Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

M Parkes; J C Barrett; N J Prescott; M Tremelling; C A Anderson; S A Fisher; R G Roberts; E R Nimmo; F R Cummings; D Soars; H Drummond; C W Lees; S A Khawaja; R Bagnall; D A Burke; C E Todhunter; T Ahmad; C M Onnie; W McArdle; D Strachan; G Bethel; C Bryan; C M Lewis; P Deloukas; A Forbes; J Sanderson; D P Jewell; J Satsangi; J C Mansfield; L Cardon; C G Mathew

doi:10.1038/ng2061

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

M Parkes, J C Barrett, N J Prescott, M Tremelling, C A Anderson, S A Fisher, R G Roberts, E R Nimmo, F R Cummings, D Soars, H Drummond, C W Lees, S A Khawaja, R Bagnall, D A Burke, C E Todhunter, T Ahmad, C M Onnie, W McArdle, D StrachanG Bethel, C Bryan, C M Lewis, P Deloukas, A Forbes, J Sanderson, D P Jewell, J Satsangi, J C Mansfield, L Cardon, C G Mathew

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Abstract

A genome- wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case- control sample. We obtained replication for the autophagy- inducing IRGM gene on chromosome 5q33.1 ( replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2- 3, PTPN2 and gene deserts on chromosomes 1q and 5p13

Original language	English
Pages (from-to)	830 - 832
Number of pages	3
Journal	Nature Genetics
Volume	39
Issue number	7
DOIs	https://doi.org/10.1038/ng2061
Publication status	Published - Jul 2007

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Parkes, M., Barrett, J. C., Prescott, N. J., Tremelling, M., Anderson, C. A., Fisher, S. A., Roberts, R. G., Nimmo, E. R., Cummings, F. R., Soars, D., Drummond, H., Lees, C. W., Khawaja, S. A., Bagnall, R., Burke, D. A., Todhunter, C. E., Ahmad, T., Onnie, C. M., McArdle, W., ... Mathew, C. G. (2007). Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nature Genetics, 39(7), 830 - 832. https://doi.org/10.1038/ng2061

@article{e63d917e18e440e2ac7d1b5d1a13efd8,

title = "Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility",

abstract = "A genome- wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case- control sample. We obtained replication for the autophagy- inducing IRGM gene on chromosome 5q33.1 ( replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2- 3, PTPN2 and gene deserts on chromosomes 1q and 5p13",

author = "M Parkes and Barrett, {J C} and Prescott, {N J} and M Tremelling and Anderson, {C A} and Fisher, {S A} and Roberts, {R G} and Nimmo, {E R} and Cummings, {F R} and D Soars and H Drummond and Lees, {C W} and Khawaja, {S A} and R Bagnall and Burke, {D A} and Todhunter, {C E} and T Ahmad and Onnie, {C M} and W McArdle and D Strachan and G Bethel and C Bryan and Lewis, {C M} and P Deloukas and A Forbes and J Sanderson and Jewell, {D P} and J Satsangi and Mansfield, {J C} and L Cardon and Mathew, {C G}",

year = "2007",

month = jul,

doi = "10.1038/ng2061",

language = "English",

volume = "39",

pages = "830 -- 832",

journal = "Nature Genetics",

issn = "1546-1718",

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Parkes, M, Barrett, JC, Prescott, NJ, Tremelling, M, Anderson, CA, Fisher, SA , Roberts, RG, Nimmo, ER, Cummings, FR, Soars, D, Drummond, H, Lees, CW, Khawaja, SA, Bagnall, R, Burke, DA, Todhunter, CE, Ahmad, T, Onnie, CM, McArdle, W, Strachan, D, Bethel, G, Bryan, C, Lewis, CM, Deloukas, P, Forbes, A, Sanderson, J, Jewell, DP, Satsangi, J, Mansfield, JC, Cardon, L & Mathew, CG 2007, 'Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility', Nature Genetics, vol. 39, no. 7, pp. 830 - 832. https://doi.org/10.1038/ng2061

TY - JOUR

T1 - Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

AU - Parkes, M

AU - Barrett, J C

AU - Prescott, N J

AU - Tremelling, M

AU - Anderson, C A

AU - Fisher, S A

AU - Roberts, R G

AU - Nimmo, E R

AU - Cummings, F R

AU - Soars, D

AU - Drummond, H

AU - Lees, C W

AU - Khawaja, S A

AU - Bagnall, R

AU - Burke, D A

AU - Todhunter, C E

AU - Ahmad, T

AU - Onnie, C M

AU - McArdle, W

AU - Strachan, D

AU - Bethel, G

AU - Bryan, C

AU - Lewis, C M

AU - Deloukas, P

AU - Forbes, A

AU - Sanderson, J

AU - Jewell, D P

AU - Satsangi, J

AU - Mansfield, J C

AU - Cardon, L

AU - Mathew, C G

PY - 2007/7

Y1 - 2007/7

N2 - A genome- wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case- control sample. We obtained replication for the autophagy- inducing IRGM gene on chromosome 5q33.1 ( replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2- 3, PTPN2 and gene deserts on chromosomes 1q and 5p13

AB - A genome- wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case- control sample. We obtained replication for the autophagy- inducing IRGM gene on chromosome 5q33.1 ( replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2- 3, PTPN2 and gene deserts on chromosomes 1q and 5p13

U2 - 10.1038/ng2061

DO - 10.1038/ng2061

M3 - Article

SN - 1546-1718

VL - 39

SP - 830

EP - 832

JO - Nature Genetics

JF - Nature Genetics

IS - 7

ER -

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Abstract

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