King's College London

Research portal

Research Outputs

  1. 2019
  2. Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology

    Reichenstein, I., Eitan, C., Diaz-Garcia, S., Haim, G., Magen, I., Siany, A., Hoye, M. L., Rivkin, N., Olender, T., Toth, B., Ravid, R., Mandelbaum, A. D., Yanowski, E., Liang, J., Rymer, J. K., Levy, R., Beck, G., Ainbinder, E., Farhan, S. M. K., Lennox, K. A. & 25 others, Bode, N. M., Behlke, M. A., Möller, T., Saxena, S., Moreno, C. A. M., Costaguta, G., van Eijk, K. R., Phatnani, H., Al-Chalabi, A., Başak, A. N., van den Berg, L. H., Hardiman, O., Landers, J. E., Mora, J. S., Morrison, K. E., Shaw, P. J., Veldink, J. H., Pfaff, S. L., Yizhar, O., Gross, C., Brown, R. H., Ravits, J. M., Harms, M. B., Miller, T. M. & Hornstein, E., 18 Dec 2019, In : Science Translational Medicine. 11, 523, eaav5264.

    Research output: Contribution to journalArticle

  3. Cardiac monocytes and macrophages after myocardial infarction

    Peet, C., Ivetic, A., Bromage, D. I. & Shah, A. M., 16 Dec 2019, In : Cardiovascular Research. cvz336.

    Research output: Contribution to journalArticle

  4. Critical design considerations for time-to-event endpoints in amyotrophic lateral sclerosis clinical trials

    Van Eijk, R. P. A., Nikolakopoulos, S., Roes, K. C. B., Middelkoop, B. M., Ferguson, T. A., Shaw, P. J., Leigh, P. N., Al-Chalabi, A., Eijkemans, M. J. C. & Van Den Berg, L. H., 1 Dec 2019, In : Journal of Neurology, Neurosurgery and Psychiatry. 90, 12, p. 1331-1337 7 p.

    Research output: Contribution to journalArticle

  5. Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein

    ALSGENS Consortium, FALS Consortium, Project MinE Consortium & CReATe Consortium, 1 Dec 2019, In : Nature Neuroscience. 22, 12, p. 1966-1974 9 p.

    Research output: Contribution to journalArticle

  6. Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data

    Bean, D., Teo, J., Wu, H., Oliveira, R., Patel, R., Bendayan, R., Shah, A. M., Dobson, R. J. B. & Scott, P. A., 25 Nov 2019, In : PLOS One. 14, 11, e0225625.

    Research output: Contribution to journalArticle

  7. Association of troponin level and age with mortality in 250 000 patients: cohort study across five UK acute care centres

    Kaura, A., Panoulas, V., Glampson, B., Davies, J., Mulla, A., Woods, K., Omigie, J., Shah, A. D., Channon, K. M., Weber, J. N., Thursz, M. R., Elliott, P., Hemingway, H., Williams, B., Asselbergs, F., O'Sullivan, M., Kharbanda, R., Lord, G. M., Melikian, N., Patel, R. S. & 4 others, Perera, D., Shah, A. M., Francis, D. P. & Mayet, J., 20 Nov 2019, In : BMJ (Clinical research ed.). 367, p. l6055 l6055.

    Research output: Contribution to journalArticle

  8. Prelamin A mediates myocardial inflammation in dilated and HIV-Associated cardiomyopathies

    Brayson, D., Frustaci, A., Verardo, R., Chimenti, C., Russo, M. A., Hayward, R., Ahmad, S. M., Vizcay-barrena, G., Protti, A., Zammit, P. S., Dos Remedios, C. G., Ehler, E., Shah, A. M. & Shanahan, C. M., 14 Nov 2019, In : JCI Insight. 4, 22, e126315.

    Research output: Contribution to journalArticle

  9. Potential of the Cardiovascular Drug Levosimendan in the Management of Amyotrophic Lateral Sclerosis: An Overview of a Working Hypothesis

    Al-Chalabi, A., Heunks, L. M. A., Papp, Z. & Pollesello, P., 1 Nov 2019, In : Journal of Cardiovascular Pharmacology. 74, 5, p. 389-399 11 p.

    Research output: Contribution to journalArticle

  10. Therapies to limit myocardial injury in animal models of myocarditis: a systematic review and meta-analysis

    Silverblatt, J. A., Ziff, O. J., Dancy, L., Daniel, A., Carter, B. R., Scott, P. A., Sado, D., Shah, A. M. & Bromage, D. I., Nov 2019, In : Basic Research in Cardiology. 114, 6, 48.

    Research output: Contribution to journalArticle

  11. Amyotrophic lateral sclerosis as a multi-step process: an Australia population study

    Vucic, S., Westeneng, H. J., Al-Chalabi, A., Van Den Berg, L. H., Talman, P. & Kiernan, M. C., 2 Oct 2019, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration . 20, 7-8, p. 532-537 6 p.

    Research output: Contribution to journalArticle

  12. Needs and preferences for psychological interventions of people with motor neuron disease

    Weeks, K., Gould, R., McDermott, C. J., Lynch, J., Goldstein, L. H., Graham, C. D., McCracken, L., Serfaty, M., Howard, R., Al-Chalabi, A., White, D., Bradburn, M., Young, T., Cooper, C., Shaw, P. J. & Lawrence, V. C., 2 Oct 2019, In : Amyotrophic lateral sclerosis & frontotemporal degeneration. 20, 7-8, p. 521-531 11 p.

    Research output: Contribution to journalArticle

  13. Safety and tolerability of Triumeq in amyotrophic lateral sclerosis: the Lighthouse trial

    Gold, J., Rowe, D. B., Kiernan, M. C., Vucic, S., Mathers, S., van Eijk, R. P. A., Nath, A., Garcia Montojo, M., Norato, G., Santamaria, U. A., Rogers, M. L., Malaspina, A., Lombardi, V., Mehta, P. R., Westeneng, H. J., van den Berg, L. H. & Al-Chalabi, A., 2 Oct 2019, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration . 20, 7-8, p. 595-604 10 p.

    Research output: Contribution to journalArticle

  14. Assessing the role of extracellular signal-regulated kinases 1 and 2 in volume overload-induced cardiac remodelling

    Jochmann, S., Elkenani, M., Mohamed, B. A., Buchholz, E., Lbik, D., Binder, L., Lorenz, K., Shah, A. M., Hasenfuß, G., Toischer, K. & Schnelle, M., 1 Oct 2019, In : ESC Heart Failure. 6, 5, p. 1015-1026 12 p.

    Research output: Contribution to journalArticle

  15. Oral levosimendan in amyotrophic lateral sclerosis: a phase II multicentre, randomised, double-blind, placebo-controlled trial

    Al-Chalabi, A., Shaw, P., Leigh, P. N., van den Berg, L., Hardiman, O., Ludolph, A., Aho, V. V., Sarapohja, T. & Kuoppamäki, M., Oct 2019, In : Journal of neurology, neurosurgery, and psychiatry. 90, 10, p. 1165-1170 6 p.

    Research output: Contribution to journalArticle

  16. Single-cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction

    Li, Z., Solomonidis, E. G., Meloni, M., Taylor, R. S., Duffin, R., Dobie, R., Magalhaes, M. S., Henderson, B. E. P., Louwe, P. A., D'Amico, G., Hodivala-Dilke, K. M., Shah, A. M., Mills, N. L., Simons, B. D., Gray, G. A., Henderson, N. C., Baker, A. H. & Brittan, M., 7 Aug 2019, In : European Heart Journal. 40, 30, p. 2507-2520 14 p.

    Research output: Contribution to journalArticle

  17. The relationships between symptoms, disability, perceived health and quality of life in amyotrophic lateral sclerosis/motor neuron disease

    Young, C. A., Ealing, J., McDermott, C., Williams, T., Al-Chalabi, A., Majeed, T., Burke, G., Pinto, A., Dick, D., Talbot, K., Harrower, T., Walsh, J., Chandran, S., Hanemann, C. O., Mills, R. & Tennant, A., 3 Jul 2019, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration . 20, 5-6, p. 317-327 11 p.

    Research output: Contribution to journalArticle

  18. Genome-wide survey of copy number variants finds MAPT duplications in progressive supranuclear palsy

    NNIPPS and BBBIPPS Study Groups, 1 Jul 2019, In : Movement Disorders. 34, 7, p. 1049-1059 11 p.

    Research output: Contribution to journalArticle

  19. The continuous heart failure spectrum: moving beyond an ejection fraction classification

    Triposkiadis, F., Butler, J., Abboud, F. M., Armstrong, P. W., Adamopoulos, S., Atherton, J. J., Backs, J., Bauersachs, J., Burkhoff, D., Bonow, R. O., Chopra, V. K., de Boer, R. A., de Windt, L., Hamdani, N., Hasenfuss, G., Heymans, S., Hulot, J. S., Konstam, M., Lee, R. T., Linke, W. A. & 22 others, Lunde, I. G., Lyon, A. R., Maack, C., Mann, D. L., Mebazaa, A., Mentz, R. J., Nihoyannopoulos, P., Papp, Z., Parissis, J., Pedrazzini, T., Rosano, G., Rouleau, J., Seferovic, P. M., Shah, A. M., Starling, R. C., Tocchetti, C. G., Trochu, J. N., Thum, T., Zannad, F., Brutsaert, D. L., Segers, V. F. & De Keulenaer, G. W., 1 Jul 2019, In : European Heart Journal. 40, 26, p. 2155-2163B 9 p.

    Research output: Contribution to journalReview article

  20. Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension

    Rudyk, O., Rowan, A., Prysyazhna, O., Krasemann, S., Hartmann, K., Zhang, M., Shah, A. M., Ruppert, C., Weiss, A., Schermuly, R. T., Ida, T., Akaike, T., Zhao, L. & Eaton, P., 25 Jun 2019, In : PNAS. 116, 26, p. 13016-13025 10 p.

    Research output: Contribution to journalArticle

  21. Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer

    Tiwari, P., Blank, A., Cui, C., Schoenfelt, K. Q., Zhou, G., Xu, Y., Khramtsova, G., Olopade, F., Shah, A. M., Khan, S. A., Rosner, M. R. & Becker, L., 3 Jun 2019, In : The Journal of experimental medicine. 216, 6, p. 1345-1358 14 p.

    Research output: Contribution to journalArticle

  22. Effect of Iron Isomaltoside on Skeletal Muscle Energetics in Patients with Chronic Heart Failure and Iron Deficiency: FERRIC-HF II Randomized Mechanistic Trial

    Charles-Edwards, G., Amaral, N., Sleigh, A., Ayis, S., Catibog, N., McDonagh, T., Monaghan, M., Amin-Youseff, G., Kemp, G. J., Shah, A. M. & Okonko, D. O., 21 May 2019, In : Circulation. 139, 21, p. 2386-2398 13 p.

    Research output: Contribution to journalArticle

  23. Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload

    Smyrnias, I., Gray, S. P., Okonko, D. O., Sawyer, G., Zoccarato, A., Catibog, N., López, B., González, A., Ravassa, S., Díez, J. & Shah, A. M., 16 Apr 2019, In : Journal of the American College of Cardiology. 73, 14, p. 1795 - 1806 12 p.

    Research output: Contribution to journalArticle

  24. A standard operating procedure for King’s ALS clinical staging

    Balendra, R., Al Khleifat, A., Fang, T. & Al-Chalabi, A., 3 Apr 2019, In : Amyotrophic lateral sclerosis & frontotemporal degeneration. 20, 3-4, p. 159-164 6 p.

    Research output: Contribution to journalArticle

  25. Predicting the future of ALS: the impact of demographic change and potential new treatments on the prevalence of ALS in the United Kingdom, 2020–2116

    Gowland, A., Opie-Martin, S., Scott, K. M., Jones, A. R., Mehta, P. R., Batts, C. J., Ellis, C. M., Leigh, P. N., Shaw, C. E., Sreedharan, J. & Al-Chalabi, A., 3 Apr 2019, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration . 20, 3-4, p. 264-274 11 p.

    Research output: Contribution to journalArticle

  26. Telomere length is greater in ALS than in controls: A whole genome sequencing study

    Al Khleifat, A., Iacoangeli, A., Shatunov, A., Fang, T., Sproviero, W., Jones, A. R., Opie-Martin, S., Morrison, K. E., Shaw, P. J., Shaw, C. E. D., Powell, J. F., Dobson, R. J. B., Newhouse, S. & Al-Chalabi, A., 3 Apr 2019, In : Amyotrophic lateral sclerosis & frontotemporal degeneration. 20, 3-4, p. 229-234 6 p., IAFD 1586951.

    Research output: Contribution to journalArticle

  27. Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis

    Garson, J. A., Usher, L., Al-Chalabi, A., Huggett, J., Day, E. F. & McCormick, A. L., 18 Mar 2019, In : Acta Neuropathologica Communications. 7, 1, p. 45 1 p.

    Research output: Contribution to journalArticle

  28. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

    Alzheimer Disease Genetics Consortium (ADGC), Mar 2019, In : Nature Genetics. 51, 3, p. 414-430 17 p.

    Research output: Contribution to journalArticle

  29. Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis

    Cooper-Knock, J., Moll, T., Ramesh, T., Castelli, L., Beer, A., Robins, H., Fox, I., Niedermoser, I., Van Damme, P., Moisse, M., Robberecht, W., Hardiman, O., Panades, M. P., Assialioui, A., Mora, J. S., Basak, A. N., Morrison, K. E., Shaw, C. E., Al-Chalabi, A., Landers, J. E. & 9 others, Wyles, M., Heath, P. R., Higginbottom, A., Walsh, T., Kazoka, M., McDermott, C. J., Hautbergue, G. M., Kirby, J. & Shaw, P. J., 26 Feb 2019, In : Cell Reports. 26, 9, p. 2298-2306.e5

    Research output: Contribution to journalArticle

  30. Paracrine Mechanisms of Redox Signalling for Postmitotic Cell and Tissue Regeneration

    Hervera, A., Santos, C. X., De Virgiliis, F., Shah, A. M. & Di Giovanni, S., 19 Feb 2019, In : Trends in cell biology. 29, 6, p. 514-530 17 p.

    Research output: Contribution to journalReview article

  31. A machine learning approach for the prediction of pulmonary hypertension

    Leha, A., Hellenkamp, K., Unsöld, B., Mushemi-Blake, S., Shah, A. M., Hasenfuß, G. & Seidler, T., 1 Jan 2019, In : PLoS ONE. 14, 10, e0224453.

    Research output: Contribution to journalArticle

  32. New therapies for neuromuscular diseases in 2018

    Shah, A. M. & Al-Chalabi, A., 1 Jan 2019, In : The Lancet Neurology. 18, 1, p. 12-13 2 p.

    Research output: Contribution to journalComment/debate

  33. Objectively monitoring amyotrophic lateral sclerosis patient symptoms during clinical trials with sensors: Observational study

    Garcia-Gancedo, L., Kelly, M. L., Lavrov, A., Parr, J., Hart, R., Marsden, R., Turner, M. R., Talbot, K., Chiwera, T., Shaw, C. E. & Al-Chalabi, A., 1 Jan 2019, In : Journal of Medical Internet Research. 21, 12, e13433.

    Research output: Contribution to journalArticle

  34. Tolerizing CTL by sustained hepatic PD-L1 expression provides a new therapy approach in mouse sepsis

    Von Knethen, A., Schäfer, A., Kuchler, L., Knape, T., Christen, U., Hintermann, E., Fißlthaler, B., Schröder, K., Brandes, R. P., Genz, B., Abshagen, K., Pützer, B. M., Sha, L. K., Weigert, A., Syed, S. N., Schulz, M., Shah, A. M., Ernst, A., Putyrski, M., Finkelmeier, F. & 7 others, Pesic, M., Greten, F., Hogardt, M., Kempf, V. A. J., Gunne, S., Parnham, M. J. & Brüne, B., 1 Jan 2019, In : Theranostics. 9, 7, p. 2003-2016 14 p.

    Research output: Contribution to journalArticle

  35. Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease

    Nagel, E., Greenwood, J. P., McCann, G. P., Bettencourt, N., Shah, A. M., Hussain, S. T., Perera, D., Plein, S., Bucciarelli-Ducci, C., Paul, M., Westwood, M. A., Marber, M. & Investigators, MR-INFORM., 2019, In : New England Journal of Medicine. 380, 25, p. 2418-2428 11 p.

    Research output: Contribution to journalArticle

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