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Serum IgG Is Associated With Risk of Melanoma in the Swedish AMORIS Study

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Serum IgG Is Associated With Risk of Melanoma in the Swedish AMORIS Study. / Kessler, Anna; Sollie, Sam; Karagiannis, Sophia N; Walldius, Goran; Hammar, Niklas; Van Hemelrijck, Mieke.

In: Frontiers in oncology, Vol. 9, No. OCT, 1095, 29.10.2019.

Research output: Contribution to journalArticle

Harvard

Kessler, A, Sollie, S, Karagiannis, SN, Walldius, G, Hammar, N & Van Hemelrijck, M 2019, 'Serum IgG Is Associated With Risk of Melanoma in the Swedish AMORIS Study', Frontiers in oncology, vol. 9, no. OCT, 1095. https://doi.org/10.3389/fonc.2019.01095

APA

Kessler, A., Sollie, S., Karagiannis, S. N., Walldius, G., Hammar, N., & Van Hemelrijck, M. (2019). Serum IgG Is Associated With Risk of Melanoma in the Swedish AMORIS Study. Frontiers in oncology, 9(OCT), [1095]. https://doi.org/10.3389/fonc.2019.01095

Vancouver

Kessler A, Sollie S, Karagiannis SN, Walldius G, Hammar N, Van Hemelrijck M. Serum IgG Is Associated With Risk of Melanoma in the Swedish AMORIS Study. Frontiers in oncology. 2019 Oct 29;9(OCT). 1095. https://doi.org/10.3389/fonc.2019.01095

Author

Kessler, Anna ; Sollie, Sam ; Karagiannis, Sophia N ; Walldius, Goran ; Hammar, Niklas ; Van Hemelrijck, Mieke. / Serum IgG Is Associated With Risk of Melanoma in the Swedish AMORIS Study. In: Frontiers in oncology. 2019 ; Vol. 9, No. OCT.

Bibtex Download

@article{42dea046265247ce9f4883ca77e1997b,
title = "Serum IgG Is Associated With Risk of Melanoma in the Swedish AMORIS Study",
abstract = "Background: Relatively little is known about the role of the humoral immune system in melanoma. Tumor infiltrating B cells in melanoma patients have been associated with increased T cell activation in tumors as well as improved patient survival. Immunoglobulins may play an important part in the anti-tumor immune response. We hypothesized that increased levels of pre-diagnostic serum Ig may be protective against melanoma development. Hence, we evaluated associations between pre-diagnostic serum markers of the immunoglobulin A (IgA), IgG and IgM, and risk of developing melanoma in the Swedish Apolipoprotein-related MORtality RISk (AMORIS) study. Methods: Study participants aged ≥20 years with baseline measurements of IgG, IgA and IgM taken between 1985 and 1996 were selected (n = 29,876). All individuals were free from melanoma at baseline and 162 study participants developed melanoma during follow up. Cox proportional hazards regression was carried out for medical cut-offs of IgA, IgG, and IgM. Results: Compared to the reference level of 6.10–14.99 g/l, we observed a positive but not significant association with risk of melanoma for those with IgG levels <6.10 g/L [HR: 1.05 (95{\%} CI 0.39–2.86)] and an inverse association for those with IgG levels ≥15.00 g/L [HR: 0.60 (95{\%} CI 0.34–1.05); P trend = 0.08]. No associations with serum IgA or IgM were identified. Conclusions: The humoral response might provide a protective role against the development of melanoma, mediated through IgG. Further research is needed to characterize this response which may be exploitable for development of future therapies.",
keywords = "AMORIS cohort, Humoral immunity, IgG, Immunoglobin, Melanoma, Melanoma risk",
author = "Anna Kessler and Sam Sollie and Karagiannis, {Sophia N} and Goran Walldius and Niklas Hammar and {Van Hemelrijck}, Mieke",
note = "Copyright {\circledC} 2019 Kessler, Sollie, Karagiannis, Walldius, Hammar and Van Hemelrijck.",
year = "2019",
month = "10",
day = "29",
doi = "10.3389/fonc.2019.01095",
language = "English",
volume = "9",
journal = "Frontiers in oncology",
issn = "2234-943X",
publisher = "Frontiers Media S.A.",
number = "OCT",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Serum IgG Is Associated With Risk of Melanoma in the Swedish AMORIS Study

AU - Kessler, Anna

AU - Sollie, Sam

AU - Karagiannis, Sophia N

AU - Walldius, Goran

AU - Hammar, Niklas

AU - Van Hemelrijck, Mieke

N1 - Copyright © 2019 Kessler, Sollie, Karagiannis, Walldius, Hammar and Van Hemelrijck.

PY - 2019/10/29

Y1 - 2019/10/29

N2 - Background: Relatively little is known about the role of the humoral immune system in melanoma. Tumor infiltrating B cells in melanoma patients have been associated with increased T cell activation in tumors as well as improved patient survival. Immunoglobulins may play an important part in the anti-tumor immune response. We hypothesized that increased levels of pre-diagnostic serum Ig may be protective against melanoma development. Hence, we evaluated associations between pre-diagnostic serum markers of the immunoglobulin A (IgA), IgG and IgM, and risk of developing melanoma in the Swedish Apolipoprotein-related MORtality RISk (AMORIS) study. Methods: Study participants aged ≥20 years with baseline measurements of IgG, IgA and IgM taken between 1985 and 1996 were selected (n = 29,876). All individuals were free from melanoma at baseline and 162 study participants developed melanoma during follow up. Cox proportional hazards regression was carried out for medical cut-offs of IgA, IgG, and IgM. Results: Compared to the reference level of 6.10–14.99 g/l, we observed a positive but not significant association with risk of melanoma for those with IgG levels <6.10 g/L [HR: 1.05 (95% CI 0.39–2.86)] and an inverse association for those with IgG levels ≥15.00 g/L [HR: 0.60 (95% CI 0.34–1.05); P trend = 0.08]. No associations with serum IgA or IgM were identified. Conclusions: The humoral response might provide a protective role against the development of melanoma, mediated through IgG. Further research is needed to characterize this response which may be exploitable for development of future therapies.

AB - Background: Relatively little is known about the role of the humoral immune system in melanoma. Tumor infiltrating B cells in melanoma patients have been associated with increased T cell activation in tumors as well as improved patient survival. Immunoglobulins may play an important part in the anti-tumor immune response. We hypothesized that increased levels of pre-diagnostic serum Ig may be protective against melanoma development. Hence, we evaluated associations between pre-diagnostic serum markers of the immunoglobulin A (IgA), IgG and IgM, and risk of developing melanoma in the Swedish Apolipoprotein-related MORtality RISk (AMORIS) study. Methods: Study participants aged ≥20 years with baseline measurements of IgG, IgA and IgM taken between 1985 and 1996 were selected (n = 29,876). All individuals were free from melanoma at baseline and 162 study participants developed melanoma during follow up. Cox proportional hazards regression was carried out for medical cut-offs of IgA, IgG, and IgM. Results: Compared to the reference level of 6.10–14.99 g/l, we observed a positive but not significant association with risk of melanoma for those with IgG levels <6.10 g/L [HR: 1.05 (95% CI 0.39–2.86)] and an inverse association for those with IgG levels ≥15.00 g/L [HR: 0.60 (95% CI 0.34–1.05); P trend = 0.08]. No associations with serum IgA or IgM were identified. Conclusions: The humoral response might provide a protective role against the development of melanoma, mediated through IgG. Further research is needed to characterize this response which may be exploitable for development of future therapies.

KW - AMORIS cohort

KW - Humoral immunity

KW - IgG

KW - Immunoglobin

KW - Melanoma

KW - Melanoma risk

UR - http://www.scopus.com/inward/record.url?scp=85074521975&partnerID=8YFLogxK

U2 - 10.3389/fonc.2019.01095

DO - 10.3389/fonc.2019.01095

M3 - Article

C2 - 31737561

VL - 9

JO - Frontiers in oncology

JF - Frontiers in oncology

SN - 2234-943X

IS - OCT

M1 - 1095

ER -

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