylor, S., Martin-Hirsch, P. L., Stringfellow, H. F., Martin, F. L. & Phillips, D. H., 10 Jun 2014, In : BJC: British Journal of Cancer. 110, 12, p. 2874-2880 7 p.

    Research output: Contribution to journalArticle

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