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Sex differences in trajectories of depression symptoms and associations with 10-year mortality in patients with stroke: The south london stroke register

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Sex differences in trajectories of depression symptoms and associations with 10-year mortality in patients with stroke : The south london stroke register. / Ayis, Salma A; Rudd, Anthony G; Ayerbe, Luis; Wolfe, Charles D A.

In: European Journal of Neurology, Vol. 26, No. 6, 01.06.2019, p. 872-879.

Research output: Contribution to journalArticle

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Ayis, SA, Rudd, AG, Ayerbe, L & Wolfe, CDA 2019, 'Sex differences in trajectories of depression symptoms and associations with 10-year mortality in patients with stroke: The south london stroke register', European Journal of Neurology, vol. 26, no. 6, pp. 872-879. https://doi.org/10.1111/ene.13899

APA

Ayis, S. A., Rudd, A. G., Ayerbe, L., & Wolfe, C. D. A. (2019). Sex differences in trajectories of depression symptoms and associations with 10-year mortality in patients with stroke: The south london stroke register. European Journal of Neurology, 26(6), 872-879. https://doi.org/10.1111/ene.13899

Vancouver

Ayis SA, Rudd AG, Ayerbe L, Wolfe CDA. Sex differences in trajectories of depression symptoms and associations with 10-year mortality in patients with stroke: The south london stroke register. European Journal of Neurology. 2019 Jun 1;26(6):872-879. https://doi.org/10.1111/ene.13899

Author

Ayis, Salma A ; Rudd, Anthony G ; Ayerbe, Luis ; Wolfe, Charles D A. / Sex differences in trajectories of depression symptoms and associations with 10-year mortality in patients with stroke : The south london stroke register. In: European Journal of Neurology. 2019 ; Vol. 26, No. 6. pp. 872-879.

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@article{379c34a737dc439f9e4e0b6b68cd8b53,
title = "Sex differences in trajectories of depression symptoms and associations with 10-year mortality in patients with stroke: The south london stroke register",
abstract = "Background and purpose: Depression is a common neuropsychiatric consequence of stroke. We identified trajectories of depression symptoms in men and women and examined their associations with 10-year all-cause mortality. Methods: Data were obtained from the South London Stroke Register (1998–2016). Socio-demographic, stroke severity and clinical measures were collected during the acute phase. The Hospital Anxiety and Depression Scale was used to screen for depression at 3 months after stroke and then annually. We used group-based trajectory models to identify trajectories of depression and Cox proportional hazards models to study the risk of mortality in them. Results: We studied 1275 men and 1038 women. Three trajectories of depression symptoms were identified in men: I-M (42.12{\%}), low and stable symptoms; II-M (46.51{\%}), moderate increasing symptoms; and III-M (11.37{\%}), severe persistent symptoms. Four trajectories were identified in women; I-F (29.09{\%}), low symptoms; II-F (49.81{\%}), moderate symptoms; III-F (16.28{\%}), severe symptoms; and IV-F (4.82{\%}), very severe symptoms, all with stable symptoms. The 10-year adjusted mortality hazard ratios in men were: 1.68 [95{\%} confidence interval (CI), 1.38–2.04] and 2.62 (95{\%} CI, 1.97–3.48) for trajectories II-M and III-M, respectively, compared with I-M. In women these were: 1.38 (95{\%} CI, 1.09–1.75), 1.65 (95{\%} CI, 1.23–2.20) and 2.81 (95{\%} CI, 1.90–4.16) for trajectories II-F, III-F and IV-F, respectively, compared with I-F. Conclusions: Depression trajectories varied independent of sex. Severe symptoms in women were double those in men. Moderate symptoms in men became worse over time. Increased symptoms of depression were associated with higher mortality rates. Data on symptom progression may help a better long-term management of patients with stroke.",
keywords = "depression, group-based trajectory modelling, Hospital Anxiety and Depression Scale, mortality, sex, stroke",
author = "Ayis, {Salma A} and Rudd, {Anthony G} and Luis Ayerbe and Wolfe, {Charles D A}",
year = "2019",
month = "6",
day = "1",
doi = "10.1111/ene.13899",
language = "English",
volume = "26",
pages = "872--879",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "6",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Sex differences in trajectories of depression symptoms and associations with 10-year mortality in patients with stroke

T2 - The south london stroke register

AU - Ayis, Salma A

AU - Rudd, Anthony G

AU - Ayerbe, Luis

AU - Wolfe, Charles D A

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Background and purpose: Depression is a common neuropsychiatric consequence of stroke. We identified trajectories of depression symptoms in men and women and examined their associations with 10-year all-cause mortality. Methods: Data were obtained from the South London Stroke Register (1998–2016). Socio-demographic, stroke severity and clinical measures were collected during the acute phase. The Hospital Anxiety and Depression Scale was used to screen for depression at 3 months after stroke and then annually. We used group-based trajectory models to identify trajectories of depression and Cox proportional hazards models to study the risk of mortality in them. Results: We studied 1275 men and 1038 women. Three trajectories of depression symptoms were identified in men: I-M (42.12%), low and stable symptoms; II-M (46.51%), moderate increasing symptoms; and III-M (11.37%), severe persistent symptoms. Four trajectories were identified in women; I-F (29.09%), low symptoms; II-F (49.81%), moderate symptoms; III-F (16.28%), severe symptoms; and IV-F (4.82%), very severe symptoms, all with stable symptoms. The 10-year adjusted mortality hazard ratios in men were: 1.68 [95% confidence interval (CI), 1.38–2.04] and 2.62 (95% CI, 1.97–3.48) for trajectories II-M and III-M, respectively, compared with I-M. In women these were: 1.38 (95% CI, 1.09–1.75), 1.65 (95% CI, 1.23–2.20) and 2.81 (95% CI, 1.90–4.16) for trajectories II-F, III-F and IV-F, respectively, compared with I-F. Conclusions: Depression trajectories varied independent of sex. Severe symptoms in women were double those in men. Moderate symptoms in men became worse over time. Increased symptoms of depression were associated with higher mortality rates. Data on symptom progression may help a better long-term management of patients with stroke.

AB - Background and purpose: Depression is a common neuropsychiatric consequence of stroke. We identified trajectories of depression symptoms in men and women and examined their associations with 10-year all-cause mortality. Methods: Data were obtained from the South London Stroke Register (1998–2016). Socio-demographic, stroke severity and clinical measures were collected during the acute phase. The Hospital Anxiety and Depression Scale was used to screen for depression at 3 months after stroke and then annually. We used group-based trajectory models to identify trajectories of depression and Cox proportional hazards models to study the risk of mortality in them. Results: We studied 1275 men and 1038 women. Three trajectories of depression symptoms were identified in men: I-M (42.12%), low and stable symptoms; II-M (46.51%), moderate increasing symptoms; and III-M (11.37%), severe persistent symptoms. Four trajectories were identified in women; I-F (29.09%), low symptoms; II-F (49.81%), moderate symptoms; III-F (16.28%), severe symptoms; and IV-F (4.82%), very severe symptoms, all with stable symptoms. The 10-year adjusted mortality hazard ratios in men were: 1.68 [95% confidence interval (CI), 1.38–2.04] and 2.62 (95% CI, 1.97–3.48) for trajectories II-M and III-M, respectively, compared with I-M. In women these were: 1.38 (95% CI, 1.09–1.75), 1.65 (95% CI, 1.23–2.20) and 2.81 (95% CI, 1.90–4.16) for trajectories II-F, III-F and IV-F, respectively, compared with I-F. Conclusions: Depression trajectories varied independent of sex. Severe symptoms in women were double those in men. Moderate symptoms in men became worse over time. Increased symptoms of depression were associated with higher mortality rates. Data on symptom progression may help a better long-term management of patients with stroke.

KW - depression

KW - group-based trajectory modelling

KW - Hospital Anxiety and Depression Scale

KW - mortality

KW - sex

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=85060788097&partnerID=8YFLogxK

U2 - 10.1111/ene.13899

DO - 10.1111/ene.13899

M3 - Article

VL - 26

SP - 872

EP - 879

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 6

ER -

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