King's College London

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Research Outputs

  1. 2015
  2. Identification and validation of biomarkers for autism spectrum disorders

    Loth, E., Spooren, W., Ham, L. M., Isaac, M. B., Auriche-Benichou, C., Banaschewski, T., Baron-Cohen, S., Broich, K., Bölte, S., Bourgeron, T., Charman, T., Collier, D., de Andres-Trelles, F., Durston, S., Ecker, C., Elferink, A., Haberkamp, M., Hemmings, R., Johnson, M. H., Jones, E. J. H. & 18 others, Khwaja, O. S., Lenton, S., Mason, L., Mantua, V., Meyer-Lindenberg, A., Lombardo, M. V., O'Dwyer, L., Okamoto, K., Pandina, G. J., Pani, L., Persico, A. M., Simonoff, E., Tauscher-Wisniewski, S., Llinares-Garcia, J., Vamvakas, S., Williams, S., Buitelaar, J. K. & Murphy, D. G. M., 31 Dec 2015, In : Nature Reviews Drug Discovery. 15, 1, p. 70-73 4 p.

    Research output: Contribution to journalArticle

  3. Population whole-genome bisulfite sequencing across two tissues highlights the environment as the principal source of human methylome variation

    Busche, S., Shao, X., Caron, M., Kwan, T., Allum, F., Cheung, W. A., Ge, B., Westfall, S., Simon, M. M., Barrett, A., Bell, J. T., McCarthy, M. I., Deloukas, P., Blanchette, M., Bourque, G., Spector, T. D., Lathrop, M., Pastinen, T. & Grundberg, E., 23 Dec 2015, In : Genome Biology. 16

    Research output: Contribution to journalArticle

  4. The Concordance and Heritability of Type 2 Diabetes in 34,166 Twin Pairs From International Twin Registers: The Discordant Twin (DISCOTWIN) Consortium

    Willemsen, G., Ward, K. J., Bell, C. G., Christensen, K., Bowden, J., Dalgård, C., Harris, J. R., Kaprio, J., Lyle, R., Magnusson, P. K. E., Mather, K. A., Ordoňana, J. R., Perez-Riquelme, F., Pedersen, N. L., Pietiläinen, K. H., Sachdev, P. S., Boomsma, D. I. & Spector, T., 18 Dec 2015, In : TWIN RESEARCH AND HUMAN GENETICS. 18, 6, p. 762-771 10 p.

    Research output: Contribution to journalArticle

  5. A comparison of radiographic anatomic axis knee alignment measurements and cross-sectional associations with knee osteoarthritis

    Goulston, L. M., Sanchez-Santos, M. T., D'Angelo, S., Leyland, K. M., Hart, D. J., Spector, T. D., Cooper, C., Dennison, E. M., Hunter, D. & Arden, N. K., 14 Dec 2015, In : Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 24, 4, p. 612-622

    Research output: Contribution to journalArticle

  6. Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

    Artigas, M. S., Wain, L. V., Miller, S., Kheirallah, A. K., Huffman, J. E., Ntalla, I., Shrine, N., Obeidat, M., Trochet, H., McArdle, W. L., Alves, A. C., Hui, J., Zhao, J. H., Joshi, P. K., Teumer, A., Albrecht, E., Imboden, M., Rawal, R., Lopez, L. M., Marten, J. & 78 others, Enroth, S., Surakka, I., Polasek, O., Lyytikäinen, L. P., Granell, R., Hysi, P. G., Flexeder, C., Mahajan, A., Beilby, J., Bossé, Y., Brandsma, C. A., Campbell, H., Gieger, C., Gläser, S., González, J. R., Grallert, H., Hammond, C. J., Harris, S. E., Hartikainen, A. L., Heliövaara, M., Henderson, J., Hocking, L., Horikoshi, M., Hutri-Kähönen, N., Ingelsson, E., Johansson, Å., Kemp, J. P., Kolcic, I., Kumar, A., Lind, L., Melén, E., Musk, A. W., Navarro, P., Nickle, D. C., Padmanabhan, S., Raitakari, O. T., Ried, J. S., Ripatti, S., Schulz, H., Scott, R. A., Sin, D. D., Starr, J. M., Viñuela, A., Völzke, H., Wild, S. H., Wright, A. F., Zemunik, T., Jarvis, D. L., Spector, T. D., Evans, D. M., Lehtimäki, T., Vitart, V., Kähönen, M., Gyllensten, U., Rudan, I., Deary, I. J., Karrasch, S., Probst-Hensch, N. M., Heinrich, J., Stubbe, B., Wilson, J. F., Wareham, N. J., James, A. L., Morris, A. P., Jarvelin, M. R., Hayward, C., Sayers, I., Strachan, D. P., Hall, I. P., Tobin, M. D., Deloukas, P., Hansell, A. L., Hubbard, R., Jackson, V. E., Marchini, J., Pavord, I., Thomson, N. C. & Zeggini, E., 4 Dec 2015, In : Nature Communications. 6, 89658.

    Research output: Contribution to journalArticle

  7. Can Your Microbiome Tell You What to Eat?

    Vanamala, J. K. P., Knight, R. & Spector, T. D., 1 Dec 2015, In : CELL METABOLISM. 22, 6, p. 960-961 2 p.

    Research output: Contribution to journalArticle

  8. Integration of 'omics' data in aging research: From biomarkers to systems biology

    Zierer, J., Menni, C., Kastenmüller, G. & Spector, T. D., 1 Dec 2015, In : AGING CELL. 14, 6, p. 933-944 12 p.

    Research output: Contribution to journalArticle

  9. DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins

    Tsai, P. C., Van Dongen, J., Tan, Q., Willemsen, G., Christiansen, L., Boomsma, D. I., Spector, T. D., Valdes, A. M. & Bell, J. T., Dec 2015, In : TWIN RESEARCH AND HUMAN GENETICS. 18, 6, p. 635-646

    Research output: Contribution to journalArticle

  10. Food Preference Patterns in a UK Twin Cohort

    Pallister, T., Sharafi, M., Lachance, G., Pirastu, N., Mohney, R. P., MacGregor, A., Feskens, E. J. M., Duffy, V., Spector, T. D. & Menni, C., Dec 2015, In : TWIN RESEARCH AND HUMAN GENETICS. 18, 6, p. 793-805 13 p.

    Research output: Contribution to journalArticle

  11. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

    Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D. P., Curtin, J. A., Bønnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A. C., Thyssen, J. P., den Dekker, H. T., Ferreira, M. A., Altmaier, E., Sleiman, P. M. A., Xiao, F. L., Gonzalez, J. R., Marenholz, I. & 133 others, Kalb, B., Pino-Yanes, M., Xu, C-J., Carstensen, L., Groen-Blokhuis, M. M., Venturini, C., Pennell, C. E., Barton, S. J., Levin, A. M., Curjuric, I., Bustamante, M., Kreiner-Møller, E., Lockett, G. A., Bacelis, J., Bunyavanich, S., Myers, R. A., Matanovic, A., Kumar, A., Tung, J. Y., Hirota, T., Kubo, M., McArdle, W. L., Henderson, A. J., Kemp, J. P., Zheng, J., Smith, G. D., Rüschendorf, F., Bauerfeind, A., Lee-Kirsch, M. A., Arnold, A., Homuth, G., Schmidt, C. O., Mangold, E., Cichon, S., Keil, T., Rodríguez, E., Peters, A., Franke, A., Lieb, W., Novak, N., Fölster-Holst, R., Horikoshi, M., Pekkanen, J., Sebert, S., Husemoen, L. L., Grarup, N., de Jongste, J. C., Rivadeneira, F., Hofman, A., Jaddoe, V. W. V., Pasmans, S. G. M. A., Elbert, N. J., Uitterlinden, A. G., Marks, G. B., Thompson, P. J., Matheson, M. C., Robertson, C. F., (AAGC), A. A. G. C., Ried, J. S., Li, J., Zuo, X. B., Zheng, X. D., Yin, X. Y., Sun, L. D., McAleer, M. A., O'Regan, G. M., Fahy, C. M. R., Campbell, L. E., Macek, M., Kurek, M., Hu, D., Eng, C., Postma, D. S., Feenstra, B., Geller, F., Hottenga, J. J., Middeldorp, C. M., Hysi, P., Bataille, V., Spector, T., Tiesler, C. M. T., Thiering, E., Pahukasahasram, B., Yang, J. J., Imboden, M., Huntsman, S., Vilor-Tejedor, N., Relton, C. L., Myhre, R., Nystad, W., Custovic, A., Weiss, S. T., Meyers, D. A., Söderhäll, C., Melén, E., Ober, C., Raby, B. A., Simpson, A., Jacobsson, B., Holloway, J. W., Bisgaard, H., Sunyer, J., Probst-Hensch, N. M., Williams, L. K., Godfrey, K. M., Wang, C. A., Boomsma, D. I., Melbye, M., Koppelman, G. H., Jarvis, D., McLean, W. H. I., Irvine, A. D., Zhang, X. J., Hakonarson, H., Gieger, C., Burchard, E. G., Martin, N. G., Duijts, L., Linneberg, A., Jarvelin, M-R., Nöthen, M. M., Lau, S., Hübner, N., Lee, Y-A., Tamari, M., Hinds, D. A., Glass, D., Brown, S. J., Heinrich, J., Evans, D. M., Weidinger, S., Genetics, EA. & Consortium, L. E. EAGLE. E., Dec 2015, In : Nature Genetics. 47, 12, p. 1449—1456

    Research output: Contribution to journalArticle

  12. Authors' reply to Mawer and Wilcox and Mullish and Williams

    Spector, T. & Knight, R., 19 Nov 2015, In : BMJ (Clinical research ed.). 351, 3500.

    Research output: Contribution to journalArticle

  13. Association of systemic lupus erythematosus with decreased immunosuppressive potential of the IgG glycome

    Vučkovïc, F., Krištïc, J., Gudelj, I., Teruel, M., Keser, T., Pezer, M., Pučïc-Bakovïc, M., Štambuk, J., Trbojevïc-Akmačïc, I., Barrios, C., Pavïc, T., Menni, C., Wang, Y., Zhou, Y., Cui, L., Song, H., Zeng, Q., Guo, X., Pons-Estel, B. A., McKeigue, P. & 8 others, Leslie Patrick, A., Gornik, O., Spector, T. D., Harjaček, M., Alarcon-Riquelme, M., Molokhia, M., Wang, W. & Lauc, G., 1 Nov 2015, In : Arthritis and Rheumatology. 67, 11, p. 2978-2989 12 p.

    Research output: Contribution to journalArticle

  14. Neuroimaging in autism spectrum disorder: Brain structure and function across the lifespan

    Ecker, C., Bookheimer, S. Y. & Murphy, D. G. M., 1 Nov 2015, In : Lancet Neurology. 14, 11, p. 1121-1134 14 p., 147.

    Research output: Contribution to journalArticle

  15. Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels

    Danjou, F., Zoledziewska, M., Sidore, C., Steri, M., Busonero, F., Maschio, A., Mulas, A., Perseu, L., Barella, S., Porcu, E., Pistis, G., Pitzalis, M., Pala, M., Menzel, S., Metrustry, S., Spector, T. D., Leoni, L., Angius, A., Uda, M., Moi, P. & 6 others, Thein, S. L., Galanello, R., Abecasis, G. R., Schlessinger, D., Sanna, S. & Cucca, F., Nov 2015, In : Nature Genetics. 47, p. 1264–1271

    Research output: Contribution to journalArticle

  16. Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

    Day, F. R., Ruth, K. S., Thompson, D. J., Lunetta, K. L., Pervjakova, N., Chasman, D. I., Stolk, L., Finucane, H. K., Sulem, P., Bulik-Sullivan, B., Esko, T., Johnson, A. D., Elks, C. E., Franceschini, N., He, C., Altmaier, E., Brody, J. A., Franke, L. L., Huffman, J. E., Keller, M. F. & 227 others, McArdle, P. F., Nutile, T., Porcu, E., Robino, A., Rose, L. M., Schick, U. M., Smith, J. A., Teumer, A., Traglia, M., Vuckovic, D., Yao, J., Zhao, W., Albrecht, E., Amin, N., Corre, T., Hottenga, J-J., Mangino, M., Smith, A. V., Tanaka, T., Abecasis, G. R., Andrulis, I. L., Anton-Culver, H., Antoniou, A. C., Arndt, V., Arnold, A. M., Barbieri, C., Beckmann, M. W., Beeghly-Fadiel, A., Benitez, J., Bernstein, L., Bielinski, S. J., Blomqvist, C., Boerwinkle, E., Bogdanova, N. V., Bojesen, S. E., Bolla, M. K., Borresen-Dale, A-L., Boutin, T. S., Brauch, H., Brenner, H., Brüning, T., Burwinkel, B., Campbell, A., Campbell, H., Chanock, S. J., Chapman, J. R., Chen, Y-D. I., Chenevix-Trench, G., Couch, F. J., Coviello, A. D., Cox, A., Czene, K., Darabi, H., De Vivo, I., Demerath, E. W., Dennis, J., Devilee, P., Dörk, T., Dos-Santos-Silva, I., Dunning, A. M., Eicher, J. D., Fasching, P. A., Faul, J. D., Figueroa, J., Flesch-Janys, D., Gandin, I., Garcia, M. E., García-Closas, M., Giles, G. G., Girotto, G. G., Goldberg, M. S., González-Neira, A., Goodarzi, M. O., Grove, M. L., Gudbjartsson, D. F., Guénel, P., Guo, X., Haiman, C. A., Hall, P., Hamann, U., Henderson, B. E., Hocking, L. J., Hofman, A., Homuth, G., Hooning, M. J., Hopper, J. L., Hu, F. B., Huang, J., Humphreys, K., Hunter, D. J., Jakubowska, A., Jones, S. E., Kabisch, M., Karasik, D., Knight, J. A., Kolcic, I., Kooperberg, C., Kosma, V-M., Kriebel, J., Kristensen, V., Lambrechts, D., Langenberg, C., Li, J., Li, X., Lindström, S., Liu, Y., Luan, J., Lubinski, J., Mägi, R., Mannermaa, A., Manz, J., Margolin, S., Marten, J., Martin, N. G., Masciullo, C., Meindl, A., Michailidou, K., Mihailov, E., Milani, L., Milne, R. L., Müller-Nurasyid, M., Nalls, M., Neale, B. M., Nevanlinna, H., Neven, P., Newman, A. B., Nordestgaard, B. G., Olson, J. E., Padmanabhan, S., Peterlongo, P., Peters, U., Petersmann, A., Peto, J., Pharoah, P. D. P., Pirastu, N. N., Pirie, A., Pistis, G., Polasek, O., Porteous, D., Psaty, B. M., Pylkäs, K., Radice, P., Raffel, L. J., Rivadeneira, F., Rudan, I., Rudolph, A., Ruggiero, D., Sala, C. F., Sanna, S., Sawyer, E. J., Schlessinger, D., Schmidt, M. K., Schmidt, F., Schmutzler, R. K., Schoemaker, M. J., Scott, R. A., Seynaeve, C. M., Simard, J., Sorice, R., Southey, M. C., Stöckl, D., Strauch, K., Swerdlow, A., Taylor, K. D., Thorsteinsdottir, U., Toland, A. E., Tomlinson, I., Truong, T., Tryggvadottir, L., Turner, S. T., Vozzi, D., Wang, Q., Wellons, M., Willemsen, G., Wilson, J. F., Winqvist, R., Wolffenbuttel, B. B. H. R., Wright, A. F., Yannoukakos, D., Zemunik, T., Zheng, W., Zygmunt, M., Bergmann, S., Boomsma, D. I., Buring, J. E., Ferrucci, L., Montgomery, G. W., Gudnason, V., Spector, T. D., van Duijn, C. M., Alizadeh, B. Z., Ciullo, M., Crisponi, L., Easton, D. F., Gasparini, P. P., Gieger, C., Harris, T. B., Hayward, C., Kardia, S. L. R., Kraft, P., McKnight, B., Metspalu, A., Morrison, A. C., Reiner, A. P., Ridker, P. M., Rotter, J. I., Toniolo, D., Uitterlinden, A. G., Ulivi, S., Völzke, H., Wareham, N. J., Weir, D. R., Yerges-Armstrong, L. M., Consortium, PRACTICAL., Investigators, KC., Investigators, AOCS., Scotland, G., Consortium, EPIC-I., Study, L. C., Price, A. L., Stefansson, K., Visser, J. A., Ong, K. K., Chang-Claude, J., Murabito, J. M., Perry, J. R. B. & Murray, A., Nov 2015, In : Nature Genetics. 47, 11, p. 1294—1303

    Research output: Contribution to journalArticle

  17. Population genetic differentiation of height and body mass index across Europe

    Robinson, M. R., Hemani, G., Medina-Gomez, C., Mezzavilla, M., Esko, T., Shakhbazov, K., Powell, J. E., Vinkhuyzen, A., Berndt, S. I., Gustafsson, S., Justice, A. E., Kahali, B., Locke, A. E., Pers, T. H., Vedantam, S., Wood, A. R., van Rheenen, W., Andreassen, O. A., Gasparini, P., Metspalu, A. & 23 others, Berg, L. H. V. D., Veldink, J. H., Rivadeneira, F., Werge, T. M., Abecasis, G. R., Boomsma, D. I., Chasman, D. I., de Geus, E. J. C., Frayling, T. M., Hirschhorn, J. N., Hottenga, J. J., Ingelsson, E., Loos, R. J. F., Magnusson, P. K. E., Martin, N. G., Montgomery, G. W., North, K. E., Pedersen, N. L., Spector, T. D., Speliotes, E. K., Goddard, M. E., Yang, J. & Visscher, P. M., Nov 2015, In : Nature Genetics. 47, 11, p. 1357-62 6 p.

    Research output: Contribution to journalArticle

  18. Faecal transplants

    Spector, T. & Knight, R., 20 Oct 2015, In : BMJ (Clinical research ed.). 351, h5149.

    Research output: Contribution to journalArticle

  19. Family therapy for autism spectrum disorders

    Spain, D. C., Sin, P. H. J., Paliokostas, E., Furuta, M., Chalder, T., Murphy, D. G. & Happe, F. G. E., 11 Oct 2015, In : Cochrane database of systematic reviews (Online). 10CD011894

    Research output: Contribution to journalArticle

  20. An omics investigation into chronic widespread musculoskeletal pain reveals epiandrosterone sulfate as a potential biomarker

    Livshits, G., Macgregor, A. J., Gieger, C., Malkin, I., Moayyeri, A., Grallert, H., Emeny, R. T., Spector, T., Kastenmuller, G. & Williams, F. M. K., 1 Oct 2015, In : Pain. 156, 10, p. 1845-1851 7 p.

    Research output: Contribution to journalArticle

  21. Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis

    Evans, D. S., Cailotto, F., Parimi, N., Valdes, A. M., Castaño-Betancourt, M. C., Liu, Y., Kaplan, R. C., Bidlingmaier, M., Vasan, R. S., Teumer, A., Tranah, G. J., Nevitt, M. C., Cummings, S. R., Orwoll, E. S., Barrett-Connor, E., Renner, J. B., Jordan, J. M., Doherty, M., Doherty, S. A., Uitterlinden, A. G. & 4 others, Van Meurs, J. B. J., Spector, T. D., Lories, R. J. & Lane, N. E., 1 Oct 2015, In : Annals of the Rheumatic Diseases. 74, 10, p. 1861-1867 7 p.

    Research output: Contribution to journalArticle

  22. Neuroanatomy of individual differences in language in adult males with autism

    Lai, M. C., Lombardo, M. V., Ecker, C., Chakrabarti, B., Suckling, J., Bullmore, E. T., Happé, F., Murphy, D. G. M. & Baron-Cohen, S., 1 Oct 2015, In : Cerebral Cortex. 25, 10, p. 3613-3628 16 p.

    Research output: Contribution to journalArticle

  23. Relationship between surface-based brain morphometric measures and intelligence in autism spectrum disorders: Influence of history of language delay

    Balardin, J. B., Sato, J. R., Vieira, G., Feng, Y., Daly, E., Murphy, C., Murphy, D., Ecker, C. & MRC AIMS consortium, 1 Oct 2015, In : Autism research. 8, 5, p. 556-566 11 p.

    Research output: Contribution to journalArticle

  24. The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

    CHARGE Consortium, DIAGRAM Consortium, GLGC Consortium, Global-BPGen Consortium, ICBP Consortium, MAGIC Consortium & arcOGEN Consortium, 1 Oct 2015, In : PL o S Genetics. 11, 10, p. e1005378

    Research output: Contribution to journalArticle

  25. Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

    Zheng, H. F., Forgetta, V., Hsu, Y. H., Estrada, K., Rosello-Diez, A., Leo, P. J., Dahia, C. L., Park-Min, K. H., Tobias, J. H., Kooperberg, C., Kleinman, A., Styrkarsdottir, U., Liu, C. T., Uggla, C., Evans, D. S., Nielson, C. M., Walter, K., Pettersson-Kymmer, U., McCarthy, S., Eriksson, J. & 136 others, Kwan, T., Jhamai, M., Trajanoska, K., Memari, Y., Min, J., Huang, J., Danecek, P., Wilmot, B., Li, R., Chou, W. C., Mokry, L. E., Moayyeri, A., Claussnitzer, M., Cheng, C. H., Cheung, W., Medina-Gómez, C., Ge, B., Chen, S. H., Choi, K., Oei, L., Fraser, J., Kraaij, R., Hibbs, M. A., Gregson, C. L., Paquette, D., Hofman, A., Wibom, C., Tranah, G. J., Marshall, M., Gardiner, B. B., Cremin, K., Auer, P., Hsu, L., Ring, S., Tung, J. Y., Thorleifsson, G., Enneman, A. W., Van Schoor, N. M., De Groot, L. C. P. G. M., Van Der Velde, N., Melin, B., Kemp, J. P., Christiansen, C., Sayers, A., Zhou, Y., Calderari, S., Van Rooij, J., Carlson, C., Peters, U., Berlivet, S., Dostie, J., Uitterlinden, A. G., Williams, S. R., Farber, C., Grinberg, D., LaCroix, A. Z., Haessler, J., Chasman, D. I., Giulianini, F., Rose, L. M., Ridker, P. M., Eisman, J. A., Nguyen, T. V., Center, J. R., Nogues, X., Garcia-Giralt, N., Launer, L. L., Gudnason, V., Mellström, D., Vandenput, L., Amin, N., Van Duijn, C. M., Karlsson, M. K., Ljunggren, Ö., Svensson, O., Hallmans, G., Rousseau, F., Giroux, S., Bussière, J., Arp, P. P., Koromani, F., Prince, R. L., Lewis, J. R., Langdahl, B. L., Hermann, A. P., Jensen, J. E. B., Kaptoge, S., Khaw, K. T., Reeve, J., Formosa, M. M., Xuereb-Anastasi, A., Åkesson, K., McGuigan, F. E., Garg, G., Olmos, J. M., Zarrabeitia, M. T., Riancho, J. A., Ralston, S. H., Alonso, N., Jiang, X., Goltzman, D., Pastinen, T., Grundberg, E., Gauguier, D., Orwoll, E. S., Karasik, D., Davey-Smith, G., Smith, A. V., Siggeirsdottir, K., Harris, T. B., Zillikens, M. C., Van Meurs, J. B. J., Thorsteinsdottir, U., Maurano, M. T., Timpson, N. J., Soranzo, N., Durbin, R., Wilson, S. G., Ntzani, E. E., Brown, M. A., Stefansson, K., Hinds, D. A., Spector, T., Cupples, L. A., Ohlsson, C., Greenwood, C. M. T., Jackson, R. D., Rowe, D. W., Loomis, C. A., Evans, D. M., Ackert-Bicknell, C. L., Joyner, A. L., Duncan, E. L., Kiel, D. P., Rivadeneira, F. & Richards, J. B., 1 Oct 2015, In : Nature. 526, 7571, p. 112-117 6 p.

    Research output: Contribution to journalArticle

  26. Decreased centrality of cortical volume covariance networks in autism spectrum disorders

    Balardin, J. B., Comfort, W. E., Daly, E., Murphy, C., Andrews, D., Murphy, D. G. M., Ecker, C., MRC AIMS consortium & Sato, J. R., Oct 2015, In : Journal of psychiatric research. 69, p. 142-149 8 p.

    Research output: Contribution to journalArticle

  27. Truncation of POC1A associated with short stature and extreme insulin resistance

    Chen, J. H., Segni, M., Payne, F., Huang-Doran, I., Sleigh, A., Adams, C., Durbin, R., Muddyman, D., Soranzo, N., Timpson, N., Spector, T., Richards, B., Palotie, A., Owen, M., Barrett, J., Geschwind, D., Hurles, M., Fitzpatrick, D., Barroso, I., Farooqi, S. & 10 others, Zeggini, E., Kaye, J., Kennedy, K., McCarthy, S., Stalker, J., Langford, C., Keane, T., Savage, D. B., O’Rahilly, S. & Semple, R. K., Oct 2015, In : Journal of Molecular Endocrinology. 55, 2, p. 147-158 12 p.

    Research output: Contribution to journalArticle

  28. Zygosity differences in height and body mass index of twins from infancy to old age: A study of the CODATwins project

    Jelenkovic, A., Yokoyama, Y., Sund, R., Honda, C., Bogl, L. H., Aaltonen, S., Ji, F., Ning, F., Pang, Z., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Burt, S. A., Klump, K. L., Medland, S. E., Montgomery, G. W., Kandler, C., McAdams, T., Eley, T. C., Gregory, A. M. & 110 others, Saudino, K. J., Dubois, L., Boivin, M., Tarnoki, A. D., Tarnoki, D. L., Haworth, C. M. A., Plomin, R., Öncel, S. Y., Aliev, F., Stazi, M. A., Fagnani, C., D'Ippolito, C., Craig, J. M., Saffery, R., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Spector, T., Mangino, M., Lachance, G., Gatz, M., Butler, D. A., Bayasgalan, G., Narandalai, D., Freita, D. L., Maia, J. A., Harden, K. P., Tucker-Drob, E. M., Kim, B., Chong, Y., Hong, C., Shin, H. J., Christensen, K., Skytthe, A., Kyvik, K. O., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Cozen, W., Hwang, A. E., Mack, T. M., He, M., Ding, X., Chang, B., Silberg, J. L., Eaves, L. J., Maes, H. H., Cutler, T. L., Hopper, J. L., Aujard, K., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, A. K., Song, Y. M., Yang, S., Lee, K., Baker, L. A., Tuvblad, C., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Heikkilä, K., Tan, Q., Zhang, D., Swan, G. E., Krasnow, R., Jang, K. L., Knafo-Noam, A., Mankuta, D., Abramson, L., Lichtenstein, P., Krueger, R. F., McGue, M., Pahlen, S., Tynelius, P., Duncan, G. E., Buchwald, D., Corley, R. P., Huibregtse, B. M., Nelson, T. L., Whitfield, K. E., Franz, C. E., Kremen, W. S., Lyons, M. J., Ooki, S., Brandt, I., Nilsen, T. S., Inui, F., Watanabe, M., Bartels, M., Van Beijsterveldt, T. C. E. M., Wardle, J., Llewellyn, C. H., Fisher, A., Rebato, E., Martin, N. G., Iwatani, Y., Hayakawa, K., Sung, J., Harris, J. R., Willemsen, G., Busjahn, A., Goldberg, J. H., Rasmussen, F., Hur, Y. M., Boomsma, D. I., SØrensen, T. I. A., Kaprio, J. & Silventoinen, K., 17 Sep 2015, In : TWIN RESEARCH AND HUMAN GENETICS. 18, 5, p. 557-570 14 p.

    Research output: Contribution to journalArticle

  29. Host genetic variation impacts microbiome composition across human body sites

    Blekhman, R., Goodrich, J. K., Huang, K., Sun, Q., Bukowski, R., Bell, J. T., Spector, T. D., Keinan, A., Ley, R. E., Gevers, D. & Clark, A. G., 15 Sep 2015, In : Genome Biology. 16, 1, 12 p., 191.

    Research output: Contribution to journalArticle

  30. Generalised Anxiety Disorder - A twin study of genetic architecture, genome-wide association and differential gene expression

    Davies, M. N., Verdi, S., Burri, A., Trzaskowski, M., Lee, M., Hettema, J. M., Jansen, R., Boomsma, D. I. & Spector, T. D., 14 Aug 2015, In : PL o S One . 10, 8, e0134865.

    Research output: Contribution to journalArticle

  31. Gut-microbiota-metabolite axis in early renal function decline

    Barrios, C., Beaumont, M., Pallister, T., Villar, J., Goodrich, J. K., Clark, A., Pascual, J., Ley, R. E., Spector, T. D., Bell, J. T. & Menni, C., 4 Aug 2015, In : PL o S One . 10, 8, e0134311.

    Research output: Contribution to journalArticle

  32. Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci

    Demerath, E. W., Guan, W., Grove, M. L., Aslibekyan, S., Mendelson, M., Zhou, Y. H., Hedman, Å. K., Sandling, J. K., Li, L. A., Irvin, M. R., Zhi, D., Deloukas, P., Liang, L., Liu, C., Bressler, J., Spector, T. D., North, K., Li, Y., Absher, D. M., Levy, D. & 4 others, Arnett, D. K., Fornage, M., Pankow, J. S. & Boerwinkle, E., 1 Aug 2015, In : Human Molecular Genetics. 24, 15, p. 4464-4479 16 p.

    Research output: Contribution to journalArticle

  33. Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening

    Holohan, B., De Meyer, T., Batten, K., Mangino, M., Hunt, S. C., Bekaert, S., De Buyzere, M. L., Rietzschel, E. R., Spector, T. D., Wright, W. E. & Shay, J. W., Aug 2015, In : AGING CELL. 14, 4, p. 669-77 9 p.

    Research output: Contribution to journalArticle

  34. Metabolomic Identification of a Novel Pathway of Blood Pressure Regulation Involving Hexadecanedioate

    Menni, C., Graham, D., Kastenmüller, G., Alharbi, N. H. J., Alsanosi, S. M., Mcbride, M., Mangino, M., Titcombe, P., Shin, S. Y., Psatha, M., Geisendorfer, T., Huber, A., Peters, A., Wang-Sattler, R., Xu, T., Brosnan, M. J., Trimmer, J., Reichel, C., Mohney, R. P., Soranzo, N. & 9 others, Edwards, M. H., Cooper, C., Church, A. C., Suhre, K., Gieger, C., Dominiczak, A. F., Spector, T. D., Padmanabhan, S. & Valdes, A. M., Aug 2015, In : Hypertension. 66, 2, p. 422-429 8 p.

    Research output: Contribution to journalArticle

  35. Paternal age and telomere length in twins: The germ stem cell selection paradigm

    Hjelmborg, J. B., Dalgård, C., Mangino, M., Spector, T. D., Halekoh, U., Möller, S., Kimura, M., Horvath, K., Kark, J. D., Christensen, K., Kyvik, K. O. & Aviv, A., Aug 2015, In : AGING CELL.

    Research output: Contribution to journalArticle

  36. The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits

    Silventoinen, K., Jelenkovic, A., Sund, R., Honda, C., Aaltonen, S., Yokoyama, Y., Tarnoki, A. D., Tarnoki, D. L., Ning, F., Ji, F., Pang, Z., Ordo??ana, J. R., S??nchez-romera, J. F., Colodro-conde, L., Burt, S. A., Klump, K. L., Medland, S. E., Montgomery, G. W., Kandler, C., McAdams, T. A. & 106 others, Eley, T. C., Gregory, A. M., Saudino, K. J., Dubois, L., Boivin, M., Haworth, C., Plomin, R., ??ncel, S. Y., Aliev, F., Stazi, M. A., Fagnani, C., D???ippolito, C., Craig, J. M., Saffery, R., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Spector, T., Mangino, M., Lachance, G., Gatz, M., Butler, D. A., Bayasgalan, G., Narandalai, D., Freitas, D. L., Maia, J. A., Harden, K. P., Tucker-drob, E. M., Christensen, K., Skytthe, A., Kyvik, K. O., Hong, C., Chong, Y., Derom, C. A., Vlietinck, R. F., Loos, R. J. F., Cozen, W., Hwang, A. E., Mack, T. M., He, M., Ding, X., Chang, B., Silberg, J. L., Eaves, L. J., Maes, H. H., Cutler, T. L., Hopper, J. L., Aujard, K., Magnusson, P. K. E., Pedersen, N. L., Aslan, A. K. D., Song, Y., Yang, S., Lee, K., Baker, L. A., Tuvblad, C., Bjerregaard-andersen, M., Beck-nielsen, H., Sodemann, M., Heikkil??, K., Tan, Q., Zhang, D., Swan, G. E., Krasnow, R., Jang, K. L., Knafo-noam, A., Mankuta, D., Abramson, L., Lichtenstein, P., Krueger, R. F., Mcgue, M., Pahlen, S., Tynelius, P., Duncan, G. E., Buchwald, D., Corley, R. P., Huibregtse, B. M., Nelson, T. L., Whitfield, K. E., Franz, C. E., Kremen, W. S., Lyons, M. J., Ooki, S., Brandt, I., Nilsen, T. S., Inui, F., Watanabe, M., Bartels, M., Van Beijsterveldt, T. C. E. M., Wardle, J., Llewellyn, C., Fisher, A., Rebato, E., Martin, N. G., Iwatani, Y., Hayakawa, K., Rasmussen, F., Sung, J., Harris, J. R., Willemsen, G., Busjahn, A., Goldberg, J. H., Boomsma, D. I., Hur, Y., S??rensen, T. I. A. & Kaprio, J., Aug 2015, In : TWIN RESEARCH AND HUMAN GENETICS. 18, 4, p. 348-360

    Research output: Contribution to journalArticle

  37. Directional dominance on stature and cognition in diverse human populations

    Joshi, P. K., Esko, T., Mattsson, H., Eklund, N., Gandin, I., Nutile, T., Jackson, A. U., Schurmann, C., Smith, A. V., Zhang, W., Okada, Y., Stančáková, A., Faul, J. D., Zhao, W., Bartz, T. M., Concas, M. P., Franceschini, N., Enroth, S., Vitart, V., Trompet, S. & 31 others, Guo, X., Chasman, D. I., O'Connel, J. R., Corre, T., Nongmaithem, S. S., Chen, Y., Mangino, M., Ruggiero, D., Traglia, M., Farmaki, A-E., Kacprowski, T., Bjonnes, A., van der Spek, A., Wu, Y., Giri, A. K., Yanek, L. R., Wang, L., Hofer, E., Rietveld, C. A., Lataniotis, L., Wood, A. R., Hammond, C. J., Harris, S. E., Hysi, P. G., Lehne, B., Menni, C., Wilson, J. G., Spector, T. D., Weir, D. R., Chambers, J. C. & BioBank Japan Project, 23 Jul 2015, In : NATURE. 523, 7561, p. 459-462 4 p.

    Research output: Contribution to journalArticle

  38. Nonadditive effects of genes in human metabolomics

    Tsepilov, Y. A., Shin, S. Y., Soranzo, N., Spector, T., Prehn, C., Adamski, J., Kastenmüller, G., Wang-Sattler, R., Strauch, K., Gieger, C., Aulchenko, Y. S. & Ried, J. S., 1 Jul 2015, In : Genetics. 200, 3, p. 707-718 12 p.

    Research output: Contribution to journalArticle

  39. Validation of statistical shape modelling to predict hip osteoarthritis in females: data from two prospective cohort studies (Cohort Hip and Cohort Knee and Chingford)

    Agricola, R., Leyland, K. M., Bierma-Zeinstra, S. M. A., Thomas, G. E., Emans, P. J., Spector, T. D., Weinans, H., Waarsing, J. H. & Arden, N. K., 1 Jul 2015, In : Rheumatology (Oxford, England). 54, 11, p. 2033-2041 9 p.

    Research output: Contribution to journalArticle

  40. Circulating Proteomic Signatures of Chronological Age

    Menni, C., Kiddle, S. J., Mangino, M., Viñuela, A., Psatha, M., Steves, C., Sattlecker, M., Buil, A., Newhouse, S., Nelson, S., Williams, S., Voyle, N., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Spector, T. D., Dobson, R. & 1 others, Valdes, A. M., Jul 2015, In : The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 70, 7, p. 809-816 8 p.

    Research output: Contribution to journalArticle

  41. Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

    Draisma, H. H. M., Pool, R., Kobl, M., Jansen, R., Petersen, A. K., Vaarhorst, A. A. M., Yet, I., Haller, T., Demirkan, A., Esko, T., Zhu, G., Böhringer, S., Beekman, M., Van Klinken, J. B., Römisch-Margl, W., Prehn, C., Adamski, J., De Craen, A. J. M., Van Leeuwen, E. M., Amin, N. & 28 others, Dharuri, H., Westra, H. J., Franke, L., De Geus, E. J. C., Hottenga, J. J., Willemsen, G., Henders, A. K., Montgomery, G. W., Nyholt, D. R., Whitfield, J. B., Penninx, B. W., Spector, T. D., Metspalu, A., Eline Slagboom, P., Van Dijk, K. W., 'T Hoen, P. A. C., Strauch, K., Martin, N. G., Van Ommen, G. J. B., Illig, T., Bell, J. T., Mangino, M., Suhre, K., McCarthy, M. I., Gieger, C., Isaacs, A., Van Duijn, C. M. & Boomsma, D. I., 12 Jun 2015, In : Nature Communications. 6, 7208.

    Research output: Contribution to journalArticle

  42. Episodic Recollection Difficulties in ASD Result from Atypical Relational Encoding: Behavioral and Neural Evidence

    Gaigg, S. B., Bowler, D. M., Ecker, C., Calvo-Merino, B. & Murphy, D. G., 1 Jun 2015, In : Autism research. 8, 3, p. 317-327 11 p.

    Research output: Contribution to journalArticle

  43. Longitudinal Evaluation of Sexual Function in a Cohort of Pre- and Postmenopausal Women

    Burri, A., Hilpert, P. & Spector, T., 1 Jun 2015, In : JOURNAL OF SEXUAL MEDICINE. 12, 6, p. 1427-1435 9 p.

    Research output: Contribution to journalArticle

  44. Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

    Allum, F., Shao, X., Guénard, F., Simon, M. M., Busche, S., Caron, M., Lambourne, J., Lessard, J., Tandre, K., Hedman, Å. K., Kwan, T., Ge, B., Rönnblom, L., McCarthy, M. I., Deloukas, P., Richmond, T., Burgess, D., Spector, T. D., Tchernof, A., Marceau, S. & 42 others, Lathrop, M., Vohl, M. C., Pastinen, T., Grundberg, E., Ahmadi, K. R., Ainali, C., Barrett, A., Bataille, V., Bell, J. T., Buil, A., Dermitzakis, E. T., Dimas, A. S., Durbin, R., Glass, D., Hassanali, N., Ingle, C., Knowles, D., Krestyaninova, M., Lindgren, C. M., Lowe, C. E., Meduri, E., Di Meglio, P., Min, J. L., Montgomery, S. B., Nestle, F. O., Nica, A. C., Nisbet, J., O'Rahilly, S., Parts, L., Potter, S., Sandling, J., Sekowska, M., Shin, S. Y., Small, K. S., Soranzo, N., Surdulescu, G., Travers, M. E., Tsaprouni, L., Tsoka, S., Wilk, A., Yang, T. P. & Zondervan, K. T., 29 May 2015, In : Nature Communications. 6, 11 p., 7211.

    Research output: Contribution to journalArticle

  45. Adiposity as a cause of cardiovascular disease: A Mendelian randomization study

    Hägg, S., Fall, T., Ploner, A., Mägi, R., Fischer, K., Draisma, H. H. M., Kals, M., De Vries, P. S., Dehghan, A., Willems, S. M., Sarin, A. P., Kristiansson, K., Nuotio, M. L., Havulinna, A. S., De Bruijn, R. F. A. G., Ikram, M. A., Kuningas, M., Stricker, B. H., Franco, O. H., Benyamin, B. & 43 others, Gieger, C., Hall, A. S., Huikari, V., Jula, A., Järvelin, M. R., Kaakinen, M., Kaprio, J., Kobl, M., Mangino, M., Nelson, C. P., Palotie, A., Samani, N. J., Spector, T., Strachan, D. P., Tobin, M. D., Whitfield, J. B., Uitterlinden, A. G., Salomaa, V., Syvänen, A. C., Kuulasmaa, K., Magnusson, P. K., Esko, T., Hofman, A., De Geus, E. J. C., Lind, L., Giedraitis, V., Perola, M., Evans, A., Ferriéres, J., Virtamo, J., Kee, F., Tregouet, D. A., Arveiler, D., Amouyel, P., Gianfagna, F., Brambilla, P., Ripatti, S., Van Duijn, C. M., Metspalu, A., Prokopenko, I., McCarthy, M. I., Pedersen, N. L. & Ingelsson, E., 27 May 2015, In : International Journal of Epidemiology. 44, 2, p. 578-586 9 p., dyv094.

    Research output: Contribution to journalArticle

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