Segmental identity and cerebellar granule cell induction in rhombomere 1

M Eddison, L Toole, E Bell, R.J Wingate

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Cerebellar granule cell precursors are specifically generated within the hindbrain segment, rhombomere 1, which is bounded rostrally by the midbrain/hindbrain isthmus and caudally by the boundary of the Hoxa2 expression domain. While graded signals from the isthmus have a demonstrable patterning role within this region, the significance of segmental identity for neuronal specification within rhombomere 1 is unexplored. We examined the response of granule cell precursors to the overexpression of Hoxa2, which normally determines patterns of development specific to the hindbrain. How much does the development of the cerebellum, a midbrain/hindbrain structure, reflect its neuromeric origin as a hindbrain segment?
Original languageEnglish
Article number14
JournalBMC Biology
Issue number1
Publication statusPublished - 15 Jun 2004


Dive into the research topics of 'Segmental identity and cerebellar granule cell induction in rhombomere 1'. Together they form a unique fingerprint.

Cite this