Short- and long-term plasticity at the axon initial segment

Matthew S Grubb; Yousheng Shu; Hiroshi Kuba; Matthew N Rasband; Verena C Wimmer; Kevin J Bender

doi:10.1523/JNEUROSCI.4064-11.2011

Short- and long-term plasticity at the axon initial segment

Matthew S Grubb, Yousheng Shu, Hiroshi Kuba, Matthew N Rasband, Verena C Wimmer, Kevin J Bender

Developmental Neurobiology

Research output: Contribution to journal › Article › peer-review

120 Citations (Scopus)

Abstract

The axon initial segment (AIS) is a highly specialized neuronal subregion that is the site of action potential initiation and the boundary between axonal and somatodendritic compartments. In recent years, our understanding of the molecular structure of the AIS, its maturation, and its multiple fundamental roles in neuronal function has seen major advances. We are beginning to appreciate that the AIS is dynamically regulated, both over short timescales via adaptations in ion channel function, and long timescales via activity-dependent structural reorganization. Here, we review results from this emerging field highlighting how structural and functional plasticity relate to the development of the initial segment, and to neuronal disorders linked to AIS dysfunction.

Original language	English
Pages (from-to)	16049-55
Number of pages	7
Journal	Journal of Neuroscience
Volume	31
Issue number	45
DOIs	https://doi.org/10.1523/JNEUROSCI.4064-11.2011
Publication status	Published - 9 Nov 2011

Keywords

Animals
Neurons
Humans
Nervous System Diseases
Ion Channels
Brain
Action Potentials
Axons
Neuronal Plasticity
Time Factors
Models, Biological

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10.1523/JNEUROSCI.4064-11.2011

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abstract = "The axon initial segment (AIS) is a highly specialized neuronal subregion that is the site of action potential initiation and the boundary between axonal and somatodendritic compartments. In recent years, our understanding of the molecular structure of the AIS, its maturation, and its multiple fundamental roles in neuronal function has seen major advances. We are beginning to appreciate that the AIS is dynamically regulated, both over short timescales via adaptations in ion channel function, and long timescales via activity-dependent structural reorganization. Here, we review results from this emerging field highlighting how structural and functional plasticity relate to the development of the initial segment, and to neuronal disorders linked to AIS dysfunction.",

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AU - Grubb, Matthew S

AU - Shu, Yousheng

AU - Kuba, Hiroshi

AU - Rasband, Matthew N

AU - Wimmer, Verena C

AU - Bender, Kevin J

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KW - Animals

KW - Neurons

KW - Humans

KW - Nervous System Diseases

KW - Ion Channels

KW - Brain

KW - Action Potentials

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KW - Neuronal Plasticity

KW - Time Factors

KW - Models, Biological

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DO - 10.1523/JNEUROSCI.4064-11.2011

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SP - 16049

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JO - Journal of Neuroscience

JF - Journal of Neuroscience

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Short- and long-term plasticity at the axon initial segment

Abstract

Keywords

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