Sex differences in Health-Related Quality of Life (HRQoL) 10 years after stroke

Research output: Contribution to conference typesAbstractpeer-review


Background and Aims: The James Lind Alliance deems Quality of life after stroke among the top 10 research priorities. Several studies have identified sex differences, however inconsistent findings have been reported. This study investigates the HRQoL 10 years after stroke using the South London Stroke Register (SLSR). Methods: Data from 2,462 SLSR patients (1995-2018) were utilised, 45% were female and mean age (Standard deviation) 68 (15) years. Sociodemographic; stroke severity and health status information were obtained at time of first ever stroke, 3 months and annually thereafter. The primary outcomes were the mental component summary (MCS) and physical component summary (PCS) scores of the Short Form Health Survey 12 (SF-12). Separate mixed effects models were applied for the MCS; PCS and SF-12 items using the statistical software Stata (15.1). Results: The mean MCS (-1.82, 95% Confidence Interval [CI] -2.54 to -1.10, p<0.001) and PCS (-1.91, 95% CI -2.66 to -1.17, p<0.001) scores for women were significantly lower than for men respectively, after adjustment for sociodemographic factors and stroke severity. The profiles of PCS and MCS revealed a decline in HRQOL and a persistent gap between women and men up to 10 years after stroke. (Figure 1). Conclusions: Calculation of minimum clinically important differences and causes of this difference necessitate further work. Interventions to lessen declines in HRQoL should be considered. Trial registration number: N/A
Original languageEnglish
Publication statusPublished - 22 May 2019


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