TY - JOUR
T1 - Short-term and medium-term clinical outcomes of multisystem inflammatory syndrome in children
T2 - a prospective observational cohort study
AU - Glazyrina, Anastasia
AU - Zholobova, Elena
AU - Iakovleva, Ekaterina
AU - Bobkova, Polina
AU - Krasnaya, Ekaterina
AU - Kovygina, Karina
AU - Romanova, Olga
AU - Blyuss, Oleg
AU - Tutelman, Konstantin
AU - Petrova, Polina
AU - Bairashevskaia, Anastasiia
AU - Rumyantsev, Mikhail
AU - Korsunskiy, Anatoliy A
AU - Kondrikova, Elena
AU - Nargizyan, Anzhelika
AU - Yusupova, Valeriya
AU - Korobyants, Evgeniya
AU - Sologub, Anna
AU - Kurbanova, Seda
AU - Suvorov, Aleksandr
AU - Sigfrid, Louise
AU - Buonsenso, Danilo
AU - Peroni, Diego G
AU - McArdle, Andrew James
AU - Comberiati, Pasquale
AU - Munblit, Daniel
N1 - Funding Information:
We are very grateful to the Municipal Children’s Hospital Morozovskaya clinical staff and to the patients, parents, carers, and families for their kindness and understanding during these difficult times of the COVID-19 pandemic. We are very thankful to FLIP, Eat & Talk, Luch, Black Market, and Academia for providing us with the workspace in time of need and for their support of COVID-19 research.
Publisher Copyright:
© 2023, The Author(s).
PY - 2024/1/4
Y1 - 2024/1/4
N2 - BACKGROUND: Even though the incidence of Multisystem Inflammatory Syndrome in children (MIS-C) is decreasing cases are still reported across the world. Studying the consequences of MIS-C enhances our understanding of the disease's prognosis. The objective of this study was to assess short- and medium-term clinical outcomes of MIS-C.METHODS: Prospective observational cohort study at Municipal Children's Hospital Morozovskaya, Moscow, Russia. All children meeting the Royal College of Paediatrics and Child Health (RCPCH), Centers for Disease Control and Prevention (CDC), or the World Health Organization (WHO) MIS-C case definition admitted to the hospital between 17 May and 26 October 2020 were included in the study. All survivors were invited to attend a clinic at 2 and 6 weeks after hospital discharge.RESULTS: 37 children median age 6 years (interquartile range [IQR] 3.3-9.4), 59.5% (22/37) boys were included in the study. 48.6% (18/37) of patients required ICU care. One child died. All children had increased levels of systemic inflammatory markers during the acute event. Echocardiographic investigations identified abnormal findings in 35.1% (13/37) of children. 5.6% (2/36) of children were presenting with any symptoms six weeks after discharge. By six weeks the inflammatory markers were within the reference norms in all children. The echocardiographic evaluation showed persistent coronary dilatation in one child.CONCLUSIONS: Despite the severity of their acute MIS-C, the majority of children in our cohort fully recovered with none having elevated laboratory markers of inflammation at 6 weeks, few (< 10%) reporting persistent symptoms at 6 weeks, and only one with persistent echocardiographic abnormalities.
AB - BACKGROUND: Even though the incidence of Multisystem Inflammatory Syndrome in children (MIS-C) is decreasing cases are still reported across the world. Studying the consequences of MIS-C enhances our understanding of the disease's prognosis. The objective of this study was to assess short- and medium-term clinical outcomes of MIS-C.METHODS: Prospective observational cohort study at Municipal Children's Hospital Morozovskaya, Moscow, Russia. All children meeting the Royal College of Paediatrics and Child Health (RCPCH), Centers for Disease Control and Prevention (CDC), or the World Health Organization (WHO) MIS-C case definition admitted to the hospital between 17 May and 26 October 2020 were included in the study. All survivors were invited to attend a clinic at 2 and 6 weeks after hospital discharge.RESULTS: 37 children median age 6 years (interquartile range [IQR] 3.3-9.4), 59.5% (22/37) boys were included in the study. 48.6% (18/37) of patients required ICU care. One child died. All children had increased levels of systemic inflammatory markers during the acute event. Echocardiographic investigations identified abnormal findings in 35.1% (13/37) of children. 5.6% (2/36) of children were presenting with any symptoms six weeks after discharge. By six weeks the inflammatory markers were within the reference norms in all children. The echocardiographic evaluation showed persistent coronary dilatation in one child.CONCLUSIONS: Despite the severity of their acute MIS-C, the majority of children in our cohort fully recovered with none having elevated laboratory markers of inflammation at 6 weeks, few (< 10%) reporting persistent symptoms at 6 weeks, and only one with persistent echocardiographic abnormalities.
KW - Male
KW - Humans
KW - Child
KW - Prospective Studies
KW - Systemic Inflammatory Response Syndrome/diagnosis
KW - Connective Tissue Diseases
KW - COVID-19
UR - http://www.scopus.com/inward/record.url?scp=85181503635&partnerID=8YFLogxK
U2 - 10.1186/s13052-023-01569-7
DO - 10.1186/s13052-023-01569-7
M3 - Article
C2 - 38178192
SN - 1720-8424
VL - 50
SP - 1
JO - Italian Journal Of Pediatrics
JF - Italian Journal Of Pediatrics
IS - 1
M1 - 1
ER -
