Abstract
A theranostic conjugate for use as a positron emission tomography (PET) radiotracer and as a photosensitiser for photodynamic therapy (PDT) has been synthesised. A water-soluble porphyrin was coupled with the bifunctional chelate, H4Dpaa.ga. This conjugate is capable of rapid 68Ga complexation under physiological conditions; with 93% and 80% radiochemical yields achieved, at pH 4.5 and pH 7.4 respectively, in 15 min at 25 °C. Photocytotoxicity was evaluated on HT-29 cells and showed the conjugate was capable of >50% cell death at 50 μM upon irradiation with light, while causing minimal toxicity in the absence of light (>95% cell survival).
Original language | English |
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Pages (from-to) | 7952-7954 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 54 |
Issue number | 57 |
Early online date | 25 Jun 2018 |
DOIs | |
Publication status | Published - 2018 |