Self-Assessment of Disability in Parkinson's Disease: The MDS-UPDRS Part II Versus Clinician-Based Ratings

Carmen Rodríguez-Blázquez; Mario Alvarez; Tomoko Arakaki; Víctor Campos Arillo; Pedro Chaná; William Fernández; Nélida Garretto; Juan Carlos Martínez-Castrillo; Mayela Rodríguez-Violante; Marcos Serrano-Dueñas; Diego Ballesteros; Jose Manuel Rojo-Abuin; Kallol Ray Chaudhuri; Marcelo Merello; Pablo Martínez-Martín

doi:10.1002/mdc3.12462

Self-Assessment of Disability in Parkinson's Disease: The MDS-UPDRS Part II Versus Clinician-Based Ratings

Carmen Rodríguez-Blázquez, Mario Alvarez, Tomoko Arakaki, Víctor Campos Arillo, Pedro Chaná, William Fernández, Nélida Garretto, Juan Carlos Martínez-Castrillo, Mayela Rodríguez-Violante, Marcos Serrano-Dueñas, Diego Ballesteros, Jose Manuel Rojo-Abuin, Kallol Ray Chaudhuri, Marcelo Merello, Pablo Martínez-Martín^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Background: Parkinson's disease (PD) is characterized by motor and nonmotor symptoms that progress with time, causing disability. The performance of a disease-specific, self-applied tool for assessing disability, the MDS-UPDRS Part II, is tested against generic and rater-based rating scales. Methods: An international, cross-sectional, observational study was performed. Patients were assessed with the Hoehn and Yahr (HY) and five disability measures: MDS-UPDRS Part II, Schwab and England Scale (S&E), Clinical Impression of Severity Index-PD (CISI-PD) Disability item, Barthel Index (BI), and Rapid Assessment of Disability Scale (RADS). Data analysis included correlation coefficients, Mann-Whitney and Kruskal-Wallis tests, and intraclass-correlation coefficient for concordance. Results: The sample was composed of 451 patients, 55.2% men, with a mean age of 65.06 years (SD = 10.71). Disability rating scales correlated from |0.75| (CISI-PD Disability with BI) to 0.87 (MDS-UPDRS Part II with RADS). In general, MDS-UPDRS Part II showed high correlation coefficients with clinical variables and satisfactory concordance with the rest of disability measures, with ICC ranging from 0.83 (with BI) to 0.93 (with RADS). All disability rating scales showed statistical significant differences in the sample grouped by sex, age, disease duration, and severity level. Conclusions: The MDS-UPDRS Part II showed an appropriate performance to assess disability in PD, even better than some rater-based, generic or specific, scales applied in this study.

Original language	English
Pages (from-to)	529-535
Number of pages	7
Journal	Movement Disorders Clinical Practice
Volume	4
Issue number	4
DOIs	https://doi.org/10.1002/mdc3.12462
Publication status	Published - 1 Jul 2017

Keywords

assessment
disability
MDS-UPDRS
Parkinson's disease
rating scales

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10.1002/mdc3.12462

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Rodríguez-Blázquez, C., Alvarez, M., Arakaki, T., Campos Arillo, V., Chaná, P., Fernández, W., Garretto, N., Martínez-Castrillo, J. C., Rodríguez-Violante, M., Serrano-Dueñas, M., Ballesteros, D., Rojo-Abuin, J. M., Ray Chaudhuri, K., Merello, M., & Martínez-Martín, P. (2017). Self-Assessment of Disability in Parkinson's Disease: The MDS-UPDRS Part II Versus Clinician-Based Ratings. Movement Disorders Clinical Practice, 4(4), 529-535. https://doi.org/10.1002/mdc3.12462

@article{43e4c42ee5864e7f85fba9fd95973b45,

title = "Self-Assessment of Disability in Parkinson's Disease: The MDS-UPDRS Part II Versus Clinician-Based Ratings",

abstract = "Background: Parkinson's disease (PD) is characterized by motor and nonmotor symptoms that progress with time, causing disability. The performance of a disease-specific, self-applied tool for assessing disability, the MDS-UPDRS Part II, is tested against generic and rater-based rating scales. Methods: An international, cross-sectional, observational study was performed. Patients were assessed with the Hoehn and Yahr (HY) and five disability measures: MDS-UPDRS Part II, Schwab and England Scale (S&E), Clinical Impression of Severity Index-PD (CISI-PD) Disability item, Barthel Index (BI), and Rapid Assessment of Disability Scale (RADS). Data analysis included correlation coefficients, Mann-Whitney and Kruskal-Wallis tests, and intraclass-correlation coefficient for concordance. Results: The sample was composed of 451 patients, 55.2% men, with a mean age of 65.06 years (SD = 10.71). Disability rating scales correlated from |0.75| (CISI-PD Disability with BI) to 0.87 (MDS-UPDRS Part II with RADS). In general, MDS-UPDRS Part II showed high correlation coefficients with clinical variables and satisfactory concordance with the rest of disability measures, with ICC ranging from 0.83 (with BI) to 0.93 (with RADS). All disability rating scales showed statistical significant differences in the sample grouped by sex, age, disease duration, and severity level. Conclusions: The MDS-UPDRS Part II showed an appropriate performance to assess disability in PD, even better than some rater-based, generic or specific, scales applied in this study.",

keywords = "assessment, disability, MDS-UPDRS, Parkinson's disease, rating scales",

author = "Carmen Rodr{\'i}guez-Bl{\'a}zquez and Mario Alvarez and Tomoko Arakaki and {Campos Arillo}, V{\'i}ctor and Pedro Chan{\'a} and William Fern{\'a}ndez and N{\'e}lida Garretto and Mart{\'i}nez-Castrillo, {Juan Carlos} and Mayela Rodr{\'i}guez-Violante and Marcos Serrano-Due{\~n}as and Diego Ballesteros and Rojo-Abuin, {Jose Manuel} and {Ray Chaudhuri}, Kallol and Marcelo Merello and Pablo Mart{\'i}nez-Mart{\'i}n",

year = "2017",

month = jul,

day = "1",

doi = "10.1002/mdc3.12462",

language = "English",

volume = "4",

pages = "529--535",

journal = "Movement Disorders Clinical Practice",

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Rodríguez-Blázquez, C, Alvarez, M, Arakaki, T, Campos Arillo, V, Chaná, P, Fernández, W, Garretto, N, Martínez-Castrillo, JC, Rodríguez-Violante, M, Serrano-Dueñas, M, Ballesteros, D, Rojo-Abuin, JM, Ray Chaudhuri, K, Merello, M & Martínez-Martín, P 2017, 'Self-Assessment of Disability in Parkinson's Disease: The MDS-UPDRS Part II Versus Clinician-Based Ratings', Movement Disorders Clinical Practice, vol. 4, no. 4, pp. 529-535. https://doi.org/10.1002/mdc3.12462

TY - JOUR

T1 - Self-Assessment of Disability in Parkinson's Disease

T2 - The MDS-UPDRS Part II Versus Clinician-Based Ratings

AU - Rodríguez-Blázquez, Carmen

AU - Alvarez, Mario

AU - Arakaki, Tomoko

AU - Campos Arillo, Víctor

AU - Chaná, Pedro

AU - Fernández, William

AU - Garretto, Nélida

AU - Martínez-Castrillo, Juan Carlos

AU - Rodríguez-Violante, Mayela

AU - Serrano-Dueñas, Marcos

AU - Ballesteros, Diego

AU - Rojo-Abuin, Jose Manuel

AU - Ray Chaudhuri, Kallol

AU - Merello, Marcelo

AU - Martínez-Martín, Pablo

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Background: Parkinson's disease (PD) is characterized by motor and nonmotor symptoms that progress with time, causing disability. The performance of a disease-specific, self-applied tool for assessing disability, the MDS-UPDRS Part II, is tested against generic and rater-based rating scales. Methods: An international, cross-sectional, observational study was performed. Patients were assessed with the Hoehn and Yahr (HY) and five disability measures: MDS-UPDRS Part II, Schwab and England Scale (S&E), Clinical Impression of Severity Index-PD (CISI-PD) Disability item, Barthel Index (BI), and Rapid Assessment of Disability Scale (RADS). Data analysis included correlation coefficients, Mann-Whitney and Kruskal-Wallis tests, and intraclass-correlation coefficient for concordance. Results: The sample was composed of 451 patients, 55.2% men, with a mean age of 65.06 years (SD = 10.71). Disability rating scales correlated from |0.75| (CISI-PD Disability with BI) to 0.87 (MDS-UPDRS Part II with RADS). In general, MDS-UPDRS Part II showed high correlation coefficients with clinical variables and satisfactory concordance with the rest of disability measures, with ICC ranging from 0.83 (with BI) to 0.93 (with RADS). All disability rating scales showed statistical significant differences in the sample grouped by sex, age, disease duration, and severity level. Conclusions: The MDS-UPDRS Part II showed an appropriate performance to assess disability in PD, even better than some rater-based, generic or specific, scales applied in this study.

AB - Background: Parkinson's disease (PD) is characterized by motor and nonmotor symptoms that progress with time, causing disability. The performance of a disease-specific, self-applied tool for assessing disability, the MDS-UPDRS Part II, is tested against generic and rater-based rating scales. Methods: An international, cross-sectional, observational study was performed. Patients were assessed with the Hoehn and Yahr (HY) and five disability measures: MDS-UPDRS Part II, Schwab and England Scale (S&E), Clinical Impression of Severity Index-PD (CISI-PD) Disability item, Barthel Index (BI), and Rapid Assessment of Disability Scale (RADS). Data analysis included correlation coefficients, Mann-Whitney and Kruskal-Wallis tests, and intraclass-correlation coefficient for concordance. Results: The sample was composed of 451 patients, 55.2% men, with a mean age of 65.06 years (SD = 10.71). Disability rating scales correlated from |0.75| (CISI-PD Disability with BI) to 0.87 (MDS-UPDRS Part II with RADS). In general, MDS-UPDRS Part II showed high correlation coefficients with clinical variables and satisfactory concordance with the rest of disability measures, with ICC ranging from 0.83 (with BI) to 0.93 (with RADS). All disability rating scales showed statistical significant differences in the sample grouped by sex, age, disease duration, and severity level. Conclusions: The MDS-UPDRS Part II showed an appropriate performance to assess disability in PD, even better than some rater-based, generic or specific, scales applied in this study.

KW - assessment

KW - disability

KW - MDS-UPDRS

KW - Parkinson's disease

KW - rating scales

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U2 - 10.1002/mdc3.12462

DO - 10.1002/mdc3.12462

M3 - Article

AN - SCOPUS:85067370683

SN - 2330-1619

VL - 4

SP - 529

EP - 535

JO - Movement Disorders Clinical Practice

JF - Movement Disorders Clinical Practice

IS - 4

ER -

Self-Assessment of Disability in Parkinson's Disease: The MDS-UPDRS Part II Versus Clinician-Based Ratings

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Keywords

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