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Research Outputs

  1. 2015
  2. TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts

    Kucab, J. E., Zwart, E. P., van Steeg, H., Luijten, M., Schmeiser, H. H., Phillips, D. H. & Arlt, V. M., 8 Dec 2015, In : DNA REPAIR.

    Research output: Contribution to journalArticle

  3. A Randomized Trial of Progesterone in Women with Recurrent Miscarriages

    Coomarasamy, A., Williams, H., Truchanowicz, E., Seed, P. T., Small, R., Quenby, S., Gupta, P., Dawood, F., Koot, Y. E. M., Bender Atik, R., Bloemenkamp, K. W. M., Brady, R., Briley, A. L., Cavallaro, R., Cheong, Y. C., Chu, J. J., Eapen, A., Ewies, A., Hoek, A., Kaaijk, E. M. & 15 others, Koks, C. A. M., Li, T-C., MacLean, M., Mol, B. W., Moore, J., Ross, J. A., Sharpe, L., Stewart, J., Vaithilingam, N., Farquharson, R. G., Kilby, M. D., Khalaf, Y., Goddijn, M., Regan, L. & Rai, R., 26 Nov 2015, In : New England Journal of Medicine. 373, 22, p. 2141-8 8 p.

    Research output: Contribution to journalArticle

  4. A novel “humanized mouse” model for autoimmune hepatitis and the association of gut microbiota with liver inflammation: Association of Gut Microbiota With Liver Inflammation

    Yuksel, M., Wang, Y., Tai, N., Peng, J., Guo, J., Beland, K., Lapierre, P., David, C., Alvarez, F., Colle, I., Yan, H., Mieli-vergani, G., Vergani, D., Ma, Y. & Wen, L., Nov 2015, In : Hepatology. 62, 5, p. 1536-1550

    Research output: Contribution to journalArticle

  5. The genome as a record of environmental exposure

    Nik-Zainal, S., Kucab, J. E., Morganella, S., Glodzik, D., Alexandrov, L. B., Arlt, V. M., Weninger, A., Hollstein, M., Stratton, M. R. & Phillips, D. H., Nov 2015, In : Mutagenesis. 30, 6, p. 763-770 8 p.

    Research output: Contribution to journalArticle

  6. Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial

    Poston, L., Bell, R., Croker, H., Flynn, A. C., Godfrey, K. M., Goff, L., Hayes, L., Khazaezadeh, N., Nelson, S. M., Oteng-Ntim, E., Pasupathy, D., Patel, N., Robson, S. C., Sandall, J., Sanders, T. A. B., Sattar, N., Seed, P. T., Wardle, J., Whitworth, M. K., Briley, A. L. & 1 others, UPBEAT Trial Consortium, Oct 2015, In : The Lancet Diabetes and Endocrinology. 3, 10, p. 767-777 11 p.

    Research output: Contribution to journalArticle

  7. Prenatal exposure to polycyclic aromatic hydrocarbons/aromatics, BDNF and child development

    Perera, F., Phillips, D. H., Wang, Y., Roen, E., Herbstman, J., Rauh, V., Wang, S. & Tang, D., 21 Aug 2015, In : Environmental Research. 142, p. 602-608 7 p., 6575.

    Research output: Contribution to journalArticle

  8. Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundus height

    Griffin, M., Seed, P. T., Webster, L., Myers, J., Mackillop, L., Simpson, N., Anumba, D., Khalil, A., Denbow, M., Sau, A., Hinshaw, K., Von Dadelszen, P., Benton, S., Girling, J., Redman, C. W. G., Chappell, L. C. & Shennan, A. H., 1 Aug 2015, In : Ultrasound in Obstetrics and Gynecology. 46, 2, p. 182-190 9 p.

    Research output: Contribution to journalArticle

  9. Th-17 cells infiltrate the liver in human biliary atresia and are related to surgical outcome

    Hill, R., Quaglia, A., Hussain, M., Hadzic, N., Mieli-vergani, G., Vergani, D. & Davenport, M., 1 Aug 2015, In : Journal of Pediatric Surgery. 50, 8, p. 1297-1303

    Research output: Contribution to journalArticle

  10. A mismatch between population health literacy and the complexity of health information: An observational study

    Rowlands, G., Protheroe, J., Winkley, J., Richardson, M., Seed, P. T. & Rudd, R., 1 Jun 2015, In : The British journal of general practice : the journal of the Royal College of General Practitioners. 65, 635, p. 379-386 8 p.

    Research output: Contribution to journalArticle

  11. Adverse maternal and perinatal outcomes in pregnant women with sickle cell disease: Systematic review and meta-analysis

    Oteng-Ntim, E., Meeks, D., Seed, P. T., Webster, L., Howard, J., Doyle, P. & Chappell, L. C., 21 May 2015, In : Blood. 125, 21, p. 3316-3325 10 p.

    Research output: Contribution to journalArticle

  12. RIPOSTE: A framework for improving the design and analysis of laboratory-based research

    Masca, N. G. D., Hensor, E. M. A., Cornelius, V., Buffa, F. M., Marriott, H. M., Eales, J. M., Messenger, M. P., Anderson, A. E., Boot, C., Bunce, C., Goldin, R. D., Harris, J., Hinchliffe, R. F., Junaid, H., Kingston, S., Martin-Ruiz, C., Nelson, C. P., Peacock, J., Seed, P. T., Shinkins, B. & 4 others, Staples, K. J., Toombs, J., Wright, A. K. A. & Dawn Teare, M., 7 May 2015, In : eLife. 4, p. 1-27 27 p.

    Research output: Contribution to journalArticle

  13. Quantitative fetal fibronectin to predict preterm birth in asymptomatic women at high risk

    Abbott, D. S., Hezelgrave, N. L., Seed, P. T., Norman, J. E., David, A. L., Bennett, P. R., Girling, J. C., Chandirimani, M., Stock, S. J., Carter, J., Cate, R., Kurtzman, J., Tribe, R. M. & Shennan, A. H., 1 May 2015, In : Obstetrics and Gynecology. 125, 5, p. 1168-1176 9 p.

    Research output: Contribution to journalArticle

  14. The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants

    Arlt, V. M., Henderson, C. J., Wolf, C. R., Stiborova, M. & Phillips, D. H., 1 May 2015, In : Toxicology Research. 4, 3, p. 548-562 15 p.

    Research output: Contribution to journalLiterature review

  15. Pulmonary inflammation impacts on CYP1A1-mediated respiratory tract DNA damage induced by the carcinogenic air pollutant benzo[a]pyrene

    Arlt, V. M., Krais, A., Godschalk, R. W., Riffo-Vasquez, Y., Mrizova, I., Roufosse, C. A., Corbin, C., Shi, Q., Frei, E., Stiborova, M., van Schooten, F-J., Phillips, D. H. & Spina, D., 23 Apr 2015, In : Toxicological sciences : an official journal of the Society of Toxicology. 146, 2, p. 213-225 13 p.

    Research output: Contribution to journalArticle

  16. TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts

    Kucab, J. E., van Steeg, H., Luijten, M., Schmeiser, H. H., White, P. A., Phillips, D. H. & Arlt, V. M., 1 Mar 2015, In : Mutation Research. 773, p. 48-62 15 p.

    Research output: Contribution to journalArticle

  17. Acute alcoholic hepatitis and cellular Th1 immune responses to alcohol dehydrogenase

    Blackmore, L. J., Ryan, J. M., Huang, X., Hussain, M., Triantafyllou, E., Vergis, N., Manakkat Vijay, G., Antoniades, C. G., Thursz, M. R., Jassem, W., Vergani, D., Shawcross, D. L. & Ma, Y., 26 Feb 2015, In : Lancet. 385 , S1, p. S22-S22 1 p., 61.

    Research output: Contribution to journalPoster abstract

  18. Dalteparin for pregnant women with thrombophilia

    Hunt, B. J., Seed, P. T. & Lefkou, E., 21 Feb 2015, In : Lancet. 385, 9969, p. 689 1 p.

    Research output: Contribution to journalLiterature review

  19. Endothelial and platelet microparticles in patients with antiphospholipid antibodies

    Breen, K. A., Sanchez, K., Kirkman, N., Seed, P. T., Parmar, K., Moore, G. W. & Hunt, B. J., 1 Feb 2015, In : Thrombosis Research. 135, 2, p. 368-374 7 p.

    Research output: Contribution to journalArticle

  20. Reply

    Grant, C. R., Liberal, R., Ma, Y., Robson, S. C., Mieli-Vergani, G., Vergani, D. & Longhi, M. S., 1 Feb 2015, In : Hepatology. 61, 2, p. 737-738 2 p.

    Research output: Contribution to journalLetter

  21. Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts

    Krais, A. M., Mühlbauer, K-R., Kucab, J. E., Chinbuah, H., Cornelius, M. G., Wei, Q-X., Hollstein, M., Phillips, D. H., Arlt, V. M. & Schmeiser, H. H., Feb 2015, In : Toxicology in Vitro. 29, 1, p. 34-43 10 p.

    Research output: Contribution to journalArticle

  22. Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks' gestation in nulliparous women who subsequently develop pre-eclampsia

    Mistry, H. D., Gill, C. A., Kurlak, L. O., Seed, P. T., Hesketh, J. E., Méplan, C., Schomburg, L., Chappell, L. C., Morgan, L., Poston, L. & on behalf of SCOPE consortium, 1 Jan 2015, In : Free Radical Biology and Medicine. 78, p. 147-155 9 p.

    Research output: Contribution to journalArticle

  23. Shock index: An effective predictor of outcome in postpartum haemorrhage?

    Nathan, H. L., El Ayadi, A., Hezelgrave, N. L., Seed, P., Butrick, E., Miller, S., Briley, A., Bewley, S. & Shennan, A. H., 1 Jan 2015, In : BJOG: An International Journal of Obstetrics and Gynaecology. 122, 2, p. 268-275 8 p.

    Research output: Contribution to journalArticle

  24. Assessment of a Full Dilatation Cesarean Delivery Simulator

    Vousden, N., Hamakarim, Z., Briley, A., Girling, J., Seed, P. T., Tydeman, G. & Shennan, A. H., 2015, In : Obstetrics and Gynecology.

    Research output: Contribution to journalArticle

  25. Science forum: RIPOSTE: a framework for improving the design and analysis of laboratory-based research.

    Masca, N. G. D., Hensor, E. M. A., Cornelius, V. R., Buffa, F. M., Marriott, H. M., Eales, J. M., Messenger, M. P., Anderson, A. E., Boot, C., Bunce, C., Goldin, R. D., Harris, J., Hinchliffe, R. F., Junaid, H., Kingston, S., Martin-Ruiz, C., Nelson, C. P., Peacock, J., Seed, P. T., Shinkins, B. & 4 others, Staples, K. J., Toombs, J., Wright, A. K. A. & Teare, M. D., 2015, eLife. p. e05519 (eLife; vol. 4).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  26. 2014
  27. Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice

    Zuo, J., Brewer, D. S., Arlt, V. M., Cooper, C. S. & Phillips, D. H., 8 Oct 2014, In : BMC GENOMICS. 15, 20 p., 880.

    Research output: Contribution to journalArticle

  28. AN INTERVENTION TRIAL FOR PEOPLE WITH EPILEPSY ATTENDING A&E

    Ridsdale, L. L., McCrone, P. R., Morgan, M. A., Seed, P., Goldstein, L. H. & Noble, A. J., 1 Oct 2014, In : Journal of Neurology, Neurosurgery and Psychiatry. 85, e4, p. A20 1 p., 075.

    Research output: Contribution to journalMeeting abstract

  29. Endocervical and high vaginal quantitative fetal fibronectin in predicting preterm birth

    Kuhrt, K., Unwin, C., Hezelgrave, N., Seed, P. & Shennan, A., 1 Oct 2014, In : JOURNAL OF MATERNAL FETAL AND NEONATAL MEDICINE. 27, 15, p. 1576-1579 4 p.

    Research output: Contribution to journalArticle

  30. Prediction of gestational diabetes in obese pregnant women from the UK Pregnancies Better Eating and Activity (UPBEAT) pilot trial

    Maitland, R. A., Seed, P. T., Briley, A. L., Homsy, M., Thomas, S., Pasupathy, D., Robson, S. C., Nelson, S. M., Sattar, N., Poston, L. & UPBEAT Trial Consortium, Aug 2014, In : Diabetic Medicine. 31, 8, p. 963-970 8 p.

    Research output: Contribution to journalArticle

  31. Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy

    Schmeiser, H. H., Nortier, J. L., Singh, R., da Costa, G. G., Sennesael, J., Cassuto-Viguier, E., Ambrosetti, D., Rorive, S., Pozdzik, A., Phillips, D. H., Stiborova, M. & Arlt, V. M., 15 Jul 2014, In : International Journal of Cancer. 135, 2, p. 502-507 6 p.

    Research output: Contribution to journalArticle

  32. Variation of DNA damage levels in peripheral blood mononuclear cells isolated in different laboratories

    Godschalk, R. W. L., Ersson, C., Stępnik, M., Ferliłska, M., Palus, J., Teixeira, J. P., Costa, S., Jones, G. D. D., Higgins, J. A., Kain, J., Möller, L., Forchhammer, L., Loft, S., Lorenzo, Y., Collins, A. R., van Schooten, F-J., Laffon, B., Valdiglesias, V., Cooke, M., Mistry, V. & 12 others, Karbaschi, M., Phillips, D. H., Sozeri, O., Routledge, M. N., Nelson-Smith, K., Riso, P., Porrini, M., López de Cerain, A., Azqueta, A., Matullo, G., Allione, A. & Møller, P., Jul 2014, In : Mutagenesis. 29, 4, p. 241-249 9 p.

    Research output: Contribution to journalArticle

  33. MGMT promoter hypermethylation and K-RAS, PTEN and TP53 mutations in tamoxifen-exposed and non-exposed endometrial cancer cases

    Nagy, E., Gajjar, K. B., Patel, I. I., Taylor, S., Martin-Hirsch, P. L., Stringfellow, H. F., Martin, F. L. & Phillips, D. H., 10 Jun 2014, In : BJC: British Journal of Cancer. 110, 12, p. 2874-2880 7 p.

    Research output: Contribution to journalArticle

  34. Association between response to ovarian stimulation and miscarriage following IVF: an analysis of 124 351 IVF pregnancies

    Sunkara, S., Khalaf, Y., Maheshwari, A., Seed, P. & Coomarasamy, A., Jun 2014, In : Human Reproduction. 29, 6, p. 1218-1224 7 p.

    Research output: Contribution to journalArticle

  35. Cytochronne b(5) and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions

    Stiborová, M., Moserová, M., Cerná, V., Indra, R., Dračínský, M., Sulc, M., Henderson, C. J., Wolf, C. R., Schmeiser, H. H., Phillips, D. H., Frei, E. & Arlt, V. M., 6 Apr 2014, In : Toxicology. 318, p. 1-12 12 p.

    Research output: Contribution to journalArticle

  36. Secretory leukocyte protease inhibitor: A pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure

    Antoniades, C. G., Khamri, W., Abeles, R. D., Taams, L. S., Triantafyllou, E., Possamai, L. A., Bernsmeier, C., Mitry, R. R., O'Brien, A., Gilroy, D., Goldin, R., Heneghan, M., Heaton, N., Jassem, W., Bernal, W., Vergani, D., Ma, Y., Quaglia, A., Wendon, J. & Thursz, M., 1 Apr 2014, In : Hepatology. 59, 4, p. 1564-1576 13 p.

    Research output: Contribution to journalArticle

  37. Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: A prospective population-based case-control study

    Geenes, V., Chappell, L. C., Seed, P. T., Steer, P. J., Knight, M. & Williamson, C., Apr 2014, In : Hepatology. 59, 4, p. 1482-1491 10 p.

    Research output: Contribution to journalArticle

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