Segmental identity and cerebellar granule cell induction in rhombomere 1

TY - JOUR

T1 - Segmental identity and cerebellar granule cell induction in rhombomere 1

AU - Eddison, M

AU - Toole, L

AU - Bell, E

AU - Wingate, R.J

PY - 2004/6/15

Y1 - 2004/6/15

N2 - Cerebellar granule cell precursors are specifically generated within the hindbrain segment, rhombomere 1, which is bounded rostrally by the midbrain/hindbrain isthmus and caudally by the boundary of the Hoxa2 expression domain. While graded signals from the isthmus have a demonstrable patterning role within this region, the significance of segmental identity for neuronal specification within rhombomere 1 is unexplored. We examined the response of granule cell precursors to the overexpression of Hoxa2, which normally determines patterns of development specific to the hindbrain. How much does the development of the cerebellum, a midbrain/hindbrain structure, reflect its neuromeric origin as a hindbrain segment?

AB - Cerebellar granule cell precursors are specifically generated within the hindbrain segment, rhombomere 1, which is bounded rostrally by the midbrain/hindbrain isthmus and caudally by the boundary of the Hoxa2 expression domain. While graded signals from the isthmus have a demonstrable patterning role within this region, the significance of segmental identity for neuronal specification within rhombomere 1 is unexplored. We examined the response of granule cell precursors to the overexpression of Hoxa2, which normally determines patterns of development specific to the hindbrain. How much does the development of the cerebellum, a midbrain/hindbrain structure, reflect its neuromeric origin as a hindbrain segment?

U2 - 10.1186/1741-7007-2-14

DO - 10.1186/1741-7007-2-14

M3 - Article

VL - 2

JO - BMC Biology

JF - BMC Biology

IS - 1

M1 - 14

ER -