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Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL

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Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL. / Osório, Catarina; Chacón, Pedro J; White, Matthew; Kisiswa, Lilian; Wyatt, Sean; Rodríguez-Tébar, Alfredo; Davies, Alun M.

In: Molecular and Cellular Neurosciences, Vol. 59, 03.2014, p. 24-36.

Research output: Contribution to journalArticle

Harvard

Osório, C, Chacón, PJ, White, M, Kisiswa, L, Wyatt, S, Rodríguez-Tébar, A & Davies, AM 2014, 'Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL', Molecular and Cellular Neurosciences, vol. 59, pp. 24-36. https://doi.org/10.1016/j.mcn.2014.01.002

APA

Osório, C., Chacón, P. J., White, M., Kisiswa, L., Wyatt, S., Rodríguez-Tébar, A., & Davies, A. M. (2014). Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL. Molecular and Cellular Neurosciences, 59, 24-36. https://doi.org/10.1016/j.mcn.2014.01.002

Vancouver

Osório C, Chacón PJ, White M, Kisiswa L, Wyatt S, Rodríguez-Tébar A et al. Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL. Molecular and Cellular Neurosciences. 2014 Mar;59:24-36. https://doi.org/10.1016/j.mcn.2014.01.002

Author

Osório, Catarina ; Chacón, Pedro J ; White, Matthew ; Kisiswa, Lilian ; Wyatt, Sean ; Rodríguez-Tébar, Alfredo ; Davies, Alun M. / Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL. In: Molecular and Cellular Neurosciences. 2014 ; Vol. 59. pp. 24-36.

Bibtex Download

@article{def2bb2c5ac945a1bdfbd071524c8254,
title = "Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL",
abstract = "APRIL (A Proliferation-Inducing Ligand, TNFSF13) is a member of the tumor necrosis factor superfamily that regulates lymphocyte survival and activation and has been implicated in tumorigenesis and autoimmune diseases. Here we report the expression and first known activity of APRIL in the nervous system. APRIL and one of its receptors, BCMA (B-Cell Maturation Antigen, TNFRSF17), are expressed by hippocampal pyramidal cells of fetal and postnatal mice. In culture, these neurons secreted APRIL, and function-blocking antibodies to either APRIL or BCMA reduced axonal elongation. Recombinant APRIL enhanced axonal elongation, but did not influence dendrite elongation. The effect of APRIL on axon elongation was inhibited by anti-BCMA and the expression of a signaling-defective BCMA mutant in these neurons, suggesting that the axon growth-promoting effect of APRIL is mediated by BCMA. APRIL promoted phosphorylation and activation of ERK1, ERK2 and Akt and serine phosphorylation and inactivation of GSK-3β in cultured hippocampal pyramidal cells. Inhibition of MEK1/MEK2 (activators of ERK1/ERK2), PI3-kinase (activator of Akt) or Akt inhibited the axon growth-promoting action of APRIL, as did pharmacological activation of GSK-3β and the expression of a constitutively active form of GSK-3β. These findings suggest that APRIL promotes axon elongation by a mechanism that depends both on ERK signaling and PI3-kinase/Akt/GSK-3β signaling.",
keywords = "Animals, Axons, B-Cell Maturation Antigen, Cells, Cultured, Dendrites, Glycogen Synthase Kinase 3, Glycogen Synthase Kinase 3 beta, Hippocampus, MAP Kinase Kinase 1, MAP Kinase Kinase 2, Mice, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Neurogenesis, Phosphatidylinositol 3-Kinases, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Pyramidal Cells, Signal Transduction, Tumor Necrosis Factor Ligand Superfamily Member 13, Journal Article, Research Support, Non-U.S. Gov't",
author = "Catarina Os{\'o}rio and Chac{\'o}n, {Pedro J} and Matthew White and Lilian Kisiswa and Sean Wyatt and Alfredo Rodr{\'i}guez-T{\'e}bar and Davies, {Alun M}",
note = "Copyright {\circledC} 2014 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2014",
month = "3",
doi = "10.1016/j.mcn.2014.01.002",
language = "English",
volume = "59",
pages = "24--36",
journal = "Molecular and Cellular Neurosciences",
issn = "1044-7431",
publisher = "ACADEMIC PRESS INC",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL

AU - Osório, Catarina

AU - Chacón, Pedro J

AU - White, Matthew

AU - Kisiswa, Lilian

AU - Wyatt, Sean

AU - Rodríguez-Tébar, Alfredo

AU - Davies, Alun M

N1 - Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2014/3

Y1 - 2014/3

N2 - APRIL (A Proliferation-Inducing Ligand, TNFSF13) is a member of the tumor necrosis factor superfamily that regulates lymphocyte survival and activation and has been implicated in tumorigenesis and autoimmune diseases. Here we report the expression and first known activity of APRIL in the nervous system. APRIL and one of its receptors, BCMA (B-Cell Maturation Antigen, TNFRSF17), are expressed by hippocampal pyramidal cells of fetal and postnatal mice. In culture, these neurons secreted APRIL, and function-blocking antibodies to either APRIL or BCMA reduced axonal elongation. Recombinant APRIL enhanced axonal elongation, but did not influence dendrite elongation. The effect of APRIL on axon elongation was inhibited by anti-BCMA and the expression of a signaling-defective BCMA mutant in these neurons, suggesting that the axon growth-promoting effect of APRIL is mediated by BCMA. APRIL promoted phosphorylation and activation of ERK1, ERK2 and Akt and serine phosphorylation and inactivation of GSK-3β in cultured hippocampal pyramidal cells. Inhibition of MEK1/MEK2 (activators of ERK1/ERK2), PI3-kinase (activator of Akt) or Akt inhibited the axon growth-promoting action of APRIL, as did pharmacological activation of GSK-3β and the expression of a constitutively active form of GSK-3β. These findings suggest that APRIL promotes axon elongation by a mechanism that depends both on ERK signaling and PI3-kinase/Akt/GSK-3β signaling.

AB - APRIL (A Proliferation-Inducing Ligand, TNFSF13) is a member of the tumor necrosis factor superfamily that regulates lymphocyte survival and activation and has been implicated in tumorigenesis and autoimmune diseases. Here we report the expression and first known activity of APRIL in the nervous system. APRIL and one of its receptors, BCMA (B-Cell Maturation Antigen, TNFRSF17), are expressed by hippocampal pyramidal cells of fetal and postnatal mice. In culture, these neurons secreted APRIL, and function-blocking antibodies to either APRIL or BCMA reduced axonal elongation. Recombinant APRIL enhanced axonal elongation, but did not influence dendrite elongation. The effect of APRIL on axon elongation was inhibited by anti-BCMA and the expression of a signaling-defective BCMA mutant in these neurons, suggesting that the axon growth-promoting effect of APRIL is mediated by BCMA. APRIL promoted phosphorylation and activation of ERK1, ERK2 and Akt and serine phosphorylation and inactivation of GSK-3β in cultured hippocampal pyramidal cells. Inhibition of MEK1/MEK2 (activators of ERK1/ERK2), PI3-kinase (activator of Akt) or Akt inhibited the axon growth-promoting action of APRIL, as did pharmacological activation of GSK-3β and the expression of a constitutively active form of GSK-3β. These findings suggest that APRIL promotes axon elongation by a mechanism that depends both on ERK signaling and PI3-kinase/Akt/GSK-3β signaling.

KW - Animals

KW - Axons

KW - B-Cell Maturation Antigen

KW - Cells, Cultured

KW - Dendrites

KW - Glycogen Synthase Kinase 3

KW - Glycogen Synthase Kinase 3 beta

KW - Hippocampus

KW - MAP Kinase Kinase 1

KW - MAP Kinase Kinase 2

KW - Mice

KW - Mitogen-Activated Protein Kinase 1

KW - Mitogen-Activated Protein Kinase 3

KW - Neurogenesis

KW - Phosphatidylinositol 3-Kinases

KW - Protein Kinase Inhibitors

KW - Proto-Oncogene Proteins c-akt

KW - Pyramidal Cells

KW - Signal Transduction

KW - Tumor Necrosis Factor Ligand Superfamily Member 13

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.mcn.2014.01.002

DO - 10.1016/j.mcn.2014.01.002

M3 - Article

C2 - 24444792

VL - 59

SP - 24

EP - 36

JO - Molecular and Cellular Neurosciences

JF - Molecular and Cellular Neurosciences

SN - 1044-7431

ER -

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