Sensitivity of the modified Children's Yale-Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials

Lawrence Scahill; Denis G. Sukhodolsky; Emily Anderberg; Anastasia Dimitropoulos; James Dziura; Michael G. Aman; James McCracken; Elaine Tierney; Victoria Hallett; Karol Katz; Benedetto Vitiello; Christopher McDougle

doi:10.1177/1362361315574889

Sensitivity of the modified Children's Yale-Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials

Lawrence Scahill^*, Denis G. Sukhodolsky, Emily Anderberg, Anastasia Dimitropoulos, James Dziura, Michael G. Aman, James McCracken, Elaine Tierney, Victoria Hallett, Karol Katz, Benedetto Vitiello, Christopher McDougle

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Repetitive behavior is a core feature of autism spectrum disorder. We used 8-week data from two federally funded, multi-site, randomized trials with risperidone conducted by the Research Units on Pediatric Psychopharmacology Autism Network to evaluate the sensitivity of the Children's Yale-Brown Obsessive Compulsive Scale modified for autism spectrum disorder to detect change with treatment. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. In Study 2, 49 subjects received risperidone only and 75 subjects received risperidone plus parent training. The combined sample consisted of 187 boys and 38 girls (aged 4-17 years). At the medication-free baseline, the internal consistency on the Children's Yale-Brown Obsessive Compulsive Scale modified for autism spectrum disorder total score was excellent (Cronbach's alpha = 0.84) and the mean scores were similar across the four groups. Compared to placebo in Study 1, all three active treatment groups showed significant improvement (effect sizes: 0.74-0.88). There were no differences between active treatment groups. These results indicate that the Children's Yale-Brown Obsessive Compulsive Scale modified for autism spectrum disorder has acceptable test-retest as evidenced by the medium to high correlations in the placebo group and demonstrated sensitivity to change with treatment.

Original language	English
Pages (from-to)	145-152
Number of pages	8
Journal	Autism
Volume	20
Issue number	2
DOIs	https://doi.org/10.1177/1362361315574889
Publication status	Published - 1 Feb 2016

Keywords

autism spectrum disorder
clinical trials
outcome measurement
repetitive behavior
risperidone

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Scahill, L., Sukhodolsky, D. G., Anderberg, E., Dimitropoulos, A., Dziura, J., Aman, M. G., McCracken, J., Tierney, E., Hallett, V., Katz, K., Vitiello, B., & McDougle, C. (2016). Sensitivity of the modified Children's Yale-Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials. Autism, 20(2), 145-152. https://doi.org/10.1177/1362361315574889

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abstract = "Repetitive behavior is a core feature of autism spectrum disorder. We used 8-week data from two federally funded, multi-site, randomized trials with risperidone conducted by the Research Units on Pediatric Psychopharmacology Autism Network to evaluate the sensitivity of the Children's Yale-Brown Obsessive Compulsive Scale modified for autism spectrum disorder to detect change with treatment. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. In Study 2, 49 subjects received risperidone only and 75 subjects received risperidone plus parent training. The combined sample consisted of 187 boys and 38 girls (aged 4-17 years). At the medication-free baseline, the internal consistency on the Children's Yale-Brown Obsessive Compulsive Scale modified for autism spectrum disorder total score was excellent (Cronbach's alpha = 0.84) and the mean scores were similar across the four groups. Compared to placebo in Study 1, all three active treatment groups showed significant improvement (effect sizes: 0.74-0.88). There were no differences between active treatment groups. These results indicate that the Children's Yale-Brown Obsessive Compulsive Scale modified for autism spectrum disorder has acceptable test-retest as evidenced by the medium to high correlations in the placebo group and demonstrated sensitivity to change with treatment.",

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Scahill, L, Sukhodolsky, DG, Anderberg, E, Dimitropoulos, A, Dziura, J, Aman, MG, McCracken, J, Tierney, E, Hallett, V, Katz, K, Vitiello, B & McDougle, C 2016, 'Sensitivity of the modified Children's Yale-Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials', Autism, vol. 20, no. 2, pp. 145-152. https://doi.org/10.1177/1362361315574889

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AU - Scahill, Lawrence

AU - Sukhodolsky, Denis G.

AU - Anderberg, Emily

AU - Dimitropoulos, Anastasia

AU - Dziura, James

AU - Aman, Michael G.

AU - McCracken, James

AU - Tierney, Elaine

AU - Hallett, Victoria

AU - Katz, Karol

AU - Vitiello, Benedetto

AU - McDougle, Christopher

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AB - Repetitive behavior is a core feature of autism spectrum disorder. We used 8-week data from two federally funded, multi-site, randomized trials with risperidone conducted by the Research Units on Pediatric Psychopharmacology Autism Network to evaluate the sensitivity of the Children's Yale-Brown Obsessive Compulsive Scale modified for autism spectrum disorder to detect change with treatment. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. In Study 2, 49 subjects received risperidone only and 75 subjects received risperidone plus parent training. The combined sample consisted of 187 boys and 38 girls (aged 4-17 years). At the medication-free baseline, the internal consistency on the Children's Yale-Brown Obsessive Compulsive Scale modified for autism spectrum disorder total score was excellent (Cronbach's alpha = 0.84) and the mean scores were similar across the four groups. Compared to placebo in Study 1, all three active treatment groups showed significant improvement (effect sizes: 0.74-0.88). There were no differences between active treatment groups. These results indicate that the Children's Yale-Brown Obsessive Compulsive Scale modified for autism spectrum disorder has acceptable test-retest as evidenced by the medium to high correlations in the placebo group and demonstrated sensitivity to change with treatment.

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Sensitivity of the modified Children's Yale-Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials

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Keywords

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