Sensorimotor gating and clinical outcome following cognitive behaviour therapy for psychosis

Veena Kumari; Preethi Premkumar; Dominic Fannon; Ingrid Aasen; Satya Raghuvanshi; Anantha P. Anilkumar; Elena Antonova; Emmanuelle R. Peters; Elizabeth Kuipers

doi:10.1016/j.schres.2011.11.020

Sensorimotor gating and clinical outcome following cognitive behaviour therapy for psychosis

Veena Kumari, Preethi Premkumar, Dominic Fannon, Ingrid Aasen, Satya Raghuvanshi, Anantha P. Anilkumar, Elena Antonova, Emmanuelle R. Peters, Elizabeth Kuipers

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Background: Prepulse inhibition (PPI) of the startle response refers to the ability of a weak prestimulus to transiently inhibit the response to a closely following strong sensory stimulus. PPI provides an operational index of sensorimotor gating and is reduced, on average, in people with schizophrenia, relative to healthy people. Given the variable response to Cognitive Behaviour Therapy for psychosis (CBTp) and positive associations between pre-therapy brain and cognitive functions and CBT outcome across disorders, we examined whether pre-therapy level of PPI is associated with clinical outcome following CBTp. Method: Fifty-six outpatients stable on medication with at least one distressing symptom of schizophrenia and willing to receive CBTp in addition to their usual treatment were assessed on acoustic PPI. Subsequently, 28 patients received CBTp (CBTp + treatment-as-usual, 23 completers) for 6-8 months and 28 continued with their treatment-as-usual (TAU-alone, 17 completers). Symptoms were assessed (blindly) at entry and follow-up. Results: The CBTp + TAU and TAU-alone groups did not differ demographically, clinically or in PPI at baseline. The CBTp + TAU group showed improved symptoms relative to the TAU-alone group, which showed no change, at follow-up. Pre-therapy PPI level correlated positively with post-CBTp symptom improvement. Conclusions: Relatively intact sensorimotor gating is associated with a good clinical response following a 6-8 months course of NICE compliant CBTp in schizophrenia. Pharmacological or psychological interventions capable of improving PPI may enhance the effectiveness of CBTp in people with schizophrenia, particularly in those who fail to show clinical improvement with currently available antipsychotic drugs and adjunctive CBTp. (C) 2011 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	232 - 238
Number of pages	7
Journal	Schizophrenia Research
Volume	134
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2011.11.020
Publication status	Published - Feb 2012

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10.1016/j.schres.2011.11.020

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@article{def8ca10289148c099d867eeaede1b91,

title = "Sensorimotor gating and clinical outcome following cognitive behaviour therapy for psychosis",

abstract = "Background: Prepulse inhibition (PPI) of the startle response refers to the ability of a weak prestimulus to transiently inhibit the response to a closely following strong sensory stimulus. PPI provides an operational index of sensorimotor gating and is reduced, on average, in people with schizophrenia, relative to healthy people. Given the variable response to Cognitive Behaviour Therapy for psychosis (CBTp) and positive associations between pre-therapy brain and cognitive functions and CBT outcome across disorders, we examined whether pre-therapy level of PPI is associated with clinical outcome following CBTp. Method: Fifty-six outpatients stable on medication with at least one distressing symptom of schizophrenia and willing to receive CBTp in addition to their usual treatment were assessed on acoustic PPI. Subsequently, 28 patients received CBTp (CBTp + treatment-as-usual, 23 completers) for 6-8 months and 28 continued with their treatment-as-usual (TAU-alone, 17 completers). Symptoms were assessed (blindly) at entry and follow-up. Results: The CBTp + TAU and TAU-alone groups did not differ demographically, clinically or in PPI at baseline. The CBTp + TAU group showed improved symptoms relative to the TAU-alone group, which showed no change, at follow-up. Pre-therapy PPI level correlated positively with post-CBTp symptom improvement. Conclusions: Relatively intact sensorimotor gating is associated with a good clinical response following a 6-8 months course of NICE compliant CBTp in schizophrenia. Pharmacological or psychological interventions capable of improving PPI may enhance the effectiveness of CBTp in people with schizophrenia, particularly in those who fail to show clinical improvement with currently available antipsychotic drugs and adjunctive CBTp. (C) 2011 Elsevier B.V. All rights reserved.",

author = "Veena Kumari and Preethi Premkumar and Dominic Fannon and Ingrid Aasen and Satya Raghuvanshi and Anilkumar, {Anantha P.} and Elena Antonova and Peters, {Emmanuelle R.} and Elizabeth Kuipers",

year = "2012",

month = feb,

doi = "10.1016/j.schres.2011.11.020",

language = "English",

volume = "134",

pages = "232 -- 238",

journal = "Schizophrenia Research",

issn = "1573-2509",

publisher = "Elsevier",

number = "2-3",

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T1 - Sensorimotor gating and clinical outcome following cognitive behaviour therapy for psychosis

AU - Kumari, Veena

AU - Premkumar, Preethi

AU - Fannon, Dominic

AU - Aasen, Ingrid

AU - Raghuvanshi, Satya

AU - Anilkumar, Anantha P.

AU - Antonova, Elena

AU - Peters, Emmanuelle R.

AU - Kuipers, Elizabeth

PY - 2012/2

Y1 - 2012/2

N2 - Background: Prepulse inhibition (PPI) of the startle response refers to the ability of a weak prestimulus to transiently inhibit the response to a closely following strong sensory stimulus. PPI provides an operational index of sensorimotor gating and is reduced, on average, in people with schizophrenia, relative to healthy people. Given the variable response to Cognitive Behaviour Therapy for psychosis (CBTp) and positive associations between pre-therapy brain and cognitive functions and CBT outcome across disorders, we examined whether pre-therapy level of PPI is associated with clinical outcome following CBTp. Method: Fifty-six outpatients stable on medication with at least one distressing symptom of schizophrenia and willing to receive CBTp in addition to their usual treatment were assessed on acoustic PPI. Subsequently, 28 patients received CBTp (CBTp + treatment-as-usual, 23 completers) for 6-8 months and 28 continued with their treatment-as-usual (TAU-alone, 17 completers). Symptoms were assessed (blindly) at entry and follow-up. Results: The CBTp + TAU and TAU-alone groups did not differ demographically, clinically or in PPI at baseline. The CBTp + TAU group showed improved symptoms relative to the TAU-alone group, which showed no change, at follow-up. Pre-therapy PPI level correlated positively with post-CBTp symptom improvement. Conclusions: Relatively intact sensorimotor gating is associated with a good clinical response following a 6-8 months course of NICE compliant CBTp in schizophrenia. Pharmacological or psychological interventions capable of improving PPI may enhance the effectiveness of CBTp in people with schizophrenia, particularly in those who fail to show clinical improvement with currently available antipsychotic drugs and adjunctive CBTp. (C) 2011 Elsevier B.V. All rights reserved.

AB - Background: Prepulse inhibition (PPI) of the startle response refers to the ability of a weak prestimulus to transiently inhibit the response to a closely following strong sensory stimulus. PPI provides an operational index of sensorimotor gating and is reduced, on average, in people with schizophrenia, relative to healthy people. Given the variable response to Cognitive Behaviour Therapy for psychosis (CBTp) and positive associations between pre-therapy brain and cognitive functions and CBT outcome across disorders, we examined whether pre-therapy level of PPI is associated with clinical outcome following CBTp. Method: Fifty-six outpatients stable on medication with at least one distressing symptom of schizophrenia and willing to receive CBTp in addition to their usual treatment were assessed on acoustic PPI. Subsequently, 28 patients received CBTp (CBTp + treatment-as-usual, 23 completers) for 6-8 months and 28 continued with their treatment-as-usual (TAU-alone, 17 completers). Symptoms were assessed (blindly) at entry and follow-up. Results: The CBTp + TAU and TAU-alone groups did not differ demographically, clinically or in PPI at baseline. The CBTp + TAU group showed improved symptoms relative to the TAU-alone group, which showed no change, at follow-up. Pre-therapy PPI level correlated positively with post-CBTp symptom improvement. Conclusions: Relatively intact sensorimotor gating is associated with a good clinical response following a 6-8 months course of NICE compliant CBTp in schizophrenia. Pharmacological or psychological interventions capable of improving PPI may enhance the effectiveness of CBTp in people with schizophrenia, particularly in those who fail to show clinical improvement with currently available antipsychotic drugs and adjunctive CBTp. (C) 2011 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.schres.2011.11.020

DO - 10.1016/j.schres.2011.11.020

M3 - Article

SN - 1573-2509

VL - 134

SP - 232

EP - 238

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 2-3

ER -

Sensorimotor gating and clinical outcome following cognitive behaviour therapy for psychosis

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