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Research Outputs

  1. 2019
  2. Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology

    Reichenstein, I., Eitan, C., Diaz-Garcia, S., Haim, G., Magen, I., Siany, A., Hoye, M. L., Rivkin, N., Olender, T., Toth, B., Ravid, R., Mandelbaum, A. D., Yanowski, E., Liang, J., Rymer, J. K., Levy, R., Beck, G., Ainbinder, E., Farhan, S. M. K., Lennox, K. A. & 25 others, Bode, N. M., Behlke, M. A., Möller, T., Saxena, S., Moreno, C. A. M., Costaguta, G., van Eijk, K. R., Phatnani, H., Al-Chalabi, A., Başak, A. N., van den Berg, L. H., Hardiman, O., Landers, J. E., Mora, J. S., Morrison, K. E., Shaw, P. J., Veldink, J. H., Pfaff, S. L., Yizhar, O., Gross, C., Brown, R. H., Ravits, J. M., Harms, M. B., Miller, T. M. & Hornstein, E., 18 Dec 2019, In : Science Translational Medicine. 11, 523, eaav5264.

    Research output: Contribution to journalArticle

  3. Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

    Postema, M. C., van Rooij, D., Anagnostou, E., Arango, C., Auzias, G., Behrmann, M., Filho, G. B., Calderoni, S., Calvo, R., Daly, E., Deruelle, C., Di Martino, A., Dinstein, I., Duran, F. L. S., Durston, S., Ecker, C., Ehrlich, S., Fair, D., Fedor, J., Feng, X. & 38 others, Fitzgerald, J., Floris, D. L., Freitag, C. M., Gallagher, L., Glahn, D. C., Gori, I., Haar, S., Hoekstra, L., Jahanshad, N., Jalbrzikowski, M., Janssen, J., King, J. A., Kong, X. Z., Lazaro, L., Lerch, J. P., Luna, B., Martinho, M. M., McGrath, J., Medland, S. E., Muratori, F., Murphy, C. M., Murphy, D. G. M., O'Hearn, K., Oranje, B., Parellada, M., Puig, O., Retico, A., Rosa, P., Rubia, K., Shook, D., Taylor, M. J., Tosetti, M., Wallace, G. L., Zhou, F., Thompson, P. M., Fisher, S. E., Buitelaar, J. K. & Francks, C., 1 Dec 2019, In : Nature Communications. 10, 1, 4958.

    Research output: Contribution to journalArticle

  4. Critical design considerations for time-to-event endpoints in amyotrophic lateral sclerosis clinical trials

    Van Eijk, R. P. A., Nikolakopoulos, S., Roes, K. C. B., Middelkoop, B. M., Ferguson, T. A., Shaw, P. J., Leigh, P. N., Al-Chalabi, A., Eijkemans, M. J. C. & Van Den Berg, L. H., 1 Dec 2019, In : Journal of Neurology, Neurosurgery and Psychiatry. 90, 12, p. 1331-1337 7 p.

    Research output: Contribution to journalArticle

  5. Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein

    ALSGENS Consortium, FALS Consortium, Project MinE Consortium & CReATe Consortium, 1 Dec 2019, In : Nature Neuroscience. 22, 12, p. 1966-1974 9 p.

    Research output: Contribution to journalArticle

  6. Potential of the Cardiovascular Drug Levosimendan in the Management of Amyotrophic Lateral Sclerosis: An Overview of a Working Hypothesis

    Al-Chalabi, A., Heunks, L. M. A., Papp, Z. & Pollesello, P., 1 Nov 2019, In : Journal of Cardiovascular Pharmacology. 74, 5, p. 389-399 11 p.

    Research output: Contribution to journalArticle

  7. Father-infant interactions and infant regional brain volumes: a cross-sectional MRI study

    Sethna, V., Pote, I., Wang, S., Gudbrandsen, C. M., Lee, C., Perry, E. L., P H Adams, K., Watson, C., Kangas, J., Murphy, D. G., Daly, E., Stoencheva, V. V., Kuklisova-Murgasova, M., Williams, S. C. R., Craig, M. C. & McAlonan, G. M., 16 Oct 2019, In : Developmental Cognitive Neuroscience.

    Research output: Contribution to journalArticle

  8. Amyotrophic lateral sclerosis as a multi-step process: an Australia population study

    Vucic, S., Westeneng, H. J., Al-Chalabi, A., Van Den Berg, L. H., Talman, P. & Kiernan, M. C., 2 Oct 2019, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration . 20, 7-8, p. 532-537 6 p.

    Research output: Contribution to journalArticle

  9. Needs and preferences for psychological interventions of people with motor neuron disease

    Weeks, K., Gould, R., McDermott, C. J., Lynch, J., Goldstein, L. H., Graham, C. D., McCracken, L., Serfaty, M., Howard, R., Al-Chalabi, A., White, D., Bradburn, M., Young, T., Cooper, C., Shaw, P. J. & Lawrence, V. C., 2 Oct 2019, In : Amyotrophic lateral sclerosis & frontotemporal degeneration. 20, 7-8, p. 521-531 11 p.

    Research output: Contribution to journalArticle

  10. Safety and tolerability of Triumeq in amyotrophic lateral sclerosis: the Lighthouse trial

    Gold, J., Rowe, D. B., Kiernan, M. C., Vucic, S., Mathers, S., van Eijk, R. P. A., Nath, A., Garcia Montojo, M., Norato, G., Santamaria, U. A., Rogers, M. L., Malaspina, A., Lombardi, V., Mehta, P. R., Westeneng, H. J., van den Berg, L. H. & Al-Chalabi, A., 2 Oct 2019, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration . 20, 7-8, p. 595-604 10 p.

    Research output: Contribution to journalArticle

  11. Oral levosimendan in amyotrophic lateral sclerosis: a phase II multicentre, randomised, double-blind, placebo-controlled trial

    Al-Chalabi, A., Shaw, P., Leigh, P. N., van den Berg, L., Hardiman, O., Ludolph, A., Aho, V. V., Sarapohja, T. & Kuoppamäki, M., Oct 2019, In : Journal of neurology, neurosurgery, and psychiatry. 90, 10, p. 1165-1170 6 p.

    Research output: Contribution to journalArticle

  12. From pattern classification to stratification: towards conceptualizing the heterogeneity of Autism Spectrum Disorder

    Wolfers, T., Floris, D. L., Dinga, R., van Rooij, D., Isakoglou, C., Kia, S. M., Zabihi, M., Llera, A., Chowdanayaka, R., Kumar, V. J., Peng, H., Laidi, C., Batalle, D., Dimitrova, R., Charman, T., Loth, E., Lai, M-C., Jones, E., Baumeister, S., Moessnang, C. & 8 others, Banaschewski, T., Ecker, C., Dumas, G., O'Muircheartaigh, J., Murphy, D., Buitelaar, J. K., Marquand, A. F. & Beckmann, C. F., Sep 2019, In : Neuroscience and biobehavioral reviews. 104, p. 240-254 15 p.

    Research output: Contribution to journalReview article

  13. The relationships between symptoms, disability, perceived health and quality of life in amyotrophic lateral sclerosis/motor neuron disease

    Young, C. A., Ealing, J., McDermott, C., Williams, T., Al-Chalabi, A., Majeed, T., Burke, G., Pinto, A., Dick, D., Talbot, K., Harrower, T., Walsh, J., Chandran, S., Hanemann, C. O., Mills, R. & Tennant, A., 3 Jul 2019, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration . 20, 5-6, p. 317-327 11 p.

    Research output: Contribution to journalArticle

  14. Genome-wide survey of copy number variants finds MAPT duplications in progressive supranuclear palsy

    NNIPPS and BBBIPPS Study Groups, 1 Jul 2019, In : Movement Disorders. 34, 7, p. 1049-1059 11 p.

    Research output: Contribution to journalArticle

  15. Investigating the Factors Underlying Adaptive Functioning in Autism in the EU-AIMS Longitudinal European Autism Project

    Tillmann, J., San Jose Caceres, A., Chatham, C. H., Crawley, D., Holt, R., Oakley, B., Banaschewski, T., Baron-Cohen, S., Bölte, S., Buitelaar, J. K., Durston, S., Ham, L., Loth, E., Simonoff, E., Spooren, W., Murphy, D. G. & Charman, T., 5 Apr 2019, In : Autism research. 12, 4, p. 645-657 13 p.

    Research output: Contribution to journalArticle

  16. A standard operating procedure for King’s ALS clinical staging

    Balendra, R., Al Khleifat, A., Fang, T. & Al-Chalabi, A., 3 Apr 2019, In : Amyotrophic lateral sclerosis & frontotemporal degeneration. 20, 3-4, p. 159-164 6 p.

    Research output: Contribution to journalArticle

  17. Predicting the future of ALS: the impact of demographic change and potential new treatments on the prevalence of ALS in the United Kingdom, 2020–2116

    Gowland, A., Opie-Martin, S., Scott, K. M., Jones, A. R., Mehta, P. R., Batts, C. J., Ellis, C. M., Leigh, P. N., Shaw, C. E., Sreedharan, J. & Al-Chalabi, A., 3 Apr 2019, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration . 20, 3-4, p. 264-274 11 p.

    Research output: Contribution to journalArticle

  18. Telomere length is greater in ALS than in controls: A whole genome sequencing study

    Al Khleifat, A., Iacoangeli, A., Shatunov, A., Fang, T., Sproviero, W., Jones, A. R., Opie-Martin, S., Morrison, K. E., Shaw, P. J., Shaw, C. E. D., Powell, J. F., Dobson, R. J. B., Newhouse, S. & Al-Chalabi, A., 3 Apr 2019, In : Amyotrophic lateral sclerosis & frontotemporal degeneration. 20, 3-4, p. 229-234 6 p., IAFD 1586951.

    Research output: Contribution to journalArticle

  19. Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis

    Garson, J. A., Usher, L., Al-Chalabi, A., Huggett, J., Day, E. F. & McCormick, A. L., 18 Mar 2019, In : Acta Neuropathologica Communications. 7, 1, p. 45 1 p.

    Research output: Contribution to journalArticle

  20. Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project

    Oldehinkel, M., Mennes, M., Marquand, A., Charman, T., Tillmann, J., Ecker, C., Dell’acqua, F., Brandeis, D., Banaschewski, T., Baumeister, S., Moessnang, C., Holt, R., Baron-cohen, S., Bölte, S., Durston, S., Kundu, P., Lombardo, M. V., Spooren, W., Loth, E., Murphy, D. G. M. & 31 others, Beckmann, C. F., Buitelaar, J. K., EU-AIMS LEAP group, Ahmad, J., Ambrosino, S., Auyeung, B., Banaschewski, T., Baron-cohen, S., Baumeister, S., Beckmann, C. F., Bölte, S., Bourgeron, T., Bours, C., Brammer, M., Brandeis, D., Brogna, C., Charman, T., Crawley, D., Ecker, C., Faulkner, J., Hayward, H., Loth, E., Lythgoe, D. J., Marquand, A., Murphy, D. G. M., Oakley, B., Ruggeri, B., San José Cáceres, A., Simonoff, E., Tillmann, J. & Williams, S. C. R., Mar 2019, In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 3, p. 260-270

    Research output: Contribution to journalArticle

  21. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

    Alzheimer Disease Genetics Consortium (ADGC), Mar 2019, In : Nature Genetics. 51, 3, p. 414-430 17 p.

    Research output: Contribution to journalArticle

  22. Patients with autism spectrum disorders display reproducible functional connectivity alterations

    Holiga, Š., Hipp, J. F., Chatham, C. H., Garces, P., Spooren, W., D’Ardhuy, X. L., Bertolino, A., Bouquet, C., Buitelaar, J. K., Bours, C., Rausch, A., Oldehinkel, M., Bouvard, M., Amestoy, A., Caralp, M., Gueguen, S., Moal, M. L. L., Houenou, J., Beckmann, C. F., Loth, E. & 15 others, Murphy, D., Charman, T., Tillmann, J., Laidi, C., Delorme, R., Beggiato, A., Gaman, A., Scheid, I., Leboyer, M., d’Albis, M. A., Sevigny, J., Czech, C., Bolognani, F., Honey, G. D. & Dukart, J., 27 Feb 2019, In : Science Translational Medicine. 11, 481, eaat9223.

    Research output: Contribution to journalArticle

  23. Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis

    Cooper-Knock, J., Moll, T., Ramesh, T., Castelli, L., Beer, A., Robins, H., Fox, I., Niedermoser, I., Van Damme, P., Moisse, M., Robberecht, W., Hardiman, O., Panades, M. P., Assialioui, A., Mora, J. S., Basak, A. N., Morrison, K. E., Shaw, C. E., Al-Chalabi, A., Landers, J. E. & 9 others, Wyles, M., Heath, P. R., Higginbottom, A., Walsh, T., Kazoka, M., McDermott, C. J., Hautbergue, G. M., Kirby, J. & Shaw, P. J., 26 Feb 2019, In : Cell Reports. 26, 9, p. 2298-2306.e5

    Research output: Contribution to journalArticle

  24. New therapies for neuromuscular diseases in 2018

    Shah, A. M. & Al-Chalabi, A., 1 Jan 2019, In : The Lancet Neurology. 18, 1, p. 12-13 2 p.

    Research output: Contribution to journalComment/debate

  25. Objectively monitoring amyotrophic lateral sclerosis patient symptoms during clinical trials with sensors: Observational study

    Garcia-Gancedo, L., Kelly, M. L., Lavrov, A., Parr, J., Hart, R., Marsden, R., Turner, M. R., Talbot, K., Chiwera, T., Shaw, C. E. & Al-Chalabi, A., 1 Jan 2019, In : Journal of Medical Internet Research. 21, 12, e13433.

    Research output: Contribution to journalArticle

  26. Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study

    Villalon-Reina, J. E., Martínez, K., Qu, X., Ching, C. R. K., Nir, T., Kothapalli, D., Corbin, C., Sun, D., Lin, A., Forsyth, J. K., Kushan, L., Vajdi, A., Jalbrzikowski, M., Hansen, L., Jonas, R. K., Van Amelsvoort, T., Bakker, G., Kates, W. R., Antshel, K. M., Fremont, W. & 33 others, Campbell, L. E., McCabe, K. L., Gudbrandsen, C. M., Daly, E. M., Gudbrandsen, C. M., Murphy, C., Murphy, D. G., Craig, M., Emanuel, B. S., McDonald-McGinn, D. M., Vorstman, J. A. S., Fiksinski, A., Koops, S., Ruparel, K., Roalf, D. R., Gur, R. E., Schmitt, J. E., Simon, T. J., Goodrich-hunsaker, N. J., Durdle, C. A., Doherty, J., Cunningham, A. C., van den Bree, M., Linden, D. E. J., Owen, M. J., Moss, H., Kelly, S., Donohoe, G., Murphy, K. C., Arango, C., Jahanshad, N., Thompson, P. M. & Bearden, C. E., 2019, In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

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