Sedentary behaviour is associated with elevated C-reactive protein levels in people with psychosis

Brendon Stubbs; Poonam Gardner-Sood; Shubulade Smith; Khalida Ismail; Kathryn Greenwood; Ross Farmer; Fiona Gaughran

doi:10.1016/j.schres.2015.07.003

Sedentary behaviour is associated with elevated C-reactive protein levels in people with psychosis

Brendon Stubbs, Poonam Gardner-Sood, Shubulade Smith, Khalida Ismail, Kathryn Greenwood, Ross Farmer, Fiona Gaughran

Research output: Contribution to journal › Article › peer-review

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Abstract

Psychosis is associated with elevated inflammatory markers including C-reactive protein (CRP), a marker of cardiovascular disease (CVD) risk. Using a cross sectional design, 250 participants with established psychosis (48.2years (SD 10.2), 39.2% female) were classified as having normal (<5.0mg/μl, N=159) or high CRP levels (>5.0mg/μl, N=91). Regression analysis demonstrated that higher sedentary behaviour was associated with elevated CRP levels (β=.155, p=.01) after adjustment for confounding variables. Female gender (β=.229, p=.001), waist circumference (β=.205, p=.003) and non-white ethnicity (β=.181, p=.005) were also associated with elevated CRP. Sedentary behaviour is modifiable and increasing physical activity may reduce CRP levels.

Original language	English
Pages (from-to)	461-4
Number of pages	4
Journal	Schizophrenia Research
Volume	168
Issue number	1-2
DOIs	https://doi.org/10.1016/j.schres.2015.07.003
Publication status	Published - Oct 2015

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title = "Sedentary behaviour is associated with elevated C-reactive protein levels in people with psychosis",

abstract = "Psychosis is associated with elevated inflammatory markers including C-reactive protein (CRP), a marker of cardiovascular disease (CVD) risk. Using a cross sectional design, 250 participants with established psychosis (48.2years (SD 10.2), 39.2% female) were classified as having normal (<5.0mg/μl, N=159) or high CRP levels (>5.0mg/μl, N=91). Regression analysis demonstrated that higher sedentary behaviour was associated with elevated CRP levels (β=.155, p=.01) after adjustment for confounding variables. Female gender (β=.229, p=.001), waist circumference (β=.205, p=.003) and non-white ethnicity (β=.181, p=.005) were also associated with elevated CRP. Sedentary behaviour is modifiable and increasing physical activity may reduce CRP levels.",

author = "Brendon Stubbs and Poonam Gardner-Sood and Shubulade Smith and Khalida Ismail and Kathryn Greenwood and Ross Farmer and Fiona Gaughran",

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TY - JOUR

T1 - Sedentary behaviour is associated with elevated C-reactive protein levels in people with psychosis

AU - Stubbs, Brendon

AU - Gardner-Sood, Poonam

AU - Smith, Shubulade

AU - Ismail, Khalida

AU - Greenwood, Kathryn

AU - Farmer, Ross

AU - Gaughran, Fiona

PY - 2015/10

Y1 - 2015/10

N2 - Psychosis is associated with elevated inflammatory markers including C-reactive protein (CRP), a marker of cardiovascular disease (CVD) risk. Using a cross sectional design, 250 participants with established psychosis (48.2years (SD 10.2), 39.2% female) were classified as having normal (<5.0mg/μl, N=159) or high CRP levels (>5.0mg/μl, N=91). Regression analysis demonstrated that higher sedentary behaviour was associated with elevated CRP levels (β=.155, p=.01) after adjustment for confounding variables. Female gender (β=.229, p=.001), waist circumference (β=.205, p=.003) and non-white ethnicity (β=.181, p=.005) were also associated with elevated CRP. Sedentary behaviour is modifiable and increasing physical activity may reduce CRP levels.

AB - Psychosis is associated with elevated inflammatory markers including C-reactive protein (CRP), a marker of cardiovascular disease (CVD) risk. Using a cross sectional design, 250 participants with established psychosis (48.2years (SD 10.2), 39.2% female) were classified as having normal (<5.0mg/μl, N=159) or high CRP levels (>5.0mg/μl, N=91). Regression analysis demonstrated that higher sedentary behaviour was associated with elevated CRP levels (β=.155, p=.01) after adjustment for confounding variables. Female gender (β=.229, p=.001), waist circumference (β=.205, p=.003) and non-white ethnicity (β=.181, p=.005) were also associated with elevated CRP. Sedentary behaviour is modifiable and increasing physical activity may reduce CRP levels.

U2 - 10.1016/j.schres.2015.07.003

DO - 10.1016/j.schres.2015.07.003

M3 - Article

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SN - 0920-9964

VL - 168

SP - 461

EP - 464

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-2

ER -

Sedentary behaviour is associated with elevated C-reactive protein levels in people with psychosis

Abstract

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