Selective deficit of hippocampal N-acetylaspartate in antipsychotic-naive patients with schizophrenia.

D Fannon; A Simmons; L Tennakoon; S O'Ceallaigh; A Sumich; V Doku; C Shew; T Sharma

doi:10.1016/S0006-3223(03)00185-9

Selective deficit of hippocampal N-acetylaspartate in antipsychotic-naive patients with schizophrenia.

D Fannon, A Simmons, L Tennakoon, S O'Ceallaigh, A Sumich, V Doku, C Shew, T Sharma

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Studies using proton magnetic resonance spectroscopy in schizophrenia have demonstrated abnormality of N-acetylaspartate but are confounded by the effects of phase of illness and medication. There is mounting evidence that antipsychotic medication influences N-acetylaspartate. Methods: A group of first-episode patients who had received no, or minimal, antipsychotic medication was examined at baseline and after 3 months treatment. Normal comparison subjects were examined at the same interval. Ratios of N-acetylaspartate, creatine plus phosphocreatine, and choline-containing compounds in the left prefrontal cortex, hippocampus, and basal ganglia were measured. Results: The mean duration of symptoms for all patients was 31.6 (SD 26.1) weeks. A significant reduction of hippocampal N-acetylaspartate/creatine plus phosphocreatine was found in the antipsychotic-naive group relative to those previously treated and to controls at baseline (F=7.3, p

Original language	English
Pages (from-to)	587 - 598
Number of pages	12
Journal	Biological psychiatry
Volume	54
Issue number	6
DOIs	https://doi.org/10.1016/S0006-3223(03)00185-9
Publication status	Published - 15 Sept 2003

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title = "Selective deficit of hippocampal N-acetylaspartate in antipsychotic-naive patients with schizophrenia.",

abstract = "Background: Studies using proton magnetic resonance spectroscopy in schizophrenia have demonstrated abnormality of N-acetylaspartate but are confounded by the effects of phase of illness and medication. There is mounting evidence that antipsychotic medication influences N-acetylaspartate. Methods: A group of first-episode patients who had received no, or minimal, antipsychotic medication was examined at baseline and after 3 months treatment. Normal comparison subjects were examined at the same interval. Ratios of N-acetylaspartate, creatine plus phosphocreatine, and choline-containing compounds in the left prefrontal cortex, hippocampus, and basal ganglia were measured. Results: The mean duration of symptoms for all patients was 31.6 (SD 26.1) weeks. A significant reduction of hippocampal N-acetylaspartate/creatine plus phosphocreatine was found in the antipsychotic-naive group relative to those previously treated and to controls at baseline (F=7.3, p",

author = "D Fannon and A Simmons and L Tennakoon and S O'Ceallaigh and A Sumich and V Doku and C Shew and T Sharma",

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T1 - Selective deficit of hippocampal N-acetylaspartate in antipsychotic-naive patients with schizophrenia.

AU - Fannon, D

AU - Simmons, A

AU - Tennakoon, L

AU - O'Ceallaigh, S

AU - Sumich, A

AU - Doku, V

AU - Shew, C

AU - Sharma, T

PY - 2003/9/15

Y1 - 2003/9/15

N2 - Background: Studies using proton magnetic resonance spectroscopy in schizophrenia have demonstrated abnormality of N-acetylaspartate but are confounded by the effects of phase of illness and medication. There is mounting evidence that antipsychotic medication influences N-acetylaspartate. Methods: A group of first-episode patients who had received no, or minimal, antipsychotic medication was examined at baseline and after 3 months treatment. Normal comparison subjects were examined at the same interval. Ratios of N-acetylaspartate, creatine plus phosphocreatine, and choline-containing compounds in the left prefrontal cortex, hippocampus, and basal ganglia were measured. Results: The mean duration of symptoms for all patients was 31.6 (SD 26.1) weeks. A significant reduction of hippocampal N-acetylaspartate/creatine plus phosphocreatine was found in the antipsychotic-naive group relative to those previously treated and to controls at baseline (F=7.3, p

AB - Background: Studies using proton magnetic resonance spectroscopy in schizophrenia have demonstrated abnormality of N-acetylaspartate but are confounded by the effects of phase of illness and medication. There is mounting evidence that antipsychotic medication influences N-acetylaspartate. Methods: A group of first-episode patients who had received no, or minimal, antipsychotic medication was examined at baseline and after 3 months treatment. Normal comparison subjects were examined at the same interval. Ratios of N-acetylaspartate, creatine plus phosphocreatine, and choline-containing compounds in the left prefrontal cortex, hippocampus, and basal ganglia were measured. Results: The mean duration of symptoms for all patients was 31.6 (SD 26.1) weeks. A significant reduction of hippocampal N-acetylaspartate/creatine plus phosphocreatine was found in the antipsychotic-naive group relative to those previously treated and to controls at baseline (F=7.3, p

U2 - 10.1016/S0006-3223(03)00185-9

DO - 10.1016/S0006-3223(03)00185-9

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SN - 1873-2402

VL - 54

SP - 587

EP - 598

JO - Biological psychiatry

JF - Biological psychiatry

IS - 6

ER -

Selective deficit of hippocampal N-acetylaspartate in antipsychotic-naive patients with schizophrenia.

Abstract

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