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Research Outputs

  1. 2015
  2. TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts

    Kucab, J. E., Zwart, E. P., van Steeg, H., Luijten, M., Schmeiser, H. H., Phillips, D. H. & Arlt, V. M., 8 Dec 2015, In : DNA REPAIR.

    Research output: Contribution to journalArticle

  3. A Randomized Trial of Progesterone in Women with Recurrent Miscarriages

    Coomarasamy, A., Williams, H., Truchanowicz, E., Seed, P. T., Small, R., Quenby, S., Gupta, P., Dawood, F., Koot, Y. E. M., Bender Atik, R., Bloemenkamp, K. W. M., Brady, R., Briley, A. L., Cavallaro, R., Cheong, Y. C., Chu, J. J., Eapen, A., Ewies, A., Hoek, A., Kaaijk, E. M. & 15 others, Koks, C. A. M., Li, T-C., MacLean, M., Mol, B. W., Moore, J., Ross, J. A., Sharpe, L., Stewart, J., Vaithilingam, N., Farquharson, R. G., Kilby, M. D., Khalaf, Y., Goddijn, M., Regan, L. & Rai, R., 26 Nov 2015, In : New England Journal of Medicine. 373, 22, p. 2141-8 8 p.

    Research output: Contribution to journalArticle

  4. The genome as a record of environmental exposure

    Nik-Zainal, S., Kucab, J. E., Morganella, S., Glodzik, D., Alexandrov, L. B., Arlt, V. M., Weninger, A., Hollstein, M., Stratton, M. R. & Phillips, D. H., Nov 2015, In : Mutagenesis. 30, 6, p. 763-770 8 p.

    Research output: Contribution to journalArticle

  5. Authors' reply

    Fu, C. H. Y., Legge, R. M., Cohen-Woods, S., Cole, J. H., Aitchison, K. J. & McGuffin, P., 1 Oct 2015, In : British Journal of Psychiatry. 207, 4, p. 363-364 2 p.

    Research output: Contribution to journalLetter

  6. Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial

    Poston, L., Bell, R., Croker, H., Flynn, A. C., Godfrey, K. M., Goff, L., Hayes, L., Khazaezadeh, N., Nelson, S. M., Oteng-Ntim, E., Pasupathy, D., Patel, N., Robson, S. C., Sandall, J., Sanders, T. A. B., Sattar, N., Seed, P. T., Wardle, J., Whitworth, M. K., Briley, A. L. & 1 others, UPBEAT Trial Consortium, Oct 2015, In : The Lancet Diabetes and Endocrinology. 3, 10, p. 767-777 11 p.

    Research output: Contribution to journalArticle

  7. Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): A genetic association study in UK Biobank

    Wain, L. V., Shrine, N., Miller, S., Jackson, V. E., Ntalla, I., Artigas, M. S., Billington, C. K., Kheirallah, A. K., Allen, R., Cook, J. P., Probert, K., Obeidat, M., Bossé, Y., Hao, K., Postma, D. S., Paré, P. D., Ramasamy, A., Mägi, R., Mihailov, E., Reinmaa, E. & 138 others, Melén, E., O'Connell, J., Frangou, E., Delaneau, O., Freeman, C., Petkova, D., McCarthy, M., Sayers, I., Deloukas, P., Hubbard, R., Pavord, I., Hansell, A. L., Thomson, N. C., Zeggini, E., Morris, A. P., Marchini, J., Strachan, D. P., Tobin, M. D., Hall, I. P., Farrall, M., Barroso, I., Anderson, C. A., Botía, J., Vandrocova, J., Guelfi, S., D'Sa, K., Ryten, M., Trabzuni, D., Matarin, M., Hardy, J. A., Weale, M. E., Varghese, V., Forabosco, P., Farmer, A., McGuffin, P., Zgaga, L., Wilson, J. F., Wild, S. H., Campbell, H., Rudan, I., Smith, C., Walker, R., Liu, J. Z., Tozzi, F., Muglia, P., Waterworth, D. M., Pillai, S. G., Yuan, X., Mooser, V., Middleton, L., Kooner, J., Chambers, J. C., Berrettini, W., Knouff, C. W., Waeber, G., Vollenweider, P., Preisig, M., Wareham, N. J., Zhao, J. H., Loos, R. J. F., Khaw, K. T., Grundy, S., Barter, P., Mahley, R., Kesaniemi, A., McPherson, R., Vincent, J. B., Strauss, J., Kennedy, J. L., Day, R., Matthews, K., Bakke, P., Gulsvik, A., Lucae, S., Ising, M., Brueckl, T., Horstmann, S., Wichmann, H. E., Rawal, R., Wichmann, H. E., Lamina, C., Dahmen, N., Polasek, O., Kolcic, I., Huffman, J., Campbell, S., Vitart, V., Hayward, C., Wright, A. F., Burnett, M. S., Devaney, J. M., Pichard, A. D., Kent, K. M., Satler, L., Lindsay, J. M., Waksman, R., Epstein, S., Reilly, M. P., Li, M., Qu, L., Wilensky, R., Matthai, W., Hakonarson, H. H., Rader, D. J., Ellinghaus, D., Lieb, W., Franke, A., Uda, M., Busonero, F., Terracciano, A., Schlessinger, D., Xiao, X., Scheet, P., St Clair, D., Rujescu, D., Abecasis, G. R., Grabe, H. J., Teumer, A., Völzke, H., Petersmann, A., John, U., Wright, B. J., Thompson, J. R., Balmforth, A. J., Hall, A. S., Samani, N. J., Ahmad, T., Mathew, C. G., Parkes, M., Satsangi, J., Caulfield, M., Munroe, P. B., Dominiczak, A., Worthington, J., Thomson, W., Eyre, S., Barton, A. & Francks, C., Oct 2015, In : The Lancet Respiratory Medicine. 3, 10, p. 769-781 13 p.

    Research output: Contribution to journalArticle

  8. Prenatal exposure to polycyclic aromatic hydrocarbons/aromatics, BDNF and child development

    Perera, F., Phillips, D. H., Wang, Y., Roen, E., Herbstman, J., Rauh, V., Wang, S. & Tang, D., 21 Aug 2015, In : Environmental Research. 142, p. 602-608 7 p., 6575.

    Research output: Contribution to journalArticle

  9. Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundus height

    Griffin, M., Seed, P. T., Webster, L., Myers, J., Mackillop, L., Simpson, N., Anumba, D., Khalil, A., Denbow, M., Sau, A., Hinshaw, K., Von Dadelszen, P., Benton, S., Girling, J., Redman, C. W. G., Chappell, L. C. & Shennan, A. H., 1 Aug 2015, In : Ultrasound in Obstetrics and Gynecology. 46, 2, p. 182-190 9 p.

    Research output: Contribution to journalArticle

  10. Exploring the role of drug-metabolising enzymes in antidepressant side effects

    Hodgson, K., Tansey, K. E., Uher, R., Dernovšek, M. Z., Mors, O., Hauser, J., Souery, D., Maier, W., Henigsberg, N., Rietschel, M., Placentino, A., Craig, I. W., Aitchison, K. J., Farmer, A., Dobson, R. J. B. & McGuffin, P., Jul 2015, In : Psychopharmacology. 232, 14, p. 2609-2617 9 p.

    Research output: Contribution to journalArticle

  11. A mismatch between population health literacy and the complexity of health information: An observational study

    Rowlands, G., Protheroe, J., Winkley, J., Richardson, M., Seed, P. T. & Rudd, R., 1 Jun 2015, In : The British journal of general practice : the journal of the Royal College of General Practitioners. 65, 635, p. 379-386 8 p.

    Research output: Contribution to journalArticle

  12. The interaction between stress and genetic factors in the etiopathogenesis of depression

    McGuffin, P. & Rivera, M., Jun 2015, In : World Psychiatry. 14, 2, p. 161-163 3 p.

    Research output: Contribution to journalReview article

  13. Adverse maternal and perinatal outcomes in pregnant women with sickle cell disease: Systematic review and meta-analysis

    Oteng-Ntim, E., Meeks, D., Seed, P. T., Webster, L., Howard, J., Doyle, P. & Chappell, L. C., 21 May 2015, In : Blood. 125, 21, p. 3316-3325 10 p.

    Research output: Contribution to journalArticle

  14. RIPOSTE: A framework for improving the design and analysis of laboratory-based research

    Masca, N. G. D., Hensor, E. M. A., Cornelius, V., Buffa, F. M., Marriott, H. M., Eales, J. M., Messenger, M. P., Anderson, A. E., Boot, C., Bunce, C., Goldin, R. D., Harris, J., Hinchliffe, R. F., Junaid, H., Kingston, S., Martin-Ruiz, C., Nelson, C. P., Peacock, J., Seed, P. T., Shinkins, B. & 4 others, Staples, K. J., Toombs, J., Wright, A. K. A. & Dawn Teare, M., 7 May 2015, In : eLife. 4, p. 1-27 27 p.

    Research output: Contribution to journalArticle

  15. Quantitative fetal fibronectin to predict preterm birth in asymptomatic women at high risk

    Abbott, D. S., Hezelgrave, N. L., Seed, P. T., Norman, J. E., David, A. L., Bennett, P. R., Girling, J. C., Chandirimani, M., Stock, S. J., Carter, J., Cate, R., Kurtzman, J., Tribe, R. M. & Shennan, A. H., 1 May 2015, In : Obstetrics and Gynecology. 125, 5, p. 1168-1176 9 p.

    Research output: Contribution to journalArticle

  16. The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Stiborova, M. & Phillips, D. H., 1 May 2015, In : Toxicology Research. 4, 3, p. 548-562 15 p.

    Research output: Contribution to journalLiterature review

  17. Pulmonary inflammation impacts on CYP1A1-mediated respiratory tract DNA damage induced by the carcinogenic air pollutant benzo[a]pyrene

    Arlt, V. M., Krais, A., Godschalk, R. W., Riffo-Vasquez, Y., Mrizova, I., Roufosse, C. A., Corbin, C., Shi, Q., Frei, E., Stiborova, M., van Schooten, F-J., Phillips, D. H. & Spina, D., 23 Apr 2015, In : Toxicological sciences : an official journal of the Society of Toxicology. 146, 2, p. 213-225 13 p.

    Research output: Contribution to journalArticle

  18. A genetic risk score combining 32 SNPs is associated with body mass index and improves obesity prediction in people with major depressive disorder

    Hung, C-F., Breen, G., Czamara, D., Corre, T., Wolf, C., Kloiber, S., Bergmann, S., Craddock, N., Gill, M., Holsboer, F., Jones, L., Jones, I., Korszun, A., Kutalik, Z., Lucae, S., Maier, W., Mors, O., Owen, M. J., Rice, J., Rietschel, M. & 10 others, Uher, R., Vollenweider, P., Waeber, G., Craig, I. W., Farmer, A. E., Lewis, C. M., Müller-Myhsok, B., Preisig, M., McGuffin, P. & Rivera, M., 17 Apr 2015, In : BMC Medicine. 13, 10 p., 86.

    Research output: Contribution to journalArticle

  19. TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts

    Kucab, J. E., van Steeg, H., Luijten, M., Schmeiser, H. H., White, P. A., Phillips, D. H. & Arlt, V. M., 1 Mar 2015, In : Mutation Research. 773, p. 48-62 15 p.

    Research output: Contribution to journalArticle

  20. Dalteparin for pregnant women with thrombophilia

    Hunt, B. J., Seed, P. T. & Lefkou, E., 21 Feb 2015, In : Lancet. 385, 9969, p. 689 1 p.

    Research output: Contribution to journalLiterature review

  21. DNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons

    Oh, G., Wang, S-C., Pal, M., Chen, Z. F., Khare, T., Tochigi, M., Ng, C., Yang, Y. A., Kwan, A., Kaminsky, Z. A., Mill, J., Gunasinghe, C., Tackett, J. L., Gottesman, I. I., Willemsen, G., de Geus, E. J. C., Vink, J. M., Slagboom, P. E., Wray, N. R., Heath, A. C. & 7 others, Montgomery, G. W., Turecki, G., Martin, N. G., Boomsma, D. I., McGuffin, P., Kustra, R. & Petronis, A., 1 Feb 2015, In : Biological psychiatry. 77, 3, p. 246-255 10 p.

    Research output: Contribution to journalArticle

  22. Endothelial and platelet microparticles in patients with antiphospholipid antibodies

    Breen, K. A., Sanchez, K., Kirkman, N., Seed, P. T., Parmar, K., Moore, G. W. & Hunt, B. J., 1 Feb 2015, In : Thrombosis Research. 135, 2, p. 368-374 7 p.

    Research output: Contribution to journalArticle

  23. Phenotypic Association Analyses with Copy Number Variation in Recurrent Depressive Disorder.

    Rucker, J. J. H., Tansey, K. E., Rivera, M., Pinto, D., Cohen-Woods, S., Uher, R., Aitchison, K. J., Craddock, N., Owen, M. J., Jones, L., Jones, I., Korszun, A., Barnes, M. R., Preisig, M., Mors, O., Maier, W., Rice, J., Rietschel, M., Holsboer, F., Farmer, A. E. & 4 others, Craig, I. W., Scherer, S. W., McGuffin, P. & Breen, G., 1 Feb 2015, In : Biological psychiatry.

    Research output: Contribution to journalArticle

  24. Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts

    Krais, A. M., Mühlbauer, K-R., Kucab, J. E., Chinbuah, H., Cornelius, M. G., Wei, Q-X., Hollstein, M., Phillips, D. H., Arlt, V. M. & Schmeiser, H. H., Feb 2015, In : Toxicology in Vitro. 29, 1, p. 34-43 10 p.

    Research output: Contribution to journalArticle

  25. Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks' gestation in nulliparous women who subsequently develop pre-eclampsia

    Mistry, H. D., Gill, C. A., Kurlak, L. O., Seed, P. T., Hesketh, J. E., Méplan, C., Schomburg, L., Chappell, L. C., Morgan, L., Poston, L. & on behalf of SCOPE consortium, 1 Jan 2015, In : Free Radical Biology and Medicine. 78, p. 147-155 9 p.

    Research output: Contribution to journalArticle

  26. Shock index: An effective predictor of outcome in postpartum haemorrhage?

    Nathan, H. L., El Ayadi, A., Hezelgrave, N. L., Seed, P., Butrick, E., Miller, S., Briley, A., Bewley, S. & Shennan, A. H., 1 Jan 2015, In : BJOG: An International Journal of Obstetrics and Gynaecology. 122, 2, p. 268-275 8 p.

    Research output: Contribution to journalArticle

  27. Assessment of a Full Dilatation Cesarean Delivery Simulator

    Vousden, N., Hamakarim, Z., Briley, A., Girling, J., Seed, P. T., Tydeman, G. & Shennan, A. H., 2015, In : Obstetrics and Gynecology.

    Research output: Contribution to journalArticle

  28. Familiality and SNP heritability of age at onset and episodicity in major depressive disorder

    Ferentinos, P., Koukounari, A., Power, R., Rivera, M., Uher, R., Craddock, N., Owen, M. J., Korszun, A., Jones, L., Jones, I., Gill, M., Rice, J. P., Ising, M., Maier, W., Mors, O., Rietschel, M., Preisig, M., Binder, E. B., Aitchison, K. J., Mendlewicz, J. & 9 others, Souery, D., Hauser, J., Henigsberg, N., Breen, G., Craig, I. W., Farmer, A. E., Müller-Myhsok, B., McGuffin, P. & Lewis, C. M., 2015, In : Psychological Medicine. 11 p.

    Research output: Contribution to journalArticle

  29. Science forum: RIPOSTE: a framework for improving the design and analysis of laboratory-based research.

    Masca, N. G. D., Hensor, E. M. A., Cornelius, V. R., Buffa, F. M., Marriott, H. M., Eales, J. M., Messenger, M. P., Anderson, A. E., Boot, C., Bunce, C., Goldin, R. D., Harris, J., Hinchliffe, R. F., Junaid, H., Kingston, S., Martin-Ruiz, C., Nelson, C. P., Peacock, J., Seed, P. T., Shinkins, B. & 4 others, Staples, K. J., Toombs, J., Wright, A. K. A. & Teare, M. D., 2015, eLife. p. e05519 (eLife; vol. 4).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  30. The successful search for genetic loci associated with depression

    Rivera, M. & McGuffin, P., 2015, In : Genome medicine. 7, 1, 92.

    Research output: Contribution to journalArticle

  31. 2014
  32. Trauma, post-traumatic stress disorder and psychiatric disorders in a middle-income setting: prevalence and comorbidity

    Dorrington, S., Zavos, H., Ball, H., McGuffin, P., Rijsdijk, F., Siribaddana, S., Sumathipala, A. & Hotopf, M., 3 Nov 2014, In : British Journal of Psychiatry. 205, 5, p. 383-389 7 p.

    Research output: Contribution to journalArticle

  33. Interplay Between Childhood Physical Abuse and Familial Risk in the Onset of Psychotic Disorders

    Fisher, H. L., McGuffin, P., Boydell, J., Fearon, P., Craig, T. K., Dazzan, P., Morgan, K., Doody, G. A., Jones, P. B., Leff, J., Murray, R. M. & Morgan, C., Nov 2014, In : Schizophrenia Bulletin. 40, 6, p. 1443–1451 9 p.

    Research output: Contribution to journalArticle

  34. Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice

    Zuo, J., Brewer, D. S., Arlt, V. M., Cooper, C. S. & Phillips, D. H., 8 Oct 2014, In : BMC GENOMICS. 15, 20 p., 880.

    Research output: Contribution to journalArticle

  35. AN INTERVENTION TRIAL FOR PEOPLE WITH EPILEPSY ATTENDING A&E

    Ridsdale, L. L., McCrone, P. R., Morgan, M. A., Seed, P., Goldstein, L. H. & Noble, A. J., 1 Oct 2014, In : Journal of Neurology, Neurosurgery and Psychiatry. 85, e4, p. A20 1 p., 075.

    Research output: Contribution to journalMeeting abstract

  36. Endocervical and high vaginal quantitative fetal fibronectin in predicting preterm birth

    Kuhrt, K., Unwin, C., Hezelgrave, N., Seed, P. & Shennan, A., 1 Oct 2014, In : JOURNAL OF MATERNAL FETAL AND NEONATAL MEDICINE. 27, 15, p. 1576-1579 4 p.

    Research output: Contribution to journalArticle

  37. A genome-wide association study of anorexia nervosa

    Boraska, V., Franklin, C. S., Floyd, J. A. B., Thornton, L. M., Huckins, L. M., Southam, L., Rayner, N. W., Tachmazidou, I., Klump, K. L., Treasure, J., Lewis, C. M., Schmidt, U., Tozzi, F., Kiezebrink, K., Hebebrand, J., Gorwood, P., Adan, R. A. H., Kas, M. J. H., Favaro, A., Santonastaso, P. & 31 others, Fernández-Aranda, F., Gratacos, M., Rybakowski, F., Dmitrzak-Weglarz, M., Kaprio, J., Keski-Rahkonen, A., Raevuori, A., Van Furth, E. F., Slof-Op 't Landt, M. C. T., Hudson, J. I., Reichborn-Kjennerud, T., Knudsen, G. P. S., Monteleone, P., Kaplan, A. S., Karwautz, A., Hakonarson, H., Berrettini, W. H., Guo, Y., Li, D., Schork, N. J., Davis, O. S. P., Helder, S., Breen, G., Cohen-Woods, S., Farmer, A., McGuffin, P., Kalsi, G., Roberts, M., Collier, D. A., The Wellcome Trust Case Control Consortium 3 & Lord, G., Oct 2014, In : Molecular Psychiatry. 19, p. 1085–1094

    Research output: Contribution to journalArticle

  38. Prediction of gestational diabetes in obese pregnant women from the UK Pregnancies Better Eating and Activity (UPBEAT) pilot trial

    Maitland, R. A., Seed, P. T., Briley, A. L., Homsy, M., Thomas, S., Pasupathy, D., Robson, S. C., Nelson, S. M., Sattar, N., Poston, L. & UPBEAT Trial Consortium, Aug 2014, In : Diabetic Medicine. 31, 8, p. 963-970 8 p.

    Research output: Contribution to journalArticle

  39. Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy

    Schmeiser, H. H., Nortier, J. L., Singh, R., da Costa, G. G., Sennesael, J., Cassuto-Viguier, E., Ambrosetti, D., Rorive, S., Pozdzik, A., Phillips, D. H., Stiborova, M. & Arlt, V. M., 15 Jul 2014, In : International Journal of Cancer. 135, 2, p. 502-507 6 p.

    Research output: Contribution to journalArticle

  40. Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study

    Hung, C-F., Rivera, M., Craddock, N., Owen, M. J., Gill, M., Korszun, A., Maier, W., Mors, O., Preisig, M., Rice, J. P., Rietschel, M., Jones, L., Middleton, L., Aitchison, K. J., Davis, O. S. P., Breen, G., Lewis, C., Farmer, A. & McGuffin, P., Jul 2014, In : British Journal of Psychiatry. 205, 1, p. 24-28 5 p.

    Research output: Contribution to journalArticle

  41. Variation of DNA damage levels in peripheral blood mononuclear cells isolated in different laboratories

    Godschalk, R. W. L., Ersson, C., Stępnik, M., Ferliłska, M., Palus, J., Teixeira, J. P., Costa, S., Jones, G. D. D., Higgins, J. A., Kain, J., Möller, L., Forchhammer, L., Loft, S., Lorenzo, Y., Collins, A. R., van Schooten, F-J., Laffon, B., Valdiglesias, V., Cooke, M., Mistry, V. & 12 others, Karbaschi, M., Phillips, D. H., Sozeri, O., Routledge, M. N., Nelson-Smith, K., Riso, P., Porrini, M., López de Cerain, A., Azqueta, A., Matullo, G., Allione, A. & Møller, P., Jul 2014, In : Mutagenesis. 29, 4, p. 241-249 9 p.

    Research output: Contribution to journalArticle

  42. MGMT promoter hypermethylation and K-RAS, PTEN and TP53 mutations in tamoxifen-exposed and non-exposed endometrial cancer cases

    Nagy, E., Gajjar, K. B., Patel, I. I., Taylor, S., Martin-Hirsch, P. L., Stringfellow, H. F., Martin, F. L. & Phillips, D. H., 10 Jun 2014, In : BJC: British Journal of Cancer. 110, 12, p. 2874-2880 7 p.

    Research output: Contribution to journalArticle

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