Separating Inhibitory and Excitatory Responses of Epileptic Brain to Single-Pulse Electrical Stimulation

Sepehr Shirani; Antonio Valentin; Gonzalo Alarcon; Farhana Kazi; Saeid Sanei

doi:10.1142/S0129065723500089

Separating Inhibitory and Excitatory Responses of Epileptic Brain to Single-Pulse Electrical Stimulation

Sepehr Shirani, Antonio Valentin, Gonzalo Alarcon, Farhana Kazi, Saeid Sanei

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

To enable an accurate recognition of neuronal excitability in an epileptic brain for modeling or localization of epileptic zone, here the brain response to single-pulse electrical stimulation (SPES) has been decomposed into its constituent components using adaptive singular spectrum analysis (SSA). Given the response at neuronal level, these components are expected to be the inhibitory and excitatory components. The prime objective is to thoroughly investigate the nature of delayed responses (elicited between 100[Formula: see text]ms-1 s after SPES) for localization of the epileptic zone. SSA is a powerful subspace signal analysis method for separation of single channel signals into their constituent uncorrelated components. The consistency in the results for both early and delayed brain responses verifies the usability of the approach.

Original language	English
Pages (from-to)	2350008
Journal	International Journal of Neural Systems
Volume	33
Issue number	2
DOIs	https://doi.org/10.1142/S0129065723500089
Publication status	Published - Feb 2023

Keywords

Humans
Electroencephalography/methods
Epilepsy/therapy
Brain
Brain Mapping/methods
Electric Stimulation/methods

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10.1142/S0129065723500089

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title = "Separating Inhibitory and Excitatory Responses of Epileptic Brain to Single-Pulse Electrical Stimulation",

abstract = "To enable an accurate recognition of neuronal excitability in an epileptic brain for modeling or localization of epileptic zone, here the brain response to single-pulse electrical stimulation (SPES) has been decomposed into its constituent components using adaptive singular spectrum analysis (SSA). Given the response at neuronal level, these components are expected to be the inhibitory and excitatory components. The prime objective is to thoroughly investigate the nature of delayed responses (elicited between 100[Formula: see text]ms-1 s after SPES) for localization of the epileptic zone. SSA is a powerful subspace signal analysis method for separation of single channel signals into their constituent uncorrelated components. The consistency in the results for both early and delayed brain responses verifies the usability of the approach.",

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author = "Sepehr Shirani and Antonio Valentin and Gonzalo Alarcon and Farhana Kazi and Saeid Sanei",

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AU - Alarcon, Gonzalo

AU - Kazi, Farhana

AU - Sanei, Saeid

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N2 - To enable an accurate recognition of neuronal excitability in an epileptic brain for modeling or localization of epileptic zone, here the brain response to single-pulse electrical stimulation (SPES) has been decomposed into its constituent components using adaptive singular spectrum analysis (SSA). Given the response at neuronal level, these components are expected to be the inhibitory and excitatory components. The prime objective is to thoroughly investigate the nature of delayed responses (elicited between 100[Formula: see text]ms-1 s after SPES) for localization of the epileptic zone. SSA is a powerful subspace signal analysis method for separation of single channel signals into their constituent uncorrelated components. The consistency in the results for both early and delayed brain responses verifies the usability of the approach.

AB - To enable an accurate recognition of neuronal excitability in an epileptic brain for modeling or localization of epileptic zone, here the brain response to single-pulse electrical stimulation (SPES) has been decomposed into its constituent components using adaptive singular spectrum analysis (SSA). Given the response at neuronal level, these components are expected to be the inhibitory and excitatory components. The prime objective is to thoroughly investigate the nature of delayed responses (elicited between 100[Formula: see text]ms-1 s after SPES) for localization of the epileptic zone. SSA is a powerful subspace signal analysis method for separation of single channel signals into their constituent uncorrelated components. The consistency in the results for both early and delayed brain responses verifies the usability of the approach.

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KW - Electroencephalography/methods

KW - Epilepsy/therapy

KW - Brain

KW - Brain Mapping/methods

KW - Electric Stimulation/methods

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DO - 10.1142/S0129065723500089

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JO - International Journal of Neural Systems

JF - International Journal of Neural Systems

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Separating Inhibitory and Excitatory Responses of Epileptic Brain to Single-Pulse Electrical Stimulation

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Keywords

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