King's College London

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Research Outputs

  1. 2019
  2. Intervention planning and modification of the BUMP intervention: A digital intervention for the early detection of raised blood pressure in pregnancy

    Band, R., Hinton, L., Tucker, K. L., Chappell, L. C., Crawford, C., Franssen, M., Greenfield, S., Hodgkinson, J., McCourt, C., McManus, R. J., Sandall, J., Santos, M. D., Velardo, C. & Yardley, L., 20 Dec 2019, In : Pilot and Feasibility Studies. 5, 1, 153.

    Research output: Contribution to journalArticle

  3. Cardiac monocytes and macrophages after myocardial infarction

    Peet, C., Ivetic, A., Bromage, D. I. & Shah, A. M., 16 Dec 2019, In : Cardiovascular Research. cvz336.

    Research output: Contribution to journalArticle

  4. Enzymatic quantification of total serum bile acids as a monitoring strategy for women with intrahepatic cholestasis of pregnancy receiving ursodeoxycholic acid treatment: a cohort study

    Borges Manna, L., Ovadia, C., Lövgren-Sandblom, A., Chambers, J., Begum, S., Seed, P., Walker, I., Chappell, L. C., Marschall, H-U. & Williamson, C., 1 Dec 2019, In : BJOG. 126, 13, p. 1633-1640 8 p.

    Research output: Contribution to journalArticle

  5. Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data

    Bean, D., Teo, J., Wu, H., Oliveira, R., Patel, R., Bendayan, R., Shah, A. M., Dobson, R. J. B. & Scott, P. A., 25 Nov 2019, In : PLOS One. 14, 11, e0225625.

    Research output: Contribution to journalArticle

  6. Association of troponin level and age with mortality in 250 000 patients: cohort study across five UK acute care centres

    Kaura, A., Panoulas, V., Glampson, B., Davies, J., Mulla, A., Woods, K., Omigie, J., Shah, A. D., Channon, K. M., Weber, J. N., Thursz, M. R., Elliott, P., Hemingway, H., Williams, B., Asselbergs, F., O'Sullivan, M., Kharbanda, R., Lord, G. M., Melikian, N., Patel, R. S. & 4 others, Perera, D., Shah, A. M., Francis, D. P. & Mayet, J., 20 Nov 2019, In : BMJ (Clinical research ed.). 367, p. l6055 l6055.

    Research output: Contribution to journalArticle

  7. Transplacental metoprolol for fetal supraventricular tachycardia

    Vigneswaran, T. V., Rosenthal, E., Bakalis, S., Nelson-Piercy, C., Chappell, L. & Simpson, J. M., 19 Nov 2019, In : Ultrasound in Obstetrics and Gynecology.

    Research output: Contribution to journalArticle

  8. Prelamin A mediates myocardial inflammation in dilated and HIV-Associated cardiomyopathies

    Brayson, D., Frustaci, A., Verardo, R., Chimenti, C., Russo, M. A., Hayward, R., Ahmad, S. M., Vizcay-barrena, G., Protti, A., Zammit, P. S., Dos Remedios, C. G., Ehler, E., Shah, A. M. & Shanahan, C. M., 14 Nov 2019, In : JCI Insight. 4, 22, e126315.

    Research output: Contribution to journalArticle

  9. Pregnancy-related Acute Kidney Injury in pre-eclampsia: risk factors and renal outcomes

    Conti-Ramsden, F. I., Nathan, H. L., De Greeff, A., Hall, D. R., Seed, P. T., Chappell, L. C., Shennan, A. H. & Bramham, K., Nov 2019, In : Hypertension. 74, 5, p. 1144–1151 8 p.

    Research output: Contribution to journalArticle

  10. Therapies to limit myocardial injury in animal models of myocarditis: a systematic review and meta-analysis

    Silverblatt, J. A., Ziff, O. J., Dancy, L., Daniel, A., Carter, B. R., Scott, P. A., Sado, D., Shah, A. M. & Bromage, D. I., Nov 2019, In : Basic Research in Cardiology. 114, 6, 48.

    Research output: Contribution to journalArticle

  11. Clinical practice guideline on pregnancy and renal disease

    Wiles, K., Chappell, L., Clark, K., Elman, L., Hall, M., Lightstone, L., Mohamed, G., Mukherjee, D., Nelson-Piercy, C., Webster, P., Whybrow, R. & Bramham, K., 31 Oct 2019, In : BMC Nephrology. 20, 1, 401.

    Research output: Contribution to journalReview article

  12. A randomised controlled trial of blood pressure self-monitoring in the management of hypertensive pregnancy. OPTIMUM-BP: A feasibility trial

    Pealing, L. M., Tucker, K. L., Mackillop, L. H., Crawford, C., Wilson, H., Nickless, A., Temple, E., Chappell, L. C. & McManus, R. J., 1 Oct 2019, In : Pregnancy Hypertension. 18, p. 141-149 9 p.

    Research output: Contribution to journalArticle

  13. Assessing the role of extracellular signal-regulated kinases 1 and 2 in volume overload-induced cardiac remodelling

    Jochmann, S., Elkenani, M., Mohamed, B. A., Buchholz, E., Lbik, D., Binder, L., Lorenz, K., Shah, A. M., Hasenfuß, G., Toischer, K. & Schnelle, M., 1 Oct 2019, In : ESC Heart Failure. 6, 5, p. 1015-1026 12 p.

    Research output: Contribution to journalArticle

  14. Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial

    PHOENIX Study Group, Chappell, L. C., Brocklehurst, P., Green, M. E., Hunter, R., Hardy, P., Juszczak, E., Linsell, L., Chiocchia, V., Greenland, M., Placzek, A., Townend, J., Sandall, J. & Shennan, A., 28 Sep 2019, In : The Lancet. 394, 10204, p. 1181-1190 10 p.

    Research output: Contribution to journalArticle

  15. Preeclampsia and Cardiovascular Disease in a Large UK Pregnancy Cohort of Linked Electronic Health Records: A CALIBER Study

    Leon, L. J., McCarthy, F. P., Direk, K., Gonzalez-Izquierdo, A., Prieto-Merino, D., Casas, J. P. & Chappell, L., 24 Sep 2019, In : Circulation. 140, 13, p. 1050-1060 11 p.

    Research output: Contribution to journalArticle

  16. Diagnosis and management of hypertension in pregnancy: Summary of updated NICE guidance

    Webster, K., Fishburn, S., Maresh, M., Findlay, S. C. & Chappell, L. C., 9 Sep 2019, In : The BMJ. 366, el5119.

    Research output: Contribution to journalArticle

  17. Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial

    PITCHES study group, Chappell, L. C., Bell, J. L., Smith, A., Linsell, L., Juszczak, E., Dixon, P. H., Chambers, J., Hunter, R., Dorling, J., Williamson, C. & Thornton, J. G., 7 Sep 2019, In : The Lancet. 394, 10201, p. 849-860 12 p.

    Research output: Contribution to journalArticle

  18. Single-cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction

    Li, Z., Solomonidis, E. G., Meloni, M., Taylor, R. S., Duffin, R., Dobie, R., Magalhaes, M. S., Henderson, B. E. P., Louwe, P. A., D'Amico, G., Hodivala-Dilke, K. M., Shah, A. M., Mills, N. L., Simons, B. D., Gray, G. A., Henderson, N. C., Baker, A. H. & Brittan, M., 7 Aug 2019, In : European Heart Journal. 40, 30, p. 2507-2520 14 p.

    Research output: Contribution to journalArticle

  19. Uncertainties in Screening and Prevention of Group B Streptococcus Disease

    Le Doare, K., Heath, P. T., Plumb, J., Owen, N. A., Brocklehurst, P. & Chappell, L. C., 1 Aug 2019, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 69, 4, p. 720-725 6 p.

    Research output: Contribution to journalArticle

  20. Prediction of pre-eclampsia: review of reviews

    on behalf of the IPPIC Network, 1 Jul 2019, In : Ultrasound in Obstetrics and Gynecology. 54, 1, p. 16-27 12 p.

    Research output: Contribution to journalReview article

  21. Quantifying adherence to antihypertensive medication for chronic hypertension during pregnancy

    Webster, L. M., Reed, K., Myers, J. E., Burns, A., Gupta, P., Patel, P., Wiesender, C., Seed, P. T., Nelson-Piercy, C. & Chappell, L. C., 1 Jul 2019, In : Pregnancy Hypertension. 17, p. 12-14 3 p.

    Research output: Contribution to journalArticle

  22. The continuous heart failure spectrum: moving beyond an ejection fraction classification

    Triposkiadis, F., Butler, J., Abboud, F. M., Armstrong, P. W., Adamopoulos, S., Atherton, J. J., Backs, J., Bauersachs, J., Burkhoff, D., Bonow, R. O., Chopra, V. K., de Boer, R. A., de Windt, L., Hamdani, N., Hasenfuss, G., Heymans, S., Hulot, J. S., Konstam, M., Lee, R. T., Linke, W. A. & 22 others, Lunde, I. G., Lyon, A. R., Maack, C., Mann, D. L., Mebazaa, A., Mentz, R. J., Nihoyannopoulos, P., Papp, Z., Parissis, J., Pedrazzini, T., Rosano, G., Rouleau, J., Seferovic, P. M., Shah, A. M., Starling, R. C., Tocchetti, C. G., Trochu, J. N., Thum, T., Zannad, F., Brutsaert, D. L., Segers, V. F. & De Keulenaer, G. W., 1 Jul 2019, In : European Heart Journal. 40, 26, p. 2155-2163B 9 p.

    Research output: Contribution to journalReview article

  23. Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension

    Rudyk, O., Rowan, A., Prysyazhna, O., Krasemann, S., Hartmann, K., Zhang, M., Shah, A. M., Ruppert, C., Weiss, A., Schermuly, R. T., Ida, T., Akaike, T., Zhao, L. & Eaton, P., 25 Jun 2019, In : PNAS. 116, 26, p. 13016-13025 10 p.

    Research output: Contribution to journalArticle

  24. Renal biopsy findings during and after pregnancy

    Conti-Ramsden, F., Bass, P., Chappell, L. C. & Branham, K., 15 Jun 2019, In : Obstetric Medicine.

    Research output: Contribution to journalArticle

  25. Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer

    Tiwari, P., Blank, A., Cui, C., Schoenfelt, K. Q., Zhou, G., Xu, Y., Khramtsova, G., Olopade, F., Shah, A. M., Khan, S. A., Rosner, M. R. & Becker, L., 3 Jun 2019, In : The Journal of experimental medicine. 216, 6, p. 1345-1358 14 p.

    Research output: Contribution to journalArticle

  26. Diagnostic Indicators of Superimposed Preeclampsia in Women With CKD

    Wiles, K., Bramham, K., Seed, P. T., Kurlak, L. O., Mistry, H. D., Nelson-piercy, C., Lightstone, L. & Chappell, L. C., 1 Jun 2019, In : Kidney International Reports. 4, 6, p. 842-853 12 p.

    Research output: Contribution to journalArticle

  27. Caring for women with chronic hypertension

    Lovell, H., Wilson, H. M., Whybrow, R., Harding, K. & Chappell, L. C., Jun 2019, In : British Journal of Midwifery. 27, 6, p. 343-351 9 p.

    Research output: Contribution to journalArticle

  28. InSpect: INtegrated SPECTral Component Estimation and Mapping for Multi-contrast Microstructural MRI

    Slator, P. J., Hutter, J., Marinescu, R. V., Palombo, M., Young, A. L., Jackson, L. H., Ho, A., Chappell, L. C., Rutherford, M., Hajnal, J. V. & Alexander, D. C., 22 May 2019, Information Processing in Medical Imaging - 26th International Conference, IPMI 2019, Proceedings. Bao, S., Gee, J. C., Yushkevich, P. A. & Chung, A. C. S. (eds.). p. 755-766 12 p. Chapter 59. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 11492 LNCS).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  29. Effect of Iron Isomaltoside on Skeletal Muscle Energetics in Patients with Chronic Heart Failure and Iron Deficiency: FERRIC-HF II Randomized Mechanistic Trial

    Charles-Edwards, G., Amaral, N., Sleigh, A., Ayis, S., Catibog, N., McDonagh, T., Monaghan, M., Amin-Youseff, G., Kemp, G. J., Shah, A. M. & Okonko, D. O., 21 May 2019, In : Circulation. 139, 21, p. 2386-2398 13 p.

    Research output: Contribution to journalArticle

  30. Placental growth factor testing to assess women with suspected pre-eclampsia: a multicentre, pragmatic, stepped-wedge cluster-randomised controlled trial

    Duhig, K. E., Myers, J., Seed, P. T., Sparkes, J., Lowe, J., Hunter, R. M., Shennan, A. H., Chappell, L. C., Bahl, R., Bambridge, G., Barnfield, S., Ficquet, J., Gill, C., Girling, J., Harding, K., Khalil, A., Sharp, A., Simpson, N. & Tuffnell, D., 4 May 2019, In : The Lancet. 393, 10183, p. 1807-1818 12 p.

    Research output: Contribution to journalArticle

  31. Exploring the effect of implementation and context on a stepped-wedge randomised controlled trial of a vital sign triage device in routine maternity care in low-resource settings

    Vousden, N., Lawley, E., Seed, P. T., Gidiri, M. F., Charantimath, U., Makonyola, G., Brown, A., Yadeta, L., Best, R., Chinkoyo, S., Vwalika, B., Nakimuli, A., Ditai, J., Greene, G., Chappell, L. C., Sandall, J., Shennan, A. H., Bukani, D., Toussaint, P., Vixama, A. & 30 others, Hill, C., Nakirijja, E., Birungi, D., Kalyowa, N., Namakuli, D., Byamugisha, J., Odeke, N. M., Wandabwa, J., Momodou, F., Sesay, M., Sandi, P., Conteh, J., Kamara, J., Clarke, M., Miti, J., Chima, M., Kopeka, M., Jere, C., Musonda, T., Mambo, V., Guchale, Y., Surur, F., Mungarwadi, G. M., Mastiholi, S. S., Karadiguddi, C. C., Hezelgrave, N., Duhig, K. E., Kachinjika, M., Bellad, M. & Makwakwa, J., 18 Apr 2019, In : Implementation Science. 14, 1, 38.

    Research output: Contribution to journalArticle

  32. Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload

    Smyrnias, I., Gray, S. P., Okonko, D. O., Sawyer, G., Zoccarato, A., Catibog, N., López, B., González, A., Ravassa, S., Díez, J. & Shah, A. M., 16 Apr 2019, In : Journal of the American College of Cardiology. 73, 14, p. 1795 - 1806 12 p.

    Research output: Contribution to journalArticle

  33. Incidence of eclampsia and related complications across 10 low- and middle-resource geographical regions: Secondary analysis of a cluster randomised controlled trial

    CRADLE Trial Collaborative Group, 29 Mar 2019, In : PLoS Medicine. 16, 3, 15 p., e1002775.

    Research output: Contribution to journalArticle

  34. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses

    Ovadia, C., Seed, P. T., Sklavounos, A., Geenes, V., Di Illio, C., Chambers, J., Kohari, K., Bacq, Y., Bozkurt, N., Brun-furrer, R., Bull, L., Estiú, M. C., Grymowicz, M., Gunaydin, B., Hague, W. M., Haslinger, C., Hu, Y., Kawakita, T., Kebapcilar, A. G., Kebapcilar, L. & 20 others, Kondrackienė, J., Koster, M. P. H., Kowalska-kańka, A., Kupčinskas, L., Lee, R. H., Locatelli, A., Macias, R. I. R., Marschall, H., Oudijk, M. A., Raz, Y., Rimon, E., Shan, D., Shao, Y., Tribe, R., Tripodi, V., Yayla Abide, C., Yenidede, I., Thornton, J. G., Chappell, L. C. & Williamson, C., 2 Mar 2019, In : The Lancet. 393, 10174, p. 899-909 11 p.

    Research output: Contribution to journalArticle

  35. Effect of a novel vital sign device on maternal mortality and morbidity in low-resource settings: a pragmatic, stepped-wedge, cluster-randomised controlled trial

    CRADLE Trial Collaborative Group, Vousden, N., Lawley, E., Nathan, H. L., Seed, P. T., Gidiri, M. F., Goudar, S., Sandall, J., Chappell, L. C., Shennan, A. H., Kachinjika, M., Bukani, D., Makwakwa, J., Makonyola, G., Brown, A., Toussaint, P., Vixama, A., Greene, G., Hill, C., Nakiriija, E. & 31 others, Birungi, D., Kalyowa, N., Namakula, D., Byamugisha, J., Nakimuli, A., Mackayi Odeke, N., Ditai, J., Wandabwa, J., Momodou, F., Sesay, M., Sandi, P., Conteh, J., Kamara, J., Clarke, M., Best, R., Miti, J., Kopeka, M., Vwalika, B., Chima, M., Musonda, T., Jere, C., Chinkoyo, S., Mambo, V., Guchale, Y., Yadeta, L., Surur, F., Mungarwadi, G. M., Mastiholi, S. S., Karadiguddi, C. C., Hezelgrave, N. & Duhig, K. E., Mar 2019, In : The Lancet. Global health. 7, 3, p. e347-e356

    Research output: Contribution to journalArticle

  36. Serum creatinine in pregnancy: a systematic review

    Wiles, K., Bramham, K., Seed, P. T., Nelson-Piercy, C., Lightstone, L. & Chappell, L. C., Mar 2019, In : Kidney International Reports. 4, 3, p. 408-419 12 p.

    Research output: Contribution to journalArticle

  37. Paracrine Mechanisms of Redox Signalling for Postmitotic Cell and Tissue Regeneration

    Hervera, A., Santos, C. X., De Virgiliis, F., Shah, A. M. & Di Giovanni, S., 19 Feb 2019, In : Trends in cell biology. 29, 6, p. 514-530 17 p.

    Research output: Contribution to journalReview article

  38. Planned delivery or expectant management for late preterm pre-eclampsia: Study protocol for a randomised controlled trial (PHOENIX trial)

    Chappell, L. C., Green, M., Marlow, N., Sandall, J., Hunter, R., Robson, S., Bowler, U., Chiocchia, V., Hardy, P., Juszczak, E., Linsell, L., Placzek, A., Brocklehurst, P. & Shennan, A., 28 Jan 2019, In : Trials. 20, 1, p. 85 85.

    Research output: Contribution to journalArticle

  39. A machine learning approach for the prediction of pulmonary hypertension

    Leha, A., Hellenkamp, K., Unsöld, B., Mushemi-Blake, S., Shah, A. M., Hasenfuß, G. & Seidler, T., 1 Jan 2019, In : PLoS ONE. 14, 10, e0224453.

    Research output: Contribution to journalArticle

  40. Reducing maternal deaths from hypertensive disorders: Learning from confidential inquiries

    Conti-Ramsden, F., Knight, M., Green, M., Shennan, A. H. & Chappell, L. C., 1 Jan 2019, In : BMJ (Online). 364, l230.

    Research output: Contribution to journalArticle

  41. Tolerizing CTL by sustained hepatic PD-L1 expression provides a new therapy approach in mouse sepsis

    Von Knethen, A., Schäfer, A., Kuchler, L., Knape, T., Christen, U., Hintermann, E., Fißlthaler, B., Schröder, K., Brandes, R. P., Genz, B., Abshagen, K., Pützer, B. M., Sha, L. K., Weigert, A., Syed, S. N., Schulz, M., Shah, A. M., Ernst, A., Putyrski, M., Finkelmeier, F. & 7 others, Pesic, M., Greten, F., Hogardt, M., Kempf, V. A. J., Gunne, S., Parnham, M. J. & Brüne, B., 1 Jan 2019, In : Theranostics. 9, 7, p. 2003-2016 14 p.

    Research output: Contribution to journalArticle

  42. Temporal and external validation of the fullPIERS model for the prediction of adverse maternal outcomes in women with pre-eclampsia

    Ukah, U. V., Payne, B., Karjalainen, H., Kortelainen, E., Seed, P. T., Conti-Ramsden, F. I., Cao, V., Laivuori, H., Hutcheon, J., Chappell, L., Ansermino, J. M., Vatish, M., Redman, C., Lee, T., Li, L., Magee, L. A. & von Dadelszen, P., Jan 2019, In : Pregnancy Hypertension. 15, p. 42-50 9 p.

    Research output: Contribution to journalArticle

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