Setting the clinical context to non-motor symptoms reflected by Park-pain, Park-sleep, and Park-autonomic subtypes of Parkinson's disease

Mubasher A Qamar; Phoebe Tall; Daniel van Wamelen; Yi Min Wan; Katarina Rukavina; Anna Fieldwalker; Donna Matthew; Valentina Leta; Kirsty Bannister; K Ray Chaudhuri

doi:10.1016/bs.irn.2023.08.012

Setting the clinical context to non-motor symptoms reflected by Park-pain, Park-sleep, and Park-autonomic subtypes of Parkinson's disease

Mubasher A Qamar, Phoebe Tall, Daniel van Wamelen, Yi Min Wan, Katarina Rukavina, Anna Fieldwalker, Donna Matthew, Valentina Leta, Kirsty Bannister, K Ray Chaudhuri

Department Basic and Clinical Neuroscience
1Department of Hepatology, Imperial College London, London, UK. 2Institute of Liver Studies at King's College School of Medicine at King's College Hospital, London, UK. 3Institute of Human Health and Performance, University College London, London, UK. 4Department of Asthma Allergy and Lung Biology, King's College London, London, UK. 5Division of Critical Care Medicine, University of Alberta, Edmonton, Canada.
Parkinson's Foundation Centre of Excellence and Department of Neurology and Neurosciences
Department of Orthodontics, Queen Mary's Hospital, Sidcup, King's College Hospital NHS Foundation Trust/King's College, London, UK.
Neuroimaging Department
Radboud University Medical Center
Central Modulation of Pain
Health Psychology Section, Psychology Department, Institute of Psychology, Psychiatry and Neuroscience, King's College London, United Kingdom.

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Non-motor symptoms (NMS) of Parkinson's disease (PD) are well described in both clinical practice and the literature, enabling their management and enhancing our understanding of PD. NMS can dominate the clinical pictures and NMS subtypes have recently been proposed, initially based on clinical observations, and later confirmed in data driven analyses of large datasets and in biomarker-based studies. In this chapter, we provide an update on what is known about three common subtypes of NMS in PD. The pain (Park-pain), sleep dysfunction (Park-sleep), and autonomic dysfunction (Park-autonomic), providing an overview of their individual classification, clinical manifestation, pathophysiology, diagnosis, and potential treatments.

Original language	English
Pages (from-to)	1-58
Number of pages	58
Journal	International Review of Neurobiology
Volume	174
DOIs	https://doi.org/10.1016/bs.irn.2023.08.012
Publication status	Published - Jan 2024

Keywords

Humans
Autonomic Nervous System Diseases/diagnosis
Pain/diagnosis
Parkinson Disease/complications
Sleep
Sleep Wake Disorders/diagnosis

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10.1016/bs.irn.2023.08.012

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Qamar, M. A., Tall, P., van Wamelen, D., Wan, Y. M., Rukavina, K., Fieldwalker, A., Matthew, D., Leta, V., Bannister, K., & Chaudhuri, K. R. (2024). Setting the clinical context to non-motor symptoms reflected by Park-pain, Park-sleep, and Park-autonomic subtypes of Parkinson's disease. International Review of Neurobiology, 174, 1-58. https://doi.org/10.1016/bs.irn.2023.08.012

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title = "Setting the clinical context to non-motor symptoms reflected by Park-pain, Park-sleep, and Park-autonomic subtypes of Parkinson's disease",

abstract = "Non-motor symptoms (NMS) of Parkinson's disease (PD) are well described in both clinical practice and the literature, enabling their management and enhancing our understanding of PD. NMS can dominate the clinical pictures and NMS subtypes have recently been proposed, initially based on clinical observations, and later confirmed in data driven analyses of large datasets and in biomarker-based studies. In this chapter, we provide an update on what is known about three common subtypes of NMS in PD. The pain (Park-pain), sleep dysfunction (Park-sleep), and autonomic dysfunction (Park-autonomic), providing an overview of their individual classification, clinical manifestation, pathophysiology, diagnosis, and potential treatments.",

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author = "Qamar, {Mubasher A} and Phoebe Tall and {van Wamelen}, Daniel and Wan, {Yi Min} and Katarina Rukavina and Anna Fieldwalker and Donna Matthew and Valentina Leta and Kirsty Bannister and Chaudhuri, {K Ray}",

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doi = "10.1016/bs.irn.2023.08.012",

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Qamar, MA, Tall, P, van Wamelen, D , Wan, YM , Rukavina, K , Fieldwalker, A, Matthew, D, Leta, V , Bannister, K & Chaudhuri, KR 2024, 'Setting the clinical context to non-motor symptoms reflected by Park-pain, Park-sleep, and Park-autonomic subtypes of Parkinson's disease', International Review of Neurobiology, vol. 174, pp. 1-58. https://doi.org/10.1016/bs.irn.2023.08.012

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AU - Qamar, Mubasher A

AU - Tall, Phoebe

AU - van Wamelen, Daniel

AU - Wan, Yi Min

AU - Rukavina, Katarina

AU - Fieldwalker, Anna

AU - Matthew, Donna

AU - Leta, Valentina

AU - Bannister, Kirsty

AU - Chaudhuri, K Ray

PY - 2024/1

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N2 - Non-motor symptoms (NMS) of Parkinson's disease (PD) are well described in both clinical practice and the literature, enabling their management and enhancing our understanding of PD. NMS can dominate the clinical pictures and NMS subtypes have recently been proposed, initially based on clinical observations, and later confirmed in data driven analyses of large datasets and in biomarker-based studies. In this chapter, we provide an update on what is known about three common subtypes of NMS in PD. The pain (Park-pain), sleep dysfunction (Park-sleep), and autonomic dysfunction (Park-autonomic), providing an overview of their individual classification, clinical manifestation, pathophysiology, diagnosis, and potential treatments.

AB - Non-motor symptoms (NMS) of Parkinson's disease (PD) are well described in both clinical practice and the literature, enabling their management and enhancing our understanding of PD. NMS can dominate the clinical pictures and NMS subtypes have recently been proposed, initially based on clinical observations, and later confirmed in data driven analyses of large datasets and in biomarker-based studies. In this chapter, we provide an update on what is known about three common subtypes of NMS in PD. The pain (Park-pain), sleep dysfunction (Park-sleep), and autonomic dysfunction (Park-autonomic), providing an overview of their individual classification, clinical manifestation, pathophysiology, diagnosis, and potential treatments.

KW - Humans

KW - Autonomic Nervous System Diseases/diagnosis

KW - Pain/diagnosis

KW - Parkinson Disease/complications

KW - Sleep

KW - Sleep Wake Disorders/diagnosis

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DO - 10.1016/bs.irn.2023.08.012

M3 - Review article

C2 - 38341227

SN - 0074-7742

VL - 174

SP - 1

EP - 58

JO - International Review of Neurobiology

JF - International Review of Neurobiology

ER -

Setting the clinical context to non-motor symptoms reflected by Park-pain, Park-sleep, and Park-autonomic subtypes of Parkinson's disease

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Keywords

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