Serum glucose, triglycerides and cholesterol in relation to prostate cancer death in the Swedish AMORIS study

Rhonda Arthur, Henrik Møller, Hans Garmo, Christel Häggström, Lars Holmberg, Pär Stattin, Håkan Malmström, Mats Lambe, Niklas Hammar, Göran Walldius, David Robinson, Ingmar Jungner, Mieke Van Hemelrijck

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    Abstract

    Purpose
    Lifestyle-related conditions such as obesity are associated with prostate cancer progression, but the associations with hyperglycemia and dyslipidemia are unclear. This study, therefore, aims to examine the association of glucose, triglycerides, and total cholesterol with prostate cancer death.

    Methods
    From the Swedish AMORIS cohort, we selected 14,150 men diagnosed with prostate cancer between 1996 and 2011 who had prediagnostic measurements of serum glucose, triglycerides, and total cholesterol. Multivariable Cox proportional hazards regression models were used to determine the hazard ratios for death in relation to the aforementioned metabolic markers.

    Results
    Using clinical cut-off points, a non-significant positive association was observed between glucose and prostate cancer death. When compared to those with glucose in the lowest quartile, those in the highest quartile had greater risk of prostate cancer death (HR 1.19; 95% CI 1.02–1.39). However, neither total cholesterol nor triglycerides were associated with prostate cancer death. Glucose and triglycerides were positively associated with overall, cardiovascular, and other deaths. Hypercholesterolemia was only associated with risk of CVD death.

    Conclusion
    Our results suggest that glucose levels may influence prostate cancer survival, but further studies using repeated measurements are needed to further elucidate how glucose levels may influence prostate cancer progression.
    Original languageEnglish
    JournalCancer Causes and Control
    Early online date12 Nov 2018
    DOIs
    Publication statusPublished - 12 Nov 2018

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