Funding Information:
Conflicts of interest These authors disclose the following: Rebecca C. Fitzgerald received an educational grant from Roche, is a share-holder and consultant for Cyted Ltd, and has received grant support from Medtronic. Emma Ococks has received honoraria and/or travel and accommodation expenses from Roche. Elizabeth Smyth has received an honorarium from Roche, Astellas, AstraZeneca, BMS, Merck, Celgene, Five Prime, Gritstone Oncology, and Servier. Shruti Sharma and Alexey Aleshin are employees of Natera, Inc, with stock/options to own stock in the company. Alvin Wei Tian Ng discloses no conflicts. CRediT Authorship Contributions Emma Ococks, MSci (Formal analysis: Lead; Visualization: Lead; Writing ? original draft: Equal). Shruti Sharma, PhD (Formal analysis: Equal; Visualization: Supporting; support with clinical interpretation: Equal). Alvin Wei Tian Ng, PhD (Data curation: Lead). Oesophageal Cancer Clinical and Molecular Stratification Consortium, UK (Consortium: Supporting). Alexey Aleshin, MD, MBA (support with clinical interpretation: Supporting). Rebecca C. Fitzgerald, MD (Funding acquisition: Lead; Supervision: Lead; Writing ? original draft: Equal). Elizabeth Smyth, MD (Supervision: Equal; Writing ? original draft: Equal). Funding Oesophageal Cancer Clinical and Molecular Stratification and whole genome sequencing of primary tumor samples was funded by a Cancer Research UK Program Grant (RG66287). The laboratory of RCF is funded by a Medical Research Council Core Program Grant. Plasma sample library preparation and sequencing cost was covered by Natera. Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium Rebecca C. Fitzgerald,1 Paul A.W. Edwards,1,2 Nicola Grehan,1 Barbara Nutzinger,1 Elwira Fidziukiewicz,1 Aisling M. Redmond,1 Alex Northrop,1 Sujath Abbas,1 Elizabeth C. Smyth,3 Maria O'Donovan,1,4 Ahmad Miremadi,1,4 Shalini Malhotra,1,4 Monika Tripathi,1,4 Amber Grantham,1 Calvin Cheah,1 Hannah Coles,1 Connor Flint,1 Matthew Eldridge,2 Maria Secrier,2 Ginny Devonshire,2 Sriganesh Jammula,2 Jim Davies,5 Charles Crichton,5 Nick Carroll,3 Richard H. Hardwick,3 Peter Safranek,3 Andrew Hindmarsh,3 Vijayendran Sujendran,3 Stephen J. Hayes,6,7 Yeng Ang,6,8,9 Andrew Sharrocks,9 Shaun R. Preston,10 Izhar Bagwan,10 Vicki Save,11 Richard J.E. Skipworth,11 Ted R. Hupp,12 J. Robert O'Neill,3,11,12 Olga Tucker,13,14 Andrew Beggs,13,15 Philippe Taniere,13 Sonia Puig,13 Gianmarco Contino,13 Timothy J. Underwood,16,17 Robert C. Walker,16,17 Ben L. Grace,16 Jesper Lagergren,18,19 James Gossage,18,20 Andrew Davies,18,20 Fuju Chang,18,20 Ula Mahadeva,18 Vicky Goh,20 Francesca D. Ciccarelli,20 Grant Sanders,21 Richard Berrisford,21 David Chan,21 Ed Cheong,22 Bhaskar Kumar,22 L. Sreedharan,22 Simon L. Parsons,23 Irshad Soomro,23 Philip Kaye,23 John Saunders,6,23 Laurence Lovat,24 Rehan Haidry,24 Michael Scott,25 Sharmila Sothi,26 Suzy Lishman,27 George B. Hanna,28 Christopher J. Peters,28 Krishna Moorthy,28 Anna Grabowska,29 Richard Turkington,30 Damian McManus,30 Helen Coleman,30 and Russell D. Petty.31 1Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge, Cambridge, United Kingdom; 2Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom; 3Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, United Kingdom; 4Department of Histopathology, Addenbrooke's Hospital, Cambridge, United Kingdom; 5Department of Computer Science, University of Oxford, Oxford, United Kingdom; 6Salford Royal National Health Service Foundation Trust, Salford, United Kingdom; 7Faculty of Medical and Human Sciences, University of Manchester, United Kingdom; 8Wigan and Leigh National Health Service Foundation Trust, Wigan, Manchester, United Kingdom; 9GI Science Centre, University of Manchester, United Kingdom; 10Royal Surrey County Hospital National Health Service Foundation Trust, Guildford, United Kingdom; 11Edinburgh Royal Infirmary, Edinburgh, United Kingdom; 12Edinburgh University, Edinburgh, United Kingdom; 13University Hospitals Birmingham National Health Service Foundation Trust, Birmingham, United Kingdom; 14Heart of England National Health Service Foundation Trust, Birmingham, United Kingdom; 15Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom; 16University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom; 17Cancer Sciences Division, University of Southampton, Southampton, United Kingdom; 18Guy's and St Thomas's National Health Service Foundation Trust, London, United Kingdom; 19Karolinska Institute, Stockholm, Sweden; 20King's College London, London, United Kingdom; 21Plymouth Hospitals National Health Service Trust, Plymouth, United Kingdom; 22Norfolk and Norwich University Hospital National Health Service Foundation Trust, Norwich, United Kingdom; 23Nottingham University Hospitals National Health Service Trust, Nottingham, United Kingdom; 24University College London, London, United Kingdom; 25Wythenshawe Hospital, Manchester, United Kingdom; 26University Hospitals Coventry and Warwickshire National Health Service Trust, Coventry, United Kingdom; 27Peterborough Hospitals National Health Service Trust, Peterborough City Hospital, Peterborough, United Kingdom; 28Department of Surgery and Cancer, Imperial College, London, United Kingdom; 29Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom; 30Centre for Cancer Research and Cell Biology, Queen's University Belfast, Northern Ireland, United Kingdom; 31Tayside Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom.