Short-chain fatty acids as modulators of redox signaling in health and disease

TY - JOUR

T1 - Short-chain fatty acids as modulators of redox signaling in health and disease

AU - González-Bosch, Carmen

AU - Boorman, Emily

AU - Zunszain, Patricia A.

AU - Mann, Giovanni E.

N1 - Funding Information: The authors acknowledge the support of Heart Research UK (Ref. RG2672 , G.E.M.), British Heart Foundation ( FS/15/6/31298 , G.E.M.), Evgen Pharma (G.E.M.), Medical Research Council (E.B., P.Z., G.E.M.), Spanish Ministry of Science, Innovation and Universities ( PRX19/00247 , C.G.B.) Publisher Copyright: © 2021

PY - 2021/11

Y1 - 2021/11

N2 - Short-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet, have been linked to beneficial effects on human health associated with their metabolic and signaling properties. Their physiological functions are related to their aliphatic tail length and dependent on the activation of specific membrane receptors. In this review, we focus on the mechanisms underlying SCFAs mediated protection against oxidative and mitochondrial stress and their role in regulating metabolic pathways in specific tissues. We critically evaluate the evidence for their cytoprotective roles in suppressing inflammation and carcinogenesis and the consequences of aging. The ability of these natural compounds to induce signaling pathways, involving nuclear erythroid 2-related factor 2 (Nrf2), contributes to the maintenance of redox homeostasis under physiological conditions. SCFAs may thus serve as nutritional and therapeutic agents in healthy aging and in vascular and other diseases such as diabetes, neuropathologies and cancer.

AB - Short-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet, have been linked to beneficial effects on human health associated with their metabolic and signaling properties. Their physiological functions are related to their aliphatic tail length and dependent on the activation of specific membrane receptors. In this review, we focus on the mechanisms underlying SCFAs mediated protection against oxidative and mitochondrial stress and their role in regulating metabolic pathways in specific tissues. We critically evaluate the evidence for their cytoprotective roles in suppressing inflammation and carcinogenesis and the consequences of aging. The ability of these natural compounds to induce signaling pathways, involving nuclear erythroid 2-related factor 2 (Nrf2), contributes to the maintenance of redox homeostasis under physiological conditions. SCFAs may thus serve as nutritional and therapeutic agents in healthy aging and in vascular and other diseases such as diabetes, neuropathologies and cancer.

KW - Aging

KW - Cancer

KW - Cardiovascular diseases

KW - Epigenetics

KW - Inflammation

KW - Keap1-Nrf2

KW - Long-chain fatty acids

KW - Medium-chain fatty acid

KW - Neurodegenerative diseases

KW - Redox signaling

KW - Short-chain fatty acids

UR - http://www.scopus.com/inward/record.url?scp=85117244658&partnerID=8YFLogxK

U2 - 10.1016/j.redox.2021.102165

DO - 10.1016/j.redox.2021.102165

M3 - Article

AN - SCOPUS:85117244658

SN - 2213-2317

VL - 47

JO - Redox Biology

JF - Redox Biology

M1 - 102165

ER -