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Serum glutamine, set-shifting ability and anorexia nervosa

Research output: Contribution to journalArticle

Michiko Nakazato, Kenji Hashimoto, Ulrike Schmidt, Kate Tchanturia, Iain C Campbell, David A Collier, Masaomi Iyo, Janet Treasure

Original languageEnglish
Article number29
JournalAnnals of General Psychiatry
Volume9
DOIs
Publication statusPublished - 25 Jun 2010

King's Authors

Abstract

Set-shifting is impaired in people with anorexia nervosa (AN), but the underlying physiological and biochemical processes are unclear. Animal studies have established that glutamatergic pathways in the prefrontal cortex play an important role in set-shifting ability. However, it is not yet understood whether levels of serum glutamatergic amino acids are associated with set-shifting performance in humans. The aim of this study was to determine whether serum concentrations of amino acids related to glutamatergic neurotransmission (glutamine, glutamate, glycine, l-serine, d-serine) are associated with set-shifting ability in people with acute AN and those after recovery.

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