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Short-term cardiovascular effects of e-cigarettes in adults making a stop-smoking attempt: a randomized controlled trial

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Short-term cardiovascular effects of e-cigarettes in adults making a stop-smoking attempt: a randomized controlled trial. / Klonizakis, Markos; Gumber, Anil; McIntosh, Emma; Brose, Leonie.

In: BMC Medicine, 2020.

Research output: Contribution to journalArticle

Harvard

Klonizakis, M, Gumber, A, McIntosh, E & Brose, L 2020, 'Short-term cardiovascular effects of e-cigarettes in adults making a stop-smoking attempt: a randomized controlled trial', BMC Medicine.

APA

Klonizakis, M., Gumber, A., McIntosh, E., & Brose, L. (2020). Short-term cardiovascular effects of e-cigarettes in adults making a stop-smoking attempt: a randomized controlled trial. Manuscript in preparation.

Vancouver

Klonizakis M, Gumber A, McIntosh E, Brose L. Short-term cardiovascular effects of e-cigarettes in adults making a stop-smoking attempt: a randomized controlled trial. BMC Medicine. 2020.

Author

Klonizakis, Markos ; Gumber, Anil ; McIntosh, Emma ; Brose, Leonie. / Short-term cardiovascular effects of e-cigarettes in adults making a stop-smoking attempt: a randomized controlled trial. In: BMC Medicine. 2020.

Bibtex Download

@article{fda3e2c940eb49c3bf9383221073e734,
title = "Short-term cardiovascular effects of e-cigarettes in adults making a stop-smoking attempt: a randomized controlled trial",
abstract = "Background: Smoking is a major risk factor for cardiovascular disease and smoking cessation reduces excess risk. E-cigarettes are popular for smoking cessation but there is little evidence on their effect on cardiovascular health.Objective: To compare short-term cardiovascular effects in smokers who quit smoking using e-cigarettes with or without nicotine or prescription nicotine replacement therapy (NRT).Design: Single-centre pragmatic three-arm randomised (1: 1: 1) controlled trial with recruitment from May 2017 to June 2019.Setting: Sheffield, UK.Participants: Adult smokers of ≥10 cigarettes per day willing to attempt to stop smoking with support (n=284).Interventions: a) behavioural support and e-cigarettes with 18mg/ml nicotine; b) behavioural support and e-cigarettes without nicotine; c) behavioural support and NRT.Measurements: Flow Mediated Dilation ({\%}FMD), peak cutaneous vascular conductance (CVC max) responses to acetylcholine (ACh) and sodium nitroprusside (SNP), mean arterial pressure (MAP), recorded at baseline and three days after stopping smoking. General linear model using intention-to-treat approach and adjusting for age, gender, group, Body Mass Index or physical activity, and years smoked.Results: Adjusting for baseline, at follow-up, all outcomes with the exception of SNP had improved significantly over baseline and there were no differences between the three groups ({\%}FMD F=1.03, p=0.360, df=2,207; ACh F=0.172, p=0.84, df=2,207; SNP F=0.382, p=0.68, df=2,207; MAP F=0.176, p=0.84, df=2,207). For smokers≥ 20 cigarettes per day, benefits were particularly pronounced.Limitations: 16{\%} loss to follow-up, intervention limited to a single device and liquid manufacturer.Conclusion: Smoking cessation showed positive cardiovascular impact even after a short, 3-day period and the effects did not differ between nicotine-containing e-cigarettes, nicotine-free e-cigarettes, and NRT.",
author = "Markos Klonizakis and Anil Gumber and Emma McIntosh and Leonie Brose",
year = "2020",
language = "English",
journal = "BMC Medicine",
issn = "1741-7015",
publisher = "BIOMED CENTRAL LTD",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Short-term cardiovascular effects of e-cigarettes in adults making a stop-smoking attempt: a randomized controlled trial

AU - Klonizakis, Markos

AU - Gumber, Anil

AU - McIntosh, Emma

AU - Brose, Leonie

PY - 2020

Y1 - 2020

N2 - Background: Smoking is a major risk factor for cardiovascular disease and smoking cessation reduces excess risk. E-cigarettes are popular for smoking cessation but there is little evidence on their effect on cardiovascular health.Objective: To compare short-term cardiovascular effects in smokers who quit smoking using e-cigarettes with or without nicotine or prescription nicotine replacement therapy (NRT).Design: Single-centre pragmatic three-arm randomised (1: 1: 1) controlled trial with recruitment from May 2017 to June 2019.Setting: Sheffield, UK.Participants: Adult smokers of ≥10 cigarettes per day willing to attempt to stop smoking with support (n=284).Interventions: a) behavioural support and e-cigarettes with 18mg/ml nicotine; b) behavioural support and e-cigarettes without nicotine; c) behavioural support and NRT.Measurements: Flow Mediated Dilation (%FMD), peak cutaneous vascular conductance (CVC max) responses to acetylcholine (ACh) and sodium nitroprusside (SNP), mean arterial pressure (MAP), recorded at baseline and three days after stopping smoking. General linear model using intention-to-treat approach and adjusting for age, gender, group, Body Mass Index or physical activity, and years smoked.Results: Adjusting for baseline, at follow-up, all outcomes with the exception of SNP had improved significantly over baseline and there were no differences between the three groups (%FMD F=1.03, p=0.360, df=2,207; ACh F=0.172, p=0.84, df=2,207; SNP F=0.382, p=0.68, df=2,207; MAP F=0.176, p=0.84, df=2,207). For smokers≥ 20 cigarettes per day, benefits were particularly pronounced.Limitations: 16% loss to follow-up, intervention limited to a single device and liquid manufacturer.Conclusion: Smoking cessation showed positive cardiovascular impact even after a short, 3-day period and the effects did not differ between nicotine-containing e-cigarettes, nicotine-free e-cigarettes, and NRT.

AB - Background: Smoking is a major risk factor for cardiovascular disease and smoking cessation reduces excess risk. E-cigarettes are popular for smoking cessation but there is little evidence on their effect on cardiovascular health.Objective: To compare short-term cardiovascular effects in smokers who quit smoking using e-cigarettes with or without nicotine or prescription nicotine replacement therapy (NRT).Design: Single-centre pragmatic three-arm randomised (1: 1: 1) controlled trial with recruitment from May 2017 to June 2019.Setting: Sheffield, UK.Participants: Adult smokers of ≥10 cigarettes per day willing to attempt to stop smoking with support (n=284).Interventions: a) behavioural support and e-cigarettes with 18mg/ml nicotine; b) behavioural support and e-cigarettes without nicotine; c) behavioural support and NRT.Measurements: Flow Mediated Dilation (%FMD), peak cutaneous vascular conductance (CVC max) responses to acetylcholine (ACh) and sodium nitroprusside (SNP), mean arterial pressure (MAP), recorded at baseline and three days after stopping smoking. General linear model using intention-to-treat approach and adjusting for age, gender, group, Body Mass Index or physical activity, and years smoked.Results: Adjusting for baseline, at follow-up, all outcomes with the exception of SNP had improved significantly over baseline and there were no differences between the three groups (%FMD F=1.03, p=0.360, df=2,207; ACh F=0.172, p=0.84, df=2,207; SNP F=0.382, p=0.68, df=2,207; MAP F=0.176, p=0.84, df=2,207). For smokers≥ 20 cigarettes per day, benefits were particularly pronounced.Limitations: 16% loss to follow-up, intervention limited to a single device and liquid manufacturer.Conclusion: Smoking cessation showed positive cardiovascular impact even after a short, 3-day period and the effects did not differ between nicotine-containing e-cigarettes, nicotine-free e-cigarettes, and NRT.

M3 - Article

JO - BMC Medicine

JF - BMC Medicine

SN - 1741-7015

ER -

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