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Research Outputs

  1. 2019
  2. Cardiac monocytes and macrophages after myocardial infarction

    Peet, C., Ivetic, A., Bromage, D. I. & Shah, A. M., 16 Dec 2019, In : Cardiovascular Research. cvz336.

    Research output: Contribution to journalArticle

  3. Treatment response classes in major depressive disorder identified by model-based clustering and validated by clinical prediction models

    Paul, R., Andlauer, T. F. M., Czamara, D., Hoehn, D., Lucae, S., Pütz, B., Lewis, C. M., Uher, R., Müller-Myhsok, B., Ising, M. & Sämann, P. G., 1 Dec 2019, In : Translational psychiatry. 9, 1, 187.

    Research output: Contribution to journalArticle

  4. Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data

    Bean, D., Teo, J., Wu, H., Oliveira, R., Patel, R., Bendayan, R., Shah, A. M., Dobson, R. J. B. & Scott, P. A., 25 Nov 2019, In : PLOS One. 14, 11, e0225625.

    Research output: Contribution to journalArticle

  5. Association of troponin level and age with mortality in 250 000 patients: cohort study across five UK acute care centres

    Kaura, A., Panoulas, V., Glampson, B., Davies, J., Mulla, A., Woods, K., Omigie, J., Shah, A. D., Channon, K. M., Weber, J. N., Thursz, M. R., Elliott, P., Hemingway, H., Williams, B., Asselbergs, F., O'Sullivan, M., Kharbanda, R., Lord, G. M., Melikian, N., Patel, R. S. & 4 others, Perera, D., Shah, A. M., Francis, D. P. & Mayet, J., 20 Nov 2019, In : BMJ (Clinical research ed.). 367, p. l6055 l6055.

    Research output: Contribution to journalArticle

  6. Prelamin A mediates myocardial inflammation in dilated and HIV-Associated cardiomyopathies

    Brayson, D., Frustaci, A., Verardo, R., Chimenti, C., Russo, M. A., Hayward, R., Ahmad, S. M., Vizcay-barrena, G., Protti, A., Zammit, P. S., Dos Remedios, C. G., Ehler, E., Shah, A. M. & Shanahan, C. M., 14 Nov 2019, In : JCI Insight. 4, 22, e126315.

    Research output: Contribution to journalArticle

  7. Therapies to limit myocardial injury in animal models of myocarditis: a systematic review and meta-analysis

    Silverblatt, J. A., Ziff, O. J., Dancy, L., Daniel, A., Carter, B. R., Scott, P. A., Sado, D., Shah, A. M. & Bromage, D. I., Nov 2019, In : Basic Research in Cardiology. 114, 6, 48.

    Research output: Contribution to journalArticle

  8. Assessing the role of extracellular signal-regulated kinases 1 and 2 in volume overload-induced cardiac remodelling

    Jochmann, S., Elkenani, M., Mohamed, B. A., Buchholz, E., Lbik, D., Binder, L., Lorenz, K., Shah, A. M., Hasenfuß, G., Toischer, K. & Schnelle, M., 1 Oct 2019, In : ESC Heart Failure. 6, 5, p. 1015-1026 12 p.

    Research output: Contribution to journalArticle

  9. Genetic variation of the endocannabinoids system and risk of first episode psychosis

    Quattrone, D., Vassos, E., Richards, A., Reininghaus, U., Sham, P., O'Donovan, M. C., Lewis, C. M., Murray, R. M. & Di Forti, M., 24 Sep 2019, Genetic variation of the endocannabinoids system and risk of first episode psychosis.

    Research output: Chapter in Book/Report/Conference proceedingConference paper

  10. Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals: Genomic Precision Medicine May Dispense With Ethnicity

    Iniesta, R., Campbell, D., Venturini, C., Faconti, L., Singh, S., Irvin, M. R., Cooper-DeHoff, R. M., Johnson, J. A., Turner, S. T., Arnett, D. K., Weale, M. E., Warren, H., Munroe, P. B., Cruickshank, K., Padmanabhan, S., Lewis, C. & Chowienczyk, P., 1 Sep 2019, In : Hypertension (Dallas, Tex. : 1979). 74, 3, p. 614-622 9 p.

    Research output: Contribution to journalArticle

  11. Prevalence of Advanced Liver Fibrosis in Patients With Severe Psoriasis

    Maybury, C. M., Porter, H. F., Kloczko, E., Duckworth, M., Cotton, A., Thornberry, K., Dew, T., Crook, M., Natas, S., Miquel, R., Lewis, C. M., Wong, T., Smith, C. H. & Barker, J. N., 1 Sep 2019, In : JAMA dermatology. 155, 9, p. 1028-1032 5 p.

    Research output: Contribution to journalArticle

  12. Single-cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction

    Li, Z., Solomonidis, E. G., Meloni, M., Taylor, R. S., Duffin, R., Dobie, R., Magalhaes, M. S., Henderson, B. E. P., Louwe, P. A., D'Amico, G., Hodivala-Dilke, K. M., Shah, A. M., Mills, N. L., Simons, B. D., Gray, G. A., Henderson, N. C., Baker, A. H. & Brittan, M., 7 Aug 2019, In : European Heart Journal. 40, 30, p. 2507-2520 14 p.

    Research output: Contribution to journalArticle

  13. Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Mullins, N., Bigdeli, T. B., Børglum, A. D., Coleman, J. R. I., Demontis, D., Mehta, D., Power, R. A., Ripke, S., Stahl, E. A., Starnawska, A., Anjorin, A., Corvin, A., Sanders, A. R., Forstner, A. J., Reif, A., Koller, A. C., Świątkowska, B., Baune, B. T. & 95 others, Müller-Myhsok, B., Penninx, B. W. J. H., Pato, C. N., Zai, C. C., Rujescu, D., Hougaard, D. M., Quested, D., Levinson, D. F., Binder, E. B., Byrne, E. M., Agerbo, E., Streit, F., Mayoral, F., Bellivier, F., Degenhardt, F., Breen, G. D., Morken, G., Turecki, G., Rouleau, G., Grabe, H. J., Volzke, H., Jones, I., Giegling, I., Agartz, I., Melle, I., Lawrence, J., Walters, J. T. R., Strohmaier, J., Shi, J., Hauser, J., Biernacka, J. M., Vincent, J. B., Kelsoe, J., Strauss, J. S., Lissowska, J., Pimm, J., Smoller, J. W., Guzman-Parra, J., Berger, K., Scott, L. J., Jones, L. A., Azevedo, M. H., Trzaskowski, M., Kogevinas, M., Rietschel, M., Boks, M. P., Ising, M., Grigoroiu-Serbanescu, M., Hamshere, M. L., Leboyer, M., Frye, M. A., Alda, M., Nordentoft, M., Boehnke, M., O'Donovan, M. C., Owen, M. J., Pato, M. T., Renteria, M. E., Wray, N. R., Bass, N., Craddock, N., Smeland, O. B., Andreassen, O. A., Mors, O., Gejman, P. V., Sklar, P., McGrath, P. J., Hoffmann, P., McGuffin, P., Lee, P. H., Mortensen, P. B., Kahn, R. S., Ophoff, R. A., Adolfsson, R., Van der Auwera Affiliations, S., Djurovic, S., Kloiber, S., Heilmann-Heimbach, S., Jamain, S., Hamilton, S. P., Mcelroy, S. L., Lucae, S., Cichon, S., Schulze, T. G., Hansen, T., Werge, T., Air, T. M., Nimgaonkar, V., Appadurai, V., Cahn, W., Milaneschi, Y., Fanous, A. H., Kendler, K. S., McQuillin, A. & Lewis, C. M., 1 Aug 2019, In : The American Journal of Psychiatry. 176, 8, p. 651-660 10 p.

    Research output: Contribution to journalArticle

  14. Polygenic risk for circulating reproductive hormone levels and their influence on hippocampal volume and depression susceptibility

    Smeeth, D. M., Dima, D., Jones, L., Jones, I., Craddock, N., Owen, M. J., Rietschel, M., Maier, W., Korszun, A., Rice, J. P., Mors, O., Preisig, M., Uher, R., Lewis, C. M., Thuret, S. & Powell, T. R., Aug 2019, In : Psychoneuroendocrinology. 106, p. 284-292 9 p.

    Research output: Contribution to journalArticle

  15. Genome-wide survey of copy number variants finds MAPT duplications in progressive supranuclear palsy

    NNIPPS and BBBIPPS Study Groups, 1 Jul 2019, In : Movement Disorders. 34, 7, p. 1049-1059 11 p.

    Research output: Contribution to journalArticle

  16. The continuous heart failure spectrum: moving beyond an ejection fraction classification

    Triposkiadis, F., Butler, J., Abboud, F. M., Armstrong, P. W., Adamopoulos, S., Atherton, J. J., Backs, J., Bauersachs, J., Burkhoff, D., Bonow, R. O., Chopra, V. K., de Boer, R. A., de Windt, L., Hamdani, N., Hasenfuss, G., Heymans, S., Hulot, J. S., Konstam, M., Lee, R. T., Linke, W. A. & 22 others, Lunde, I. G., Lyon, A. R., Maack, C., Mann, D. L., Mebazaa, A., Mentz, R. J., Nihoyannopoulos, P., Papp, Z., Parissis, J., Pedrazzini, T., Rosano, G., Rouleau, J., Seferovic, P. M., Shah, A. M., Starling, R. C., Tocchetti, C. G., Trochu, J. N., Thum, T., Zannad, F., Brutsaert, D. L., Segers, V. F. & De Keulenaer, G. W., 1 Jul 2019, In : European Heart Journal. 40, 26, p. 2155-2163B 9 p.

    Research output: Contribution to journalReview article

  17. Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension

    Rudyk, O., Rowan, A., Prysyazhna, O., Krasemann, S., Hartmann, K., Zhang, M., Shah, A. M., Ruppert, C., Weiss, A., Schermuly, R. T., Ida, T., Akaike, T., Zhao, L. & Eaton, P., 25 Jun 2019, In : PNAS. 116, 26, p. 13016-13025 10 p.

    Research output: Contribution to journalArticle

  18. Genome-wide burden of rare short deletions is enriched in Major Depressive Disorder in four cohorts

    Zhang, X., Abdellaoui, A., Rucker, J., de Jong, S., Potash, J. B., Weissman, M. M., Shi, J., Knowles, J. A., Pato, C., Pato, M., Sobell, J., Smit, J. H., Hottenga, J. J., de Geus, E. J. C., Lewis, C. M., Buttenschøn, H. N., Craddock, N., Jones, I., Jones, L., McGuffin, P. & 13 others, Mors, O., Owen, M. J., Preisig, M., Rietschel, M., Rice, J. P., Rivera, M., Uher, R., Gejman, P. V., Sanders, A. R., Boomsma, D., Penninx, B. W. J. H., Breen, G. & Levinson, D. F., 15 Jun 2019, In : Biological psychiatry. 85, 12, p. 1065-1073 9 p.

    Research output: Contribution to journalArticle

  19. Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 11 Jun 2019, In : Nature Communications. 10, 1, p. 1-18 18 p., 2548.

    Research output: Contribution to journalArticle

  20. Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer

    Tiwari, P., Blank, A., Cui, C., Schoenfelt, K. Q., Zhou, G., Xu, Y., Khramtsova, G., Olopade, F., Shah, A. M., Khan, S. A., Rosner, M. R. & Becker, L., 3 Jun 2019, In : The Journal of experimental medicine. 216, 6, p. 1345-1358 14 p.

    Research output: Contribution to journalArticle

  21. Using genetics to understand the causal influence of higher BMI on depression

    Tyrrell, J., Mulugeta, A., Wood, A. R., Zhou, A., Beaumont, R. N., Tuke, M. A., Jones, S. E., Ruth, K. S., Yaghootkar, H., Sharp, S., Thompson, W. D., Ji, Y., Harrison, J., Freathy, R. M., Murray, A., Weedon, M. N., Lewis, C., Frayling, T. M. & Hyppönen, E., 1 Jun 2019, In : International Journal of Epidemiology. 48, 3, p. 834-848 15 p.

    Research output: Contribution to journalArticle

  22. ukbTools: An R package to manage and query UK Biobank data

    Hanscombe, K. B., Coleman, J. R. I., Traylor, M. & Lewis, C. M., 31 May 2019, In : PLoS ONE. 14, 5, 6 p., e0214311.

    Research output: Contribution to journalArticle

  23. Effect of Iron Isomaltoside on Skeletal Muscle Energetics in Patients with Chronic Heart Failure and Iron Deficiency: FERRIC-HF II Randomized Mechanistic Trial

    Charles-Edwards, G., Amaral, N., Sleigh, A., Ayis, S., Catibog, N., McDonagh, T., Monaghan, M., Amin-Youseff, G., Kemp, G. J., Shah, A. M. & Okonko, D. O., 21 May 2019, In : Circulation. 139, 21, p. 2386-2398 13 p.

    Research output: Contribution to journalArticle

  24. Evidence of causal effect of major depression on alcohol dependence: Findings from the psychiatric genomics consortium

    Polimanti, R., Peterson, R. E., Ong, J. S., MacGregor, S., Edwards, A. C., Clarke, T. K., Frank, J., Gerring, Z., Gillespie, N. A., Lind, P. A., Maes, H. H., Martin, N. G., Mbarek, H., Medland, S. E., Streit, F., Agrawal, A., Edenberg, H. J., Kendler, K. S., Lewis, C. M., Sullivan, P. F. & 3 others, Wray, N. R., Gelernter, J. & Derks, E. M., 1 May 2019, In : Psychological Medicine. 49, 7, p. 1218-1226 9 p.

    Research output: Contribution to journalArticle

  25. Progressing Polygenic Medicine in Psychiatry Through Electronic Health Records

    Lewis, C. M. & Hagenaars, S. P., 1 May 2019, In : JAMA Psychiatry. 76, 5, p. 470-472 3 p.

    Research output: Contribution to journalEditorial

  26. The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study

    EU-GEI WP2 Group, Di Forti, M., Quattrone, D., Freeman, T. P., Tripoli, G., Gayer-Anderson, C., Quigley, H., Rodriguez, V., Jongsma, H. E., Ferraro, L., La Cascia, C., La Barbera, D., Tarricone, I., Berardi, D., Szöke, A., Arango, C., Tortelli, A., Velthorst, E., Bernardo, M., Del-Ben, C. M. & 31 others, Menezes, P. R., Selten, J. P., Jones, P. B., Kirkbride, J. B., Rutten, B. PF., de Haan, L., Sham, P. C., van Os, J., Lewis, C. M., Lynskey, M., Morgan, C., Murray, R. M., Amoretti, S., Arrojo, M., Baudin, G., Beards, S., Bernardo, M., Bobes, J., Bonetto, C., Cabrera, B., Carracedo, A., Charpeaud, T., Costas, J., Cristofalo, D., Cuadrado, P., Díaz-Caneja, C. M., Ferchiou, A., Franke, N., Frijda, F., Hubbard, K. & Stilo, S. A., 1 May 2019, In : The Lancet Psychiatry. 6, 5, p. 427-436 10 p.

    Research output: Contribution to journalArticle

  27. Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder

    eQTLGen Consortium, May 2019, In : Nature Genetics. 51, 5, p. 793-803 11 p.

    Research output: Contribution to journalArticle

  28. Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload

    Smyrnias, I., Gray, S. P., Okonko, D. O., Sawyer, G., Zoccarato, A., Catibog, N., López, B., González, A., Ravassa, S., Díez, J. & Shah, A. M., 16 Apr 2019, In : Journal of the American College of Cardiology. 73, 14, p. 1795 - 1806 12 p.

    Research output: Contribution to journalArticle

  29. Uncovering the Genetic Architecture of Major Depression

    McIntosh, A. M., Sullivan, P. F. & Lewis, C. M., 3 Apr 2019, In : Neuron. 102, 1, p. 91-103 13 p.

    Research output: Contribution to journalReview article

  30. Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population

    Chen, W. C., Bye, H., Matejcic, M., Amar, A., Govender, D., Khew, Y. W., Beynon, V., Kerr, R., Singh, E., Prescott, N. J., Lewis, C. M., Babb de Villiers, C., Parker, M. I. & Mathew, C. G., Apr 2019, In : Carcinogenesis. 40, 4, p. 513-520 8 p., bgz026.

    Research output: Contribution to journalArticle

  31. Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

    Howard, D. M., Adams, M. J., Clarke, T., Hafferty, J. D., Gibson, J., Shirali, M., Coleman, J. R. I., Hagenaars, S. P., Ward, J., Wigmore, E. M., Alloza, C., Shen, X., Barbu, M. C., Xu, E. Y., Whalley, H. C., Marioni, R. E., Porteous, D. J., Davies, G., Deary, I. J., Hemani, G. & 18 others, Berger, K., Teismann, H., Rawal, R., Arolt, V., Baune, B. T., Dannlowski, U., Domschke, K., Tian, C., Hinds, D. A., Trzaskowski, M., Byrne, E. M., Ripke, S., Smith, D. J., Sullivan, P. F., Wray, N. R., Breen, G., Lewis, C. M. & Mcintosh, A. M., Mar 2019, In : Nature Neuroscience. 22, 3, p. 343-352 10 p.

    Research output: Contribution to journalArticle

  32. Identification of common genetic risk variants for autism spectrum disorder

    Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, BUPGEN, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23andMe Research Team, 25 Feb 2019, In : Nature Genetics. 51, 3, p. 431-444 14 p.

    Research output: Contribution to journalArticle

  33. Paracrine Mechanisms of Redox Signalling for Postmitotic Cell and Tissue Regeneration

    Hervera, A., Santos, C. X., De Virgiliis, F., Shah, A. M. & Di Giovanni, S., 19 Feb 2019, In : Trends in cell biology. 29, 6, p. 514-530 17 p.

    Research output: Contribution to journalReview article

  34. Quantifying between-cohort and between-sex genetic heterogeneity in major depressive disorder

    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 1 Feb 2019, In : American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 180, 6, p. 439-447 9 p.

    Research output: Contribution to journalArticle

  35. Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP

    Wigmore, E. M., Hafferty, J. D., Hall, L. S., Howard, D. M., Clarke, T-K., Fabbri, C., Lewis, C. M., Uher, R., Navrady, L. B., Adams, M. J., Zeng, Y., Campbell, A., Gibson, J., Thomson, P. A., Hayward, C., Smith, B. H., Hocking, L. J., Padmanabhan, S., Deary, I. J., Porteous, D. J. & 4 others, Mors, O., Mattheisen, M., Nicodemus, K. K. & McIntosh, A. M., 31 Jan 2019, In : The pharmacogenomics journal.

    Research output: Contribution to journalArticle

  36. A machine learning approach for the prediction of pulmonary hypertension

    Leha, A., Hellenkamp, K., Unsöld, B., Mushemi-Blake, S., Shah, A. M., Hasenfuß, G. & Seidler, T., 1 Jan 2019, In : PLoS ONE. 14, 10, e0224453.

    Research output: Contribution to journalArticle

  37. Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

    Bipolar Disorder Working Group of the Psychiatric Genomics Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 1 Jan 2019, In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

  38. Cannabis use, depression and self-harm: phenotypic and genetic relationships

    Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 1 Jan 2019, In : Addiction.

    Research output: Contribution to journalArticle

  39. Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases

    Traylor, M., Knevel, R., Cui, J., Taylor, J., Harm-Jan, W., Conaghan, P. G., Cope, A. P., Curtis, C., Emery, P., Newhouse, S., Patel, H., Steer, S., Gregersen, P., Shadick, N. A., Weinblatt, M. E., van der Helm-Van Mil, A., Barrett, J. H., Morgan, A. W., Lewis, C. M. & Scott, I. C., 1 Jan 2019, In : PLoS ONE. 14, 10, e0223246.

    Research output: Contribution to journalArticle

  40. Tolerizing CTL by sustained hepatic PD-L1 expression provides a new therapy approach in mouse sepsis

    Von Knethen, A., Schäfer, A., Kuchler, L., Knape, T., Christen, U., Hintermann, E., Fißlthaler, B., Schröder, K., Brandes, R. P., Genz, B., Abshagen, K., Pützer, B. M., Sha, L. K., Weigert, A., Syed, S. N., Schulz, M., Shah, A. M., Ernst, A., Putyrski, M., Finkelmeier, F. & 7 others, Pesic, M., Greten, F., Hogardt, M., Kempf, V. A. J., Gunne, S., Parnham, M. J. & Brüne, B., 1 Jan 2019, In : Theranostics. 9, 7, p. 2003-2016 14 p.

    Research output: Contribution to journalArticle

  41. IS THE ERA OF CANDIDATE GENES X CANNABIS USE REALLY DEAD?

    Quattrone, D., Lewis, C., Richards, A., Vassos, E., Gayer-Anderson, C., Ferraro, L., Tripoli, G., Rutten, B., O'Donovan, M., Morgan, C., Van Os, J., Sham, P., Reininghaus, U., Murray, R. & Di Forti, M., 2019, In : European Neuropsychopharmacology. 29, p. 1324-1325

    Research output: Contribution to journalMeeting Abstract

  42. Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease

    Nagel, E., Greenwood, J. P., McCann, G. P., Bettencourt, N., Shah, A. M., Hussain, S. T., Perera, D., Plein, S., Bucciarelli-Ducci, C., Paul, M., Westwood, M. A., Marber, M. & Investigators, MR-INFORM., 2019, In : New England Journal of Medicine. 380, 25, p. 2418-2428 11 p.

    Research output: Contribution to journalArticle

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