Shooting the messenger: The neurobiology of depression

Niall McCrae*, Ehsan Khan

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

1 Citation (Scopus)

Abstract

Depression is a very common disorder with both psychological and biological manifestations. The prevailing rationale for antidepressant drug treatment is the serotonin hypothesis, but this is no longer accepted as an adequate explanation for depressive disorder. The role of other neurotransmitters such as glutamate may be important, but there is much to be learned. This review considers current evidence for neurophysiological factors in depression, and implications for care and treatment.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalBritish Journal of Neuroscience Nursing
Volume10
Issue number4
DOIs
Publication statusPublished - 1 Aug 2014

Keywords

  • Antidepressants
  • Depression
  • Neurotransmitters
  • Serotonin

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