Semantic Speech Networks Linked to Formal Thought Disorder in Early Psychosis

Caroline Nettekoven*, Kelly Diederen, Oscar Giles, Helen Duncan, Iain Stenson, Julianna Olah, Toni Gibbs-Dean, Nigel Collier, Petra Vertes, Tom Spencer, Sarah Morgan, Philip McGuire

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Background and Hypothesis
Mapping a patient’s speech as a network has proved to be a useful way of understanding formal thought disorder in psychosis. However, to date, graph theory tools have not explicitly modelled the semantic content of speech, which is altered in psychosis.
Study Design
We developed an algorithm, “netts,” to map the semantic content of speech as a network, then applied netts to construct semantic speech networks for a general population sample (N = 436), and a clinical sample comprising patients with first episode psychosis (FEP), people at clinical high risk of psychosis (CHR-P), and healthy controls (total N = 53).
Study Results
Semantic speech networks from the general population were more connected than size-matched randomized networks, with fewer and larger connected components, reflecting the nonrandom nature of speech. Networks from FEP patients were smaller than from healthy participants, for a picture description task but not a story recall task. For the former task, FEP networks were also more fragmented than those from controls; showing more connected components, which tended to include fewer nodes on average. CHR-P networks showed fragmentation values in-between FEP patients and controls. A clustering analysis suggested that semantic speech networks captured novel signals not already described by existing NLP measures. Network features were also related to negative symptom scores and scores on the Thought and Language Index, although these relationships did not survive correcting for multiple comparisons.
Conclusions
Overall, these data suggest that semantic networks can enable deeper phenotyping of formal thought disorder in psychosis. Whilst here we focus on network fragmentation, the semantic speech networks created by Netts also contain other, rich information which could be extracted to shed further light on formal thought disorder. We are releasing Netts as an open Python package alongside this manuscript.
Original languageEnglish
Pages (from-to)S142-S152
JournalSchizophrenia Bulletin
Volume49
Issue number2
DOIs
Publication statusPublished - 22 Mar 2023

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