Self-Assessment of Disability in Parkinson's Disease: The MDS-UPDRS Part II Versus Clinician-Based Ratings

Carmen Rodríguez-Blázquez, Mario Alvarez, Tomoko Arakaki, Víctor Campos Arillo, Pedro Chaná, William Fernández, Nélida Garretto, Juan Carlos Martínez-Castrillo, Mayela Rodríguez-Violante, Marcos Serrano-Dueñas, Diego Ballesteros, Jose Manuel Rojo-Abuin, Kallol Ray Chaudhuri, Marcelo Merello, Pablo Martínez-Martín*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Background: Parkinson's disease (PD) is characterized by motor and nonmotor symptoms that progress with time, causing disability. The performance of a disease-specific, self-applied tool for assessing disability, the MDS-UPDRS Part II, is tested against generic and rater-based rating scales. Methods: An international, cross-sectional, observational study was performed. Patients were assessed with the Hoehn and Yahr (HY) and five disability measures: MDS-UPDRS Part II, Schwab and England Scale (S&E), Clinical Impression of Severity Index-PD (CISI-PD) Disability item, Barthel Index (BI), and Rapid Assessment of Disability Scale (RADS). Data analysis included correlation coefficients, Mann-Whitney and Kruskal-Wallis tests, and intraclass-correlation coefficient for concordance. Results: The sample was composed of 451 patients, 55.2% men, with a mean age of 65.06 years (SD = 10.71). Disability rating scales correlated from |0.75| (CISI-PD Disability with BI) to 0.87 (MDS-UPDRS Part II with RADS). In general, MDS-UPDRS Part II showed high correlation coefficients with clinical variables and satisfactory concordance with the rest of disability measures, with ICC ranging from 0.83 (with BI) to 0.93 (with RADS). All disability rating scales showed statistical significant differences in the sample grouped by sex, age, disease duration, and severity level. Conclusions: The MDS-UPDRS Part II showed an appropriate performance to assess disability in PD, even better than some rater-based, generic or specific, scales applied in this study.

Original languageEnglish
Pages (from-to)529-535
Number of pages7
JournalMovement Disorders Clinical Practice
Issue number4
Publication statusPublished - 1 Jul 2017


  • assessment
  • disability
  • Parkinson's disease
  • rating scales


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