Sex differences in peripheral not central immune responses to pain-inducing injury

Douglas M. Lopes; Natalia Malek; Michelle Edye; Sara Buskbjerg Jager; Sheridan McMurray; Stephen B. McMahon; Franziska Denk

doi:10.1038/s41598-017-16664-z

Sex differences in peripheral not central immune responses to pain-inducing injury

Douglas M. Lopes, Natalia Malek, Michelle Edye, Sara Buskbjerg Jager, Sheridan McMurray, Stephen B. McMahon^*, Franziska Denk

^*Corresponding author for this work

Wolfson SPaRC

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Abstract

Women suffer chronic pain more frequently than men. It is not clear whether this is due to differences in higher level cognitive processes or basic nociceptive responses. In this study we used a mouse model of neuropathic pain to dissociate these factors. We performed RNA-seq on purified peripheral afferent neurons, but found no striking differences in gene expression between male and female mice, neither before nor after nerve injury. Similarly, spinal cord immune responses between the sexes appeared to be indistinguishable when studied by flow cytometry or qRT-PCR. Differences emerged only upon studying peripheral immune cell infiltration into the dorsal root ganglion, suggesting that adaptive immune responses in neuropathic pain could be sexually dimorphic.

Original language	English
Article number	16460
Pages (from-to)	1-8
Number of pages	8
Journal	Scientific Reports
Volume	7
Issue number	1
Early online date	28 Nov 2017
DOIs	https://doi.org/10.1038/s41598-017-16664-z
Publication status	Published - 2017

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Sex diferences in peripheral_LOPES_Acc14Nov2017Epub28Nov2017_GOLD VoR(CC BY)Final published version, 2.71 MBLicence: CC BY

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AU - McMahon, Stephen B.

AU - Denk, Franziska

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Sex differences in peripheral not central immune responses to pain-inducing injury

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