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Research Outputs

  1. 2017
  2. Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease

    Horgusluoglu-Moloch, E., Nho, K., Risacher, S. L., Kim, S., Foroud, T., Shaw, L. M., Trojanowski, J. Q., Aisen, P. S., Petersen, R. C., Jack, C. R., Lovestone, S., Simmons, A., Weiner, M. W. & Saykin, A. J., 1 Dec 2017, In : Neurobiology of Aging. 60, p. 92-103 12 p.

    Research output: Contribution to journalArticle

  3. Prediction of uncomplicated pregnancies in obese women: a prospective multicentre study

    C Vieira, M., White, S. L., Patel, N., Seed, P. T., Briley, A. L., Sandall, J., Welsh, P., Sattar, N., Nelson, S. M., Lawlor, D. A., Poston, L., Pasupathy, D. & UPBEAT Consortium, 3 Nov 2017, In : BMC Medicine. 15, 1, p. 194

    Research output: Contribution to journalArticle

  4. The TMEM106B risk allele is associated with lower cortical volumes in a clinically diagnosed frontotemporal dementia cohort

    Harding, S. R., Bocchetta, M., Gordon, E., Cash, D. M., Cash, D. M., Cardoso, M. J., Druyeh, R., Ourselin, S., Warren, J. D., Mead, S. & Rohrer, J. D., 1 Nov 2017, In : Journal of Neurology, Neurosurgery and Psychiatry. 88, 11, p. 997-999 3 p.

    Research output: Contribution to journalArticle

  5. DISCOVERY, REPLICATION AND EXTENSION STUDY OF PLASMA PROTEOMIC BIOMARKERS RELATING TO BRAIN AMYLOID BURDEN (CSF Aβ OR AMYLOID-PET) IN THE EMIF-AD BIOMARKER DISCOVERY COHORT: 2017 Abstract Supplement

    Westwood, S., Baird, A. L., Hye, A., Bos, I., Vos, S. J. B., Vandenberghe, R., Scheltens, P., Engelborghs, S., Frisoni, G. B., Molinuevo, J. L., Wallin, A., Lleó, A., Popp, J., Martinez-Lage, P., Snowden, S. G., Legido-Quigley, C., Bertram, L., Barkhof, F., Zetterberg, H., Streffer, J. & 2 others, Visser, P. J. & Lovestone, S., 20 Oct 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P361-P362

    Research output: Contribution to journalArticle

  6. PATHOLOGICAL CORRELATES OF WHITE MATTER HYPERINTENSITIES ON CADAVERIC MRI IN PROGRANULIN-ASSOCIATED FRONTOTEMPORAL DEMENTIA

    Woollacott, I. OC., Bocchetta, M., Sudre, C. H., Ridha, B. H., Strand, C., Courtney, R., Ourselin, S., Cardoso, J. M., Warren, J. D., Rossor, M. N., Fox, N. C., Revesz, T., Lashley, T., Holton, J. & Rohrer, J. D., 20 Oct 2017, In : Alzheimer's & Dementia. 13, 7, p. P805

    Research output: Contribution to journalArticle

  7. PET TAU AND AMYLOID-BETA DIFFER IN THEIR RELATIONSHIP TO AGE, COGNITION AND CSF BIOMARKERS IN MILD ALZHEIMER’S DISEASE: AN OBSERVATIONAL STUDY: 2017 Abstract Supplement

    Koychev, I. G., Gunn, R. N., Firouzian, A., Lawson, J., Zamboni, G., Ridha, B. H., Sahakian, B., Rowe, J. B., Thomas, A., Rochester, L., Ffytche, D., Howard, R. J., Zetterberg, H., MacKay, C. & Lovestone, S., 20 Oct 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P243

    Research output: Contribution to journalPoster abstract

  8. PET TAU AND AMYLOID-BETA DIFFER IN THEIR RELATIONSHIP TO AGE, COGNITION AND CSF BIOMARKERS IN MILD ALZHEIMER’S DISEASE: AN OBSERVATIONAL STUDY: 2017 Abstract Supplement

    Koychev, I. G., Gunn, R. N., Firouzian, A., Lawson, J., Zamboni, G., Ridha, B. H., Sahakian, B., Rowe, J. B., Thomas, A., Rochester, L., Ffytche, D., Howard, R. J., Zetterberg, H., MacKay, C. & Lovestone, S., 20 Oct 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P456-P457

    Research output: Contribution to journalPoster abstract

  9. VASCULAR AND EARLY LIFE INFLUENCES ON CEREBROVASCULAR DISEASE IN INSIGHT 46: A SUB-STUDY OF THE MRC NATIONAL SURVEY OF HEALTH AND DEVELOPMENT (NSHD) BRITISH BIRTH COHORT

    Lane, C. A., Sudre, C. H., Barnes, J., Nicholas, J. M., Parker, T., Cash, D. M., Murray-Smith, H., Wong, A., Malone, I. B., Klimova, J., Kuh, D., Ourselin, S., Cardoso, M. J., Richards, M., Fox, N. C. & Schott, J. M., 20 Oct 2017, In : Alzheimer's & Dementia. 13, 7, p. P851-P853

    Research output: Contribution to journalArticle

  10. WHITE MATTER HYPERINTENSITIES AND VASCULAR RISK FACTORS IN COGNITIVELY HEALTHY ELDERLY MONOZYGOTIC TWIN PAIRS

    Kate, M. T., Sudre, C. H., Braber, A. D., Konijnenberg, E., Cardoso, M. J., Scheltens, P., Ourselin, S., Boomsma, D. I., Barkhof, F. & Visser, P. J., 20 Oct 2017, In : Alzheimer's & Dementia. 13, 7, p. P53-P54

    Research output: Contribution to journalArticle

  11. WHITE MATTER HYPERINTENSITIES ARE ASSOCIATED WITH HIPPOCAMPAL ATROPHY RATES AFTER ADJUSTING FOR OTHER VASCULAR MARKERS IN PREDEMENTIA DISEASE STAGES

    Biessels, G. J., Barnes, J., Sudre, C. H., Pemberton, H., Fiford, C. M., Carmichael, O. T., Barkhof, F., Walsh, P. & Cardoso, M. J., 20 Oct 2017, In : Alzheimer's & Dementia. 13, 7, p. P1547-P1548

    Research output: Contribution to journalArticle

  12. WHITE MATTER HYPERINTENSITIES IN GENETIC FRONTOTEMPORAL DEMENTIA: A GENFI STUDY

    Sudre, C. H., Bocchetta, M., Cash, D. M., Thomas, D. L., Woollacott, I. OC., Dick, K. M., van Swieten, J. C., Borroni, B., Galimberti, D., Masellis, M., Tartaglia, M. C., Rowe, J. B., Graff, C., Tagliavini, F., Frisoni, G. B., Laforce, R., Finger, E., de Mendonca, A., Sorbi, S., Ourselin, S. & 2 others, Cardoso, M. J. & Rohrer, J. D., 20 Oct 2017, In : Alzheimer's & Dementia. 13, 7, p. P9-P10

    Research output: Contribution to journalArticle

  13. Amyloid beta synaptotoxicity is Wnt–planar cell polarity dependent and blocked by fasudil

    Sellers, K. J., Elliott, C., Jackson, J., Ghosh, A., Ribe, E., Rojo-Sanchís, A., Jarosz-Griffiths, H. H., Watson, I. A., Xia, W., Semenov, M., Morin, P., Hooper, N. M., Porter, R., Preston, J., Al-Shawi, R., Baillie, G., Lovestone, S., Cuadrado, A., Harte, M., Simons, P. & 2 others, Srivastava, D. P. & Killick, R., 19 Oct 2017, In : Alzheimer's & Dementia.

    Research output: Contribution to journalArticle

  14. Hormone-secreting adrenal tumours cause severe hypertension and high rates of poor pregnancy outcome: a UKOSS study with case control comparisons

    Quartermaine, G., Lambert, K., Rees, K., Seed, P. T., Dhanjal, M. K., Knight, M., McCance, D. R. & Williamson, C., 5 Sep 2017, In : BJOG.

    Research output: Contribution to journalArticle

  15. Automated T2 relaxometry of the hippocampus for temporal lobe epilepsy

    Winston, G. P., Vos, S. B., Burdett, J. L., Cardoso, M. J., Ourselin, S. & Duncan, J. S., Sep 2017, In : Epilepsia. 58, 9, p. 1645-1652 8 p.

    Research output: Contribution to journalArticle

  16. OP 2 Placental growth factor informed management of suspected pre-eclampsia and/or fetal growth restriction: The MAPPLE cohort study

    Sharp, A., Chappell, L., Dekker, G., Pelletier, S., Garnier, Y., Zeren, O., Hillerer, K. M., Fischer, T., Seed, P., Turner, M., Shennan, A. & Alfirevic, Z., 12 Aug 2017, In : Pregnancy Hypertension. 9, p. 9-10 2 p.

    Research output: Contribution to journalMeeting abstract

  17. Metabolic profiling of gestational diabetes in obese women during pregnancy

    White, S. L., Pasupathy, D., Sattar, N., Nelson, S. M., Lawlor, D. A., Briley, A. L., Seed, P. T., Welsh, P., Poston, L. & UPBEAT Consortium, 1 Aug 2017, In : Diabetologia. 60, 10, p. 1603-1912 10 p.

    Research output: Contribution to journalArticle

  18. Effect of high-dose simvastatin on cognitive, neuropsychiatric, and health-related quality-of-life measures in secondary progressive multiple sclerosis: secondary analyses from the MS-STAT randomised, placebo-controlled trial

    Chan, D., Binks, S., Nicholas, J. M., Frost, C., Cardoso, M. J., Ourselin, S., Wilkie, D., Nicholas, R. & Chataway, J., Aug 2017, In : The Lancet Neurology. 16, 8, p. 591-600 10 p.

    Research output: Contribution to journalArticle

  19. EXPLORING THE RELATIONSHIP BETWEEN ANAEMIA AND ALZHEIMER’S DISEASE: 2017 Abstract Supplement

    Winchester, L., Nevado-Holgado, A. J. & Lovestone, S., 20 Jul 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P221

    Research output: Contribution to journalMeeting abstract

  20. Generative diffeomorphic atlas construction from brain and spinal cord MRI data

    Blaiotta, C., Freund, P., Cardoso, M. J. & Ashburner, J., 5 Jul 2017, In : arXiv.

    Research output: Contribution to journalArticle

  21. NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

    Rojo, A. I., Pajares, M., Rada, P., Nuñez, A., Nevado-Holgado, A. J., Killik, R., Van Leuven, F., Ribe, E., Lovestone, S., Yamamoto, M. & Cuadrado, A., 5 Jul 2017, In : Redox Biology.

    Research output: Contribution to journalArticle

  22. DISCOVERY AND VALIDATION OF MULTIMODAL BIOMARKER SIGNATURES RELATING TO ALZHEIMER'S DISEASE PATHOLOGY AND PROGRESSION: 2017 Abstract Supplement

    Westwood, S., Hye, A., Lleó, A., Nevado-Holgado, A. J., Baird, A. L., Wallin, A., Leslie, A., Jimenez, B., Liu, B. Y., Legido-Quigley, C., Dima, D., Ruvolo, D., Holmes, E., D'Hondt, E., Westman, E., Barkhof, F., Frisoni, G. B., Zetterberg, H., Bos, I., Pearce, J. & 27 others, Streffer, J., Molinuevo, J. L., Popp, J., Bertram, L., Whiley, L., Maslen, L., Gomez-Romero, M., David, M., Lewis, M., Kurbatova, N., Ashton, N. J., Voyle, N., Kowalczyk, O., Martinez-Lage, P., Proitsi, P., Scheltens, P., Visser, P. J., Dobson, R. JB., Vandenberghe, R., Engelborghs, S., Vos, S. J. B., Snowden, S. G., Athersuch, T., Ashby, T., Kimhofer, T., Verachtert, W. & Lovestone, S., Jul 2017, In : Alzheimer's & Dementia. 13, 7, Supplement, p. P174-P175

    Research output: Contribution to journalMeeting abstract

  23. HYdroxychloroquine to Improve Pregnancy Outcome in Women with AnTIphospholipid Antibodies (HYPATIA) Protocol: A Multinational Randomized Controlled Trial of Hydroxychloroquine versus Placebo in Addition to Standard Treatment in Pregnant Women with Antiphospholipid Syndrome or Antibodies

    Schreiber, K., Breen, K., Cohen, H., Jacobsen, S., Middeldorp, S., Pavord, S., Regan, L., Roccatello, D., Robinson, S. E., Sciascia, S., Seed, P. T., Watkins, L. & Hunt, B. J., 13 Jun 2017, In : Seminars in Thrombosis and Hemostasis.

    Research output: Contribution to journalArticle

  24. Maternal BMI and diabetes in pregnancy: Investigating variations between ethnic groups using routine maternity data from London, UK

    Nishikawa, E., Oakley, L., Seed, P., Doyle, P. & Oteng-Ntim, E., 1 Jun 2017, In : PL o S One . 12, 6, e0179332.

    Research output: Contribution to journalArticle

  25. Cognitive reserve and TMEM106B genotype modulate brain damage in presymptomatic frontotemporal dementia: A GENFI study

    Premi, E., Grassi, M., Van Swieten, J., Galimberti, D., Graff, C., Masellis, M., Tartaglia, C., Tagliavini, F., Rowe, J. B., Laforce, R., Finger, E., Frisoni, G. B., De Mendonça, A., Sorbi, S., Gazzina, S., Cosseddu, M., Archetti, S., Gasparotti, R., Manes, M., Alberici, A. & 7 others, Cardoso, M. J., Bocchetta, M., Cash, D. M., Ourselin, S., Padovani, A., Rohrer, J. D. & Borroni, B., Jun 2017, In : Brain. 140, 6, p. 1784-1791 8 p.

    Research output: Contribution to journalArticle

  26. Real-time imaging of single neuronal cell apoptosis in patients with glaucoma

    Cordeiro, M. F., Normando, E. M., Cardoso, M. J., Miodragovic, S., Jeylani, S., Davis, B. M., Guo, L., Ourselin, S., A'Hern, R. & Bloom, P. A., Jun 2017, In : Brain. 140, 6, p. 1757-1767 11 p.

    Research output: Contribution to journalArticle

  27. VTrails: Inferring vessels with geodesic connectivity trees

    Moriconi, S., Zuluaga, M. A., Jäger, H. R., Nachev, P., Ourselin, S. & Cardoso, M. J., 23 May 2017, Information Processing in Medical Imaging - 25th International Conference, IPMI 2017, Proceedings. Springer Verlag, Vol. 10265 LNCS. p. 672-684 13 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 10265 LNCS).

    Research output: Chapter in Book/Report/Conference proceedingConference paper

  28. Spinal cord grey matter segmentation challenge

    Prados, F., Ashburner, J., Blaiotta, C., Brosch, T., Carballido-Gamio, J., Cardoso, M. J., Conrad, B. N., Datta, E., Dávid, G., Leener, B. D., Dupont, S. M., Freund, P., Wheeler-Kingshott, C. A. M. G., Grussu, F., Henry, R., Landman, B. A., Ljungberg, E., Lyttle, B., Ourselin, S., Papinutto, N. & 8 others, Saporito, S., Schlaeger, R., Smith, S. A., Summers, P., Tam, R., Yiannakas, M. C., Zhu, A. & Cohen-Adad, J., 15 May 2017, In : NeuroImage. 152, p. 312-329 18 p.

    Research output: Contribution to journalArticle

  29. Iterative framework for the joint segmentation and CT synthesis of MR images: Application to MRI-only radiotherapy treatment planning

    Burgos, N., Guerreiro, F., McClelland, J., Presles, B., Modat, M., Nill, S., Dearnaley, D., DeSouza, N., Oelfke, U., Knopf, A. C., Ourselin, S. & Jorge Cardoso, M., 5 May 2017, In : Physics in Medicine and Biology. 62, 11, p. 4237-4253 17 p.

    Research output: Contribution to journalArticle

  30. Longitudinal segmentation of age-related white matter hyperintensities

    Sudre, C. H., Cardoso, M. J., Ourselin, S. & Alzheimer's Disease Neuroimaging Initiative, 1 May 2017, In : Medical Image Analysis. 38, p. 50-64 15 p.

    Research output: Contribution to journalArticle

  31. Mitochondrial genes are altered in blood early in Alzheimer's disease

    Lunnon, K., Keohane, A., Pidsley, R., Newhouse, S., Riddoch-Contreras, J., Thubron, E. B., Devall, M., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Schalkwyk, L., Dobson, R., Malik, A. N., Powell, J., Lovestone, S. & Hodges, A., 1 May 2017, In : Neurobiology of Aging. 53, p. 36-47 12 p.

    Research output: Contribution to journalArticle

  32. APOE ε4 status is associated with white matter hyperintensities volume accumulation rate independent of AD diagnosis

    Sudre, C. H., Cardoso, M. J., Frost, C., Barnes, J., Barkhof, F., Fox, N. & Ourselin, S., May 2017, In : Neurobiology of Aging. 53, p. 67-75 9 p.

    Research output: Contribution to journalArticle

  33. Study protocol: Insight 46: a neuroscience sub-study of the MRC National Survey of Health and Development

    Lane, C. A., Parker, T. D., Cash, D. M., Macpherson, K., Donnachie, E., Murray-Smith, H., Barnes, A., Barker, S., Beasley, D. G., Bras, J., Brown, D., Burgos, N., Byford, M., Cardoso, M. J., Carvalho, A., Collins, J., De Vita, E., Dickson, J. C., Epie, N., Espak, M. & 23 others, Henley, S. M. D., Hoskote, C., Hutel, M., Klimova, J., Malone, I. B., Markiewicz, P., Melbourne, A., Modat, M., Schrag, A., Shah, S., Sharma, N., Sudre, C. H., Thomas, D. L., Wong, A., Zhang, H., Hardy, J., Zetterberg, H., Ourselin, S., Crutch, S. J., Kuh, D., Richards, M., Fox, N. C. & Schott, J. M., 18 Apr 2017, In : BMC Neurology. 17, 75.

    Research output: Contribution to journalArticle

  34. A Comparison of Accelerated and Non-accelerated MRI Scans for Brain Volume and Boundary Shift Integral Measures of Volume Change: Evidence from the ADNI Dataset

    Alzheimer’s Disease Neuroimaging Initiative, Manning, E. N., Leung, K. K., Nicholas, J. M., Malone, I. B., Cardoso, M. J., Schott, J. M., Fox, N. C. & Barnes, J., 1 Apr 2017, In : Neuroinformatics. 15, 2, p. 215-226 12 p.

    Research output: Contribution to journalArticle

  35. Corrigendum to “3rd ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 3)” [Breast 31 (February 2017) 244–259]

    Cardoso, F., Costa, A., Senkus, E., Aapro, M., André, F., Barrios, C. H., Bergh, J., Bhattacharyya, G., Biganzoli, L., Cardoso, M. J., Carey, L., Corneliussen-James, D., Curigliano, G., Dieras, V., El Saghir, N., Eniu, A., Fallowfield, L., Fenech, D., Francis, P., Gelmon, K. & 25 others, Gennari, A., Harbeck, N., Hudis, C., Kaufman, B., Krop, I., Mayer, M., Meijer, H., Mertz, S., Ohno, S., Pagani, O., Papadopoulos, E., Peccatori, F., Penault-Llorca, F., Piccart, M. J., Pierga, J. Y., Rugo, H., Shockney, L., Sledge, G., Swain, S., Thomssen, C., Tutt, A., Vorobiof, D., Xu, B., Norton, L. & Winer, E., Apr 2017, In : BREAST. 32, p. 269-270 2 p.

    Research output: Contribution to journalArticle

  36. Comparison of In vivo and Ex vivo MRI for the detection of structural abnormalities in a mouse model of tauopathy

    Holmes, H. E., Powell, N. M., Ma, D., Ismail, O., Harrison, I. F., Wells, J. A., Colgan, N., O’Callaghan, J. M., Johnson, R. A., Murray, T. K., Ahmed, Z., Heggenes, M., Fisher, A., Cardoso, M. J., Modat, M., O’Neill, M. J., Collins, E. C., Fisher, E. M. C., Ourselin, S. & Lythgoe, M. F., 31 Mar 2017, In : Frontiers in Neuroinformatics. 11, 20.

    Research output: Contribution to journalArticle

  37. Effect of reproductive ageing on pregnant mouse uterus and cervix

    Patel, R., Moffatt, J. D., Mourmoura, E., Demaison, L., Seed, P. T., Poston, L. & Tribe, R. M., 15 Mar 2017, In : The Journal of physiology. 595, 6, p. 2065–2084

    Research output: Contribution to journalArticle

  38. Evaluation of a multi-atlas CT synthesis approach for MRI-only radiotherapy treatment planning

    Guerreiro, F., Burgos, N., Dunlop, A., Wong, K., Petkar, I., Nutting, C., Harrington, K., Bhide, S., Newbold, K., Dearnaley, D., deSouza, N. M., Morgan, V. A., McClelland, J., Nill, S., Cardoso, M. J., Ourselin, S., Oelfke, U. & Knopf, A. C., 1 Mar 2017, In : Physica Medica. 35, p. 7-17 11 p.

    Research output: Contribution to journalArticle

  39. Longitudinal multiple sclerosis lesion segmentation: Resource and challenge

    Carass, A., Roy, S., Jog, A., Cuzzocreo, J. L., Magrath, E., Gherman, A., Button, J., Nguyen, J., Prados, F., Sudre, C. H., Jorge Cardoso, M., Cawley, N., Ciccarelli, O., Wheeler-Kingshott, C. A. M., Ourselin, S., Catanese, L., Deshpande, H., Maurel, P., Commowick, O., Barillot, C. & 26 others, Tomas-Fernandez, X., Warfield, S. K., Vaidya, S., Chunduru, A., Muthuganapathy, R., Krishnamurthi, G., Jesson, A., Arbel, T., Maier, O., Handels, H., Iheme, L. O., Unay, D., Jain, S., Sima, D. M., Smeets, D., Ghafoorian, M., Platel, B., Birenbaum, A., Greenspan, H., Bazin, P. L., Calabresi, P. A., Crainiceanu, C. M., Ellingsen, L. M., Reich, D. S., Prince, J. L. & Pham, D. L., 1 Mar 2017, In : NeuroImage. 148, p. 77-102 26 p.

    Research output: Contribution to journalArticle

  40. White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy

    Fiford, C. M., Manning, E. N., Bartlett, J. W., Cash, D. M., Malone, I. B., Ridgway, G. R., Lehmann, M., Leung, K. K., Sudre, C. H., Ourselin, S., Biessels, G. J., Carmichael, O. T., Fox, N. C., Cardoso, M. J., Barnes, J. & for the Alzheimer's Disease Neuroimaging Initiative, Mar 2017, In : Hippocampus. 27, 3, p. 249-262 14 p.

    Research output: Contribution to journalArticle

  41. Reply: Rapid changes in practice make analysis of historical databases irrelevant for contemporary counselling

    Sunkara, S. K., Lamarca, A., Polyzos, N. P., Seed, P. T. & Khalaf, Y., 25 Feb 2017, In : Human reproduction (Oxford, England). 32, 4, p. 964-965 2 p.

    Research output: Contribution to journalArticle

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