King's College London

Research portal

Sex differences in peripheral not central immune responses to pain-inducing injury

Research output: Contribution to journalArticlepeer-review

Douglas M. Lopes, Natalia Malek, Michelle Edye, Sara Buskbjerg Jager, Sheridan McMurray, Stephen B. McMahon, Franziska Denk

Original languageEnglish
Article number16460
Pages (from-to)1-8
Number of pages8
JournalScientific Reports
Issue number1
Early online date28 Nov 2017
Accepted/In press14 Nov 2017
E-pub ahead of print28 Nov 2017


King's Authors


Women suffer chronic pain more frequently than men. It is not clear whether this is due to differences in higher level cognitive processes or basic nociceptive responses. In this study we used a mouse model of neuropathic pain to dissociate these factors. We performed RNA-seq on purified peripheral afferent neurons, but found no striking differences in gene expression between male and female mice, neither before nor after nerve injury. Similarly, spinal cord immune responses between the sexes appeared to be indistinguishable when studied by flow cytometry or qRT-PCR. Differences emerged only upon studying peripheral immune cell infiltration into the dorsal root ganglion, suggesting that adaptive immune responses in neuropathic pain could be sexually dimorphic.

Download statistics

No data available

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454