Semistructured Interview for Bipolar At Risk States (SIBARS)

Paolo Fusar-Poli; Andrea De Micheli; Matteo Rocchetti; Marco Cappucciati; Valentina Ramella-Cravaro; Grazia Rutigliano; Ilaria Bonoldi; Philip McGuire; Irina Falkenberg

doi:10.1016/j.psychres.2018.03.074

Semistructured Interview for Bipolar At Risk States (SIBARS)

Paolo Fusar-Poli, Andrea De Micheli, Matteo Rocchetti, Marco Cappucciati, Valentina Ramella-Cravaro, Grazia Rutigliano, Ilaria Bonoldi, Philip McGuire, Irina Falkenberg

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Abstract

The external prognostic accuracy of Bipolar At Risk (BAR) criteria is undetermined and no psychometric tools are available to measure them. We present here three studies that overcome these limitations. Study 1 and 2 investigated the prognostic accuracy (Harrell's C) of the original BAR and revised Bipolar At Risk States (BARS) criteria respectively for the prediction of bipolar disorders, using a retrospective cohort of individuals at Clinical High Risk for Psychosis (CHR-P). Study 3 validated externally the prognostic accuracy of a newly developed Semistructured Interview of At Risk Bipolar States (SIBARS) in an independent prospective CHR-P cohort. In study 1 (n = 205), those meeting BAR criteria had an increased risk of developing bipolar disorders (HR = 5.30) relative to those not meeting them, but the prognostic accuracy was poor (Harrell's C = 0.659). In study 2 (n = 205), those meeting the refined BARS criteria had a higher risk of developing bipolar disorders than those not meeting them (HR = 12.364), with an adequate prognostic accuracy (Harrell's C = 0.777). Study 3 (n = 71) confirmed that SIBARS criteria had an adequate prognostic accuracy (Harrell's C = 0.742) and clinical utility. Overall, these findings suggest that the SIBARS could be used for the detection of individuals at risk of developing bipolar disorders in CHR-P services.

Original language	English
Pages (from-to)	302-309
Journal	Psychiatry Research
Volume	264
Early online date	24 Apr 2018
DOIs	https://doi.org/10.1016/j.psychres.2018.03.074
Publication status	Published - Jun 2018

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10.1016/j.psychres.2018.03.074

Semistructured interview for bipolar_FUSAR-POLI_Accepted27March2018_GREEN AAMAccepted author manuscript, 349 KBLicence: CC BY-NC-ND

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@article{e8d7692ea2ba4a13ba12246114f642a2,

title = "Semistructured Interview for Bipolar At Risk States (SIBARS)",

abstract = "The external prognostic accuracy of Bipolar At Risk (BAR) criteria is undetermined and no psychometric tools are available to measure them. We present here three studies that overcome these limitations. Study 1 and 2 investigated the prognostic accuracy (Harrell's C) of the original BAR and revised Bipolar At Risk States (BARS) criteria respectively for the prediction of bipolar disorders, using a retrospective cohort of individuals at Clinical High Risk for Psychosis (CHR-P). Study 3 validated externally the prognostic accuracy of a newly developed Semistructured Interview of At Risk Bipolar States (SIBARS) in an independent prospective CHR-P cohort. In study 1 (n = 205), those meeting BAR criteria had an increased risk of developing bipolar disorders (HR = 5.30) relative to those not meeting them, but the prognostic accuracy was poor (Harrell's C = 0.659). In study 2 (n = 205), those meeting the refined BARS criteria had a higher risk of developing bipolar disorders than those not meeting them (HR = 12.364), with an adequate prognostic accuracy (Harrell's C = 0.777). Study 3 (n = 71) confirmed that SIBARS criteria had an adequate prognostic accuracy (Harrell's C = 0.742) and clinical utility. Overall, these findings suggest that the SIBARS could be used for the detection of individuals at risk of developing bipolar disorders in CHR-P services.",

author = "Paolo Fusar-Poli and {De Micheli}, Andrea and Matteo Rocchetti and Marco Cappucciati and Valentina Ramella-Cravaro and Grazia Rutigliano and Ilaria Bonoldi and Philip McGuire and Irina Falkenberg",

year = "2018",

month = jun,

doi = "10.1016/j.psychres.2018.03.074",

language = "English",

volume = "264",

pages = "302--309",

journal = "Psychiatry Research",

issn = "0165-1781",

publisher = "Elsevier",

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T1 - Semistructured Interview for Bipolar At Risk States (SIBARS)

AU - Fusar-Poli, Paolo

AU - De Micheli, Andrea

AU - Rocchetti, Matteo

AU - Cappucciati, Marco

AU - Ramella-Cravaro, Valentina

AU - Rutigliano, Grazia

AU - Bonoldi, Ilaria

AU - McGuire, Philip

AU - Falkenberg, Irina

PY - 2018/6

Y1 - 2018/6

N2 - The external prognostic accuracy of Bipolar At Risk (BAR) criteria is undetermined and no psychometric tools are available to measure them. We present here three studies that overcome these limitations. Study 1 and 2 investigated the prognostic accuracy (Harrell's C) of the original BAR and revised Bipolar At Risk States (BARS) criteria respectively for the prediction of bipolar disorders, using a retrospective cohort of individuals at Clinical High Risk for Psychosis (CHR-P). Study 3 validated externally the prognostic accuracy of a newly developed Semistructured Interview of At Risk Bipolar States (SIBARS) in an independent prospective CHR-P cohort. In study 1 (n = 205), those meeting BAR criteria had an increased risk of developing bipolar disorders (HR = 5.30) relative to those not meeting them, but the prognostic accuracy was poor (Harrell's C = 0.659). In study 2 (n = 205), those meeting the refined BARS criteria had a higher risk of developing bipolar disorders than those not meeting them (HR = 12.364), with an adequate prognostic accuracy (Harrell's C = 0.777). Study 3 (n = 71) confirmed that SIBARS criteria had an adequate prognostic accuracy (Harrell's C = 0.742) and clinical utility. Overall, these findings suggest that the SIBARS could be used for the detection of individuals at risk of developing bipolar disorders in CHR-P services.

AB - The external prognostic accuracy of Bipolar At Risk (BAR) criteria is undetermined and no psychometric tools are available to measure them. We present here three studies that overcome these limitations. Study 1 and 2 investigated the prognostic accuracy (Harrell's C) of the original BAR and revised Bipolar At Risk States (BARS) criteria respectively for the prediction of bipolar disorders, using a retrospective cohort of individuals at Clinical High Risk for Psychosis (CHR-P). Study 3 validated externally the prognostic accuracy of a newly developed Semistructured Interview of At Risk Bipolar States (SIBARS) in an independent prospective CHR-P cohort. In study 1 (n = 205), those meeting BAR criteria had an increased risk of developing bipolar disorders (HR = 5.30) relative to those not meeting them, but the prognostic accuracy was poor (Harrell's C = 0.659). In study 2 (n = 205), those meeting the refined BARS criteria had a higher risk of developing bipolar disorders than those not meeting them (HR = 12.364), with an adequate prognostic accuracy (Harrell's C = 0.777). Study 3 (n = 71) confirmed that SIBARS criteria had an adequate prognostic accuracy (Harrell's C = 0.742) and clinical utility. Overall, these findings suggest that the SIBARS could be used for the detection of individuals at risk of developing bipolar disorders in CHR-P services.

U2 - 10.1016/j.psychres.2018.03.074

DO - 10.1016/j.psychres.2018.03.074

M3 - Article

SN - 0165-1781

VL - 264

SP - 302

EP - 309

JO - Psychiatry Research

JF - Psychiatry Research

ER -

Semistructured Interview for Bipolar At Risk States (SIBARS)

Abstract

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