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Semantic memory: Which side are you on?

Research output: Contribution to journalArticle

Karalyn Patterson, Michael D. Kopelman, Anna M. Woolams, Sonia L.E. Brownsett, Fatemeh Geranmayeh, Richard J.S. Wise

Original languageEnglish
Pages (from-to)182-191
Early online date22 Nov 2015
Publication statusE-pub ahead of print - 22 Nov 2015



King's Authors


We present two patients in whom the combination of lesion site and cognitive performance was uniquely informative about the organisation and functional anatomy of semantic memory. One had had a single lobar stroke with an unusual distribution,largely destroying the whole of the left temporal lobe ventral to the superior temporal sulcus.The other patient had had her pessimplex encephalitis with destruction that was confined to the left cerebral hemisphere.The lesion again mainly encompassed the
left temporal lobe,but also extended to the left inferior frontal gyrus.Cognitive outcomes in the two patients were compared with each other and with published results from patients with semantic dementia. This output: Contribution to journal › Article
is because, whereas the majority of semantic dementia patients present with more prominent atrophy of the left rostroventral temporal lobe, they invariably have a degree of atrophy in the mirror region on the right that progresses.Semantic dementia therefore provides no clear evidence about the specific role of the left rostroventral temporal lobe.

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