TY - JOUR
T1 - SEX DIFFERENCES IN ISCHEMIC STROKE SUBTYPES, STROKE CARE AND OUTCOMES
T2 - THE SOUTH LONDON STROKE REGISTER
AU - Zhang, Jingxue
AU - Wolfe, Charles David Alexander
AU - Wang, Yanzhong
PY - 2019/5/22
Y1 - 2019/5/22
N2 - Background and Aims: To identify sex differences in ischemic stroke subtypes, stroke care and outcomes.Methods: From 1999 to 2016, 2684 first-ever ischemic stroke patients were recorded in the South London Stroke Register (SLSR). The SLSR data includes stroke subtypes (modified TOAST), sociodemographic factors, case mix, stroke care and pre-stroke risk factors, together with functional and survival outcome. Sex differences in poor outcomes (BI<15 or death) among subtypes were examined through multiple logistic regression analysis. Sex differences in survival outcomes among subtypes were examined using Kaplan-Meier curves and multivariate Cox proportional hazard models.Results: The mean age for stroke onset in women is 6 years higher than for men (74 vs. 68, P<0.001). Women are more likely to experience a poorer case mix (P<0.001). Cardioembolism (CE) stroke is more common in women (29.15% vs. 24.11%, P=0.003) and Small vessel occlusion (SVO) stroke is more common in men (28.27% vs. 23.71%, P=0.006). There was no difference between men and women with regard to the rates of stroke unit admission and secondary prevention management. After adjusting for confounding factors, there were no sex differences in poor outcomes identified; however, being female had a lower risk of death for ischemic stroke (Hazard Ratio (HR)=0.882, [95%CI: 0.790,0.984]).Conclusions: CE subtype is more common in women while SVO is more common in men. There were no significant sex differences in stroke care. After adjusting for potential confounding factors, women had a lower risk of death, however, there were no sex differences in poor outcomes.
AB - Background and Aims: To identify sex differences in ischemic stroke subtypes, stroke care and outcomes.Methods: From 1999 to 2016, 2684 first-ever ischemic stroke patients were recorded in the South London Stroke Register (SLSR). The SLSR data includes stroke subtypes (modified TOAST), sociodemographic factors, case mix, stroke care and pre-stroke risk factors, together with functional and survival outcome. Sex differences in poor outcomes (BI<15 or death) among subtypes were examined through multiple logistic regression analysis. Sex differences in survival outcomes among subtypes were examined using Kaplan-Meier curves and multivariate Cox proportional hazard models.Results: The mean age for stroke onset in women is 6 years higher than for men (74 vs. 68, P<0.001). Women are more likely to experience a poorer case mix (P<0.001). Cardioembolism (CE) stroke is more common in women (29.15% vs. 24.11%, P=0.003) and Small vessel occlusion (SVO) stroke is more common in men (28.27% vs. 23.71%, P=0.006). There was no difference between men and women with regard to the rates of stroke unit admission and secondary prevention management. After adjusting for confounding factors, there were no sex differences in poor outcomes identified; however, being female had a lower risk of death for ischemic stroke (Hazard Ratio (HR)=0.882, [95%CI: 0.790,0.984]).Conclusions: CE subtype is more common in women while SVO is more common in men. There were no significant sex differences in stroke care. After adjusting for potential confounding factors, women had a lower risk of death, however, there were no sex differences in poor outcomes.
U2 - DOI: 10.1177/2396987319845578
DO - DOI: 10.1177/2396987319845578
M3 - Meeting abstract
SN - 2396-9873
VL - 4
SP - 118
EP - 118
JO - European Stroke Journal
JF - European Stroke Journal
IS - 1_suppl
M1 - AS30-007
ER -
