TY - JOUR
T1 - Severe deprivation in early childhood leads to permanent growth stunting
T2 - Longitudinal analysis of height trajectories from childhood-to-adulthood
AU - the ERA Young Adult Follow-up team
AU - Sonuga-Barke, Edmund J.S.
AU - Hanć, Tomasz
AU - Stehli, Annamarie
AU - Trampush, Joey W.
AU - Kennedy, Mark
AU - Kreppner, Jana
AU - Rutter, Michael
AU - Swanson, James M.
N1 - Funding Information:
Funding: This work was supported by the Economic Social Research Council, Medical Research Council . The funders were not involved in any aspect of the research or writing of the paper.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2022/1
Y1 - 2022/1
N2 - Background: Childhood institutional deprivation is associated with growth stunting in childhood but long-term effects in adulthood remain uncertain. Objective: To examine the impact of global institutional deprivation experienced in early childhood on subsequent growth with a special focus on final adult height and puberty timing. Participants & setting: The study was originally set in the UK, though some adoptive families lived abroad by the time of the adult follow up. 165 individuals adopted by UK families before 43 months of age from Romanian orphanages after the fall of the Ceaușescu regime in the early 1990's were compared to 51 non-deprived UK adoptees, adopted before the age of 6 months. Methods: The English and Romanian Adoptees (ERA) study is a 20-year longitudinal natural experiment on the effects of institutional deprivation on development. Key growth milestones were extracted from growth curve modelling of height data collected at ages 4, 6, 11, 15 and 23 years using a Bayesian approach to fit the JPA2 model. Results: Deprivation effects on height were present at the take-off point of accelerating adolescent growth and persisted into adulthood – the largest effects being for individuals who experienced over six months of deprivation. Deprivation was associated with earlier take-off and achievement of peak height velocity of adolescent growth acceleration – an effect driven largely by females' data and correlated with parent ratings of pubertal development. Conclusions: Early deprivation appears to reset tempo of growth early in development leading to permanent growth stunting in adulthood and accelerated onset of puberty, specifically in females.
AB - Background: Childhood institutional deprivation is associated with growth stunting in childhood but long-term effects in adulthood remain uncertain. Objective: To examine the impact of global institutional deprivation experienced in early childhood on subsequent growth with a special focus on final adult height and puberty timing. Participants & setting: The study was originally set in the UK, though some adoptive families lived abroad by the time of the adult follow up. 165 individuals adopted by UK families before 43 months of age from Romanian orphanages after the fall of the Ceaușescu regime in the early 1990's were compared to 51 non-deprived UK adoptees, adopted before the age of 6 months. Methods: The English and Romanian Adoptees (ERA) study is a 20-year longitudinal natural experiment on the effects of institutional deprivation on development. Key growth milestones were extracted from growth curve modelling of height data collected at ages 4, 6, 11, 15 and 23 years using a Bayesian approach to fit the JPA2 model. Results: Deprivation effects on height were present at the take-off point of accelerating adolescent growth and persisted into adulthood – the largest effects being for individuals who experienced over six months of deprivation. Deprivation was associated with earlier take-off and achievement of peak height velocity of adolescent growth acceleration – an effect driven largely by females' data and correlated with parent ratings of pubertal development. Conclusions: Early deprivation appears to reset tempo of growth early in development leading to permanent growth stunting in adulthood and accelerated onset of puberty, specifically in females.
KW - Adoption
KW - Growth
KW - Height
KW - Institutional deprivation
KW - Puberty
KW - Subnutrition
UR - http://www.scopus.com/inward/record.url?scp=85120901519&partnerID=8YFLogxK
U2 - 10.1016/j.chiabu.2021.105427
DO - 10.1016/j.chiabu.2021.105427
M3 - Article
AN - SCOPUS:85120901519
SN - 0145-2134
VL - 123
JO - Child abuse & neglect
JF - Child abuse & neglect
M1 - 105427
ER -
