Selective radiolabelling with 68Ga under mild conditions: A route towards a porphyrin PET/PDT theranostic agent

Steven Y. Yap, Thomas W. Price, Huguette Savoie, Ross W. Boyle*, Graeme J. Stasiuk

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

A theranostic conjugate for use as a positron emission tomography (PET) radiotracer and as a photosensitiser for photodynamic therapy (PDT) has been synthesised. A water-soluble porphyrin was coupled with the bifunctional chelate, H4Dpaa.ga. This conjugate is capable of rapid 68Ga complexation under physiological conditions; with 93% and 80% radiochemical yields achieved, at pH 4.5 and pH 7.4 respectively, in 15 min at 25 °C. Photocytotoxicity was evaluated on HT-29 cells and showed the conjugate was capable of >50% cell death at 50 μM upon irradiation with light, while causing minimal toxicity in the absence of light (>95% cell survival).

Original languageEnglish
Pages (from-to)7952-7954
Number of pages3
JournalChemical Communications
Volume54
Issue number57
Early online date25 Jun 2018
DOIs
Publication statusPublished - 2018

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