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Research Outputs

  1. 2017
  2. Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease

    Horgusluoglu-Moloch, E., Nho, K., Risacher, S. L., Kim, S., Foroud, T., Shaw, L. M., Trojanowski, J. Q., Aisen, P. S., Petersen, R. C., Jack, C. R., Lovestone, S., Simmons, A., Weiner, M. W. & Saykin, A. J., 1 Dec 2017, In : Neurobiology of Aging. 60, p. 92-103 12 p.

    Research output: Contribution to journalArticle

  3. Prediction of uncomplicated pregnancies in obese women: a prospective multicentre study

    C Vieira, M., White, S. L., Patel, N., Seed, P. T., Briley, A. L., Sandall, J., Welsh, P., Sattar, N., Nelson, S. M., Lawlor, D. A., Poston, L., Pasupathy, D. & UPBEAT Consortium, 3 Nov 2017, In : BMC Medicine. 15, 1, p. 194

    Research output: Contribution to journalArticle

  4. Cardiac CT assessment of tissue thickness at the ostium of the left atrial appendage predicts acute success of radiofrequency ablation

    Whitaker, J., Panikker, S., Fastl, T., Corrado, C., Virmani, R., Kutys, R., Lim, E., O'Neill, M., Nicol, E., Niederer, S. & Wong, T., 1 Nov 2017, In : Pacing and clinical electrophysiology : PACE. 40, 11, p. 1218-1226 9 p.

    Research output: Contribution to journalArticle

  5. DISCOVERY, REPLICATION AND EXTENSION STUDY OF PLASMA PROTEOMIC BIOMARKERS RELATING TO BRAIN AMYLOID BURDEN (CSF Aβ OR AMYLOID-PET) IN THE EMIF-AD BIOMARKER DISCOVERY COHORT: 2017 Abstract Supplement

    Westwood, S., Baird, A. L., Hye, A., Bos, I., Vos, S. J. B., Vandenberghe, R., Scheltens, P., Engelborghs, S., Frisoni, G. B., Molinuevo, J. L., Wallin, A., Lleó, A., Popp, J., Martinez-Lage, P., Snowden, S. G., Legido-Quigley, C., Bertram, L., Barkhof, F., Zetterberg, H., Streffer, J. & 2 others, Visser, P. J. & Lovestone, S., 20 Oct 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P361-P362

    Research output: Contribution to journalArticle

  6. PET TAU AND AMYLOID-BETA DIFFER IN THEIR RELATIONSHIP TO AGE, COGNITION AND CSF BIOMARKERS IN MILD ALZHEIMER’S DISEASE: AN OBSERVATIONAL STUDY: 2017 Abstract Supplement

    Koychev, I. G., Gunn, R. N., Firouzian, A., Lawson, J., Zamboni, G., Ridha, B. H., Sahakian, B., Rowe, J. B., Thomas, A., Rochester, L., Ffytche, D., Howard, R. J., Zetterberg, H., MacKay, C. & Lovestone, S., 20 Oct 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P243

    Research output: Contribution to journalPoster abstract

  7. PET TAU AND AMYLOID-BETA DIFFER IN THEIR RELATIONSHIP TO AGE, COGNITION AND CSF BIOMARKERS IN MILD ALZHEIMER’S DISEASE: AN OBSERVATIONAL STUDY: 2017 Abstract Supplement

    Koychev, I. G., Gunn, R. N., Firouzian, A., Lawson, J., Zamboni, G., Ridha, B. H., Sahakian, B., Rowe, J. B., Thomas, A., Rochester, L., Ffytche, D., Howard, R. J., Zetterberg, H., MacKay, C. & Lovestone, S., 20 Oct 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P456-P457

    Research output: Contribution to journalPoster abstract

  8. Amyloid beta synaptotoxicity is Wnt–planar cell polarity dependent and blocked by fasudil

    Sellers, K. J., Elliott, C., Jackson, J., Ghosh, A., Ribe, E., Rojo-Sanchís, A., Jarosz-Griffiths, H. H., Watson, I. A., Xia, W., Semenov, M., Morin, P., Hooper, N. M., Porter, R., Preston, J., Al-Shawi, R., Baillie, G., Lovestone, S., Cuadrado, A., Harte, M., Simons, P. & 2 others, Srivastava, D. P. & Killick, R., 19 Oct 2017, In : Alzheimer's & Dementia.

    Research output: Contribution to journalArticle

  9. Efficient computation of electrograms and ECGs in human whole heart simulations using a reaction-eikonal model

    Neic, A., Campos, F. O., Prassl, A. J., Niederer, S. A., Bishop, M. J., Vigmond, E. J. & Plank, G., 1 Oct 2017, In : JOURNAL OF COMPUTATIONAL PHYSICS. 346, p. 191-211 21 p.

    Research output: Contribution to journalArticle

  10. Hormone-secreting adrenal tumours cause severe hypertension and high rates of poor pregnancy outcome: a UKOSS study with case control comparisons

    Quartermaine, G., Lambert, K., Rees, K., Seed, P. T., Dhanjal, M. K., Knight, M., McCance, D. R. & Williamson, C., 5 Sep 2017, In : BJOG.

    Research output: Contribution to journalArticle

  11. A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity

    Kuepfer, L., Clayton, O., Thiel, C., Cordes, H., Nudischer, R., Blank, L. M., Baier, V., Heymans, S., Caiment, F., Roth, A., Fluri, D. A., Kelm, J. M., Castell, J., Selevsek, N., Schlapbach, R., Keun, H., Hynes, J., Sarkans, U., Gmuender, H., Herwig, R. & 4 others, Niederer, S., Schuchhardt, J., Segall, M. & Kleinjans, J., 29 Aug 2017, In : Archives of Toxicology. p. 1-3 3 p.

    Research output: Contribution to journalArticle

  12. OP 2 Placental growth factor informed management of suspected pre-eclampsia and/or fetal growth restriction: The MAPPLE cohort study

    Sharp, A., Chappell, L., Dekker, G., Pelletier, S., Garnier, Y., Zeren, O., Hillerer, K. M., Fischer, T., Seed, P., Turner, M., Shennan, A. & Alfirevic, Z., 12 Aug 2017, In : Pregnancy Hypertension. 9, p. 9-10 2 p.

    Research output: Contribution to journalMeeting abstract

  13. Cardiac computational modeling of ventricular tachycardia and cardiac resynchronization therapy: A clinical perspective

    Chen, Z., Niederer, S., Shanmugam, N., Sermesant, M. & Rinaldi, C. A., 1 Aug 2017, In : Minerva Cardioangiologica. 65, 4, p. 380-397 18 p.

    Research output: Contribution to journalReview article

  14. Metabolic profiling of gestational diabetes in obese women during pregnancy

    White, S. L., Pasupathy, D., Sattar, N., Nelson, S. M., Lawlor, D. A., Briley, A. L., Seed, P. T., Welsh, P., Poston, L. & UPBEAT Consortium, 1 Aug 2017, In : Diabetologia. 60, 10, p. 1603-1912 10 p.

    Research output: Contribution to journalArticle

  15. EXPLORING THE RELATIONSHIP BETWEEN ANAEMIA AND ALZHEIMER’S DISEASE: 2017 Abstract Supplement

    Winchester, L., Nevado-Holgado, A. J. & Lovestone, S., 20 Jul 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P221

    Research output: Contribution to journalMeeting abstract

  16. NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

    Rojo, A. I., Pajares, M., Rada, P., Nuñez, A., Nevado-Holgado, A. J., Killik, R., Van Leuven, F., Ribe, E., Lovestone, S., Yamamoto, M. & Cuadrado, A., 5 Jul 2017, In : Redox Biology.

    Research output: Contribution to journalArticle

  17. DISCOVERY AND VALIDATION OF MULTIMODAL BIOMARKER SIGNATURES RELATING TO ALZHEIMER'S DISEASE PATHOLOGY AND PROGRESSION: 2017 Abstract Supplement

    Westwood, S., Hye, A., Lleó, A., Nevado-Holgado, A. J., Baird, A. L., Wallin, A., Leslie, A., Jimenez, B., Liu, B. Y., Legido-Quigley, C., Dima, D., Ruvolo, D., Holmes, E., D'Hondt, E., Westman, E., Barkhof, F., Frisoni, G. B., Zetterberg, H., Bos, I., Pearce, J. & 27 others, Streffer, J., Molinuevo, J. L., Popp, J., Bertram, L., Whiley, L., Maslen, L., Gomez-Romero, M., David, M., Lewis, M., Kurbatova, N., Ashton, N. J., Voyle, N., Kowalczyk, O., Martinez-Lage, P., Proitsi, P., Scheltens, P., Visser, P. J., Dobson, R. JB., Vandenberghe, R., Engelborghs, S., Vos, S. J. B., Snowden, S. G., Athersuch, T., Ashby, T., Kimhofer, T., Verachtert, W. & Lovestone, S., Jul 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P174-P175

    Research output: Contribution to journalMeeting abstract

  18. HYdroxychloroquine to Improve Pregnancy Outcome in Women with AnTIphospholipid Antibodies (HYPATIA) Protocol: A Multinational Randomized Controlled Trial of Hydroxychloroquine versus Placebo in Addition to Standard Treatment in Pregnant Women with Antiphospholipid Syndrome or Antibodies

    Schreiber, K., Breen, K., Cohen, H., Jacobsen, S., Middeldorp, S., Pavord, S., Regan, L., Roccatello, D., Robinson, S. E., Sciascia, S., Seed, P. T., Watkins, L. & Hunt, B. J., 13 Jun 2017, In : Seminars in Thrombosis and Hemostasis.

    Research output: Contribution to journalArticle

  19. Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation

    Ribba, B., Grimm, HP., Agoram, B., Davies, MR., Gadkar, K., Niederer, S., van Riel, N., Timmis, J. & van der Graaf, PH., 6 Jun 2017, In : CPT: Pharmacometrics and Systems Pharmacology.

    Research output: Contribution to journalArticle

  20. Maternal BMI and diabetes in pregnancy: Investigating variations between ethnic groups using routine maternity data from London, UK

    Nishikawa, E., Oakley, L., Seed, P., Doyle, P. & Oteng-Ntim, E., 1 Jun 2017, In : PL o S One . 12, 6, e0179332.

    Research output: Contribution to journalArticle

  21. Restitution slope is principally determined by steady-state action potential duration

    Shattock, M. J., Park, K. C., Yang, H-Y., Lee, A. W. C., Niederer, S., MacLeod, K. T. & Winter, J., Jun 2017, In : Cardiovascular Research. 113, 7, p. 817–828 12 p., cvx063.

    Research output: Contribution to journalArticle

  22. Compensatory and decompensatory alterations in cardiomyocyte Ca(2+) dynamics in hearts with diastolic dysfunction following aortic banding

    Gattoni, S., Treu Røe, Å., Aronsen, J. M., Sjaastad, I., Louch, W. E., Smith, N. P. & Niederer, S. A., 21 May 2017, In : The Journal of physiology.

    Research output: Contribution to journalArticle

  23. Comprehensive use of cardiac computed tomography to guide left ventricular lead placement in cardiac resynchronization therapy

    Behar, J. M., Rajani, R., Pourmorteza, A., Preston, R., Razeghi, O., Niederer, S., Adhya, S., Claridge, S., Jackson, T., Sieniewicz, B., Gould, J., Carr-White, G., Razavi, R., McVeigh, E. & Rinaldi, C. A., 4 May 2017, In : Heart Rhythm. 14, 9, p. 1364-1372 9 p.

    Research output: Contribution to journalArticle

  24. Mitochondrial genes are altered in blood early in Alzheimer's disease

    Lunnon, K., Keohane, A., Pidsley, R., Newhouse, S., Riddoch-Contreras, J., Thubron, E. B., Devall, M., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Schalkwyk, L., Dobson, R., Malik, A. N., Powell, J., Lovestone, S. & Hodges, A., 1 May 2017, In : Neurobiology of Aging. 53, p. 36-47 12 p.

    Research output: Contribution to journalArticle

  25. A predictive patient specific model for the human atrium

    Corrado, C., Williams, S., Plank, G., O'Neill, M. & Niederer, S., May 2017, CMBE 2017 Proceedings. Nithiarasu, P. & Robertson, A. (eds.). Vol. 2. p. 972-975 4 p. (CMBE series; vol. 2017, no. 2).

    Research output: Chapter in Book/Report/Conference proceedingConference paper

  26. Effect of reproductive ageing on pregnant mouse uterus and cervix

    Patel, R., Moffatt, J. D., Mourmoura, E., Demaison, L., Seed, P. T., Poston, L. & Tribe, R. M., 15 Mar 2017, In : The Journal of physiology. 595, 6, p. 2065–2084

    Research output: Contribution to journalArticle

  27. Personalised biophysical model to optimize left ventricle pacing location for Cardiac Resynchronisation Therapy over time

    Lee, A., Sohal, M., Behar, J., Claridge, S., Shetty, A., Jackson, T., Hyde, E., Plank, G., Razavi, R., Lamata, P., Rinaldi, C. A. & Niederer, S., 1 Mar 2017, Computing in Cardiology. IEEE Computer Society Press, Vol. 43. p. 757-759 3 p. 7868853

    Research output: Chapter in Book/Report/Conference proceedingConference paper

  28. Personalized modeling pipeline for left atrial electromechanics

    Fastl, T., Tobon Gomez, C., Crozier, W. A., Whitaker, J., Rajani, R., McCarthy, K. P., Sanchez-Quintana, D., Ho, S. Y., O'Neill, M., Plank, G., Bishop, M. J. & Niederer, S., 1 Mar 2017, Computing in Cardiology Conference, CinC 2016. IEEE Computer Society, Vol. 43. p. 225-228 4 p. 7868720

    Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

  29. Reply: Rapid changes in practice make analysis of historical databases irrelevant for contemporary counselling

    Sunkara, S. K., Lamarca, A., Polyzos, N. P., Seed, P. T. & Khalaf, Y., 25 Feb 2017, In : Human reproduction (Oxford, England). 32, 4, p. 964-965 2 p.

    Research output: Contribution to journalArticle

  30. Infant adiposity following a randomised controlled trial of a behavioural intervention in obese pregnancy

    Patel, N., Godfrey, K. M., Pasupathy, D., Levin, J., Flynn, A. C., Hayes, L., Briley, A. L., Bell, R., Lawlor, D. A., Oteng-Ntim, E., Nelson, S. M., Robson, S. C., Sattar, N., Singh, C., Wardle, J., White, S., Seed, P. T. & Poston, L., 20 Feb 2017, In : International Journal of Obesity.

    Research output: Contribution to journalArticle

  31. A Multi-Cohort Study of ApoE ϵ 4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease

    Khan, W., Giampietro, V., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., Conrod, P., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Lemaître, H., Nees, F., Paus, T., Pausova, Z., Rietschel, M., Smolka, M. N., Ströhle, A. & 19 others, Gallinat, J., Vellas, B., Soininen, H., Kloszewska, I., Tsolaki, M., Mecocci, P., Spenger, C., Villemagne, V. L., Masters, C. L., Muehlboeck, J. S., Bäckman, L., Fratiglioni, L., Kalpouzos, G., Wahlund, L. O., Schumann, G., Lovestone, S., Williams, S. C. R., Westman, E. & Simmons, A., 3 Feb 2017, In : JOURNAL OF ALZHEIMERS DISEASE. 56, 3, p. 1159-1174 16 p.

    Research output: Contribution to journalArticle

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