King's College London

Funding Information: We appreciate V. Warrier’s advice on statistical methods for gene set enrichment analyses. We thank J. Spindel for sharing expertise on epigenetic data. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care, UK. Funding: This work was funded by the Wellcome Trust collaborative award for the Neuroscience in Psychiatry Network at University College London and the University of Cambridge Wellcome Trust collaborative award for the Neuroimmunology of Mood Disorders and Alzheimer’s Disease (NIMA) (grant number: 104025/Z/14/Z), which was also funded by Janssen, GlaxoSmithKline, Lundbeck, and Pfizer; NIH Research (NIHR) Cambridge Biomedical Research Centre (BRC-1215-20014) Mental Health Theme (to E.T.B.); NIH Research Senior Investigator award (to E.T.B.); Gates Cambridge Trust (to L.D.) MQ: Transforming Mental Health grant MQF17_24 (to P.E.V.), Alan Turing Institute (to S.E.M.), and EPSRC grant EP/N510129/1 (to P.E.V.); British Academy Post-Doctoral fellowship (to R.A.B.); Autism Research Trust (to R.A.B.); Cambridge Philosophical Society Henslow Fellowship Lucy Cavendish College, University of Cambridge (to S.E.M.); UK Research and Innovation (UKRI) Data to Early Diagnosis and Precision Medicine Industrial Strategy Challenge Fund (to F.V.); and MRC Clinical Research Infra-structure award MR/M009041/1. Author contributions: Research design: L.D., P.E.V., and E.T.B. Data analysis: L.D., R.A.B., and J.S. Research performance: L.D., R.R.-G., F.V., M.G.K., and P.E.V. Contribution of analytical tools: J.S., R.A.B., S.E.M., M.G.K., and A.R.A. Advice on statistical methods: S.R.W. NSPN study design: E.T.B., P.B.J., R.J.D., I.M.G., and P.F. BIODEP study design: E.T.B. and N.A.H. Manuscript writing: E.T.B., L.D., and P.E.V. Competing interests: E.T.B. serves on the Scientific Advisory Board of Sosei Heptares and as a consultant for GlaxoSmithKline, Boehringer Ingelheim, and Monument Therapeutics. The other authors declare that they have no competing interests. Data and materials availability: External gene lists used for the gene enrichment analyses are available in the respective cited manuscripts. All other data needed to evaluate the conclusions in the manuscript are archived at 10.5281/zenodo.6390851. The code required to run the analyses can be found at 10.5281/zenodo.6390752. Publisher Copyright: Copyright © 2022 The Authors, some rights reserved.